检索结果-南通市图书馆

Characteristics and outcomes of chronic liver disease patients with acute deteriorated liver function by severity of underlying liver disease

引用

World Journal of Gastroenterology 2016年第14期22卷 3785-3792页

作者： Yun Soo Hong Dong Hyun Sinn Geum-Youn Gwak Juhee Cho Danbee Kang Yong-Han paik Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh seung woon paik Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Department of Health Sciences and Technology SAIHST Sungkyunkwan University Deaprtment of Health Behavior and Society and Epidemiology Johns Hopkins Bloomberg School of Public Health

AIM: To analyze characteristics and outcome of patients with acute-on-chronic liver failure(ACLF) according to the severity of underlying liver disease. METHODS: One hundred and sixty-seven adult patients with chronic liver disease and acute deteriorated liver function, defined by jaundice and coagulopathy, were analyzed. Predisposition, type of injury, response, organ failure, and survival were analyzed and compared between patients with non-cirrhosis(type A), cirrhosis(type B) and cirrhosis with previous decompensation(type C).RESULTS: The predisposition was mostly hepatitis B in type A, while it was alcoholic liver disease in typesB and C. Injury was mostly hepatic in type A, but was non-hepatic in type C. Liver failure, defined by CLIF-SOFA, was more frequent in types A and B, and circulatory failure was more frequent in type C. The 30-d overall survival rate(85.3%, 81.1% and 83.7% for types A, B and C, respectively, P = 0.31) and the 30-d transplant-free survival rate(55.9%, 65.5% and 62.5% for types A, B and C, respectively P = 0.33) were not different by ACLF subtype, but 1-year overall survival rate were different(85.3%, 71.7% and 58.7% for types A, B and C, respectively, P = 0.02).CONCLUSION: There were clear differences in predisposition, type of injury, accompanying organ failure and long-term mortality according to spectrum of chronic liver disease, implying classifying subtype according to the severity of underlying liver disease is useful for defining, clarifying and comparing ACLF.

关键词： Acute-on chronic liver failure Classification Injury Organ failure Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures

引用

World Journal of Gastroenterology 2012年第47期18卷 6996-7002页

作者： Yu Jin Kim Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh seung woon paik Byung Chul Yoo Joon Hyeok Lee Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135-710South Korea

AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple ***:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were *** subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 *** virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during *** assessment was based on serum creatinine and phosphorus *** patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ***-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/*** median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to *** to ADV was present in 7 patients and 10 subjects had a resistance to *** patient had a resistance to both ADV and *** cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,*** one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near *** patients in this study showed viral breakthrough or primary non-response during the follow-up *** cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,*** efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutatio

关键词： Tenofovir Chronic hepatitis B Treatment failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical course of sub-centimeter-sized nodules detected during surveillance for hepatocellular carcinoma

引用

World Journal of Gastroenterology 2012年第21期18卷 2654-2660页

作者： Yang Won Min Geum-Youn Gwak Min Woo Lee Moon Seok Choi Joon Hyoek Lee Kwang Cheol Koh seung woon paik Byung Chul Yoo Department of Medicine Samsung Medical Center Sungkyunkwan University School of MedicineSeoul 135-710 South Korea Department of Radiology Samsung Medical Center Sungkyunkwan University School of MedicineSeoul 135-710 South Korea

AIM: To evaluate the outcome of sub-centimeter-sized nodules (SCSNs) detected during surveillance for hepatocellular carcinoma (HCC) in patients at risk. METHODS: We retrospectively analyzed a total of 142 patients with liver cirrhosis or chronic hepatitis B or C without a prior history of HCC in whom a SCSN was detected during HCC surveillance. We calculated the rate of HCC development from SCSNs in the study population and analyzed the differences in the baseline clinical characteristics and imaging features between the patients with SCSNs that eventually developed into HCC and patients with SCSNs that did not develop into ***: During 667 person-years of follow-up, HCC developed in 33 patients. The calculated HCC development rate was 4.9% per year. The cumulative one-, two-, three- and five-year HCC development rates were 5.6%, 10.6%, 14.1% and 20.4%, respectively. Upon baseline comparison, the HCC group was older (54.4 ± 8.3 years vs 48.9 ± 9.4 years; P = 0.003) and had lower albumin levels (3.56 ± 0.58 g/dL vs 3.84 ± 0.55 g/dL; P = 0.012) and higher baseline alpha-fetoprotein (AFP) levels (8.5 ng/mL vs 5.4 ng/mL; P = 0.035) compared to the non-HCC group. Nodule pattern and initial radiologic diagnosis also differed between the two groups. Multivariate analysis revealed that age [P = 0.012, odds ratio (OR) =1.075, 95% confidence interval (CI) =1.016-1.137], sex (P = 0.009, OR = 3.969, 95% CI: 1.403-11.226), and baseline AFP level (P = 0.024, OR = 1.039, 95% CI: 1.005-1.073) were independent risk factors for developing HCC. CONCLUSION: The overall risk of HCC development in patients with SCSNs is similar to that in liver cirrhosis patients. Patients with these risk factors need to be closely monitored during follow-up.

