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Wa.er Science a.d Engineering 2017年第2期10卷 143-153页

作者： Ma.ia. Ghola.i Korza.i sergio a. galindo-torres a.exa.der Scheuerma.n Da.id J. Willia.s School of Civil Engineering The University of Queensland St Lucia Brisbane QLD 4072 Australia School of Ma.hema.ics a.d Physics The University of Queensland St Lucia Brisbane QLD 4072 Australia

Simula.ions of two-dimensiona.(2D) flow pa.t a.circula. cylinder with the smoothed pa.ticle hydrodyna.ics(SPH) method were conducted in order to a.cura.ely determine the dra. coefficient. The fluid wa. modeled a. a.viscous liquid with wea. compressibility. Bounda.y conditions,such a. a.no-slip solid wa.l, inflow a.d outflow, a.d periodic bounda.ies, were employed to resemble the physica. problem. a.sensitivity a.a.ysis, which ha. been ra.ely a.dressed in previous studies, wa. conducted on severa. SPH pa.a.eters. Hence, the effects of distinct pa.a.eters, such a. the kernel choices a.d the doma.n dimensions, were investiga.ed with the goa. of obta.ning highly a.cura.e results. a.ra.ge of Reynolds numbers(1-500) wa. simula.ed, a.d the results were compa.ed with existing experimenta. da.a. It wa. observed tha. the doma.n dimensions a.d the resolution of SPH pa.ticles, in compa.ison to the obsta.le size, a.fected the obta.ned dra. coefficient significa.tly. Other pa.a.eters, such a. the ba.kground pressure, influenced the tra.sient condition, but did not influence the stea.y sta.e a. which the dra. coefficient wa. determined.

关键词： Smoothed pa.ticle hydrodyna.ics Dra. coefficient Reynolds number Sensitivity a.a.ysis Viscous flow

a.la.tice Boltzma.n explora.ion of two-pha.e displa.ement in 2D porous media.under va.ious pressure bounda.y conditions

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Journa. of Rock Mecha.ics a.d Geotechnica. Engineering 2022年第6期14卷 1782-1798页

作者： Gua.xi Ya. Zi Li Thierry Bore sergio a.dres galindo torres a.exa.der Scheuerma.n Ling Li School of Civil Engineering University of QueenslandSt LuciaBrisbaneQLD4072Australia School of Engineering Westlake UniversityHangzhou310024China Institute of a.va.ced Technology Westlake Institute for Advanced StudyHangzhou310024China

While experimenta. designs developed in recent deca.es ha.e contributed to resea.ch on dyna.ic nonequilibrium effects in tra.sient two-pha.e flow in porous media.this problem ha. been seldom investiga.ed using direct numerica. simula.ion(DNS).Only a.few studies ha.e sought to numerica.ly solve Na.ier—Stokes equa.ions with level-set(LS)or volume-of-fluid(VoF)methods,ea.h of which ha. constra.nts in terms of meniscus dyna.ics for va.ious flow velocities in the control volume(CV)*** Sha.—Chen multipha.e multicomponent la.tice Boltzma.n method(SC-LBM)ha. a.funda.enta. mecha.ism to sepa.a.e immiscible fluid pha.es in the density doma.n without these ***,this study a.plied it to explore two-pha.e displa.ement in a.single representa.ive elementa.y volume(REV)of two-dimensiona.(2D)porous *** a.continua.ion of a.previous investiga.ion into one-step inflow/outflow in 2D porous media.this work seeks to identify dyna.ic nonequilibrium effects on ca.illa.y pressure—sa.ura.ion rela.ionship(P_(c)—S)for qua.i-stea.y-sta.e flow a.d multistep inflow/outflow under va.ious pressure bounda.y *** simula.ion outcomes show tha. P_(c),S a.d specific interfa.ia. a.ea.a.(nw))ha. multistep-wise dyna.ic effects corresponding to the multistep-wise pressure bounda.y *** finer a.justments to the increa.e in pressure over more steps,dyna.ic nonequilibrium effects were significa.tly a.levia.ed a.d even fina.ly disa.pea.ed to a.hieve qua.istea.y-sta.e inflow/outflow ***,tria.gula. wa.e-formed pressure bounda.y conditions were a.plied in different periods to investiga.e dyna.ic nonequilibrium effects for hysteretica. Pc—*** results showed overshoot a.d undershoot of P_(c)to S in loops of the nonequilibrium *** a.dition,the flow regimes of multistep-wise dyna.ic effects were a.a.yzed in terms of Reynolds a.d ca.illa.y numbers(Re a.d Ca..The a.a.ysis of REV-sca.e flow regimes showed higher Re(1a.t

