Effect of acupuncture therapy on fracture healing in rats with femur fractures

作     者：Seval Yilmaz Emre Kaya Erhan Yilmaz Ahmet Kavakli Suleyman Gurbuz Mustafa Ozkaraca Seval Yilmaz;Emre Kaya;Erhan Yilmaz;Ahmet Kavakli;Suleyman Gurbuz;Mustafa Ozkaraca

作者机构：Firat UniversityFaculty of Veterinary MedicineDepartment of BiochemistryElazig 23119Turkey Firat UniversityFaculty of MedicineDepartment of Orthopedics and TraumatologyElazig 23119Turkey Firat UniversityFaculty of MedicineDepartment of AnatomyElazig 23119Turkey Ataturk UniversityFaculty of Veterinary MedicineDepartment of PathologyErzurum 25240Turkey 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2020年第40卷第2期

页      面：275-283页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by a Grant from the Firat University Scientific Research Projects Coordination Unit Subject(No.VF.12.12) 

主　　题：Femur Fracture healing Acupuncture Malondialdehyde Antioxidants 

摘      要：OBJECTIVE: To investigate the effect of acupuncture therapy on fracture healing in rats with femur ***: A total of 10 groups were formed;control group, groups sacrificed on 7 th, 14 th, and 21 st days of fracture formation, groups to which acupuncture was applied for 7, 14, and 21 d, groups to which fracture and acupuncture were applied for 7,14, and 21 d. A transverse fracture line was formed in femurs of rats by using a Gigli saw. The Kirschner wire was driven retrograde down from the fracture line to proximal part of the bone and then, the fracture was fixed towards distal part. Acupuncture was applied to the rats for 7, 14, and 21 d as 4 sessions per week after formation of the ***: Malondialdehyde(MDA), reduced glutathione(GSH) levels, catalase(CAT), glutathione-Stransferase(GST), superoxide dismutase(SOD), and glucose-6-phosphate dehydrogenase(G6 PD) activities were measured. Despite the increased MDA levels, G6 PD and SOD activities reduced during the fracture healing. There was a statistically significant increase in MDA, GSH levels, and G6 PD activity in fracture groups compared to control group, but CAT, GST, and SOD activities decreased. The use of acupuncture enhanced callus development and bone mineralization during bone ***: The acupuncture therapy can affect suppression of the effects of free oxygen radicals and regulation of the antioxidant enzyme activity in fracture healing. Thus, it is suggested that acupuncture treatment would be beneficial for fracture healing in order to eliminate the negative effects induced by oxygen free radicals.