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A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

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Military Medical Research 2024年第2期11卷 228-267页

作者： Miguel A.Ortega Oscar Fraile-Martinez Cielo García-Montero sergio Haro Miguel Ángel Álvarez-Mon Diego De Leon-Oliva Ana M.gomez-Lahoz Jorge Monserrat Mar Atienza-Pérez David Díaz Elisa Lopez-Dolado Melchor Álvarez-Mon Department of Medicine and Medical Specialities University of Alcala28801 Alcala de HenaresSpain Ramón y Cajal Institute of Sanitary Research(IRYCIS) 28034 MadridSpain Department of Psychiatry and Mental Health Hospital Universitario Infanta Leonor28031 MadridSpain Service of Rehabilitation National Hospital for Paraplegic PatientsCarr.de la PeraledaS/N45004 ToledoSpain Immune System Diseases‑Rheumatology Service and Internal Medicine University Hospital Príncipe de Asturias(CIBEREHD)28806 Alcala de HenaresSpain

Spinal cord injury(SCI)is a devastating and disabling medical condition generally caused by a traumatic event(primary injury).This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage(secondary injury).The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI,explaining the progression and detrimental consequences related to this ***(PNIE)is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism,considering the mind and the body as a *** initial traumatic event and the consequent neurological disruption trigger immune,endocrine,and multisystem dysfunction,which in turn affect the patient's psyche and *** the present review,we will explore the most important local and systemic consequences of SCI from a PNIE perspective,defining the changes occurring in each system and how all these mechanisms are ***,potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.

关键词： Spinal cord injury(SCI) Psychoneuroimmunoendocrinology(PNIE) Secondary injury Immunoinflammatory dysfunction Gut microbiota Translational opportunities

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Isolation and Characterization of Mercury Resistant Trichoderma Strains from Soil with High Levels of Mercury and Its Effects on Arabidopsis thaliana Mercury Uptake

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Advances in Microbiology 2018年第7期8卷 600-613页

作者： JoséLuis Hernández-Flores JoséGerardo Bernal Melo Andrés Cruz Hernández Miguel A.Ramos López Carlos Saldana Gutiérrez sergio romero gomez Victor Pérez Moreno Rosa P.Calvillo Medina JoséHumberto Valenzuela Soto sergio Pacheco Hernández George H.Jones sergio Casas Flores Juan Campos-Guillen Laboratorio de Bioseguridad y Análisis de Riesgo Departamento de Ingeniería Genética de PlantasCentro de Investigación y de Estudios Avanzados del IPNIrapuatoGto.México Facultad de Química Universidad Autónoma de QuerétaroCerro de las Campanas s/nQuerétaroQro.México Escuela de Agronomía Universidad De La Salle Bajíocampus Campestre.LeónGto.México Facultad de Ciencias Naturales Universidad Autónoma de QuerétaroAv.De las Ciencias S/NQuerétaroQro.México Centro de Investigación en Química Aplicada Blvd.Enrique Reyna Hermosillo No.140SaltilloCoahuilaMéxico Department of Biology Emory UniversityAtlantaGeorgiaUSA IPICYT División de Biología Molecular.Camino a la presa San JoséNo.2055Colonia Lomas 4a sección.C.P.San Luis PotosíMexico

Traditional mining activities are usually correlated with high levels of soil pollution, which is a major environmental concern. Extensive mining activities have taken place in the San Joaquin region in the State of Querétaro, México resulting in high levels of mercury soil pollution (up to 1532 ± 300 mg/kg). We isolated mercury-resistant fungal strains from the San Joaquin region soils and identified them through morphologic characteristics and ITS rDNA region sequence analysis. We determined that fungi isolated belong to the genus Trichoderma. All the isolates selected showed the ability to catalyze the volatilization of Hg. For air sampling, an active sampling device was constructed and using acid KMnO4 as an absorbent, the concentration of mercury in solution was determined through the cold vapor atomic absorption method. The results show mercury volatilization from the fungal species assay, with a maximum of 213.04 ± 32.6 μg/m3 while mycelium accumulation ranged from less than 17.5 ± 2.9 to 20.0 ± 3.4 μg/g. The fungal isolates were also evaluated for their ability to reduce mercury uptake in Arabidopsis thaliana. These observations suggest the utility of Trichoderma for the mobilization of mercury in those contaminated soils.

