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Conceptual Modeling of Contaminated Solute Transport Based on Stream Tube Model

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Advances in Chemical Engineering and Science 2012年第4期2卷 481-489页

作者： seung-Gun chung Soon-Jae Lee Dong-Ju Kim Sang-Hyup Lee Jae-Woo Choi Center for Water Resource Cycle Research Korea Institute of Science and Technology Seoul Republic of Korea Department of Earth and Environmental Sciences College of Science Korea University Seoul Republic of Korea

In this study, we performed a conceptual modeling on solute transport based on theoretical stream tube model (STM) with various travel time distributions assuming a pure convective flow through each tube in order to investigate how the lengths and distributions of solute travel time through STM affect the breakthrough curves at the end mixing surface. The conceptual modeling revealed that 1) the shape of breakthrough curve (BTC) at the mixing surface was determined by not only input travel time distributions but also solute injection mode such as sampling time and pulse lengths;2) the increase of pulse length resulted in the linear increase of the first time moment (mean travel time) and quadratic increase of the second time moment (variance of travel time) leading to more spreading of solute, however, the second time moment was not affected by travel time distributions and 3) for a given input distributions the increase in travel distance resulted in more dispersion with the quadratic increase of travel time variance. This indicates that stream tube model obeying strictly pure convective flow follows the concept of convective-lognormal transport (CLT) model regardless the input travel time distributions.

关键词： Conceptual Modeling Solute Transport Pure Convective Flow Stream Tube Model Travel Time Distribution

Hepatitis B virus infection, diabetes mellitus, and their synergism for cholangiocarcinoma development: A casecontrol study in Korea

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World Journal of Gastroenterology 2015年第2期21卷 502-510页

作者： Ban Seok Lee Eun-Cheol Park seung Woo Park chung Mo Nam Jaehoon Roh Department of Medicine Graduate SchoolYonsei University College of MedicineSeoul 120-752South Korea Digestive Disease Center and Department of Internal Medicine Cheju Halla General HospitalJeju 690-766South Korea Department of Preventive Medicine Yonsei University College of MedicineSeoul 120-752South Korea Institute of Health Services Research Yonsei University College of MedicineSeoul 120-752South Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea

AIM: To identify possible risk factors and their synergism for cholangiocarcinoma ***: A hospital-based, case-control study in which we included 276 cholangiocarcinoma patients [193 extrahepatic cholangiocarcinoma(ECC) and 83 intrahepatic cholangiocarcinoma(ICC)], diagnosed at a training hospital in Korea between 2007 and 2013, and 552 healthy controls matched 2:1 for age, sex, and date of diagnosis. Risk factors for cholangiocarcinoma and possible synergism between those factors were evaluated using conditional logistic regression and synergism index, ***:There was an association between cholangiocarcinoma and hepatitis B virus(HBV) infection, diabetes mellitus(DM), cholecystolithiasis, choledocholithiasis, and hepatolithiasis, with the adjusted odds ratios(AORs) of 4.1, 2.6, 1.7, 12.4, and 39.9, respectively. Synergistic interaction on the additive model was investigated between HBV infection and DM(AOR = 12.2; 95%CI: 1.9-80.1). In the subgroup analyses, cholecystolithiasis, choledocholithiasis, hepatolithiasis, and DM were significant risk factors for ECC(AOR = 2.0, 18.1, 14.9, and 2.0, respectively), whereas choledocholithiasis, hepatolithiasis, HBV infection, and DM were risk factors for ICC(AOR = 8.6, 157.4, 5.3 and 4.9, respectively). Synergistic interaction was also observed between HBV infection and DM(OR = 22.7; 95%CI: 2.4-214.1). However, there was no synergistic interaction between other significant risk factors for ***: In this Korean study, HBV infection and DM were found to exert independent and synergistic effects on the risk for cholangiocarcinoma, including ICC. Exploring the underlying mechanismsfor such synergy may lead to the development of cholangiocarcinoma prevention strategies in high-risk individuals.

关键词： Cholangiocarcinoma Risk factor Hepatitis Synergism

Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

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Molecular Plant 2023年第12期16卷 1867-1870页

作者： Hong Gil Lee Seo Young Jang Eun Yee Jie seung Hee Choi Ok-Sun Park Soon Hyung Bae Hyun-Soon Kim Suk Weon Kim Geum-Sook Hwang Pil Joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Integrated Metabolomics Research Group Western Seoul CenterKorea Basic Science InstituteSeoul 03759Korea Biological Resource Center Korea Research Institute of Bioscience and BiotechnologyJeongeup56212Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea College of Pharmacy Chung-Ang UniversitySeoul 06974Korea

Dear Editor,Plant tissue culture involves callus formation and de novo shoot ***,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。

