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12周的索磷布韦/维帕他韦用于接受透析的患者时安全有效

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12周的索磷布韦/维帕他韦用于接受透析的患者时安全有效

Management of chronic heart failure:Role of home echocardiography in monitoring care programs

第十届全国疑难及重症肝病大会

作者： sergio M Borgia Janet Dearden Yoav Lurie Stephen D Shafran Ashley Brown Robert Hyland Sophia Lu Svetlana Markova Hadas Dvory-Sobol Anu O Osinusi Eric M Yoshida Jose Luis Calleja Edward J Gane William Osler Health System Saint Bartholomew’s Hospital Shaare Zedek Medical Center University of Alberta Imperial College Healthcare NHS Trust Gilead Sciences Inc. Gordon and Leslie Diamond Health Care Centre Hospital Universitario Puerta De Hierro Auckland City Hospital

背景经批准的用于接受透析的患者的HCV治疗方案与多种因素相关,其中包括药物-药物相互作用、基线耐药性检测、利巴韦林的使用,以及肝毒性风险等。虽然在重度肾功能损伤患者中的索磷布韦(SOF)主要循环代谢物GS-331007的浓度较高,但真实...

背景经批准的用于接受透析的患者的HCV治疗方案与多种因素相关,其中包括药物-药物相互作用、基线耐药性检测、利巴韦林的使用,以及肝毒性风险等。虽然在重度肾功能损伤患者中的索磷布韦(SOF)主要循环代谢物GS-331007的浓度较高,但真实世界病例表明,在该人群中大量使用基于SOF的方案时未发现安全性问题。本研究评估了12周的SOF/维帕他韦(VEL)用于接受

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World Journal of Cardiology 2012年第3期4卷 72-76页

作者： Silvia Soreca sergio Aprile Andrea Cardone Giovanni Carella Biagio Fimiani Franco Guarnaccia Giosuè Santoro Valentina Apuzzi Giorgio Bosso Antonio Valvano Giovanni Zito Ugo Oliviero Associazioni Regionali Cardiologi Ambulatoriali CampaniaVia M.Testa 884127 SalernoItaly Department of Clinical Medicine and Cardiovascular Sciences Federico Ⅱ UniversityVia S.Pansini 580131 NaplesItaly

AIM:To identify a possible role of home echocardiography for monitoring chronic heart failure(CHF)***:We prospectively investigated 118 patients hospitalized during the last year for CHF who could not easily reach the pertaining District Healthcare *** patients were followed up with 2 home management programs:one including clinical and electrocardiographic evaluations and also periodic home echocardiographic examinations(group A),the other including clinical and electrocardiographic evaluations only(group B).RESULTS:At the end of the 18-mo follow-up no significant differences were observed between the 2 groups as regards the primary endpoint:rehospitalization occurred in 4 patients of the group A and in 6 patients of the group B;major cardiovascular events occurred in 2 and in 3 patients,*** significant differences were observed with respect to the secondary endpoints:one vascular event appeared in both the groups,3 cardiovascular deaths occurred in group A and 2 in group *** significant differences were observed between the 2 groups as regards the composite endpoint of death plus ***:Home echocardiography for monitoring of CHF patients does not improve the cardiovascular *** our CHF patients,a low incidence of vascular events was observed.

关键词： Echocardiography Chronic heart failure Home monitoring Care programs Cardiovascular events

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权益资本流入、公司融资与经济增长

中国经济报告 2019年第1期 118-120页

作者：查尔斯.凯罗米里斯墨里西欧.拉兰塞尔吉奥.斯库勒哥伦比亚大学智利天主教大学世界银行

在新兴市场经济体中,对外国投资者参与公共股权投资市场与总体经济活动相互关系的研究发现,外国投资者参与公共股权投资市场对生产率、投资、经济增长和股票交易价格具有显著影响。但产生这一影响的原因尚不清晰。本文的研究发现,跨国... 详细信息

在新兴市场经济体中,对外国投资者参与公共股权投资市场与总体经济活动相互关系的研究发现,外国投资者参与公共股权投资市场对生产率、投资、经济增长和股票交易价格具有显著影响。但产生这一影响的原因尚不清晰。本文的研究发现,跨国权益资本的流入增加了新兴市场经济体企业可获得的资金供给,从而鼓励企业通过更多的股权融资来扩大投资和扩张规模。大型企业从跨国权益资本流入中受益最大。

