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Phagocytosis: A Practical Approach for Evaluating Neutrophil Function in Health and Disease

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Modern Research in Inflammation 2024年第2期13卷 9-28页

作者： Oscar Rojas-Espinosa Patricia Arce-Paredes sergio Islas-Trujillo Luis Enrique Becerril-Villanueva María Dolores Ponce-Regalado Departamento de Inmunologa Escuela Nacional de Ciencias Biolgicas Instituto Politcnico Nacional Ciudad de Mxico Mxico Laboratorio de Psicoinmunologa Instituto Nacional de Psiquiatra Ramn de la Fuente Ciudad de Mxico Mxico Departamento de Ciencias de la Salud Centro Universitario de los Altos Universidad de Guadalajara Jalisco Mxico

Neutrophils, crucial players in the effector phase of the immune response, are recognized as important mediators of both innate and adaptive immune responses. Through the production of pro- and anti-inflammatory cytokines, they modulate the function of T and other lymphoid cells. Countless reports have highlighted the importance of these cells as efficient antimicrobial agents and annotated their involvement in the pathology of infectious and noninfectious diseases. The development of modern, sophisticated technologies has allowed the study of the functions of these cells in clinical settings. These advanced technologies include fluorescence-activated cell sorters, confocal microscopy, automated cell image analyzers, and live cell analysis instruments. Unfortunately, the cost of these modern instruments, maintenance, reagents, and the need for qualified technicians prohibit their use in low-income laboratories and universities in developing countries. With this in mind, we propose a series of basic tests that can be used in low-input clinical laboratories and universities to evaluate the function of neutrophils in health and disease. Our methodology allows us to assess in a practical and low-cost manner the functions of neutrophils in the phagocytic process, including opsonization, ingestion, ROI production (NBT reduction), myeloperoxidase content, phagosome-lysosome fusion, microbicidal activity, and NET production. Thus, under a disadvantageous ambiance, this may guide physicians in deciding whether a patient’s illness involves phagocytic defects without imposing a heavy financial *** Abstract[-rId13-]

关键词： Phagocytosis Neutrophils Microbicidal Activity Netosis

Alpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury

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Neural Regeneration Research 2023年第4期18卷 875-880页

作者： Gabriela García-Díaz Laura ERamos-Languren Carmen Parra-Cid Joel Lomelí sergio Montes Camilo Ríos Antonio Bueno-Nava Ignacio Valencia-Hernández Rigoberto gonzález-Piña Department of Pharmacology Section of Postgraduate Studies and ResearchHigh Medical SchoolInstituto Politécnico NacionalSalvador Díaz MirónAlcaldía Miguel HidalgoMexico CityMexico Department of Neurobiology of Aging and Brain Damage Coordination of Psychobiology and NeurosciencesFaculty of PsychologyNational Autonomous University of MexicoAv.Universidad 3040Col.Copilco UniversidadAlcaldía CoyoacánMexico CityMexico Direction of Research National Institute of Rehabilitation LGIICalz.Mexico-Xochimilco 289Col.Arenal de GuadalupeAlcaldía TlalpanMexico CityMexico Department of Pharmacology Multidisciplinary Academic Unit Reynosa-Aztlan ReynosaAutonomous University of Tamaulipascalle 16 y lago de ChapalaCol.AztlánTamaulipasMexico Department of Neurochemistry National Institute of Neurology and Neurosurgery MVSAv.Insurgentes Sur 3877Col.La FamaAlcaldia TlalpanMexico CityMexico Department of Special Education University of the AmericasPuebla 223Col.RomaAlcaldía CuauhtémocMexico CityMexico