关键词： Adenosine callus

Epirubicin,Cisplatin,5-FU combination chemotherapy in sorafenib-refractory metastatic hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第1期20卷 235-241页

作者： Ji Eun Lee Si Hyun Bae Jong Young Choi seung Kew Yoon Young Kyoung You Myung ah Lee Division of Medical Oncology Hepato-Biliary-Pancreatic Cancer CenterCancer Research Institute Seoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Internal Medicine Hepato-Biliary-Pancreatic Cancer CenterCancer Research InstituteSeoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Division of Hepatology Hepato-Biliary-Pancreatic Cancer CenterCancer Research Institute Seoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Surgery Hepato-Biliary-Pancreatic Cancer CenterCancer Research InstituteSeoul St. Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 137-040South Korea

AIM:To evaluate the clinical efficacy and safety of epirubicin,cisplatin,and 5-FU combination chemotherapy for the sorafenib-refractory metastatic hepatocellular carcinoma(HCC).METHODS:From April 2009 to June 2012,31 patients who were diagnosed with metastatic and progressive HCC after sorafenib treatment were retrospectively *** were treated with the combination of epirubicin(50 mg/m2Ⅳ;day 1),cisplatin(60 mg/m2Ⅳ;day 1),and 5-FU(1000 mg/m2Ⅳ;day 1-3)[Epirubicin,cisplatin,5-FU combination(ECF)],repeated every 4 ***:The overall response rate was 12.9%.Patients who responded to ECF chemotherapy showed a longer overall survival(OS)and time to progression(TTP)relative to those in the non-responder group(OS:20.4 mo vs 4.9 mo,P<0.001,TTP:9.4 mo vs 2.2 mo,P<0.001).Patients with a stable primary liver mass also exhibited a longer OS and TTP relative to those with progressive disease(OS:13.4 mo vs 5.3 mo,P=0.003;TTP:9.4 mo vs 2.3 mo,P=0.003).The most common hematologic toxicity was thrombocytopenia(87.2%),and the incidence of grade 3-4 neutropenia was 53.9%.Age older than 60,a stable primary mass,and a good response to chemotherapy were prognostic factors for OS and ***:This combination cytotoxic chemotherapy can serve as another treatment option after sorafenib failure for the subset of patients with advanced metastatic HCC.

关键词： Hepatocellular carcinoma Sorafenib Epirubicin Cisp

Comparison of Protein Profiles in Sputum between COPD and Acute Exacerbation of COPD

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Open Journal of Respiratory Diseases 2012年第2期2卷 25-30页

作者： Soo-Taek Uh seung ah Ko An Soo Jang Sung Woo Park Yong-Hoon Kim Young-Ki Paik Choon Sik Park Division of Respiratory and Allergy Medicine Soon Chun Hyang University Hospital Seoul South Korea Division of Respiratory Medicine Soonchunhyang University Chunan Hospital Asan South Korea Genome Research Center for Allergy and Respiratory Disease Soonchunhyang University Bucheon Hospital Bucheon South Korea Yonsei Proteome Research Center Department of Biochemistry and Biomedical Science College of Life Science and Biotechnology Yonsei University Seoul South Korea

Background and objective: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation that is associated with an abnormal inflammatory response of the lung to noxious particles or gases. Cigarette smoking is the major risk factor for the development of COPD. This study evaluated the levels of cyclophilin B in sputa from patients with COPD and COPD with acute exacerbation (AECOPD). Materials and Methods: Two-dimensional electrophoresis was used for differential display proteomics. Western blotting was used to identify and quantify cyclophilin B in sputum from subjects with AECOPD and COPD. Results: Forty-nine protein spots differed in relative intensity between the AECOPD (n = 6) and COPD (n = 6) subjects. Twenty proteins showed increased expression in the sputum of AECOPD subjects, and 29 proteins were present at lower levels in AECOPD sputum compared with COPD sputum. One of these proteins was associated with cyclophilin B. Cyclophilin B concentrations were lower in sputum from subjects with COPD (n = 4) versus AECOPD (n = 4). Conclusion: The sputum proteomic analysis suggests that changes in various proteins are associated with the development of AECOPD.

关键词： Proteomics COPD Acute Exacerbation Chromatography Liquid Mass Spectrometry

Mobile-Assisted Frame-based PRMA Protocol for Integration of Voice and Data Services in Broadband Wireless Access Networks

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Mobile-Assisted Frame-based PRMA Protocol for Integration of...

Growth-inhibitory effect of neurotrophin-3-secreting adipose tissue-derived mesenchymal stem cells on the D283-MED human medulloblastoma cell line

IEEE第14届国际个人无线移动通信大会

作者： seung E.Hong chung G.Kang Eung B.Kim Broadb and Wireless Multimedia Research Team ETRI DaejonKorea College of Information ＆ Communication Korea University SeoulKorea Broadb and Wireless Multimedia Research Team ETRI DaejonKorea

This paper presents a mobile-assisted frame-basedPRMA (MAF-PRMA) protocol, which optimizes random accesscontrol between heterogeneous traffic aiming at more efficientvoice/data integrated services in

关键词： PRMA Mobile-assisted Broadbandwirelessaccess

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Growth-inhibitory effect of neurotrophin-3-secreting adipose...