关键词： Chronic liver disease Hepatocellular carcinoma Risk factor Sub-centimeter-sized nodule

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virological response to adefovir monotherapy and the risk of adefovir resistance

引用

World Journal of Gastroenterology 2011年第30期17卷 3526-3530页

作者： Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh seung woon paik Byung Chul Yoo Joon Hyeok Lee Hyang Ie Lee Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine135-710 SeoulSouth Korea Department of Internal Medicine Eulji University Hospital302-799 DaejeonSouth Korea

AIM:To evaluate virological response to adefovir(ADV) monotherapy and emergence of ADV-resistant mutations in lamivudine(LAM)-resistant chronic hepatitis B ***:Seventy-seven patients with documented LAM resistance who were treated with 10 mg/d ADV for>96 wk were analyzed for ADV ***:At week 48 and 96,eight(10%)and 14(18%)of 77 LAM-resistant patients developed the ADV-resistant strain(rtA181V/T and/or rtN236T mutations),*** B virus(HBV)DNA levels during therapy were significantly higher in patients who developed ADV resistance than in those who did *** of ADV resistance at week 96 was 11%,8%and 6%among patients with complete virological response(HBV DNA level2000 IU/mL)at week 12,week 24 and week 48,*** DNA levels >2000 IU/mL at week 24 showed best performance characteristics in predicting ADV ***:Development of ADV resistance mutations was associated with HBV DNA levels,which could identify patients with LAM resistance who are likely to respond to ADV monotherapy.

关键词： Hepatitis B virus Viral DNA Adefovir Lamivudine Drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Disease progression in chronic hepatitis C patients with normal alanine aminotransferase levels

引用

World Journal of Gastroenterology 2013年第14期19卷 2256-2261页

作者： Dong Hyun Sinn Geum-Youn Gwak Jae-uk Shin Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh seung woon paik Byung Chul Yoo Department of Internal Medicine Sanggye Paik HospitalInje University School of Medicine Department of Medicine Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate whether the disease progression of chronic hepatitis C patients with normal alanine aminotransferase(ALT) levels differs by ALT ***:A total of 232 chronic hepatitis C patients with normal ALT( 26 IU/L(highnormal),respectively(P = 0.043),and it was 1.4% and 4.8% for female patients with baseline ALT levels ≤ 22 IU/L(low-normal) and > 23 IU/L(high-normal),respectively(P = 0.023).ALT levels fluctuated during the follow-up *** the follow-up,more patients with "high-normal" ALT levels at baseline experienced ALT elevation(> 41 IU/L) than did patients with "lownormal" ALT levels at baseline(47.7% vs 27.9%,P = 0.002).The 5 year cumulative incidence of disease progression was significantly lower in patients with persistently "low-normal" ALT levels than "high-normal" ALT levels or those who exhibited an ALT elevation > 41 U/L during the follow-up period(0%,8.3% and 34.3%,P < 0.001).CONCLUSION:A "high normal" ALT level in chronic hepatitis C patients was associated with disease progression,suggesting that the currently accepted normal threshold of serum ALT should be lowered.

关键词： Alanine aminotransferase Upper limits of normal Disease progression Hepatitis C virus Hepatocellular carcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Seroprevalence of anti-HAV among patients with chronic viral liver disease

引用

World Journal of Gastroenterology 2011年第2期17卷 236-241页

作者： Hyun Chin Cho seung woon paik Yu Jin Kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Byung Chul Yoo Hee Jung Son Seon Woo Kim Division of Gastroenterology Samsung Medical CenterSungkyunkwan University School of Medicine Division of Gastroenterology Center for Health PromotionSamsung Medical CenterSungkyunkwan University School of Medicine Biostatics Team Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in *** also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December ***:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health *** anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver *** anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of *** analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus.

