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Adjuvant Therapy on Cancer of the Lower Rectum. Evaluation of the Effects of Preoperative Radiotherapy on the Prognosis of Patients with Cancer of the Lower Rectum

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Journal of Cancer Therapy 2012年第6期3卷 912-919页

作者： Jose Alfredo Reis Neto Jose Alfredo Reis Junior Odorino Kagohara Joaquim Simoes Neto sergio obanci Luciane HOliveira Surgery Catholic University of CampinasCampinasBrazil Surgery Clinica Reis NetoCatholic University CampinasCampinasBrazil Coloproctology Clinica Reis NetoCatholic University CampinasCampinasBrazil.

Aims: The prognosis on treatment of the cancer of the rectum has not changed in the last fifty years. Survival rates of 50 to 55% seems immutable in several published series. The main cause for those results is the high incidence of recurrence, either local or widespread. Local recurrence is directly related to the number of undifferentiated cells and to the grade of wall invasion. Widespread recurrence depends specifically on the lymphatic and vascular spreading. So any kind of treatment that would diminish the number of undifferentiated cells and the size or the tumor wall penetration would certainly decrease the local recurrence rate, lengthening the interval free from cancer and, perhaps, modifying the long term survival rate. Between 1978 and 2009, a total of 538 patients with adenocarcinoma of the lower rectum (from the pectinate line to 10 cm above) were treated by preoperative radiotherapy. Methodology: The same protocol was used in all the patients – 400 cGy, 200 cGy/day, during 4 consecutive weeks (anterior and posterior pelvic fields) by means of a Linear Megavoltage Accelerator (25 MeV). Surgery was performed 2 months after completion of the radiotherapy. Results: Statistical analysis of the whole group showed that preoperative radiotherapy does decrease frequency of undifferentiated cells. Moreover, the incidence of local recurrence diminished after irradiation by 3.4%. Preoperative radiotherapy reduces tumor volume (ERUS) and wall invasion, as well as the mortality rate due to local recurrence (2.4%) and alters long-term survival rate (80.1%). Conclusion: Preoperative radiotherapy is really effective in reducing the number of undifferentiated cells and in diminishing the tumor volume and the carcinomatous infiltration of the rectal wall.

关键词： Rectal Cancer Cancer of the Lower Rectum Irradiation Preoperative Radiotherapy Local Recurrence Mortality Survival

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An Optimal Design Method Based on Small Amplitude Homogenization

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Chinese Annals of Mathematics,Series B 2015年第5期36卷 843-854页

作者： sergio GUTIERREZ Department of Structural and Geotechnical Engineering Pontificia Universidad Catolica de Chile

An optimal design method for two materials based on small amplitude homogenization is presented. The method allows to use quite general objective functions at the price that the two materials should have small contrasts in their relevant physical parameters. The following two applications are shown: Stress constrained compliance minimization and defect location in elastic bodies.

关键词： Homogenization Inverse problems Relaxation Stress concentration

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Molecular and crystal assembly inside the carbon nanotube:encapsulation and manufacturing approaches

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Advances in Manufacturing 2013年第3期1卷 198-210页

作者： sergio Manzetti Fjordforsk A.S. Institute of Science and Technology6896 FresvikNorway Van der Spoel Lab.Computational Systems and Biology Biomedical CentreUniversity of UppsalaP.O.Box 25675105 UppsalaSweden

Encapsulation of different guestspecies such as molecules and ions inside carbon nanotubes （CNTs） has been reported in the literatures during the last 15 years and repre sents an exciting development of nanoengineering of novel materials and composites. The reported nanocomposite mate rials show the semiconducting properties with potential applications in nanosensors, nanounits and nanocircuits as well as advanced energy transfer and storage properties, and encompass manufacturing for novel nanowires, nanoelectronic devices with properties designed with optoelectronic, spin tronic and nanomagnetic qualities. This review reports on a wide range of encapsulation references with particular focus on single molecules, atomic chains, metal halides and polymers encapsulated inside CNTs. The encapsulation methods and the chemical and physical qualities of these novel materials are crucial for the future manufacturing of novel innovations in nanotechnology, and represent therefore the current stateof theart of encapsulation methods in advanced manufacturing.