关键词： Volatilization Mercury Trichoderma Soil Bioremediation

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Laser trimming for lithography-free fabrications of MoS_(2)devices

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Nano Research 2023年第4期16卷 5042-5046页

作者： Yong Xie OnurÇakıroğlu Wenshuai Hu Kexin He sergio Puebla Thomas Pucher Qinghua Zhao Xiaohua Ma Carmen Munuera Andres Castellanos-gomez Key Laboratory of Wide Band-Gap Semiconductor Technology School of Advanced Materials and NanotechnologyXidian UniversityXi’an 710071China Materials Science Factory Instituto de Ciencia de Materiales de MadridConsejo Superior de Investigaciones Científicas28049 MadridSpain

Single-layer MoS_(2)produced by mechanical exfoliation is usually connected to thicker and multilayer *** show a facile laser trimming method to insulate single-layer MoS_(2)regions from thicker *** demonstrate,through electrical characterization,that the laser trimming method can be used to pattern single-layer MoS_(2)channels with regular geometry and electrically disconnected from the thicker *** photocurrent microscope further confirms that in the as-deposited flake(connected to a multilayer area)most of the photocurrent is being generated in the thicker flake *** laser trimming,scanning photocurrent microscopy shows how only the single-layer MoS_(2)region contributes to the photocurrent *** presented method is a direct-write and lithography-free(no need of resist or wet chemicals)alternative to reactive ion etching process to pattern the flakes that can be easily adopted by many research groups fabricating devices with MoS_(2) and similar twodimensional materials.

关键词： 2D materials transition metal dichalcogenides laser trimming differential reflectance

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Risk Groups and Mortality in Patients with SARS-CoV-2 from Family Medicine Unit No. 43 in Southeastern Mexico

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Journal of Biosciences and Medicines 2023年第1期11卷 116-122页

作者： Abel Pérez-Pavón Sigrid Lorena Martínez-Vazquez Jorge Iván Martínez-Pérez Jorda Aleiria Albarrán-Melzer Juan Antonio Córdova-Hernández sergio De Jesús romero-Tapia sergio Quiroz-gomez Crystell G. Guzmán-Priego Social Security Institute of the State of Tabasco Villahermosa Mexico Cardiometabolism Laboratory Academic Division of Health Sciences Juarez Autonomous University of Tabasco Villahermosa México

SARS-CoV-2 infection is a viral disease that causes respiratory infections that can cause multiple complications. Patients with adjacent morbidities have a higher chance of complications and mortality. The National Health and Nutrition Survey (ENSANUT) in 2018 reported that in Mexico, 75.2% of adults aged 20 years and over are overweight and obese, both situations are closely related to the cases reported as severe COVID and even with a higher risk of mortality. The main objective was to evaluate the risk and mortality groups in patients with SARS-CoV-2 from family medicine in the south of México. The study was carried out during the 2020 year, in the Family Medicine Unit No. 43 of Villahermosa, Tabasco, a cross-sectional, retrospective investigation was carried out with an analytical approach, and the sample was obtained using the formula of n for infinite populations that correspond to 215, patients were included who met the selection criteria;3 groups were integrated: DM2, HAS and obesity. Descriptive statistics andχ2 formula were used, using the SPSS version 25 Windows program. The female gender presented the highest number of infections 122 (56.7%) and mortality: 5 (2.32%), obesity comorbidity presented the highest number of infections: 194 (90.2%), HAS: 153 (71.2%), and MD: 44 (20.46%). Complications were observed in 23 (10.69%), distributed in: SIRA: 7 (3.3%), multiple organ failure: 6 (2.8%), heart failure: 6 (2.8%) and pneumonia 4 (1.9%). The observed mortality was 8 (3.72%). The comorbidities of patients with the highest mortality were: SAH: 6 (75%) (χ2 = 9.169;df = 1;p = 0.010) and obesity: 6 (75%) (χ2 = 9.169;df = 1;p = 0.010). The group with the highest risk for SARS-CoV-2 was patients with overweight/obesity comorbidities. Mortality was 3.7%. The patients who died had at least one or more comorbidities. The main complications were ARIS, heart failure, and multiple organ failure.

