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Evaluation of Clinical Characteristics and Plasma Cortisol Concentrations in Individuals with COVID-19 and Post-COVID syndrome

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Case Reports in Clinical Medicine 2024年第1期13卷 12-24页

作者： David Alejandro García López stephania Ramos Hernández Yamile López-Hernández María Argelia López Luna Elena Donaji Ramírez Alvarado Rosa María Ramírez santoyo sergio Hugo sánchez Rodríguez Laboratorio de Biología Celular y Neurobiología Universidad Autónoma de Zacatecas México Zacatecas Unidad Académica de Ciencias Químicas Universidad Autónoma de Zacatecas México Zacatecas Laboratorio de Metabolómica y Proteómica Universidad Autónoma de Zacatecas México Zacatecas Laboratorio de Bacterias y Hongos filamentosos Universidad Autónoma de Zacatecas México Zacatecas

COVID-19 generates systematic alterations in humans both in active stages of infection and over time, called post-COVID syndrome. Cortisol is a hormone that is overexpressed in inflammation and cellular stress processes. Its main function is to return to physiological homeostasis, so its evaluation together with other clinical parameters can allow us to determine the degree of systemic affectation by COVID-19. Objective: To evaluate changes in clinical parameters and plasma cortisol concentrations in patients with active COVID-19 and post-COVID syndrome. Material and Methods: Healthy patients, in stages of mild infection, critical and with post-COVID syndrome, were recruited, obtaining, through clinical diagnoses and interviews, their main clinical characteristics, in addition to plasma, in which cortisol concentrations were determined using competitive ELIsA. Results: The critical stage group had higher frequencies of comorbidities, clinical symptoms, as well as more altered laboratory parameters compared to the other subgroups. In the post-COVID syndrome group after the initial infection, most laboratory parameters recovered, however, several clinical symptoms remained latent over time. The determination of cortisol showed an increase in its concentration, being higher in patients in critical stage and with post-COVID syndrome. Conclusion: COVID-19 disease generates clinical alterations that trigger an increase in plasma cortisol. These alterations increase as the stages of infection become more severe and some of them remain altered in patients with post-COVID syndrome.

关键词： COVID-19 Cortisol Post-COVID syndrome

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Effect of Ultraviolet Radiation on Hsp70 Protein Expression in HaCaT Cells

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World Journal of Nuclear science and Technology 2024年第1期14卷 59-71页

作者： sergio Hugo sánchez Rodríguez Jesús Rodríguez Vergil Manuel Venancio Muñoz Juárez Kevin said Ramírez Dávila Luis Martín García Ortiz Germán Flores Cortés Luz Elena Vidales Rodríguez Jesús Adrián López David Alejandro García López Laboratorio de Biología Celular y Neurobiología Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboatorio de Bacterias y Hongos Filamentosos Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboratorio de MicroRNAs Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México

Ultraviolet radiation by its wavelength is divided into: UVA, UVB and UVC. Only UVA and UVB manage to penetrate the ozone layer, but due to anthropological activities, all of them are capable of interacting with humans to a greater or lesser extent, and can generate adverse effects such as cellular stress when interacting with intra-and extracellular biomolecules. The skin is the first organ in contact with UV radiation, and the stress it generates can be analyzed by the expression of a bioindicator of cellular damage such as Hsp70. Therefore, the objective of the project was: to determine the effect of UVA, UVB and UVC radiation on HaCaT epithelial cells, by analyzing the expression of Hsp70. Materials and methods: HaCaT cells were cultured in vitro, which were irradiated with UVA, UVB and UVC light at different doses, to subsequently determine the degree of Hsp70 expression by Immunodetection by PAGE-sDs and Western Blot. Results: Basal expression of Hsp70 was observed in no irradiated HaCaT cells. When HaCaT cells were irradiated with UVA, UVB, UVC, an increase in this Hsp70 protein was observed. With UVA, a higher degree of expression was observed at a time of 30 minutes of irradiation. With UVB the highest expression shifted to a time of 20 minutes. With UVC, overexpression was observed after 10 minutes. Conclusion: UV radiation generates cellular stress on HaCaT cells, evaluated by the stress bioindicator Hsp70. According to the wavelength of UV radiation, those that have a shorter wavelength have a greater potential for cellular damage, such as UVC.