关键词： Encapsulation Carbon nanotubes (CNTs)Composites conductive Molecules

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State-of-the-art developments in metal and carbon-based semiconducting nanomaterials： applications and functions in spintronics, nanophotonics, and nanomagnetics

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Advances in Manufacturing 2017年第2期5卷 105-119页

作者： sergio Manzetti Francesco Enrichi Fjordforsk MS NanoFactory Midtun 6894 VangsnesNorway Computational Biology and Bioinformatics Uppsala University 75124 Uppsala Sweden Historical Museum of Physics and Research and Study Center Enrico Fermi 00184 Rome Italy Division of Materials Science Department of Engineering Sciences and Mathematics Lnlea University of Technology971 87 Lulea Sweden Department of Molecular and Nanosystems Sciences Ca' Foscari University of Venice 30172 Mestre VenetiaItaly Institute of Photonics and Nanotechnologies CSMFO Lab. &FBK-CMM IFN-CNR 38123 Povo Trento Italy

Nanomaterials composed of metals and metal alloys are the most valuable components in emerging micro- and nano-electronic devices and innovations to date. The composition of these nanomaterials, their quantum chemical and physical properties, and their production methods are in critical need of summarization, so that a complete state of the art of the present and future of nanotechnologies can be presented. In this review, we report on the most recent activities and results in the fields of spintronics, nanophotonics, and nanomagnetics, with particular emphasis on metallic nanoparticles in alloys and pure metals, as well as in organic combinations and in relation to carbon-based nanostructures. This review shows that the combinatory synthesis of alloys with rare metals, such as scandium, yttrium, and rare earths imparts valuable qualities to high-magnetic-field compounds, and provides unique properties with emphasis on nanoelectronic and computational components. In this review, we also shed light on the methods of synthesis and the background of spintronic, nanomagnetic, and nanophotonic materials, with applications in optics, diagnostics, nanoelectronics, and computational nanotechnology. The review is important for the industrial development of novel materials, and for summarizing both fabrication and manufacturing methods, as well as principles and functions of metallic nanoparticles.

关键词： Metal Alloy Nanoparticle Spintronics Nanophotonics Nanomagnetics Method Synthesis

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Gorenstein injective sheaves

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Frontiers of Mathematics in China 2017年第1期12卷 87-95页

作者： sergio ESTRADA Alina IACOB Departamento de Matem~ticas Universidad de Murcia Murcia 30100 Spain Department of Mathematical Sciences Georgia Southern University Statesboro GA 3O460 USA

We define Gorenstein injective quasi-coherent sheaves, and prove that the notion is local in case the scheme is Gorenstein. We also give a new characterization of a Gorenstein scheme in terms of the total acyclicity o... 详细信息

关键词： Gorenstein injective Noetherian scheme

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Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans

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Neural Regeneration Research 2020年第7期15卷 1247-1248页

作者： sergio Bagnato Cristina Boccagni Unit of Neurophysiology and Unit for Severe Acquired Brain Injuries Rehabilitation Department Giuseppe Giglio Foundation

Traumatic brain injury(TBI)is the paradigmatic example of acute brain injury,defined as sudden and unexpected structural and/or functional damage to the *** western countries,TBI is a main cause of prolonged disability,and it is even more impactful because it very often affects young *** to past belief,the cerebral damage caused by TBI is not limited to the short temporal phase following the mechanical ***,moderate/severe TBI can trigger several mechanisms of neuronal damage that operate for months or years after the acute injury,potentially leading to neuronal loss and brain atrophy.

关键词： acute damage injury

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Reactive pathways toward parasitic release of singlet oxygen in metal-air batteries

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npj Computational Materials 2021年第1期7卷 1135-1142页

作者： Adriano Pierini sergio Brutti Enrico Bodo Department of Chemistry University of Rome“La Sapienza”RomeItaly GISEL—Centro di Riferimento Nazionale per i Sistemi di Accumulo Elettrochimico di Energia FirenzeItaly

The superoxide disproportionation reaction is a key step in the chemistry of aprotic metal oxygen batteries that controls the peroxide formation upon discharge and opens the way for singlet oxygen *** we clarify the energy landscape of the disproportionation of superoxide in aprotic media catalyzed by group 1A *** analysis is based on ab initio multireference computational methods and unveils the competition between the expected reactive path leading to peroxide and an unexpected reaction channel that involves the reduction of the alkaline *** channels lead to the release of triplet and singlet O_(2).The existence of this reduction channel not only facilitates singlet oxygen release but leads to a reactive neutral solvated species that can onset parasitic chemistries due to their well-known reducing ***,we show that the application of moderate overpotentials makes both these channels accessible in aprotic batteries.

