Low-Dose Gamma Radiation Fields Decrease Cell Viability, Damage DNA, and Increase the Expression of Hsp70 and p53 Proteins in Human Leukocytes

作     者：Jessica Lizbeth Sifuentes Padilla David Alejandro García López Consuelo Letechipia de León Hector Rene Vega-Carrillo Sergio Hugo Sánchez Rodríguez Jessica Lizbeth Sifuentes Padilla;David Alejandro García López;Consuelo Letechipia de León;Hector Rene Vega-Carrillo;Sergio Hugo Sánchez Rodríguez

作者机构：Laboratorio de Biología Celular y Neurobiología Unidad Académica de Ciencias Biológicas Universidad Autónoma de Zacatecas Zacatecas México Laboratorio de Radiobiología Unidad Académica de Estudios Nucleares Universidad Autónoma de Zacatecas Zacatecas México 

出 版 物：《World Journal of Nuclear Science and Technology》 (核科学与技术国际期刊（英文）)

年 卷 期：2023年第13卷第4期

页      面：55-72页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Leukocytes Gamma Radiation Cell Damage DNA Hsp70 p53 

摘      要：Ionizing radiations are tools in diagnosis and treatment of diseases. Leukopenia from exposure to ionizing radiation has been reported. Due to their radiosensitivity, leukocytes are a biological model to analyze cell damage. Therefore, cell viability, DNA damage, and Hsp70 and p53 expression in human leukocytes exposed to low-dose gamma radiation fields from a 137Cs source were evaluated. A decrease in cell viability, DNA damage and an increase in the expression of Hsp70 and p53 proportional to the radiation dose received was found, which was 0.2, 0.4, 0.6, 0.8 and 1.0 mGy.