关键词： Chronic hepatitis B Chronic hepatitis C Hepatitis A virus Korea Seroprevalence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization

引用

World Journal of Gastroenterology 2006年第43期12卷 6992-6997页

作者： Do Young Kim Moon Seok Choi Joon Hyoek Lee Kwang Cheol Koh seung woon paik Byung Chul Yoo Sung Wook Shin Sung Wook Choo Young Soo Do Jong Chul Rhee Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea Depart- ment of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea

AIM: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). METHODS: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. RESULTS: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. CONCLUSION: The Milan criteria are still a useful selec- tion criteria showing favorable outcomes in HCC patientsreceiving TACE before LT.

关键词： Milan criteria Hepatocellular carcinoma Transarterial chemoembolization Liver transplantation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single hepatocellular carcinoma ≤ 3 cm in left lateral segment:Liver resection or radiofrequency ablation?

引用

World Journal of Gastroenterology 2014年第14期20卷 4059-4065页

作者： Jong Man Kim Tae Wook Kang Choon Hyuck David Kwon Jae-Won Joh Justin Sangwook Ko Jae Berm Park Hyunchul Rhim Joon Hyeok Lee Sung Joo Kim seung woon paik Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of Medicine Department of Anesthesiology and Pain Medicine Samsung Medical CenterSungkyunkwan University School of Medicine Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine

AIM: To evaluate the long-term results of radiofrequency ablation (RFA) compared to left lateral sectionectomy (LLS) in patients with Child-Pugh class A disease for the treatment of single and small hepatocellular car... 详细信息

关键词： Small hepatocellular carcinoma Left lateral segment Radiofrequency ablation Liver resection Tumor recurrence Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A case of long survival in poorly differentiated small cell carcinoma of the pancreas

引用

World Journal of Gastroenterology 2008年第31期14卷 4964-4967页

作者： Min Sung Chung Tae Kyung Ha Kyeung Geun Lee seung Sam paik Department of Surgery College of Medicine Hanyang University Seoul 133-792 South Korea Department of Pathology College of Medicine Hanyang University Seoul 133-792 South Korea

Small cell carcinoma (SCC) of the pancreas is rare. It has similar histological features to pulmonary small cell carcinoma and is equally aggressive. Most patients with SCC in the pancreas reported in case studies died within 1 year after diagnosis. We present a case of unusually long-term survival after surgery and combined chemotherapy for SCC of the pancreas. A 62-year-old woman presented with epigastric pain and jaundice. Computed tomography revealed dilated common bile duct caused by external compression of the mass in the pancreatic head. Exploratory laparotomy and pancreaticoduodenectomy (PPPD) was performed with histopathological analysis confirming a primary small cell carcinoma of the pancreas. After an uneventful postoperative recovery, the patient was treated with 6 cycles of combined chemotherapy consisting of cisplantin and ectoposide. During the follow-up, there was no evidence of recurrence and the patient has remained in a good health condition for 36 mo since the diagnosis.

关键词： Small cell carcinoma Pancreas Pancreatic carcinoma Extrapulmonary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Debris Flow in Metropolitan Area - 2011 Seoul Debris Flow

引用

Journal of Mountain Science 2013年第2期10卷 199-206页

作者： Chan-Young YUNE Yun-Ki CHAE Joongcheol paik Gihong KIM seung-Woo LEE Heung-Seok SEO Department of Civil Engineering Gangneung-Wonju National University Department of Civil Engineering Gangneung-Wonju National UniversityGangneungSouth Korea Department of Construction Engineering Gangneung Yeongdong College

A large number of debris flows occurred simultaneously at around 8:30 to 8:50 *** July 27,2011,at the center of Seoul,*** area is located in the southern part of Seoul and is a densely populated *** a result of the debris flow event,16 people were killed,30 houses were buried,and 116 houses were damaged around Umyeon Mountain,a relatively small mountain with a height of 312.6 *** the debris flow event,field investigations on the initiation and transportation zones of debris flows have been carried *** data were collected from the automatic weather stations(AWSs) which are operated by the Korea Meteorological Administration(KMA).Video files recorded by residents were also acquired and used to analyze the flow characteristics of the debris *** investigation shows that about 40 debris flows occurred around Umyeon Mountain and most of the debris flows were initiated by small slope *** effects of the precipitation that triggered the debris flows were analyzed as well.A landslide hazard map which considers slope gradient and aspect,strength of soil,hazard record,rainfall conditions,and vegetation,was constructed and compared with the initiation zones of debris flows.

关键词： Debris flows Field investigation Rainfall Flow characteristics Hazard map

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：