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Actin(g) toward a revised understanding of the role of cytoskeletal dynamics in neuronal bioenergetics

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Neural Regeneration Research 2024年第10期19卷 2109-2110页

作者： Sabrina M.Holland gianluca Gallo Department of Neural Sciences Shriners Pediatric Research CenterLewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

Neurons are energy-demanding *** in energy metabolism can quickly interrupt neuronal function,leading to cell death and *** instance,ischemia rapidly depletes adenosine triphosphate(ATP)thereby disrupting energy-dependent cellular processes crucial for homeostasis,and axon degeneration is preceded by a collapse of axonal ATP levels.

关键词： metabolism homeostasis degeneration

ARBITRARILY HIGH-ORDER ENERGY-CONSERVING METHODS FOR HAMILTONIAN PROBLEMS WITH QUADRATIC HOLONOMIC CONSTRAINTS

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Journal of Computational Mathematics 2024年第4期42卷 1145-1171页

作者： Pierluigi Amodio Luigi Brugnano gianluca Frasca-Caccia Felice Iavernaro Dipartimento di Matematica Università di BariItaly Dipartimento di Matematica e Informatica"U.Dini" Università di FirenzeItaly Dipartimento di Matematica Università di SalernoItaly

In this paper,we define arbitrarily high-order energy-conserving methods for Hamilto-nian systems with quadratic holonomic *** derivation of the methods is made within the so-called line integral *** tests to illustra... 详细信息

关键词： Constrained Hamiltonian systems Quadratic holonomic constraints Energy-conserving methods Line integral methods Hamiltonian Boundary Value Methods HB-VMs

Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo gianluca Tozzi Jonathan I.Dawson gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

Unveiling field-coupled nanocomputing:Leaning molecules to shape readable bits

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Nano Research 2024年第9期17卷 8447-8454页

作者： Yuri Ardesi Giuliana Beretta Fabrizio Mo Chiara Elfi Spano gianluca Piccinini Mariagrazia Graziano Corso Duca degli Abruzzi Department of Electronics and TelecommunicationsPolitecnico di TorinoTurin 10129Italy Corso Duca degli Abruzzi Department of Applied Science and TechnologyPolitecnico di TorinoTurin 10129Italy

Molecular field-coupled nanocomputing(molFCN)encodes information in the molecule charge distribution and elaborates it through electrostatic *** the advantageous sub-nanometric size and low-power dissipation,only a few attempts have been made to validate the technology *** of the obstacles is the difficulty in measuring molecule charges to validate information encoding or integrate molFCN with complementary-metal-oxide-semiconductor(CMOS).In this work,we propose a paradigm preserving the advantages of molFCN,which exploits the position of waiving molecules to augment the information *** validate the paradigm,named bend-boosted molFCN,with density functional theory using 6-(ferrocenyl)hexanethiol *** demonstrate that the encoded information can be electrically read by constituting a molecular *** paradigm is compatible with the charge-based molFCN,thus acting as a readout *** obtained results favor the experimental assessment of the molFCN principle through scanning probe microscopy techniques and the design of molFCN-CMOS heterogeneous circuits.

关键词： nanoelectronics molecular electronics field-coupled nanocomputing electronics beyond-complementary-metal-oxidesemiconductor(CMOS)

Beyond dentistry:could prevention and screening for neurodegenerative diseases start in the dental office?

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Neural Regeneration Research 2024年第1期19卷 156-157页

作者： Francesca R.Buccellato Daniela Galimberti gianluca M.Tartaglia Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilanItalyFondazione IRCCS Ca’GrandaOspedale Maggiore PoliclinicoMilanItaly

The differential diagnosis of neurodegenerative diseases is complex and relies on clinical assessment,biomarker levels in cerebrospinal fluid,neuroimaging and neuropsychological *** efforts of the scientific community are focused on two aspects:a)the discovery of minimally invasive biomarkers;b)the discovery of early biomarkers that can predict the progression to clinical disease in the presymptomatic stage of a *** the impact of the number of patients affected by chronic neurodegenerative diseases on public health expenditures,early diagnosis seems to be a primary need of our society.

