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World Journal of Clinical Cases 2023年第19期11卷 4723-4728页

作者： Joseph Hwang Won-Ho Cho seung-heon cha Jun-Kyueng Ko Department of Neurosurgery Biomedical Research InstitutePusan National University HospitalSchool of MedicinePusan National UniversityBusan 49241South Korea

BACKGROUND Posterior reversible encephalopathy syndrome(PRES)is characterized mainly by occipital and parietal lobe involvement,which can be reversible within a few ***,we report a rare case of PRES that developed after craniotomy for an unruptured intracranial aneurysm(UIA).CASE SUMMARY A 59-year-old man underwent clipping surgery for the treatment of UIA arising from the left middle cerebral *** surgery was performed uneventfully,and he regained consciousness quickly immediately after the *** the 4th hour after surgery,he developed a disorder of consciousness and *** resonance imaging revealed cortical and subcortical T2/FLAIR hyperintensities in the parietal,occipital,and frontal lobes ipsilaterally,without restricted diffusion,consistent with unilateral *** conservative treatment,his symptoms and radiological findings almost completely disappeared within *** our case,the important causative factor of PRES was suspected to be a sudden increase in cerebral perfusion pressure associated with temporary M1 *** Our unique case highlights that,to our knowledge,this is the second report of PRES developing after craniotomy for the treatment of *** must keep PRES in mind as one of the causes of perioperative neurological abnormality following clipping of an UIA.

关键词： Clipping Magnetic resonance imaging Posterior reversible encephalopathy syndrome Unruptured intracranial aneurysm Case report

Isolated recurrence of Intracranial granulocytic sarcoma mimicking a falx meningioma in acute myeloblastic leukemia

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Isolated recurrence of Intracranial granulocytic sarcoma mim...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Soon Ki Sung Won Ho Cho seung heon cha Pusan National University Yangsan Hospital Pusan National University Hospital

＜正＞PURPOSE:Intracranial granulocytic sarcomas are rare tumors,which are composed of immature granulocytic cells. Although it has been well known that these tumors are associated with acute myeloblastic leukemia（AM...

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Effect of gamma knife radiosurgery in the central nervous system lymphoma

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Effect of gamma knife radiosurgery in the central nervous sy...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Won Ho Cho Su heon Lee Beong Ik Hur seung heon cha chang Hwa Choi Department of Neurosurgery Pusan National University Hospital and School of Medicine Pusan National University BusanRepublic of Korea

＜正＞＜Introduction＞ Although there has been no established treatment protocol for central nervous system lymphoma （CNSL）,high dose methotrexatae therapy with or without external beam radiotherapy（EBRT） is gener...

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Capsaicin-induced apoptosis in the human glioblastoma U87MG cells via p-38 MAPK and Bcl-2/Bax signaling pathway

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Capsaicin-induced apoptosis in the human glioblastoma U87MG ...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Won Ho Cho Byung Kwan Choi In Ho Han seung heon cha Department of Neurosurgery Pusan National University Hospital and School of Medicine Pusan National University BusanRepublic of Korea

Objective:Capsaicin is a major pungent ingredient found in hot pepper,has long been reported to control of obesity and anti-carcinogenic *** induced apoptosis in a various cancer cells,however the precise molecular mechanisms have been poorly *** present study,the effect of capsaicin in cell viability the U87MG human glioma cells and its molecular mechanisms of cell death were ***:U87MG cells were treated with capsaicin,measured cell viability using MTT [3（4,5-Dimethylthiazol-2-yl）-2,5-Diphenyltetrazolium Bromide] *** apoptotic characteristics were detected by TUNEL [Terminal deoxynucleotidyl transferase（TdT）mediated deoxyuridine triphosphate（dUTP） nick end labeling] assay and western *** molecular mechanisms were evaluated through activity of procaspase-3,MAP kinases and mitochondrial ***:Capsaicin induced reduction of cell viability in dose-and time-dependent *** was determined based on the increase of positive TUNEL stained *** mechanisms of apoptosis were related with mitochondrial pathway（Bcl-2/Bax）,activation of MAP ***:These results suggest that capsaicin induces apoptosis in the U87MG cells and might be via a mitochondria pathway and p-38 MAPK ***,capsaicin will be a potential candidate for novel chemotherapeutic agent of human malignant gliomas.