关键词： Ultraviolet A Light (UVA) Ultraviolet B Light (UVB) Ultraviolet C Light (UVC) Heat shock Protein 70 (Hsp70) HaCaT

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Clinical approach to indeterminate biliary strictures:Clinical presentation,diagnosis,and workup

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世界胃肠病学杂志:英文版 2023年第36期29卷 5198-5210页

作者： sujani Yadlapati Ramzi Mulki sergio A sánchez-Luna Ali M Ahmed Kondal Rao Kyanam Kabir Baig shajan Peter Department of Gastroenterology and Hepatology Indiana University HospitalIndianapolisIN 46202USA Department of Gastroenterology and Hepatology University of Alabama at BirminghamBirminghamAL 35294USA

Despite advances in cross-sectional imaging and endoscopic technology,bile duct strictures remain a challenging clinical *** is crucial to make an early determination of benign or malignant nature of biliary *** diagnosis not only helps with further management but also minimizes mortality and morbidity associated with delayed *** imaging and endoscopic techniques,particularly endoscopic retrograde cholangiopancreatography(ERCP)and tissue sampling techniques play a key in establishing a *** biliary strictures(IDBss)have no definite mass on imaging or absolute histopathological diagnosis and often warrant utilization of multiple diagnostics to ascertain an *** this review,we discuss possible etiologies,clinical presentation,diagnosis,and management of *** on available data and expert opinion,we depict an evidence based diagnostic algorithm for management of *** of focus include use of traditional tissue sampling techniques such as ERCP with brush cytology,intraductal biopsies,fluorescence in situ hybridization and flow *** also describe the role of endoscopic ultrasound(EUs)-guided fine needle aspiration and biopsies,cholangioscopy,confocal laser endomicroscopy,and intraductal EUs in management of IDBss.

关键词： Biliary strictures Indeterminate strictures Biliary sampling Cholangioscopy Benign strictures Malignant strictures Indeterminate biliary strictures

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Evaluation of Clinical Characteristics and Plasma Cortisol Concentrations in Individuals with COVID-19 and Post-COVID syndrome

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Case Reports in Clinical Medicine（临床医学病理报告） 2024年第1期

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Effect of Ultraviolet Radiation on Hsp70 Protein Expression in HaCaT Cells

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World Journal of Nuclear science and Technology（核科学与技术国际期刊） 2024年第1期

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Low-Dose Gamma Radiation Fields Decrease Cell Viability, Damage DNA, and Increase the Expression of Hsp70 and p53 Proteins in Human Leukocytes

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World Journal of Nuclear science and Technology 2023年第4期13卷 55-72页

作者： Jessica Lizbeth sifuentes Padilla David Alejandro García López Consuelo Letechipia de León Hector Rene Vega-Carrillo sergio Hugo sánchez Rodríguez Laboratorio de Biología Celular y Neurobiología Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboratorio de Radiobiología Unidad Académica de Estudios Nucleares Universidad Autónoma de Zacatecas Zacatecas México

Ionizing radiations are tools in diagnosis and treatment of diseases. Leukopenia from exposure to ionizing radiation has been reported. Due to their radiosensitivity, leukocytes are a biological model to analyze cell damage. Therefore, cell viability, DNA damage, and Hsp70 and p53 expression in human leukocytes exposed to low-dose gamma radiation fields from a sup>137sup>Cs source were evaluated. A decrease in cell viability, DNA damage and an increase in the expression of Hsp70 and p53 proportional to the radiation dose received was found, which was 0.2, 0.4, 0.6, 0.8 and 1.0 mGy.

关键词： Leukocytes Gamma Radiation Cell Damage DNA Hsp70 p53

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Endoscopic retrograde cholangiopancreatography drainage for palliation of malignant hilar biliary obstruction——stent-in-stent or side-by-side?A systematic review and meta-analysis

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World Journal of Hepatology 2021年第5期13卷 595-610页

作者： Gabriel Mayo Vieira de souza Igor Braga Ribeiro Mateus Pereira Funari Diogo Turiani Hourneaux de Moura Maria Vitória Cury Vieira scatimburgo João Remíde Freitas Júnior sergio A sánchez-Luna Renato Baracat Eduardo Turiani Hourneaux de Moura Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Division of Gastroenterology Hepatology and NutritionCenter for Advanced Therapeutic EndoscopyAllegheny Health NetworkPittsburghPA 15212United States Division of Gastroenterology and Hepatology Department of Internal MedicineBasil I.Hirschowitz Endoscopic Center of ExcellenceBirminghamAL 35294United States