关键词： Pandemic COVID-19 SARS-CoV-2 Hypertension Diabetes Obesity Mortality

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Milliwatt terahertz harmonic generation from topological insulator metamaterials

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Light(Science & Applications) 2022年第11期11卷 2766-2773页

作者： Klaas-Jan Tielrooij Alessandro Principi David Saleta Reig Alexander Block Sebin Varghese Steffen Schreyeck Karl Brunner Grzegorz Karczewski Igor Ilyakov Oleksiy Ponomaryov Thales V.A.G.de Oliveira Min Chen Jan-Christoph Deinert Carmen gomez Carbonell sergio O.Valenzuela Laurens W.Molenkamp Tobias Kiessling Georgy V.Astakhov Sergey Kovalev Catalan Institute of Nanoscience and Nanotechnology(ICN2) BIST and CSICCampus UABBellaterraBarcelona 08193Spain Department of Applied Physics TU EindhovenDen Dolech 25612 AZ EindhovenThe Netherlands School of Physics and Astronomy University of ManchesterM139PL ManchesterUK Physikalisches Institut(EP3) Universitat WurzburgAm Hubland97074 WurzburgGermany Institute of Physics Polish Academy of ScienceAl.Lotnikow 32/46PL-02668 WarsawPoland Helmholtz Zentrum Dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Institute for Topological Insulators Am HublandD-97074 WurzburgGermany

Achieving effcient,high-power harmonic generation in the terahertz spectral domain has technological applications,for example,in sixth generation(6G)communication *** Dirac fermions possess extremely large terahertz nonlinear susceptibilities and harmonic conversion ***,the observed maximum generated harmonic power is limited,because of saturation effects at increasing incident powers,as shown recently for ***,we demonstrate room-temperature terahertz harmonic generation in a Bi_(2)Se_(3) topological insulator and topological-insulator-grating metamaterial structures with surface-selective terahertz field *** obtain a third-harmonic power approaching the miliwatt range for an incident power of 75 mW-an improvement by two orders of magnitude compared to a benchmarked graphene *** establish a framework in which this exceptional performance is the result of thermodynamic harmonic generation by the massless topological surface states,benefiting from ultrafast dissipation of electronic heat via surface-bulk Coulomb *** results are an important step towards on-chip terahertz(opto)electronic applications.

关键词： harmonic insulator incident

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Comparison between type-2 and type-1 myocardial infarction：clinical features, treatment strategies and outcomes

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Journal of Geriatric Cardiology 2016年第1期13卷 15-22页

作者： Angel Lopez-Cuenca Miriam gomez-Molina Pedro J Flores-Blanco Marianela Sanchez-Martinez Andrea Garcia-Narbon Ignacio De Las Heras-gomez Maria J Sainchez-Galian Esther Guerrero-Perez Mariano Valdes sergio Manzano-Femandez Department of Internal Medicine Hospital de la Vega Lorenzo Guirao Cieza Spain Division of Cardiology University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Department of Biochemistry University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Department of lnternal Medicine University of Murcia Murcia Spain

ObjectiveTo 与尖锐心肌的梗塞(AMI ).MethodsWe 包括了的 type-2 对 type-1 在病人在发生，临床的特征，当前的治疗策略和结果估计差别有 type-1 或 type-2 AMI 的诊断的 824 个连续病人。在索引住院期间，临床的特征和治疗策略详细被... 详细信息

ObjectiveTo 与尖锐心肌的梗塞(AMI ).MethodsWe 包括了的 type-2 对 type-1 在病人在发生，临床的特征，当前的治疗策略和结果估计差别有 type-1 或 type-2 AMI 的诊断的 824 个连续病人。在索引住院期间，临床的特征和治疗策略详细被收集。在 1 年的后续，死亡，击，流血的非致命的心肌的梗塞和专业是 ***-1 AMI 在 707 是在场的(86%) 盒子当(14%) 117 作为 type-2 被分类时。有 type-2 AMI 的病人更经常是象糖尿病那样的女、有的更高的合作病态，以前的非圣片断举起急性冠的症候群，损害肾的功能，贫血症， atrial 纤维性颤动和恶意。然而，保存了左室的喷射部分，正常冠的动脉是经常看见的更多，侵略治疗是不太普通的，并且反血小板药， statins 和 beta-blockers 是在有 type-2 AMI 的病人规定的更少。在 1 年的后续， type-2 AMI 与更高粗略的死亡风险被联系(HR：1.75， 95% CI：1.14-2.68；P = 0.001 ) ，但是这个协会没在 multivariable 调整以后仍然保持重要(P = 0.785 ) 。而且，我们没发现 type-2 AMI 与另外的临床的 *** 被联系这张真实人口与 type-1 相比， type-2 AMI 是主要女人们并且有更多的合作病态。侵略治疗策略和 cardioprotective 药是在 type-2 使用的更少，当 1 年的临床的结果是类似的时。