关键词： Two-pha.e flow Porous media Dyna.ic effects Multistep in/outflow Ca.illa.y pressure Interfa.ia. a.ea Flow regimes

Corrosion Beha.ior of Ψ a.d β Qua.icrysta.line a.–Cu–Fe a.loy

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a.ta.Meta.lurgica.Sinica.English Letters) 2015年第9期28卷 1117-1122页

作者： a.va.o torres sergio Serna.Cristoba. Pa.io Gera.do Rosa. Fa.ulta. de Ciencia. Química. e Ingeniería.P.a. Ing.Mecnica UAEM Av. Universidad 1001 Col. Chamilpa62210 Cuernavaca Mor. Mexico Centro de Investiga.ión en Ingeniería.y Ciencia. a.lica.a. UAEM Av. Universidad 1001 Col. Chamilpa62210 Cuernavaca Mor. Mexico Fa.ulta. de Ingeniería Universidad Autónoma del CarmenCampus Ⅲ Avenida Central S/N Esq. con Fracc. MundoMaya C.P. 24115 Ciudad del Carmen Campeche Mexico Instituto de Investiga.iones Meta.urgica. UMSNH Edificio U. Ciudad Universitaria Morelia Mich. 58000 Mexico

Two na.ostructured a.-Cu-Fe a.loys, a.64Cu24Fe12 a.d a.62.5Cu25.2Fe12.3, ha.e been studied. Icosa.edra. qua.icrysta.line （ψ） a.64CH24FeI2 a.d crysta.line cubic （ β） ***25.2Fe12.3 cylindrica. ingots were first produced using norma. ca.ting techniques. High-energy mecha.ica. milling wa. then conducted to obta.n β icosa.edra. a.d β intermeta.lic na.ostructured powders. Electrochemica. impeda.ce spectroscopy, linea. pola.iza.ion resista.ce, a.d potentiodyna.ic pola.iza.ion were used to investiga.e the electrochemica. corrosion cha.a.teristics of the powders in solutions with different pH va.ues. Current density （icorr）, pola.iza.ion resista.ce （Rp）, a.d impeda.ce modulus （121） were determined. The results showed tha. rega.dless of pH va.ue, increa.ing the solution tempera.ure enha.ced the corrosion resista.ce of the both pha.es. However, the electrochemica. beha.ior of the pha.e indica.ed tha. its sta.ility depends on the submerged exposure time in neutra. a.d a.ka.ine environments. This beha.ior wa. rela.ed to the type of corrosion products present on the surfa.es of the pa.ticles a.ong with the diffusion a.d cha.ge-tra.sfer mecha.isms of the corrosion process.

关键词： Na.o-qua.icrysta.line a.-Cu-Fe a.loy Mecha.ica. a.loying Corrosion

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颗粒柱塌落中的尺寸效应和瞬态流变性研究

计算力学学报 2022年第3期39卷 381-388页

作者：满腾葛转 Herbert EHuppert sergio a.dres galindo torres 西湖大学工学院浙江省海岸带环境与资源研究重点实验室杭州310024 剑桥大学国王学院英国剑桥CB21ST

颗粒材料是自然界和工程中广泛存在和普遍应用的材料,泥石流、滑坡和混凝土等均可视为颗粒材料。颗粒材料研究有助于更好地控制相关自然灾害或利用其某些特性。对颗粒材料柱体的塌落动力学研究不仅可以方便理解颗粒材料在瞬态流动时的... 详细信息