关键词： diagnosis diseases prevention

In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

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Nano Research 2024年第2期17卷 875-881页

作者： Rossella Labarile Danilo Vona Maria Varsalona Matteo Grattieri Melania Reggente Roberto Comparelli gianluca M.Farinola Fabian Fischer Ardemis A.Boghossian Massimo Trotta Istituto per i Processi Chimico Fisici Consiglio Nazionale delle RicercheBari 70126Italy Dipartimento di Chimica Universitàdegli Studi di BariBari 70126Italy Institute of Chemical Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Institute of Life Technologies HES-SO Valais-Wallis1950 SionSwitzerland Institute for Renewable Energy HES-SO Valais-Wallis1950 SionSwitzerland

Recent advances in coupling light-harvesting microorganisms with electronic components have led to a new generation of biohybrid devices based on microbial *** devices are limited by the poorly conductive interface between phototrophs and synthetic materials that inhibit charge *** study focuses on overcoming this bottleneck through the metabolically-driven encapsulation of photosynthetic cells with a bio-inspired conductive *** of the purple non sulfur bacterium Rhodobacter sphaeroides were coated with a polydopamine(PDA)nanoparticle layer via the self-polymerization of dopamine under anaerobic *** treated cells show preserved light absorption of the photosynthetic pigments in the presence of dopamine concentrations ranging between 0.05–3.5 *** thickness and nanoparticle formation of the membrane-associated PDA matrix were further shown to vary with the dopamine concentrations in this *** to uncoated cells,the encapsulated cells show up to a 20-fold enhancement in transient photocurrent measurements under mediatorless *** biologically synthesized PDA can thus act as a matrix for electronically coupling the light-harvesting metabolisms of cells with conductive surfaces.

关键词： bioelectronics photosynthetic bacteria purple bacteria electron transfer polydopamine biophotovoltaics

Low-temperature replacement construction of three-dimensional corrosion-resistant interface for deeply rechargeable Zn metal batteries

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Nano Materials Science 2024年第3期6卷 329-336页

作者： Jinze Li Daniel Rohrens gianluca Dalfollo Xiaochao Wu Ziheng Lu Qiang Gao Bo Han Ruimin Sun Chenggang Zhou Jindi Wang Zhao Cai Faculty of Materials Science and Chemistry China University of GeosciencesWuhan430074China Institute of Inorganic Chemistry RWTH Aachen UniversityAachen52074Germany Microsoft Research AI4Science Beijing10080China Institute of New Energy on Chemical Storage and Power Sources College of Applied Chemistry and Environmental EngineeringYancheng Teachers UniversityYancheng224000China

Aqueous Zn batteries are promising candidates for grid-scale renewable energy *** electrodes have been widely investigated and applied as anode materials for aqueous Zn batteries,however,they suffer from limited surface area and severe interfacial issues including metallic dendrites and corrosion side reactions,limiting the depth of discharge(DOD)of the foil electrode ***,a low-temperature replacement reaction is utilized to in-situ construct a three-dimensional(3D)corrosion-resistant interface for deeply rechargeable Zn foil ***,the deliberate low-temperature environment controlled the replacement rate between polycrystalline Zn metal and oxalic acid,producing a Zn foil electrode with distinct 3D corrosion-resistant interface(3DCI-Zn),which differed from conventional two-dimensional(2D)protective structure and showed an order of magnitude higher surface ***,the 3DCI-Zn electrode exhibited dendrite-free and anticorrosion properties,and achieved stable plating/stripping performance for 1000 h at 10 mA cm^(-2)and 10 mAh cm^(-2)with a remarkable DOD of 79%.After pairing with a MnO2cathode with a high areal capacity of 4.2 mAh cm^(-2),the pouch cells delivered 168 Wh L^(-1)and a capacity retention of 89.7%after 100 cycles with a low negative/positive(N/P)ratio of 3:1.

