Capsaicin-induced apoptosis in the human glioblastoma U87MG cells via p-38 MAPK and Bcl-2/Bax signaling pathway
作者单位：Department of NeurosurgeryPusan National University Hospital and School of Medicine Pusan National UniversityBusanRepublic of Korea
会议名称：《中国抗癌协会神经肿瘤专业委员会第八届学术会议》
会议日期：2011年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Objective:Capsaicin is a major pungent ingredient found in hot pepper,has long been reported to control of obesity and anti-carcinogenic *** induced apoptosis in a various cancer cells,however the precise molecular mechanisms have been poorly *** present study,the effect of capsaicin in cell viability the U87MG human glioma cells and its molecular mechanisms of cell death were ***:U87MG cells were treated with capsaicin,measured cell viability using MTT [3（4,5-Dimethylthiazol-2-yl）-2,5-Diphenyltetrazolium Bromide] *** apoptotic characteristics were detected by TUNEL [Terminal deoxynucleotidyl transferase（TdT）mediated deoxyuridine triphosphate（dUTP） nick end labeling] assay and western *** molecular mechanisms were evaluated through activity of procaspase-3,MAP kinases and mitochondrial ***:Capsaicin induced reduction of cell viability in dose-and time-dependent *** was determined based on the increase of positive TUNEL stained *** mechanisms of apoptosis were related with mitochondrial pathway（Bcl-2/Bax）,activation of MAP ***:These results suggest that capsaicin induces apoptosis in the U87MG cells and might be via a mitochondria pathway and p-38 MAPK ***,capsaicin will be a potential candidate for novel chemotherapeutic agent of human malignant gliomas.