Norepinephrine plays an important role in motor functional recovery after a brain injury caused by ferrous *** of norepinephrine release by clonidine is correlated with motor deficits after motor cortex *** aim of this study was to analyze the role ofα-adrenergic receptors in the restoration of motor deficits in recovering rats after brain *** rats were randomly assigned to the sham and injury groups and then treated with the following pharmacological agents at 3 hours before and 8 hours,3 days,and 20 days after ferrous chloride-induced cortical injury:saline,clonidine,efaroxan(a selective antagonist ofα-adrenergic receptors)and clonidine+*** sensorimotor score,the immunohistochemical staining forα-adrenergic receptors,and norepinephrine levels were *** hours post-injury,the sensorimotor score and norepinephrine levels in the locus coeruleus of the injured rats decreased,and these effects were maintained 3 days ***,20 days later,clonidine administration diminished norepinephrine levels in the pons compared with the sham *** effect was accompanied by sensorimotor *** effects were blocked by *** conclusion,an increase inα-adrenergic receptor levels was observed after *** restores motor deficits in rats recovering from cortical injury,an effect that was prevented by *** underlying mechanisms involve the stimulation of hypersensitiveα-adrenergic receptors and inhibition of norepinephrine activity in the locus *** results of this study suggest thatαreceptor agonists might restore deficits or impede rehabilitation in patients with brain injury,and therefore pharmacological therapies need to be prescribed cautiously to these patients.

关键词： alpha2-adrenoceptors ambulatory behavior clonidine cortical injury efaroxan functional recovery immunohistochemistry motor deficit norepinephrine sensorimotor score

Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez Jose Manuel Cozar Jose Antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

Fagus sylvatica and Quercus pyrenaica:Two neighbors with few things in common

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Forest Ecosystems 2023年第2期10卷 162-175页

作者： sergio de Tomás Marín Jesús Rodríguez-Calcerrada Salvador Arenas-Castro Iván Prieto Guillermo gonzález Luis Gil Enrique G.de la Riva Department of Ecology Brandenburgische Technische Universität Cottbus-SenftenbergKonrad-Wachsmann-Allee 603046CottbusGermany Forest Genetics and Ecophysiology Research Group School of Forestry EngineeringUniversidad Politécnica de MadridMadridSpain Area of Ecology Botany DepartmentEcology and Plant PhysiologyFaculty of SciencesUniversidad de CórdobaCórdobaSpain Ecology Department Faculty of Biology and Environmental SciencesUniversidad de LeónLeónSpain

Background:The Iberian Peninsula comprises one of the largest boundaries between Mediterranean and Eurosiberian vegetation,known as sub-Mediterranean *** ecotone hosts many unique plant species and communities and constitutes the low-latitude(warm)margin of numerous central European species which co-occur with Mediterranean *** of the main species found in this region are the Eurosiberian European beech(Fagus sylvatica L.)and the Mediterranean Pyrenean oak(Quercus pyrenaica Willd.).It remains unclear how the different physiological and adaptive strategies of these two species reflect their niche partitioning within a subMediterranean community and to what extent phenotypic variation(intraspecific variability)is driving niche partitioning across Eurosiberian and Mediterranean ***:We quantified functional niche partitioning,based on the n-dimensional hypervolume to nine traits related to resource acquisition strategies(leaf,stem and root)plus relative growth rate as an additional wholeplant trait,and the environmental niche similarity between Pyrenean oak and European ***,we analyzed the degree of phenotypic variation of both target species and its relationship with relative growth rates(RGR)and environmental *** recruitment was measured for both target species as a proxy for the average ***:Species’functional space was highly segregated(13.09%overlap),mainly due to differences in niche breadth(59.7%)rather than niche replacement(25.6%),and beech showed higher trait variability,i.e.,had larger functional ***,both species shared the environmental space,i.e.,environmental niches were *** plant traits were not related to abiotic variables or RGR,neither did RGR to plant ***:Both target species share similar environmental space,however,show notably different functional resource-use strategies,promoting a high complementarity that contributes to maintaining a high functiona

关键词： Environmental niche European beech Forest dynamics Functional niche Hypervolume Pyrenean oak Species coexistence Sub-Mediterranean community

Patient Safety in the Use of Mechanical Restraints: Regulatory Compliance among Hospitals in the City of Buenos Aires and Proposal for Its Improvement

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Open Journal of Emergency Medicine 2024年第2期12卷 33-39页

作者： Martín Javier Mazzoglio y Nabar sergio Giordano Edgardo Knopoff Lorena Onofrio Oscar Agustín Porta Romina Rodríguez Emergency Service Torcuato de Alvear Psychiatric Emergency Hospital Buenos Aires Argentina Department of Psychiatry and Mental Health Faculty of Medicine University of Buenos Aires Buenos Aires Argentina