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Hydrocephalus following Gamma Knife Radiosurgery in the Vestibualr Schwannoma

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Hydrocephalus following Gamma Knife Radiosurgery in the Vest...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： seung heon cha Won Ho Cho Beong Ik Hur chang Hwa Choi Department of Neurosurgery Pusan National University Hospital

＜正＞Objective:With a introduction of stereotactic radiosurgery,gamma knife radiosurgery（GKRS） has become a popular alternative to open surgery in the vestibular schwannomas（VS）.However, there has been little att...

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Dose verifying system used in Leksell GammaKnife Radiosurgery:Variable Ellipsoid Modeling Technique（VEMT）

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Dose verifying system used in Leksell GammaKnife Radiosurger...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Beong Ik Hur Dong Wan Kang Won Ho Cho seung heon cha chang Hwa Choi Byung Kwan Choi Department of Neurosurgery Pusan National University Hospital

＜正＞Purposes:The secondary,independent verification of Leksell Gamma Knife treatment planning system（LGP） is extremely important in order to minimize the risk of treatment errors.

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Organic X-Ray Image Sensors Using a Medium Bandgap Polymer Donor with Low Dark Current

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Energy & Environmental Materials 2024年第6期7卷 230-237页

作者： Jong-Woon Ha seung Hun Eom Bo Kyung cha Seyeong Song Hyeong Ju Eun Jong H.Kim Jong Mok Park BongSoo Kim Byoungwook Park Seo-Jin Ko Sung Cheol Yoon changjin Lee In Hwan Jung Do-Hoon Hwang Department of Chemistry Chemistry Institute for Functional MaterialsPusan National UniversityBusan 46241Korea Division of Advanced Energy Materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea Electro-Medical Device Research Center Korea Electrotechnology Research Institute(KERI)Ansan 15588Korea Graduate School of Carbon Neutrality School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Molecular Science and Technology Ajou UniversitySuwon 16449Korea Research Center for Advanced Specialty Chemicals Korea Research Institute of Chemical TechnologyUlsan 44412Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Department of Organic and Nano Engineering Human-Tech Convergence ProgramHanyang University222 Wangsimni-roSeongdong-guSeoul 04763Korea

The development of portable X-ray detectors is necessary for diagnosing fractures in unconscious patients in emergency ***,this is quite challenging because of the heavy weight of the scintillator and silicon *** weight and thickness of X-ray detectors can be reduced by replacing the silicon layer with an organic *** study presents a novel bithienopyrroledione-based polymer donor that exhibits excellent photodetection properties even in a thick photoactive layer(~700 nm),owing to the symmetric backbone and highly soluble molecular structure of *** ability of bithienopyrroledione-based polymer donor to strongly suppress the dark current density(Jd~10−10 A cm^(−2))at a negative bias(−2.0 V)while maintaining high responsivity(R=0.29 A W−1)even at a thickness of 700 nm results in a maximum shot-noise-limited specific detectivity of D_(sh)^(*)=2.18×10^(13)Jones in the organic *** organic photodetectors are developed by slot-die coating for use in X-ray detectors,which exhibit D_(sh)^(*)=2.73×10^(12)Jones with clear rising(0.26 s)and falling(0.29 s)response times upon X-ray *** reliability is also proven by linear response of the X-ray detector,and the X-ray detection limit is 3 mA.

关键词： low dark current low detection limit organic photodetector printable X-ray

ELK3-ID4 axis governs the metastatic features of triple negative breast cancer

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Oncology Research 2024年第1期32卷 127-138页

作者： JIN-HO CHOI JOO DONG PARK seung HEE CHOI EUN-SU KO HYE JUNG JANG KYUNG-SOON PARK Department of Biomedical Science CHA UniversitySeongnamKorea