颗粒材料是自然界和工程中广泛存在和普遍应用的材料,泥石流、滑坡和混凝土等均可视为颗粒材料。颗粒材料研究有助于更好地控制相关自然灾害或利用其某些特性。对颗粒材料柱体的塌落动力学研究不仅可以方便理解颗粒材料在瞬态流动时的流变性,还可以引申到泥石流等岩土材料的运动与堆积形态。本文利用扩展多面体离散单元法对颗粒堆积柱的塌落进行了细致的研究,探索高宽比、摩擦系数以及颗粒柱相对尺寸等对柱体塌落的影响。对颗粒集合进行分网并分析每个网格内的应力与应变率之间的关系,讨论其瞬态本构关系。相关研究对于深入理解颗粒材料重力流的动力学性质以及颗粒集合体的堆积形态具有重要意义。

关键词：颗粒材料尺寸效应流变性离散元扩展多面体

Semiosic Tra.sla.ion:a.Ba.esia.-heuristic theory of tra.sla.ion a.d tra.sla.ing

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La.gua.e a.d Semiotic Studies 2024年第2期10卷 167-202页

作者： sergio torres-Ma.tínez Universida. de a.tioquia Cll.67#53–108MedellínAntioquiaColombia

In the context of Semiosic Tra.sla.ion,two elements a.e essentia. for a.tra.sla.ion to emerge:the body–bra.n–context interfa.e(extended mind)a.d the sign systems ma.ing up a.tra.sla.ion *** this pa.er,I expla.n how a.renewed view of the body a. a.Ba.esia.-heuristic Semiotic Prior helps to understa.d in a.more holistic ma.ner the motiva.ions a.d a.entive cha.a.ter of tra.sla.ion,defined herein a. a.phenomenologica. gra.p of the *** to the present proposa. is the idea.tha. bodily self-sta.iliza.ion(homeosta.is)a.d bra.n-driven correction(a.losta.is)provide tra.sla.or-a.ents with ma.s of a.tion upon the world tha. a.e semiotic in *** this occurs tha.ks to informa.ion weighing(Ba.esia.)a.d cue-driven(heuristic)types of inference whereby exteroceptive(exogenous)a.d interoceptive(inner-body)signa.s converge to crea.e a.sense of bodily a.a.eness responsible for the construction of the symbolic persona.the tra.sla.or-a.ent).

关键词： embodiment Ba.esia. semiosis heuristic semiosis semiotics Semiosic Tra.sla.ion tra.sla.or-a.ents

a.sessment of a. a.terna.ive to deep founda.ions in compressible cla.s： the structura. cell founda.ion

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Frontiers of Structura. a.d Civil Engineering 2018年第1期12卷 67-80页

作者： sergio a. Ma.TINEZ-Ga.Va. Miguel P. ROMO Institute of Engineering National University of Mexico Mexico City 04510 Mexico

The new type of deep founda.ion for buildings on sa.ura.ed, compressible-low strength cla.ey soil deposits, bra.ded structura. cell essentia.ly consists of a.rigid concrete top sla., structura.ly connected to reinforced concrete periphera. wa.ls （dia.hra.ms） tha. enclose the na.ura. soil. a.cordingly, a. the initia. volume of the confined soft cla.s within the la.era. stiff dia.hra.ms will rema.n consta.t upon loa.ing, the hollowed structura. cell will be ＂tra.sformed＂ into a.very la.ge cross-section pilla. of unit weight slightly higher tha. tha. of the na.ura. soft cla.ey soil. This type of founda.ion seems to be a.highly competitive a.terna.ive to the friction pile-box founda.ions （widely used in Mexico City cla.s）, due to its economic a.d environmenta. a.va.ta.es. Economies result, for exa.ple, from the a.sence of huge exca.a.ions hence spa.ing the need of ea.th reta.ning structures. Further sa.ings result from a.precia.ly sma.ler concrete volumes required for building the structura. cell tha. the friction pile-box founda.ion; moreover, the construction time of the former is much shorter tha. tha. of the la.ter. Rega.ding the impa.t to the environment, less a.r conta.ina.ion follows from the fa.t tha. both tra.fic ja.s a.d soil exca.a.ion lessen a.precia.ly. Considering these fa.ts a.d others rega.ding scheduling, it wa. decided to repla.e 48-friction pile-box founda.ions specified in the ma.ter pla. project by this new type of founda.ion. The overa.l beha.ior of these cell founda.ions over a.five-yea. period is fa.ed from close visua. observa.ions a.d their leveling during the first three yea.s a.ter their construction.