Introduction: Mechanical or physical restraint is an exceptional therapeutic resource to immobilize a subject and thus guarantee the safety of the patient and/or third parties in the face of high-risk behaviors, but it entails multiple crossings (bioethical, philosophical, medical, psychological, legal). Framed in the so-called “safety culture” developed by the WHO, based on the Protocol for its implementation of the CABA and attentive to its frequent use in CABA by different hospital services (medical clinic, geriatrics, intensive care and medical guards) we consider it necessary its study in terms of compliance with the risks it entails and its management. Objectives: Identify regulatory compliance with the GCABA Mechanical restraint (MR) Protocol from a patient safety perspective, as well as describe the clinical and medicolegal aspects, and propose the usefulness of a tool for its management and control. Methodology: Observational, descriptive, transversal and prospective work through the analysis of Clinical Records with indication of MR using a rubric-type form. 177 cases were analyzed between September-November 2023 from three hospitals of the Government of the City of Buenos Aires, statistical parameters were applied and graphs were made. Results: Only 12.99% complied with the Protocol. In the mental health specialized hospital compliance was almost 5 times greater than in the general one, and in the emergency services compliance was 12 times greater than in Inpatient services. We found that the start or end time of MR was not recorded and only 43% described the causes/justifications for the indication (mostly in Emergency and Specialized hospitals), with the MR average time being shorter in Emergency. Conclusions: Only 1.3 out of 10 patients reliably completed the Protocol and it was mostly in the mental health specialized hospital and the emergency services. The results show non-compliance behavior in the application and management of the risk that the use

关键词： Mechanical Containment Patient Safety Injuries in Custody Buenos Aires City Check List

Past,present,and future perspectives of ultrasound-guided ablation of liver tumors:Where could artificial intelligence lead interventional oncology?

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Artificial Intelligence in Cancer 2024年第1期5卷 1-12页

作者： Paola Tombesi Andrea Cutini Valentina Grasso Francesca Di Vece Ugo Politti Eleonora Capatti Florence Labb Stefano Petaccia sergio Sartori Department of Internal Medicine Section of Interventional UltrasoundSt.Anna HospitalFerrara 44100Italy Esaote S.p.A. Genova 16100Italy

The first ablation procedures for small hepatocellular carcinomas were percutaneous ethanol injection under ultrasound(US)***,radiofrequency ablation was shown to achieve larger coagulation areas than percutaneous ethanol injection and became the most used ablation technique *** the past decade,microwave ablation systems have achieved larger ablation areas than radiofrequency ablation,suggesting that the 3-cm barrier could be broken in the treatment of liver ***,US techniques to guide percutaneous ablation have seen important ***-enhanced US(CEUS)can define and target the tumor better than US and can assess the size of the ablation area after the procedure,which allows immediate retreatment of the residual tumor ***,fusion imaging fuses real-time US images with computed tomography or magnetic resonance imaging with significant improvements in detecting and targeting lesions with low conspicuity on ***,software powered by artificial intelligence has been developed to allow three-dimensional segmentation and reconstruction of the anatomical structures,aiding in procedure planning,assessing ablation completeness,and targeting the residual viable foci with greater precision than ***,this could lead to the ablation of tumors up to 5-7 cm in size.

关键词： Artificial intelligence Fusion imaging Percutaneous thermal ablation Microwave ablation Radiofrequency ablation Ultrasound Contrast-enhanced ultrasound

Patients with hepatocellular carcinoma that die during the first year of liver transplantation have high blood sFasL concentrations

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World Journal of Clinical Cases 2023年第8期11卷 1753-1760页

作者： Leonardo Lorente sergio T Rodriguez Pablo Sanz Agustín F gonzález-Rivero Antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio gonzález María M Martín Alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera Intensive Care Unit Hospital Universitario de CanariasLa Laguna 38320Spain Intensive Care Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain Department of Surgery Hospital Universitario Nuestra Señora de CandelariaSanta Cruz Tenerife 38010Spain Department of Laboratory Hospital Universitario de CanariasLa Laguna 38320Spain Department of Digestive Hospital Universitario Nuestra Señora de CandelariaSanta Cruz Tenerife 38010Spain Research Unit Hospital Universitario de CanariasLa Laguna 38320Spain Transplant Unit Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain Department of Radiology Hospital Universitario Nuestra Señora CandelariaSanta Cruz Tenerife 38010Spain