关键词： properties release singlet

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Superattracting cycles for some Newton type iterative methods

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Science China Mathematics 2011年第3期54卷 539-544页

作者： AMAT sergio BUSQUIER Sonia NAVARRO Emilie PLAZA sergio Departamento de Matemtica Aplicada y Estadistica Universidad Politécnica de Cartagena Ecole Généraliste d'Ingénieurs de Marseille (EGIM) Departamento de Matemticas Facultad de Ciencias Universidad de Santiago de Chile

The paper is devoted to the analysis of certain dynamical properties of a family of iterative Newton type methods used to find roots of non-linear equations. We present a procedure for constructing polynomials in such a way that superattracting cycles of any prescribed length occur when these iterative methods are applied. This paper completes the study begun in Amat, Bermúclez, Busquier, et al., (2009).

关键词： iterative methods (super)attracting cycles dynamics

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Performance Improvement of Artificial Neural Network Model in Short-term Forecasting of Wind Farm Power Output

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Journal of Modern Power Systems and Clean Energy 2020年第3期8卷 484-490页

作者： sergio Velázquez Medina Ulises Portero Ajenjo Department of Electronics and Automatics Engineering Universidad de Las Palmas de Gran CanariaCampus de Tafira s/n35017 Las Palmas de Gran CanariaCanary IslandsSpain School of Industrial and Civil Engineering University of Las Palmas de Gran CanariaCampus de Tafira s/n35017 Las Palmas de Gran CanariaCanary IslandsSpain

Due to the low dispatchability of wind power,the massive integration of this energy source in power systems requires short-term and very short-term wind power output forecasting models to be as efficient and stable as possible.A study is conducted in the present paper of potential improvements to the performance of artificial neural network(ANN)models in terms of efficiency and ***,current ANN models have been developed by considering exclusively the meteorological information of the wind farm reference station,in addition to selecting a fixed number of time periods prior to the *** this respect,new ANN models are proposed in this paper,which are developed by:varying the number of prior 1-h periods(periods prior to the forecasting hour)chosen for the input layer parameters;and/or incorporating in the input layer data from a second weather station in addition to the wind farm reference *** has been found that the model performance is always improved when data from a second weather station are *** mean absolute relative error(MARE)of the new models is reduced by up to 7.5%.Furthermore,the longer the forecasting horizon,the greater the degree of improvement.

关键词： Artificial neural networks(ANN) wind power forecasting model performance wind power output

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Semen analysis and sperm function testing

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Asian Journal of Andrology 2012年第1期14卷 6-13,174页

作者： Daniel R Franken sergio Oehninger Department of Obstetrics and Gynaecology Tygerberg Hospita Tygerberg Cape Town 7505 South Africa Department of Obstetrics and Gynaecology Eastern Virginia Medical School Jones Institute for Reproductive Medicine Norfolk VA 23507 USA

Despite controversy regarding the clinical value of semen analysis, male fertility investigation still relies on a standardized analysis of the semen parameters. This is especially true for infertility clinics in both developing and developed countries. Other optional tests or sophisticated technologies have not been widely applied. The current review addresses important changes in the analysis of semen as described in the new World Health Organization （WHO） manual for semen analysis. The most important change in the manual is the use of evidence-based publications as references to determine cutoff values for normality. Apart from the above mentioned changes, the initial evaluation and handling methods remain, in most instances, the same as in previous editions. Furthermore, the review evaluates the importance of quality control in andrology with emphasis on the evaluation of sperm morphology. WHO sperm morphology training programmes for Sub-Saharan countries were initiated at Tygerberg Hospital in 1995. The external qualitY control programme has ensured that the majority of participants have maintained their morphological reading skills acquired during initial training. This review reports on current sperm functional tests, such as the induced acrosome reaction, and sperm-zona pellucida binding assays, as well as the impact of sperm quality in terms of DNA integrity, and the relationship of sperm function tests to sperm morphology.

关键词： male infertility quality assurance semen analysis spermatozoa sperm concentration sperm function sperm morphology sperm motility

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