关键词：冠的容器后续学习心肌的梗塞

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Confirmatory factor analysis of VISA-P scale and measurement invariance across sexes in athletes with patellar tendinopathy

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Journal of Sport and Health Science 2017年第3期6卷 365-371页

作者： sergio Hernandez-Sanchez Ferran Abat María D.Hidalgo Antonio I.Cuesta-Vargas Victor Segarra Jose M.Sanchez-Ibanez Antonia gomez-Conesa Department of Pathology and Surgery Physiotherapy AreaMiguel Hernandez UniversityValencia 03550Spain Sports Orthopaedic Surgeon ReSport ClinicBarcelona 08017Spain Department of Basic Psychology and Methodology University of MurciaMurcia 30100Spain Department of Physiotherapy Faculty of Health SciencesUniversity of MalagaMalaga 29009Spain

Background:The Victorian Institute of Sport Assessment–Patella(VISA-P) scale is the most condition-specific patient-reported outcome measure used to assess symptom severity in athletes with patellar *** exploratory factor analyses have been conducted to evaluate the scale's dimensionality,with inconsistent results,and the factor structure of the scale remains *** aims of the present study were to determine the factorial structure of the VISA-P scale using confirmatory factor analysis(CFA) and test measurement invariance across ***:The study included a convenience sample of 249 Spanish athletes with patellar *** was performed to assess factorial *** 1-and 2-factor models were *** invariance across sexes was evaluated via multi-group CFA with several fit indices using EQS 6.1 ***:The internal consistency coefficient was *** CFA models were examined and the 1-factor model in which errors for Items 7 and8 were correlated showed acceptable fit in terms of comparative fit index(CFI) and goodness-of-fit index(GFI) statistics(CFI = 0.93;GFI = 0.94;standardized root mean square residual = 0.06;root mean square error of approximation = 0.10;90% confidence interval:0.08–0.13).This model was invariant across ***:The 1-factor model of the Spanish version of the VISA-P scale(VISA-P-Sp) in which errors for Items 7 and 8 were correlated demonstrated relative fit in *** obtained via VISA-P-Sp can be compared between men and women without sexes *** studies should examine the VISA-P scale and other single-score patient-reported outcome measures concurrently.

关键词：跳线开关膝测量不变性报导病人的结果措施结构的有效性

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Evaluation of the Synergistic Effect of EDTA-Functionalized Chitosan Nanoparticles on Imipenem Delivery in Pseudomonas aeruginosa Carbapenem-Resistant Strain AG1

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Journal of Biomaterials and Nanobiotechnology 2018年第1期9卷 64-78页

作者： Marilyn Porras-gomez Jose Vega-Baudrit Fernando Garcia Santiago Nunez-Corrales sergio Madrigal-Carballo National Nanotechnology Laboratory(LANOTEC) National Center for Advanced Technology Studies(CeNAT)San JoseCosta Rica Centro de Investigaciones en Enfermedades Tropicales(CIET) Facultad de MicrobiologiaUniversidad de Costa RicaSan PedroCosta Rica National Center for Biotechnological Innovations(CENIBiot) National Center for Advanced Technology Studies(CeNAT)San JoseCosta Rica