BACKGROUND Fas ligand(FasL)is one ligand that activates extrinsic apoptosis *** expression in lymphocytes of FasL have been found in patients with acute rejection of liver transplantation(LT).No high blood concentrations of soluble FasL(sFasL)have been found in patients with acute LT rejection;however,the samples size of those studies was *** To determine whether patients with hepatocellular carcinoma(HCC)that dead during the first year of LT have higher blood sFasL concentrations previously to LT that those who that remain alive in a study of higher sample *** Patients underwent LT due to HCC were included in this retrospective *** sFasL levels prior to LT were measured and one-year LT mortality was *** Non-surviving patients(n=14)showed higher serum sFasL levels[477(269-496)vs 85(44-382)pg/mL;P<0.001]than surviving patients(n=113).Serum sFasL levels(pg/mL)were associated with mortality(OR=1.006;95%CI=1.003-1.010;P=0.001)independently of age of LT donor in the logistic regression *** We report for the first time that HCC patients who die within the first year of HT have higher blood sFasL concentrations prior to HT than those who remain alive.

关键词： sFasL Hepatocellular carcinoma Liver transplantation Mortality Outcome

Security Threats to Business Information Systems Using NFC Read/Write Mode

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Computers, Materials & Continua 2021年第6期67卷 2955-2969页

作者： sergio Rios-Aguilar Marta Beltrán gonzález-Crespo Rubén Department of Organization Engineering Business Administration and StatisticsETSI InformáticosUniversidad Politécnica de Madrid(UPM)Boadilla del Monte(Madrid)28660Spain Department of Computing ETSIIUniversidad Rey Juan CarlosMóstoles(Madrid)28933Spain ESIT Universidad Internacional de La Rioja(UNIR)Logroño(La Rioja)26006Spain

Radio Frequency IDentification(RFID)and related technologies such as Near Field Communication(NFC)are becoming essential in industrial contexts thanks to their ability to perform contactless data exchange,either device-to-device or *** of the three main operation modes of NFC,called read/write mode,makes use of the latter type of *** is extensively used in business information systems that make use of NFC tags to provide the end-user with augmented information in one of several available NFC data exchange formats,such as plain text,simple URLs or enriched *** a wide variety of physical form factors,NFC-compatible tags(wireless transponders)are currently available in many locations with applications going from smart posters,contactless tokens,tap-and-go payments or transport ticketing to automated device configuration,patient identification at hospitals or inventory management within supply *** of these applications handle sensitive processes or *** paper proposes a complete security threat model for the read/write operation mode of NFC used in Next Generation Industrial IoT(Nx-IIoT)*** model,based on a wellknown methodology,STRIDE,allows developers and users to identify NFC applications vulnerabilities or weaknesses,analyze potential threats,propose risk management strategies,and design mitigation mechanisms to mention only some significant examples.

关键词： Near field communications read/write NFC security threat modelling STRIDE Nx-IIoT

Methane Dry Reforming over Alumina Supported Co Catalysts

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Chemical Research in Chinese Universities 2004年第4期20卷 457-461页

作者： sergio L. gonzález Cortés Malcolm L. H. Green Inorganic Chemistry Laboratory University of OxfordInorganic Chemistry Laboratory University of Oxford South Parks Road OX1 3QR UKSouth Parks Road OX1 3QR UK

A series of Co/γ-Al_2O_3 catalysts were prepared with the impregnation method and characterized by means of the BET specific surface area, X-ray diffraction(XRD), thermogravimetric analysis(TGA) and Laser Raman spectroscopy. The Co/γ-Al_2O_3 catalysts were activated by using H_2, 20%CH_4/H_2 or CH_4, respectively. There was no obvious difference between the activities of the Co/γ-Al_2O_3 catalyst activated by using the different activation methods for methane dry reforming. The catalytic properties of the Co/γ-Al_2O_3 catalysts with different Co loadings were also investigated. The optimized Co loading for the Co/γ-Al_2O_3 catalyst pretreated with 20% CH_4/H_2 is around 12%(mass fraction).

关键词： Methane dry reforming Alumina supported cobalt catalysts Catalytic deactivation