关键词： deep founda.ions bea.ing ca.a.ity resista.t moment structura. cell 3D numerica. modeling

Huma. CD4 ＋ effector T lymphocytes genera.ed upon TCR enga.ement with self-peptides respond defectively to IL-7 in their tra.sition to memory cells

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Cellula. & Molecula. Immunology 2013年第3期10卷 261-274页

作者： Ga.riela.Gonza.ez-Perez Norma.C Segovia.a.a.a.ta.Riva.-Ca.va.ho Dia.a.P Reyes Honorio torres-a.uila. sergio R a.uila.-Ruiz Cla.dine Irles Gloria.Soldevila.Ca.men Sa.nchez-torres 1Depa.tment of Molecula. Biomedicine Centre de Investigacion y de Estudios Avanzados del I.P.N. (CINVESTAV-IPN) Mexico City Mexico Depa.tment of Physiology Facultad de Medicina Mexico City Mexico Depa.tment of Immunology Institute de Investigaciones Biomedicas Universidad Nacional Autonoma de Mexico (UNAM) Mexico City Mexico

The periphera. repertoire of CD4＋ T lymphocytes conta.ns a.torea.tive cells tha. rema.n tolera.t through severa. mecha.isms. However, nonspecific CD4＋ T cells ca. be a.tiva.ed in physiologica. conditions a. in the course of a. ongoing immune response, a.d their outcome is not yet fully understood. Here, we investiga.e the fa.e of huma. na.ve CD4＋ lymphocytes a.tiva.ed by dendritic cells （DCs） presenting endogenous self-peptides in compa.ison with lymphocytes involved in a.loresponses. We genera.ed memory cells （Tmem） from prima.y effectors a.tiva.ed with ma.ure a.tologous DCs plus interleukin （IL）-2 （Tma.to）, simula.ing the circumsta.ces of a. a.tive immune response, or a.logeneic DCs （Tma.lo）. Tmem were genera.ed from effector cells tha. were rested in the a.sence of a.tigenic stimuli, with or without IL-7. Tmem were less a.tiva.ed tha. effectors （demonstra.ed by CD25 downregula.ion） pa.ticula.ly with IL-7, suggesting tha. this cytokine ma. fa.our the tra.sition to quiescence. Tma.to a.d Tma.o showed a. effector memory phenotype, a.d responded simila.ly to polyclona. a.d a.tigen-specific stimuli. Biochemica.ly, IL-7-trea.ed Tma.o were closely rela.ed to conventiona. memory lymphocytes ba.ed on Erk-l/2 a.tiva.ion, wherea. Tma.to were more simila. to effectors. a.tologous effectors exhibited lower responses to IL-7 tha. a.logeneic cells, which were reflected in their reduced prolifera.ion a.d higher cell dea.h. This wa. not rela.ed to IL-7 receptor expression but ra.her to signa.ling deficiencies, a.cording to STa.5 a.tiva.ion These results suggest tha. ineffective responses to IL-7 could impa.r the tra.sition to memory cells of na.ve CD4＋ T lymphocytes recognizing self-peptides in the setting of strong costimula.ion.

关键词： huma. CD4+ T cells IL-7 memory self-peptides

a. Optima. Design Method Ba.ed on Sma.l a.plitude Homogeniza.ion

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Chinese a.na.s of Ma.hema.ics,Series B 2015年第5期36卷 843-854页

作者： sergio GUTIERREZ Depa.tment of Structura. a.d Geotechnica. Engineering Pontificia Universidad Catolica de Chile

a. optima. design method for two ma.eria.s ba.ed on sma.l a.plitude homogeniza.ion is presented. The method a.lows to use quite genera. objective functions a. the price tha. the two ma.eria.s should ha.e sma.l contra.ts in their releva.t physica. pa.a.eters. The following two a.plica.ions a.e shown: Stress constra.ned complia.ce minimiza.ion a.d defect loca.ion in ela.tic bodies.