关键词： Aqueous batteries Foil electrodes Depth of discharge Dendrites Corrosion side reactions

Management of hepatocellular carcinoma recurrence after liver surgery and thermal ablations:state of the art and future perspectives

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 71-88页

作者： Astrid Herrero Cyprien Toubert Jose Ursic Bedoya Eric Assenat Boris Guiu Fabrizio Panaro Thomas Bardol gianluca Cassese Department of HPB Surgery and Liver Transplantation Saint Eloi HospitalMontpellier UniversityMontpellierFrance Department of Hepatology and Liver Transplantation Saint Eloi HospitalMontpellier UniversityMontpellierFrance Department of Digestive Oncology Saint Eloi HospitalMontpellier UniversityMontpellierFrance Department of Radiology Saint Eloi HospitalMontpellier UniversityMontpellierFrance Laboratory of rare human Circulating Cells(LCCRH) University Medical Center of MontpellierMontpellierFrance Division of Minimally Invasive and Robotic HPB Surgery Department of Clinical Medicine and SurgeryFederico II University HospitalNaplesItaly

Despite the improvements in surgical and medical therapy for hepatocellular carcinoma(HCC),recurrence still represents a major *** to 70%of patients can experience HCC recurrence after liver resection(LR),as well as 20%of them even after liver transplantation(LT).The patterns of recurrence are different according to both the time and the ***,the risk factors and the management can change not only according to these patterns,but also according to the underlying liver condition and to the first treatment *** knowledge of such correlation is fundamental,since prevention and effective management of recurrence are undoubtedly the most important strategies to improve the outcomes of HCC *** adjuvant therapy,maintaining very close monitoring during the first 2 years in order to diagnose curable recurrence and continue this monitoring beyond 5 years because late recurrences exist,remains our only possibility *** represents the cornerstone treatment for HCC,including both LT and ***,new interesting therapeutic opportunities are coming from immunotherapy that has shown encouraging results also in the adjuvant *** such a complex and evolutionary scenario,the aim of this review is to summarize current strategies for the management of HCC recurrence,focusing on the different possible scenarios,as well as on future perspectives.

关键词： Hepatocellular carcinoma recurrence hepatocellular carcinoma management liver surgery liver transplantation thermal ablation(TA) survival after recurrence

Management of cerebral amyloid angiopathy and atrial fibrillation:We are still far from precision medicine

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World Journal of Cardiology 2024年第5期16卷 231-239页

作者： Liuba Fusco Zefferino Palamà Antonio Scarà Alessio Borrelli Antonio gianluca Robles Gabriele De Masi DeLuca Silvio Romano Luigi Sciarra Department of Cardiology University Hospital of NorthamptonshireNorthampton NN15BDUnited Kingdom Department of Cardiology Casa di Cura Villa VerdeTaranto 70124Italy Department of Life Health and Environmental SciencesUniversity of l'AquilaL'Aquila 67100Italy Department of Cardiology GVM Care and ResearchSan Carlo di Nancy HospitalRome 00100Italy

The use of anticoagulation therapy could prove to be controversial when trying to balance ischemic stroke and intracranial bleeding risks in patients with concurrent cerebral amyloid angiopathy(CAA)and atrial fibrillation(AF).In fact,CAA is an age-related cerebral vasculopathy that predisposes patients to intracerebral ***,many AF patients require oral systemic dose-adjusted warfarin,direct oral anticoagulants(such as factor Xa inhibitors)or direct thrombin inhibitors to control often associated with cardioembolic stroke *** prevalence of both CAA and AF is expected to rise,due to the aging of the *** clinical dilemma is becoming increasingly *** patients with coexisting AF and CAA,the risks/benefits profile of anticoagulant therapy must be assessed for each patient individually due to the lack of a clear-cut consensus with regard to its risks in scientific *** review aims to provide an overview of the management of patients with concomitant AF and CAA and proposes the implementation of a risk-based decision-making algorithm.

关键词： Anticoagulation Atrial fibrillation Cerebral amyloid angiopathy Intracerebral hemorrhage Stroke Watchman Secondary prevention Left atrial appendage closure