Purpose:Cancer cell metastasis is a multistep process,and the mechanism underlying extravasation remains ***3 is a transcription factor that plays a crucial role in regulating various cellular processes,including cancer *** on the finding that ELK3 promotes the metastasis of triple-negative breast cancer(TNBC),we investigated whether ELK3 regulates the extravasation of TNBC by forming the ELK3-ID4 ***4 functions as a transcriptional regulator that interacts with other transcription factors,inhibiting their activity and subsequently influencing various biological processes associated with cell differentiation,survival,growth,and ***:We assessed the correlation between the expression of ELK3 and that of ID4 in TNBCs using bioinformatics analyses,QRT-PCR,western blot analysis,luciferase reporter assays,and chromatin ***,adhesion,invasion,and lung metastasis assays were employed to determine whether the ELK3-ID4 axis regulates the metastatic features of ***:We found that ELK3 binds directly to a binding motif close to the ID4 promoter to repress promoter *** expression of E-cadherin in TNBC was regulated by the ELK3-ID4 *** vitro and in vivo analyses showed that inhibiting ID4 expression in ELK3-knockdown MDA-MB-231(ELK3KD)cells restored the ability to extravasate and ***:The results indicate that the ELK3 regulates ID4 promoter activity,and that the ELK3-ID4 axis regulates the metastatic characteristics of TNBC ***,the data suggest that the ELK3-ID4 axis regulates metastasis of TNBCs by modulating expression of E-cadherin.

关键词： E-cadherin Extravasation Colonization

Improvement in the Adhesion Between Electrode of a SOFC and Ag Paste as a Current Collector by Au Deposition

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Journal of Materials Science & Technology 2015年第3期31卷 257-263页

作者： Sang Koo Jeon seung Hoon Nahm Oh heon Kwon Department of Safety Engineering Pukyong National University Center for Energy Materials Metrology Korea Research Institute or Standards and Science

This paper reports the use of Au films to improve the performance of the stacked solid oxide fuel cell(SOFC) based on the characterization of the interface and the adhesion between the electrodes of the SOFCs and the Ag paste. The specimens were manufactured to perform the experiment as follows. A Si O2 wafer with a 300 mm notch was attached to the electrodes of a SOFC by a Ag paste and Au film, which were deposited on the electrodes by sputtering for 1 min or 5 min deposition time and annealed at300 C for 1 h. The four-point bending test was performed, which resulted in the formation of an extended crack at the tip on the wafer notch, and the crack propagation was observed using a stereo microscope equipped with a charge-coupled device(CCD). Consequently, the interfacial adhesion energy and the effect of the Au film between the each electrode and the Ag paste can be evaluated. On the cathode, the interfacial adhesion energy without Au film was 2.59 J/m2(upper value) and the adhesion energy increased to 11.59 J/m2(upper value) and 15.89 J/m2(lower value) with the Au film. On the anode,the interfacial adhesion energy without Au film was 1.74 J/m2(upper value), which increased to 11.07 J/m2(upper value) and 14.74 J/m2(lower value) with the Au film. In addition, the interface areas were analyzed by scanning electron microscopy(SEM) and energy dispersive spectroscopy(EDS) to estimate the interface delamination.

关键词： Solid oxide fuel cell Au film Interfacial adhesion

Effects of Liuwei Dihuang Decoction(Yukmijihwang-tang)on Physical Fatigue by Regulating Neurotransmitters in Brain

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Chinese Journal of Integrative Medicine 2020年第11期26卷 839-844页

作者： Ji-Ye Kee seung-heon Hong Jin-Han Park department of oriental pharmacy college of pharmacywonkwang-oriental medicines research institutewonkwang universityjeonbuk(54538)republic of korea division of bio-tech no logy and con verge nee daegu hanny un iversitygyeongbuk(8578)republic of korea

Objective:To study the effect of Liuwei Dihuang Decoction(六味地黄汤)or Yukmijihwangtang(YJT)on endurance exercise by in vivo ***:ICR mice were randomly divided into the control group(distilled water)and the YJT groups(1,10,100 mg/kg),5 animals per *** and distilled water were orally *** anti-fatigue effect of YJT was evaluated by open fifiled test(OFT),forced swimming test(FST),and tail suspension test(TST).Results:In the OFT,YJT signifificantly increased the total movement distance in a dose-dependent ***,treatment with YJT signifificantly decreased immobility time in the FST and the *** neurotransmitters such as norepinephrine(NE),serotonin(5-HT),dopamine(DA)levels were increased by *** of YJT down-regulated the expression levels of NE,5-HT,5-hydroxyindole-acetic acid(5-HIAA),and DA in the brain stem and hypothalamus of ***,protein expression of HSP70 in mice liver and heart muscles was signifificantly increased in the YJT ***:YJT could ameliorate fatigue and enhance exercise tolerance through suppressing of brain monoamines including NE,5-HT,5-HIAA,and DA in FST mice model.

关键词： Yukmijihwang-tang Liuwei Dihuang Decoction fatigue forced swimming test HSP70 neurotransmitter Chinese medicine