关键词： Homogeniza.ion Inverse problems Rela.a.ion Stress concentra.ion

Ra.S fea.ibility study of using roughness to mimic tra.sition strip effect on the crossflowsepa.a.ion over a.6:1 prola.e-spheroid

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Journa. of Hydrodyna.ics 2019年第3期31卷 570-581页

作者： Mojta.a.M. a.iri Ma.celo a. Vitola.sergio H. Spha.er, Pa.lo T. Espera.za Ocea. Technology La.ora.ory (La.Ocea.o-COPPE) Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-907 Brazil

a. a.isymmetric body a. incidence experiences the three-dimensiona. crossflow sepa.a.ion. This sepa.a.ion is a.tributed to the a.verse circumferentia. pressure gra.ient. However, the sepa.a.ion pa.tern is a.so dependent upon the structure of the bounda.y la.er. In this rega.d, utiliza.ion of tra.sition strip devices in experiments on a.isymmetric bodies ma. modify this structure, a.d consequently the crossflow sepa.a.ion pa.tern. The ma.n objective of the present resea.ch is to mimic numerica.ly the tra.sition strip effect on the crossflow sepa.a.ion over a.6:1 prola.e-spheroid up to a.= 30° incidence a.d ReL = 4.2 x 10&. However, to a.oid direct modeling of the strip, which would increa.e the computa.iona. cost, a. a.tempt wa. ma.e to a.d roughness over the body surfa.e. To estima.e the roughness tha. simula.es closely the tra.sition strip effect, three different roughness va.ues were considered. The numerica. model is ba.ed on Ra.S a.d a.Reynolds stress turbulence model implemented in STa.CCM+. The simula.ions ha.e been eva.ua.ed ba.ed on the loca. a.d globa. va.ia.les a.d va.ida.ed a.a.nst the a.a.la.le experimenta. da.a. The results demonstra.e the effectiveness of using a.proper roughness va.ue to mimic the tra.sition strip effect. They a.so show the importa.ce of modeling the tra.sition strip effect, which is norma.ly not ta.en into a.count, to ca.ture the crossflow sepa.a.ion pa.tern.

关键词： a.isymmetric body crossflow sepa.a.ion tra.sition strip device CFD Ra.S equa.ions

La.er by la.er surfa.e engineering of poly (la.tide-co-glycolide) na.opa.ticles:a.versa.ile tool for na.opa.ticle engineering for ta.geted drug delivery

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Science China.Chemistry 2013年第8期56卷 1029-1039页

作者： ROMERO Ga.riela.MURRa. Richa.d a. QIU Yua. Sa.Z Da.id MOYa.sergio E. Biosurfa.es Depa.tment CIC biomaGUNE Depa.tment of Polymer Science a.d Engineering Zhejiang University

Recent work rega.ding the La.er by La.er （LbL） engineering of poly（la.tide-co-glycolide） na.opa.ticles （PLGa.NPs） is reviewed here. The LbL engineering of PLGa.NPs is a.plied a. a.mea.s of genera.ing a.va.ced drug delivery devices with ta.lored recognition, protection, ca.go a.d relea.e properties. LbL in combina.ion with cova.ent chemistry is used to a.ta.h PEG a.d folic a.id to control cell upta.e a.d direct it towa.ds ca.cer cells. LbL coa.ings composed of chitosa. a.d a.gina.e show low protein intera.tions a.d ca. be used a. a. a.terna.ive to Pegyla.ion. The a.sembly on top of LbL coa.ings of lipid la.ers composed of va.ia.le percenta.es of 1,2-dioleoyl-sn-glycero-3-choline （DOPC） a.d 1,2-dioleoyl-sn-glycero-3-phospho- L-serine （DOPS） increa.es NP upta.e a.d directs the NPs towa.ds the endopla.mic reticulum. The a.tibody a.ti-TNF-ct is enca.sula.ed forming a.complex with a.gina.e tha. is a.sembled LbL on top of PLGa.NPs. The a.tibody is relea.ed in cell culture following first order kinetics. The relea.e kinetics of enca.sula.ed molecules inside PLGa.NPs a.e studied when the PLGa.NPs a.e coa.ed via.LbL with different polyelectrolytes. The intra.ellula. relea.e of enca.sula.ed Doxorubicin is studied in the HepG2 cell line by mea.s of Fluorescence Lifetime Ima.ing.

关键词： la.er by la.er PLGa.NPs cell upta.e a.tibody delivery lipid la.ers intra.ellula. relea.e