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N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat

World Journal of Gastroenterology 2003年第1期9卷 125-128页

作者： Resat Ozaras Veysel Tahan seval aydin Hafize Uzun Safiye Kaya Hakan Senturk Department of Infectious Diseases and Clinical Microbiology University of IstanbulIstanbulTurkey Department of Internal Medicine University of IstanbulIstanbulTurkey Department of Biochemistry University of IstanbulIstanbulTurkey

AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative *** aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ***: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver *** (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial ***-Wallis test was used for statistical ***: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P＝0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P＜0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P＜0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P＜0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model.

关键词： Oxidative Stress Acetylcysteine Animals Erythrocytes Ethanol dosage Free Radical Scavengers Glutathione Glutathione Peroxidase Lipid Peroxidation Liver Male Rats Rats, Wistar Research Support, Non-U.S. Gov't Superoxide Dismutase Thiobarbituric Acid Reactive Substances

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N-acetylcysteine attenuates alcohol-induced oxidative stess in rats

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World Journal of Gastroenterology 2003年第4期9卷 791-794页

AIM:To investigate free-radical scavenger effect of n- acetylcysteine in rats intragastrically fed with ethanol. METHODS:Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day,Group 1),ethanol and n- acetylcysteine (1 g/kg,Group 2),or isocaloric dextrose (control group,Group 3) for 4 *** animals were sacrificed under ether anesthesia,and intracardiac blood and liver tissues were *** were made in both serum and homogenized liver tissues. Malondialdehyde (MDA) level was measured by TBARS *** peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial kits. Kruskal-Wallis test was used for statistical analysis. RESULTS:ALT and AST in Group 1 (154 U/L and 302 U/L, respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001 for both).Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein) and Group 3 (0.94 nmol/ml and 49 nmol/100 mg-protein) (P<0.001 for both).On the other hand,serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2 (16 U/g Hb) and Group 3 (16 U/g-Hb) (P<0.001).Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26 U/100 rag-protein) were lower than that in Group 2 (18 U/ mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 rag-protein) (P<0.001 for both). CONCLUSION:Ethanol-induced liver damage was associated with oxidative stress,and co-administration of n-acetylolsteine attenuates this damage effectively in rat model.

关键词： Acetylcysteine Alanine Transaminase Animals Aspartate Aminotransferases Ethanol inhibitors Glutathione Glutathione Peroxidase Liver Male Malondialdehyde Oxidative Stress Rats Rats, Wistar Research Support, Non-U.S. Gov't Superoxide Dismutase

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Potential effects of L-NAME on alcohol-induced oxidative stress

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World Journal of Gastroenterology 2005年第4期11卷 600-604页

作者： Hafize Uzun Gonul Simsek seval aydin Ethem Unal Yesari Karter Nermin Karaturan Yelmen Suphi Vehid Asl Curgunlu Safiye Kaya Department of Biochemistry Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Physiology Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of General Surgery Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Internal Medicine Istanbul University Cerrahpapa School of MedicineIstanbulTurkey Department of Physiology Istanbul University Cerrahpapa School of MedicineIstanbul Turkey Department of Public Health Istanbul University Cerrahpapa School of MedicineIstanbulTurkey

AIM: Nitric oxide (NO) is a highly reactive oxidant synthesized from L-arginine by nitric oxide synthase (NOS). NO may cause injury through the generation of potent radicals. Nw-nitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 wk-period. METHODS: Thirty-six male Wistar rats were divided into 3 equal groups: group 1 (control group-isocaloric dextrose was given), group 2 (6 g/kg·d ethanol-induced group) and group 3 (both ethanol 6 g/kg·d and L-NAME 500 mg/L in drinking water-given group). Animals were sacrificed at the end of 4 wk-experimental period, and intracardiac blood and liver tissues were obtained. Biochemical measurements were performed both in plasma and in homogenized liver tissues. Alanine amino transferase (ALT), aspartate amino transferase (AST), malondialdehyde (MDA), NO, superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels were measured by spectrophotometry. RESULTS: ALT and AST in group 2 (62 U/L and 128 U/L, respectively) were higher than those in group 1 (24 U/L and 38 U/L) and group 3 (37 U/L and 81 U/L) (P<0.001 for both). Plasma and tissue levels of MDA in group 2 (4.66 μmol/L and 0.55 μmol/mg protein) were higher than in group 1 (2.65 μmol/L and 0.34 nmol/mg protein) and group 3 (3.43 μmol/L and 0.36 nmol/mg protein) (P<0.001 for both). Plasma and liver tissue levels of NO in group 2 (54.67 μmol/L and 586.50 nmol/mg protein) were higher than in group 1 (34.67 μmol/L and 435.33 nmol/mg protein) and group 3 (27.50 μmool/L and 412.75 nmol/mg protein ) (P<0.001 for both). Plasma and liver tissue SOD activities in group 2 (15.25 U/mL and 5.38 U/ mg protein, respectively) were lower than in group 1 (20.00 U/mL and 8.13 U/ mg protein) and group 3 (19.00 U/mL and 6.93 U/ mg protein) (P<0.001 for both). Plasma and liver tissue CAT activities in group 2 (145 U/mL an