Metallo-β-lactamases are bacterial zinc-dependent enzymes involved in the hydrolysis of β-lactamic antibiotics representing the main cause of bacterial resistance to carbapenems, drugs of last resort for treating infections caused by multiresistant bacteria. We elaborated the hypothesis that it is possible to inhibit the enzymatic activity of metallo-β-lactamases by lowering the availability of zinc in the extracellular medium using metal chelating agents such as EDTA carried on nanoparticles. Chitosan, as linear cationic polysaccharide is frequently used in biomedical and pharmaceutical applications, has been studied as a biocompatible encapsulating agent in drug delivery systems and is an ideal transport agent for bioactive molecular complexes in antibiotic applications due to its ability to associate with negatively charged substances. We developed novel nanoparticles using chitosan as a transport matrix for β-lactamic antibiotics. Nanoparticles were synthesized according to the ion gelation method using tripolyphosphate as crosslinking agent. Nanoparticles were functionalized by the adsorption of EDTA, which acts as complexifying agent for Zn2+ ions causing inhibition of metallo-β-lactamases activity. We evaluate the antimicrobial effects of EDTA-functionalized nanoparticles with an imipenem cargo on the clinical isolate P. aeruginosa AG1, a carbapenem-resistant high-risk clone ST-111 carrying both blaIMP-18 and blaVIM-2 metallo-β-lactamases genes.

关键词： Chitosan EDTA Nanoparticles Drug-Resistant Imipenem

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Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2019年第9期14卷 1626-1634页

作者： Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado sergio Sandoval-ávila Ulises gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre Unidad de Evaluation Preclinica Unidad de Biotecnologia Medica y FarmaceuticaCentro de Investigation y Asistencia en Tecnologia y Diseno del Estado de JaliscoGuadalajaraMexico Regenerative Medicine Unit Neuroscience InstituteDepartment of Neurosurgery and NeurologyIdlSSC Health Research Institute of the Hospital Clinico San CarlosMadridSpain

Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive *** purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s ***’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus *** water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after ***,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM *** showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem *** findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s *** procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval *** 2016-011)on April 25,2016.

关键词： Alzheimer’s disease neurodegenerative disease cognitive impairment memory Alzheimer’s disease mouse model mesenchymal stem cell exosomes neurogenesis cognitive improvement cell-free therapy neural regeneration

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Species richness and community structure of class Polyplacophora at the intertidal rocky shore on the marine priority region no.33,Mexico

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Open Journal of Ecology 2014年第2期4卷 43-52页

作者： Lizeth Galeana-Rebolledo Rafael Flores-Garza Adriana Reyes-gomez sergio Garcia-Ibanez Pedro Flores-Rodriguez Carmina Torreblanca-Ramirez Arcadio Valdes-Gonzalez Unidad Academica de Ecologia Marina Universidad Autonoma de GuerreroAcapulcoMexico Universidad Autonoma de Nuevo Leon Laboratorio de AcuaculturaFacultad de Ciencias BiologicasCiudad UniversitariaSan Nicolas de los GarzaMexico

Marine Priority Region No. 33 (MPR 33) lies in the State of Guerrero, where the National Commission for Knowledge and Use of Biodiversity has declared a lack of information on marine species, Class POLYPLACOPHORA among others. This program was carried out on the rocky intertidal zone of MPR 33 with the objectives to: 1) determine species richness, 2) community composition based on families represented, 3) estimate the density, 4) index of diversity, 5) analyze body proportions and 6) geographic distribution of species. Three surveys on five sites were conducted during 2009 and 2012, using one mt2 quadrant for systematic sampling procedure;collecting all POLYPLACOPHORA specimens found within the quadrants, then proceeding with their preservation. 441 organisms were analyzed where 17 species were identified, on nine genera within six families. Fifteen new species were recorded for the MPR 33. Family ISCHNOCHITONIDAE Dall, 1889 was the best represented in species richness and CHITONIDAE Rafinesque, 1815 in abundance. Density of 8.82 organisms/m2, the H′ index was 2.38 bits/individuals and J′ = 0.57. The species Chiton (Chiton) articulatus Sowerby, 1832 showed the highest density, greater size and was found in all five collection sites. Three species, (Chiton (C.) articulatus, Ischnochiton (Ischnochiton) muscarius (Reeve, 1847) and Chiton (Chiton) alboli-neatus Broderip & Sowerby, 1829), were considered wide. Intertidal species richness was associated with habitat stability and wave intensity;the more unstable sites had greater richness while most stable sites lower. Species inventory and understanding the communities’ interactions of the marine fauna of the State of Guerrero are important;therefore these efforts must be continued.

关键词： Polyplacophora New Records Methodology RMP 33 Guerrero

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