关键词：新兴市场经济体权益资本流入股权融资经济增长

维普期刊数据库

在 Krukenberg 肿瘤的一种情况中的 ultrasonography 和提高对比的 ultrasonography 的角色

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World Journal of Radiology 2013年第8期5卷 321-324页

作者： Paola Tombesi Francesca Di Vece Francesca Ermili Fabio Fabbian sergio Sartori sergio Sartori Section of Interventional UltrasoundSt. Anna Hospital Department of Internal Medicine St. Anna Hospital

We report a case of Krukenberg tumor of gastric origin with adnexal metastasis,in which ultrasonography(US) and contrast-enhanced US(CEUS) played a key diagnostic *** 64-year-old female patient was referred to our department for abdominal pain,nausea and *** examination was performed as first line diagnostic imaging approach,confirming the presence of ascites and detecting marked thickness of the gastric wall and a right adnexal *** was immediately performed and showed arterial enhancement followed by wash-out in the venous phase of both the gastric wall and the adnexal mass,suggesting the diagnosis of gastric cancer with right adnexal metastasis(Krukenberg syndrome).The patient underwent USguided paracentesis and esophagogastroduodenoscopy that showed linitis *** examination of the peritoneal fluid revealed the presence of signetring cells,and histologic examination of the specimen obtained by endoscopic biopsy showed primary gastric mucus-producing adenocarcinoma with signetring *** transvaginal US is undoubtedly the method of choice to evaluate ovarian tumors,abdominal US and CEUS can provide key diagnostic elements,supporting clinicians in the first steps of the diagnostic work-up of abdominal and pelvic masses.

关键词： Adnexal masses Gastric cancer Krukenberg tumor Ultrasonography Contrast-enhanced ultrasonography

Rolapitant预防术后恶心呕吐：一项前瞻性、双盲、安慰剂对照的随机试验

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麻醉与镇痛 2012年第4期8卷 23-30页

作者： Tong J. Gan Jiezhun Gu Neil Singla Frances Chung Michael H. Pearman sergio D. Bergese Ashraf S. Habib Keith A. Candiotti Yi Mo Susan Huyck Mary R. Creed Marc Cantillon Rolapitant Investigation group 黄礼兵(译) 崔苏扬(校) Department of Anesthesiology Duke University Medical Center Durham North Carolina Department of Clinical Trials Statistics Duke Clinical Research Institute Durham North Carolina Lotus Clinical Research Inc. Arcadia California Department of Anesthesia University Health Network University of Toronto Toronto Ontario Canada Department of Anesthesia Jane Phillips Medical Center Bartlesville Oldahoma Department of Anesthesiology and Neurological Surgery Ohio State University Columbus Ohio Department of Anesthesiology Duke University Medical Center Durham North Carolina University of Miami Miami Florida tt Schering-Plough Research Institute Kenilworth New Jersey Duke Clinical Research Institute Durham North Carolina See the Appendix for a full listing of Rolapitant Investigation group participating investigators 不详

背景术后恶心呕吐（postoperativenauseaandvomiting，PONV）是一种常见的术后并发症。研究证实神经激肽．1（neurokinin一1，NK，）受体拮抗剂可以安全有效地用于预防和治疗人类PONV。Rolapitant（罗纳吡坦）为一种吸收迅速、半衰期相... 详细信息