Surgical outcomes of Korean ulcerative colitis patients with and without colitis-associated cancer

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Chae-Yong Kim Young-Hoon Kim seung Hee Cho Soo Jung Lee seung ah Choi Ji Hoon Phi seung-Ki Kim Kyu-Chang Wang Byung-Kyu Cho Department of Neurosurgery Seoul National University College of Medicine Department of Neurosurgery Seoul National University Bundang Hospital Division of Pediatric Neurosurgery Seoul National University Children's Hospital

Medulloblastoma（MBL）,the most common malignant pediatric brain tumor,is incurable in about one-third of patients and can lead to long-term disabilities despite current multimodal *** purpose of this study was to demonstrate in vitro biological effects of neurotrophins-3（NT-3） on MBL cells and to evaluate the growth-inhibitory effect of neurotrophin-3（NT-3）-secreting stem cells on tumor *** confirmed by western blotting that D283-MED cells express tyrosine kinase C,a specific receptor for *** the biological effects of NT-3 on MBL cells,we evaluated autophagy,apoptosis,senescence,and differentiation of tumor cells with *** NT-3 induced a concentrationdependent increase in apoptosis in the tumor cell line（P ＜ 0.001）.The high concentrations of NT-3 increased the expression of class III β-tubulin（P ＜ 0.001） and decreased the expression of Nestin（P ＜ 0.05）.NT-3-secreting stem cells were produced by nucleofecting ***-NT3 into human adipose tissue-derived mesenchymal stem cells（hAT-MSCs） and were confirmed by fluorescence microscopy and ***-layered co-culture experiments with the NT-3-secreting hAT-MSCs and D283-MED MBL cells were performed,and NT-3-induced cell death was studied by 3-（4,5-dimethylathiazol-2-yl）-2,5-dephenyltetrazolium bromide（MTT） ***,the high concentrations of NT-3-secreting hAT-MSCs significantly（P ＜ 0.05） increased the death of D283-MED cells in *** present study demonstrated that both apoptotic cell death and neuronal differentiation of tumor cells were the mechanisms of growth-inhibitory effect of NT-3-secreting hAT-MSCs on MBL cell line.

关键词： neurotrophin-3 adipose tissue-derived mesenchymal stem cell medulloblastoma apoptosis differentiation

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World Journal of Gastroenterology 2015年第12期21卷 3547-3553页

作者： Yong Sik Yoon Yong Beom Cho Kyu Joo Park seung Hyuk Baik Sang Nam Yoon seung-Bum Ryoo Kil Yeon Lee Hungdai Kim Ryung-ah Lee Chang Sik Yu Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center epartment of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Seoul National University College of Medicine Department of Surgery Yonsei University College of Medicine Severance Hospital Department of Surgery Kangnam Sacred Heart Hospital Hallym University College of Medicine Department of Surgery Kyung Hee University School of Medicine Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Surgery Ewha Womans University School of Medicine

AIM: To determine the clinicopathologic characteristics of surgically treated ulcerative colitis(UC) patients, and to compare the characteristics of UC patients with colitis-associated cancer(CAC) to those without CAC. METHODS: Clinical data on UC patients who underwent abdominal surgery from 1980 to 2013 were collected from 11 medical institutions. Data were analyzed to compare the clinical features of patients with CAC and those of patients without ***: Among 415 UC patients, 383(92.2%) underwent total proctocolectomy, and of these, 342(89%) were subjected to ileal pouch-anal anastomosis. CAC was found in 47 patients(11.3%). Adenocarcinoma was found in 45 patients, and the others had either neuroendocrine carcinoma or lymphoma. Comparing the UC patients with and without CAC, the UC patients with CAC were characteristically older at the time of diagnosis, had longer disease duration, underwent frequent laparoscopic surgery, and were infrequently given preoperative steroid therapy(P < 0.001-0.035). During the 37 mo mean follow-up period, the 3-yearoverall survival rate was 82.2%.CONCLUSION: Most Korean UC patients experience early disease exacerbation or complications. Approximately 10% of UC patients had CAC, and UC patients with CAC had a later diagnosis, a longer disease duration, and less steroid treatment than UC patients without CAC.

关键词： Ulcerative colitis Colorectal neoplasms Colorectal

Beta2-microglobulin and antichromatin antibodies can be disease activity markers in systemic lupus erythematosus in Koreans

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Beta2-microglobulin and antichromatin antibodies can be dise...