BACKGROUND Biliary drainage,either by the stent-in-stent(sIs)or side-by-side(sBs)technique,is often required when treating a malignant hilar biliary obstruction(MHBO).Both methods differ from each other and have distinct *** To compare both techniques regarding their efficacy and safety in achieving drainage of *** A comprehensive search of multiple electronic databases(MEDLINE,Embase,LILACs,BIREME,Cochrane)was conducted and grey literature from their inception until December 2020 with no restrictions regarding the year of publication or language,since there was at least an abstract in *** included studies compared sIs and sBs techniques through endoscopic retrograde *** analyzed included technical and clinical success,early and late adverse events(AEs),stent patency,reintervention,and procedure-related *** Four cohort studies and one randomized controlled trial evaluating a total of 250 patients(127 in the sIs group and 123 in the sBs group)were included in this *** were no statistically significant differences between the two groups concerning the evaluated outcomes,except for stent patency,which was higher in the sIs compared with the sBs technique[mean difference(d)=33.31;95%confidence interval:9.73 to 56.90,I2=45%,P=0.006].CONCLUsION The sIs method showed superior stent patency when compared to sBs for achieving bilateral drainage in *** techniques are equivalent in terms of technical success,clinical success,rates of both early and late AEs,reintervention,and procedure-related mortality.

关键词： Endoscopic retrograde cholangiopancreatography Biliary tract neoplasms Biliary Hilar stenting Drainage

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Effects of intragastric balloon placement in metabolic dysfunctionassociated fatty liver disease: A systematic review and metaanalysis

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World Journal of Hepatology 2021年第7期13卷 815-829页

作者： João Remíde Freitas Júnior Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Vitor Massaro Takamatsu sagae Gabriel Mayo Vieira de souza Guilherme Henrique Peixoto de Oliveira sergio A sánchez-Luna Thiago Ferreira de souza Eduardo Turiani Hourneaux de Moura Cláudia Pinto Marques souza de Oliveira Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura serviço de Endoscopia Gastrointestinal do Hospital das Clínicas HCFMUsP Departamento de GastroenterologiaFaculdade de MedicinaUniversidade de Sao PauloSao PauloSPBR Division of Gastroenterology and Hepatology Department of Internal MedicineBasil I.Hirschowitz Endoscopic Center of ExcellenceThe University of Alabama at BirminghamBirminghamAL 35294United States Department of Gastroenterology Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil

BACKGROUND Metabolic dysfunction-associated fatty liver disease corresponds to a clinical entity that affects liver function triggered by the accumulation of fat in the liver and is linked with metabolic *** To evaluate the effects of the intragastric balloon(IGB)in patients with metabolic dysfunction-associated fatty liver disease through the assessment of liver enzymes,imaging and several metabolic *** A comprehensive search was done of multiple electronic databases(MEDLINE,EMBAsE,LILACs,Cochrane and Google scholar)and grey literature from their inception until February *** criteria involved patients with a body mass index>25 kg/m2 with evidence or previous diagnosis of hepatic *** analyzed before and after 6 mo of IGB removal were alanine aminotransferase(IU/L),gamma-glutamyltransferase(IU/L),glycated hemoglobin(%),triglycerides(mg/dL),systolic blood pressure(mmHg),homeostatic model assessment,abdominal circumference(cm),body mass index(kg/m2)and liver volume(cm3).REsULTs Ten retrospective cohort studies evaluating a total of 508 patients were *** 6 mo of IGB placement,this significantly reduced alanine aminotransferase[mean difference(MD):10.2,95%confidence interval(CI):8.12-12.3],gammaglutamyltransferase(MD:9.41,95%CI:6.94-11.88),glycated hemoglobin(MD:0.17%,95%CI:0.03-0.31),triglycerides(MD:38.58,95%CI:26.65-50.51),systolic pressure(MD:7.27,95%CI:4.79-9.76),homeostatic model assessment(MD:2.23%,95%CI:1.41-3.04),abdominal circumference(MD:12.12,95%CI:9.82-14.41)and body mass index(MD:5.07,95%CI:4.21-5.94).CONCLUsION IGB placement showed significant efficacy in improving alanine aminotransferase and gamma-glutamyltransferase levels in patients with metabolic dysfunctionassociated fatty liver disease as well as improving metabolic markers related to disease progression.