关键词： Oxidative stress Ethanol-induced liver damage L-NAME

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Potential effects of adenosine triphosphate and melatonin on oxidative and inflammatory optic nerve damage in rats caused by 5-fluorouracil

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 222-228页

作者： Ahmet Mehmet Somuncu Busra Parlak Somuncu Ahmet Duhan Ozbay Ibrahim Cicek Bahadir Suleyman Renad Mammadov seval Bulut Tugba Bal Tastan Taha Abdulkadir Coban Halis Suleyman Aliyev aydin Trabzon Kanuni Education and Research Hospital Health Sciences UniversityTrabzon 61250Turkiey Provincial Health Directorate Ministry of Health of the Republic of TurkeyTrabzon 61040Turkiey Department of Ophthalmology Erzurum City HospitalHealth Sciences UniversityErzurum 25240Turkiey Department of Ophthalmology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey Department of Pharmacology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey Department of Histology and Embryology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkiey Department of Biochemistry Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Pharmacology Azerbaijan Medical UniversityBakuAZ1022Azerbaijan

AIM:To investigate the effects of adenosine triphosphate(ATP)and melatonin,which have antioxidant and antiinflammatory activities,on potential 5-fluorouracil(5-FU)-induced optic nerve damage in ***:Twenty-four rats were categorized into four groups of six rats:healthy(HG),5-FU(FUG),ATP+5-FU(AFU),and melatonin+5-FU(MFU).ATP(4 mg/kg)and melatonin(10 mg/kg)were administered intraperitoneally and orally,*** hour after ATP and melatonin administration,rats in the AFU,MFU,and FUG were intraperitoneally injected with 5-FU(100 mg/kg).ATP and melatonin were administered once daily for 10d.5-FU was administered at a single dose on days 1,3,and 5 of the *** 10d,the rats were euthanized and optic nerve tissues were *** nerve tissues were biochemically and histopathologically ***:ATP and melatonin treatments inhibited the increase in malondialdehyde(MDA)and interleukin-6(IL-6)levels,which were elevated in the *** treatments also prevented the decrease in total glutathione(tGSH)levels and the superoxide dismutase(SOD)and catalase(CAT)activities(P<0.001).This inhibition was higher in the ATP group than in the melatonin group(P<0.001).ATP prevented histopathological damage better than melatonin(P<0.05).CONCLUSION:ATP and melatonin have the potential to be used in alleviating 5-FU-induced optic nerve *** addition,ATP treatment shows better protective effects than melatonin.

关键词： adenosine triphosphate melatonin 5-fluorouracil optic nerve damage antioxidant antiinflammatory

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Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals

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World Journal of Gastroenterology 2005年第23期11卷 3570-3573页

作者： Titiz Izzet Krand Osman Unal Ethem Yavuz Nihat Kusaslan Ramazan Dogan Mustafa Uzun Hafize Kiziler Ali Riza Aydemir Birsen Genc Habibe aydin seval Simsek Gonul Department of Surgery Department of Biochemistry Department of Biophysics Department of Physiology

AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity *** activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase used asa superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under light microscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P＜0.05 was considered statistically ***: Histopathological studies confirmed PVL induced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL and control groups (P＜0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P＜0.05 and P＜0.001, respectively in tissue; P＜0.001 for each in serum), and Zn only in tissue (P＜0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tis

关键词： Portal hypertension Nitric oxide Lipid peroxidation Antioxidants Trace metals

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A study of stability and bifurcation analysis in discrete-time predator—prey system involving the Allee effect

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International Journal of Biomathematics 2019年第1期12卷 255-269页

作者： seval Isik Department of Mathematics and Science Education Faculty of Education Sivas Cumhuriyet University Sivas 58140Turkey

This paper deals with a discrete-time predator-prey system which is subject to an Allee effect on *** investigate the existence and uniqueness and find parametric conditions for local asymptotic stability of fixed points of the discrete dynamic ***,using bifurcation theory,it is shown that the system undergoes Neimark-Sacker bifurcation in a small neighborhood of the unique positive fixed point and an inv aria nt circle will *** the direction of bifurcation is ***,numerical analysis is provided to illustrate the theoretical discussions with the help of Matlab ***,the main theoretical results are supported with numerical simulations.

关键词： Predator-Prey system fixed point stability Neimark-Sacker bifurcation Allee effect

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Dynamical analysis and chaos control of a fractional-order Leslie-type predator-prey model with Caputo derivative

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International Journal of Biomathematics 2024年第4期17卷 105-131页

作者： seval Isik Figen Kangalgil Department of Mathematics and Science Education Faculty of Education Sivas Cumhuriyet University58140 SivasTurkey Bergama Vocational School Dokuz Eylul University 35700 IzmirTurkey

In this paper,the dynamical behaviors of a discrete-time fractional-order population model are *** stability analysis and the topological classification of the model at the fixed point have been *** is shown that the model undergoes flip and Neimark-Sacker bifurcations around the co-existence fixed point by using the bifurcation and the normal form *** bifurcations lead to chaos when the parameter changes at critical *** order to control chaotic behavior in the model result from Neimark-Sacker bifurcation,the OGY feedback method has been ***,some numerical simulations,including bifurcation diagrams,phase portraits and maximum Lyapunov exponents of the presented model are plotted to support the correctness of the analytical *** positive Lyapunov exponents demonstrate that chaotic behavior exists in the considered model.