背景术后恶心呕吐（postoperativenauseaandvomiting，PONV）是一种常见的术后并发症。研究证实神经激肽．1（neurokinin一1，NK，）受体拮抗剂可以安全有效地用于预防和治疗人类PONV。Rolapitant（罗纳吡坦）为一种吸收迅速、半衰期相当长（达180小时）的强效选择性NK、受体拮抗剂，潜在的药物相互作用低。我们对Rolapitant用于预防PONV高危人群的量效关系以及术后5天的预防迟发性IK）NV的效果进行了研究。方法这项关于Rolapitant的随机、多中心、双盲、有效剂量范围的研究设有安慰剂组和阳性对照组。纳入619例行开腹手术的成年妇女，基于PONV或晕动病史进行分层，分为6个研究组：Rolapitant口服剂量5mg组、20mg组、70nag组或200mg组；静注昂丹司琼4mg组或安慰剂组。主要研究终点：不考虑补救用药，拔管后24小时的无呕吐发生率。结果Rolapitant20mg、70mg或200mg组患者的术后24小时无呕吐发生率高于安慰剂组。Rolapitant剂量与主要转归呈线性相关。与安慰剂组相比，Rolapitant70mg和200mg组的呕吐次数明显更低（P≤0．001，对数秩和检验）。尽管术后24小时无呕吐次数在Rolapitant组和昂丹司琼对照组没有明显差异，但Rolapitant200mg组和70mg组的术后72小时和120小时无呕吐发生率更高（不考虑补救用药）。结论Rolapitant降低术后呕吐的疗效优于安慰剂，呈剂量依赖性地降低呕吐发生率。而且Rolapitant与安慰剂在不良反应方面没有差异。

关键词：术后恶心呕吐安慰剂对照随机试验预防双盲受体拮抗剂阳性对照组 PONV

Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators

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World Journal of Gastrointestinal Endoscopy 2016年第2期8卷 113-121页

作者： sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung Digestive Endoscopy Unit St.Barbara Hospital09016 IglesiasItaly Digestive Diseases Center Vitkovice Hospital703 84 OstravaCzech Republic Digestive Endoscopy Unit N.S.di Bonaria Hospital09037 San Gavino MonrealeItaly Department of Surgical Sciences University of Cagliari09121 CagliariItaly Sepulveda Ambulatory Care Center Veterans Affairs Greater Los Angeles Healthcare SystemNorth HillsCA 91343United States David Geffen School of Medicine University of California at Los AngelesLos AngelesCA 90024United States

AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion ***: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale.

关键词： Colonoscopy Painless colonoscopy Waterimmersion Water exchange Colonoscopy pain

有意电磁干扰辐射智能建筑线缆系统的最坏情况分析

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安全与电磁兼容 2020年第3期 9-13页

作者：塞吉欧·皮那立梁涛乔达诺·斯巴达齐尼芙拉维亚·格拉希米兰理工大学

研究了有意电磁干扰(IEMI)对智能建筑中线缆系统安全所带来的威胁。通过优化干扰辐射场的频谱,分析了建筑中差分线系统在电磁攻击下的最坏情况,获得了线缆系统在有意电磁干扰激励下负载感应电压峰值可以达到的理论最大值。考虑到最大电... 详细信息

研究了有意电磁干扰(IEMI)对智能建筑中线缆系统安全所带来的威胁。通过优化干扰辐射场的频谱,分析了建筑中差分线系统在电磁攻击下的最坏情况,获得了线缆系统在有意电磁干扰激励下负载感应电压峰值可以达到的理论最大值。考虑到最大电压峰值是入射方向和极化角的函数,且角度具有不确定性,文章利用蒙特卡洛法对最大电压峰值的累积分布函数进行了估计,并以此为分析工具,讨论了差分线几何参数(线长、高度、线间距)和电气参数(负载阻抗值、土壤电导率、介电常数)对最大电压峰值累积分布函数的影响,研究结论可为建筑中线缆系统的电磁兼容设计提供指导。

关键词：有意电磁干扰高功率电磁环境电磁兼容统计模型

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Long-term survival of patients with stage Ⅱ and Ⅲgastric cancer who underwent gastrectomy with inadequate nodal assessment

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World Journal of Gastrointestinal Surgery 2021年第11期13卷 1463-1483页

作者： Jacopo Desiderio Andrea Sagnotta Irene Terrenato Eleonora Garofoli Claudia Mosillo Stefano Trastulli Federica Arteritano Federico Tozzi Vito D'Andrea Yuman Fong Yanghee Woo sergio Bracarda Amilcare Parisi Department of Digestive Surgery St.Mary’s HospitalTerni 05100Italy Department of Surgical Sciences Sapienza University of RomeRome 00161Italy Department of General Surgery and Surgical Oncology San Filippo Neri HospitalRome 00135Italy Biostatistics and Bioinformatic Unit Scientific DirectionIRCCS Regina Elena National Cancer InstituteRome 00144Italy Department of Medical Oncology St.Mary’s HospitalTerni 05100Italy Division of Surgical Oncology and Endocrine Surgery Mays Cancer CenterUniversity of Texas Health Science Center San AntonioSan AntonioTX 78229United States Division of Surgical Oncology Department of SurgeryCity of Hope National Medical CenterDuarteLA91010United States