关键词： Intragastric balloon Metabolic dysfunction-associated fatty liver disease Homeostatic model assessment Abdominal circumference Body mass index

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Antibiotic prophylaxis to prevent complications in endoscopic retrograde cholangiopancreatography:A systematic review and meta-analysis of randomized controlled trials

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World Journal of Gastrointestinal Endoscopy 2022年第11期14卷 718-730页

作者： Maria Fernanda shinin Merchan Diogo Turiani Hourneaux de Moura Guilherme Henrique Peixoto de Oliveira Igor Mendonça Proença Epifanio silvino do Monte Junior Edson Ide Caroline Moll sergio A sánchez-Luna Wanderley Marques Bernardo Eduardo Guimarães Hourneaux de Moura Department of Gastroenterology Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Department of Internal Medicine University of Alabama at Birmingham Heersink School of MedicineBirminghamAL 35233United States

BACKGROUND The prophylactic use of antibiotics in endoscopic retrograde cholangiopancreatography(ERCP)is still *** To assess whether antibiotic prophylaxis reduces the rates of complications in patients undergoing elective *** This systematic review and meta-analysis were performed following the Preferred Reporting Items for systematic Reviews and Meta-analysis guidelines.A comprehensive search of multiple electronic databases was *** randomized controlled trials were *** outcomes analyzed included bacteremia,cholangitis,sepsis,pancreatitis,and *** risk of bias was assessed by the Cochrane revised Risk-of-Bias tool for randomized controlled *** quality of evidence was assessed by the Grading of Recommendation Assessment,Development,and ***-analysis was performed using the Review Manager 5.4 *** Ten randomized controlled trials with a total of 1757 patients that compared the use of antibiotic and non-antibiotic prophylaxis in patients undergoing elective ERCP were *** was no significant difference between groups regarding incidence of cholangitis after ERCP[risk difference(RD)=-0.02,95%confidence interval(CI):-0.05,0.02,P=0.32,cholangitis in patients with suspected biliary obstruction(RD=0.02,95%CI:-0.08 to 0.13,P=0.66),cholangitis on intravenous antibiotic prophylaxis(RD=-0.02,95%CI:-0.05 to 0.01,P=0.25),septicemia(RD=-0.02,95%CI:-0.06 to 0.01,P=0.25),pancreatitis(RD=-0.02,95%CI:-0.06 to 0.01,P=0.19),and allcause mortality(RD=0.00,95%CI:-0.01 to 0.01,P=0.71).However,the antibiotic prophylaxis group presented a 7%risk reduction in the incidence of bacteremia(RD=-0.07,95%CI:-0.14 to-0.01,P=0.03).CONCLUsION The prophylactic use of antibiotics in patients undergoing elective ERCP reduces the risk of bacteremia but does not appear to have an impact on the rates of cholangitis,septicemia,pancreatitis,and mortality.

关键词： Endoscopy Antibiotics Endoscopic retrograde cholangiopancreatography Cholangitis Infection

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西班牙伊比利亚户外养殖系统中,诺维氏梭状芽胞杆菌感染致使猪群中母猪猝死

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国外畜牧学（猪与禽） 2011年第4期31卷 35-37页

作者：倪晓丹 Alfredo Garc í a Dolores Ayuso Jose Manuel Ben í tez Waldo Luis Garc í a Remigio Mart í nez sergio s a nchez

诺维氏梭状芽胞杆菌(Clostridium novyi)是致使两例成年伊比利亚妊娠母猪死亡的可疑致病因,其中一例伴随着充气性肝坏死,快速腐烂,尸体鼓胀,并缺乏其他任何可检测到的死因。厌氧培养能够产生大量梭状芽胞杆菌样微生物,而B型诺维氏梭状... 详细信息

诺维氏梭状芽胞杆菌(Clostridium novyi)是致使两例成年伊比利亚妊娠母猪死亡的可疑致病因,其中一例伴随着充气性肝坏死,快速腐烂,尸体鼓胀,并缺乏其他任何可检测到的死因。厌氧培养能够产生大量梭状芽胞杆菌样微生物,而B型诺维氏梭状芽胞杆菌可以通过多重PCR分析鉴定得到。在妊娠母猪意外死亡的病例中,兽医需要注意到导致死亡的最普遍因素,包括诺维氏梭状芽胞杆菌的感染。为了达到正确的诊断,尸体检查是必要的,并在死后尽快收集样本。此外,运用PCR的方法能够对诺维氏梭状芽胞杆菌及其相关种型进行快速鉴定。

关键词：猪诺维氏梭状芽胞杆菌伊比利亚种猪猝死

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