关键词： Fractional-order predator-prey model discretization bifurcation chaos

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Role of immunotherapy in the treatment of allergic asthma

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World Journal of Clinical Cases 2014年第12期2卷 859-865页

作者： Ayfer Yukselen seval Guneser Kendirli Clinic of Pediatric Allergy and Immunology Gaziantep Children Hospital Sehitkamil 27310 Gaziantep Turkey Division of Pediatric Allergy and Immunology Cukurova University Faculty of Medicine Balcali 01150 Adana Turkey

Allergen-specific immunotherapy(SIT) induces clinical and immunological tolerance as defined by persistence of clinical benefit and associated long-term immunological parameters after cessation of treatment. Although the efficacy of SIT has been shown in terms of reducing symptoms, medication consumption and ameliorating quality of life in both allergic rhinitis and asthma, there has long been some controversies about effectiveness of SIT in the treatment of allergic asthma. The type of allergen, the dose and protocol of immunotherapy, patient selection criteria, the severity and control of asthma, all are significant contributors to the power of efficacy in allergic asthma. The initiation of SIT in allergic asthma should be considered in case of coexisting of other allergic diseases such as allergic rhinitis, unacceptable adverse effects of medications, patient's preference to avoid long-term pharmacotherapy. Steroid sparing effect of SIT in allergic asthma is also an important benefit particularly in patients who have to use these drugs in high doses for a long-time. Symptomatic asthma is a risk factor for systemic reactions and asthma should be controlled at the time of administration of SIT. Both subcutaneous immunotherapy(SCIT) and sublingual immunotherapy(SLIT) have been found to be effective in patients with allergic asthma. Although the safety profile of SLIT seems to be better than SCIT, the results of some studies and meta-analyses suggest that the efficacy of SCIT may appear better and earlier than SLIT in children with allergic asthma.

关键词： Asthma Efficacy Safety Subcutaneous immunotherapy Sublingual immunotherapy

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Effect of acupuncture therapy on fracture healing in rats with femur fractures

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Journal of Traditional Chinese Medicine 2020年第2期40卷 275-283页

作者： seval Yilmaz Emre Kaya Erhan Yilmaz Ahmet Kavakli Suleyman Gurbuz Mustafa Ozkaraca Firat University Faculty of Veterinary MedicineDepartment of BiochemistryElazig 23119Turkey Firat University Faculty of MedicineDepartment of Orthopedics and TraumatologyElazig 23119Turkey Firat University Faculty of MedicineDepartment of AnatomyElazig 23119Turkey Ataturk University Faculty of Veterinary MedicineDepartment of PathologyErzurum 25240Turkey

OBJECTIVE: To investigate the effect of acupuncture therapy on fracture healing in rats with femur ***: A total of 10 groups were formed;control group, groups sacrificed on 7 th, 14 th, and 21 st days of fracture formation, groups to which acupuncture was applied for 7, 14, and 21 d, groups to which fracture and acupuncture were applied for 7,14, and 21 d. A transverse fracture line was formed in femurs of rats by using a Gigli saw. The Kirschner wire was driven retrograde down from the fracture line to proximal part of the bone and then, the fracture was fixed towards distal part. Acupuncture was applied to the rats for 7, 14, and 21 d as 4 sessions per week after formation of the ***: Malondialdehyde(MDA), reduced glutathione(GSH) levels, catalase(CAT), glutathione-Stransferase(GST), superoxide dismutase(SOD), and glucose-6-phosphate dehydrogenase(G6 PD) activities were measured. Despite the increased MDA levels, G6 PD and SOD activities reduced during the fracture healing. There was a statistically significant increase in MDA, GSH levels, and G6 PD activity in fracture groups compared to control group, but CAT, GST, and SOD activities decreased. The use of acupuncture enhanced callus development and bone mineralization during bone ***: The acupuncture therapy can affect suppression of the effects of free oxygen radicals and regulation of the antioxidant enzyme activity in fracture healing. Thus, it is suggested that acupuncture treatment would be beneficial for fracture healing in order to eliminate the negative effects induced by oxygen free radicals.

关键词： Femur Fracture healing Acupuncture Malondialdehyde Antioxidants

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Some of Semi Analytical Methods for Blasius Problem

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Applied Mathematics 2012年第7期3卷 724-728页

作者： seval Catal Department of Civil Eng. Faculty of Engineering Dokuz Eylul University Izmir Turkey

In this paper, the Adomian methods, differential transform methods, and Taylor series methods are applied to non-linear differential equations which is called Blasius problem in fluid mechanics. The solutions of the B... 详细信息

关键词： Blasius Problem Non-Linear Differential Equation Adomian Decomposition Method Differential Transform Method Taylor Series Method

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