BACKGROUND Gastric cancer is an aggressive disease with frequent lymph node(LN)*** NCCN recommends a D2 lymphadenectomy and the harvesting of at least 16 *** threshold has been the subject of great debate,not only for the extent of surgery but also for more appropriate *** reclassification of stage IIB through IIIC based on N3b nodal staging in the eighth edition of the American Joint Committee on Cancer(AJCC)staging system highlights the efforts to more accurately discriminate survival expectancy based on nodal ***,studies have suggested that pathologic assessment of 30 or more LNs improve prognostic accuracy and is required for proper staging of *** To evaluate the long-term survival of advanced gastric cancer patients who deviated from expected survival curves because of inadequate nodal *** Eligible patients were identified from the Surveillance,Epidemiology,and End Results *** with stage II-III gastric cancer were considered for *** groups were compared based on the number of analyzed *** were inadequate LN assessment(ILA,<16 LNs),adequate LN assessment(ALA,16-29 LNs),and optimal LN assessment(OLA,≥30 LNs).The main outcomes were overall survival(OS)and cancer-specific *** were analyzed by the Kaplan-Meier product-limit method,log-rank test,hazard risk,and Cox proportional univariate and multivariate *** score matching(PSM)was used to compare the ALA and OLA *** The analysis included 11607 *** had advanced T stages(T3=48%;T4=42%).The pathological AJCC stage distribution was IIA=22%,IIB=18%,IIIA=26%,IIIB=22%,and IIIC=12%.The overall sample divided by the study objective included ILA(50%),ALA(35%),and OLA(15%).Median OS was 24 mo for the ILA group,29 mo for the ALA group,and 34 mo for the OLA group(P<0.001).Univariate analysis showed that the ALA and OLA groups had better OS than the ILA group[ALA hazard ratio(HR)=0.84,95%co

关键词： Gastric Cancer Lymphadenectomy Gastrectomy Staging N stage Surveillance,Epidemiology,and End Results

TENNIS ELBOW ACUPUNCTURE INTERNATIONAL STUDY-CHINA, AUSTRALIA AND ITALY(TEA-IS-CHAI) PROJECT—A PROGRESS REPORT

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Journal of Integrative Medicine 2014年第3期 296-296页

作者： Shi-ping Zhang Marcus Gadau sergio Bangrazi Christine Berle Tie Li Wei-hong Li Yan-song Liu Peter Meier Yuan-sheng Tan Fu-chun Wang Chris Zaslawski School of Chinese Medicine Hong Kong Baptist University Instituto Paracelso 3. College of Traditional Chinese Medicine University of Technology Sydney 4. Changchun University of Traditional Chinese Medicine 5. World Federation of Acupuncture and Moxibustion Societies

It was reported in the 2013 SAR conference that the TEA-ISCHAI group was embarking on an international, multisite acupuncture trial and issues associated with conducting such trialswere *** current presentation will provide an update of the trial in *** institutions(Changchun University of TCM and Hong Kong Baptist University, China, University of Technology, Sydney and Istituto Paracelso, Italy) across four countries and regions collaborated on the trial, with the World Federation of Acupuncture and Moxibustion Societies acting as a coordinator.A randomized, placebo-controlled, patient- and assessor-blinded clinical trial with two parallel arms has been designed to evaluate the efficacy of a standardized acupuncture intervention.A pilot trial involving 40 subjects was conducted by the Changchun University of TCM and showed promising effects of the standardized acupuncture *** pilot study also helped to resolve many methodological issues in our study *** on the results of the pilot study, 96 subjects are being recruited to the trial, with each site enrolling 24 *** Disabilities of Arm Shoulder and Hand questionnaire will be the primary outcome measure, and secondary outcome measures include such objective measures as pain free grip strength and middle finger extension strength *** presentation will report on the study protocol, trial progress and experience in dealing with important issues such as standardization and monitoring of the trial.

关键词： TEA-IS-CHAI PROJECT A PROGRESS REPORT AUSTRALIA AND ITALY