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Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors

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Light(Science & Applications) 2022年第3期11卷 22-34页

作者： Elena I.Shramova Stepan P.Chumakov Victoria O.Shipunova Anastasiya V.Ryabova Georgij B.Telegin Andrei V.Kabashin sergey m.Deyev Galina m.Proshkina Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences16/10 Miklukho-Maklaya StreetMoscow 117997Russia mEPhI(moscow Engineering Physics Institute) Institute of Engineering Physics for Biomedicine(PhysBio)31 Kashirskoe shosseMoscow 115409Russia Prokhorov General Physics Institute Russian Academy of SciencesVavilova38Moscow 119991Russia Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesProspect Nauki 6Pushchino 142290Russia Aix marseille University CNRSLP3163 Ave.De LuminyCase 91713288 MarseilleFrance

Photodynamic therapy(PDT)is one of the most appealing photonic modalities for cancer treatment based on anticancer activity of light-induced photosensitizer-mediated reactive oxygen species(ROS),but a limited depth of light penetration into tissues does not make possible the treatment of deep-seated neoplasms and thus complicates its widespread clinical ***,we introduce the concept of genetically encoded bioluminescence resonance energy transfer(BRET)-activated PDT,which combines an internal light source and a photosensitizer(PS)in a single-genetic construct,which can be delivered to tumors seated at virtually unlimited depth and then triggered by the injection of a substrate to initiate their *** illustrate the concept,we engineered genetic NanoLuc-miniSOG BRET pair,combining NanoLuc luciferase flashlight and phototoxic flavoprotein miniSOG,which generates ROS under luciferase-substrate *** prove the concept feasibility in mice bearing NanoLuc-miniSOG expressing tumor,followed by its elimination under the luciferase-substrate ***,we demonstrate a targeted delivery of NanoLuc-miniSOG gene,via tumor-specific lentiviral particles,into a tumor,followed by its successful elimination,with tumor-growth inhibition(TGI)coefficient exceeding 67%,which confirms a great therapeutic potential of the proposed *** conclusion,this study provides proof-of-concept for deep-tissue“photodynamic”therapy without external light source that can be considered as an alternative for traditional PDT.

关键词： neoplasms injection treatment

LOW-RANK TENSOR STRUCTURE OF SOLUTIONS TO ELLIPTIC PROBLEmS WITH JUmPING COEFFICIENTS

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Journal of Computational mathematics 2012年第1期30卷 14-23页

作者： sergey Dolgov Boris N.Khoromskij Ivan Oseledets Eugene E.Tyrtyshnikov moscow Institute of Physics and Technology Russia max-Planck-Institute for mathematics in Sciences Inselstr.22-26D-04103 LeipzigGermany Institute of Numerical mathematics Russian Academy of SciencesGubkina 8119991 MoscowRussia Lomonosov moscow State University Russia University of Siedlce Poland(visiting professor)

We study the separability properties of solutions to elliptic equations with piecewise constant coefficients in Rd, d ≥ 2. The separation rank of the solution to diffusion equation with variable coefficients is prese... 详细信息

关键词： Structured matrices Elliptic operators Poisson equation matrix approxima-tions Lowrank matrices Tensors Canonical decomposition.

3,6-bis(2,2,2-trinitroethylnitramino)-1,2,4,*** and energy abilities as a component of solid composite propellants

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Defence Technology（防务技术） 2022年第7期18卷 1148-1155页

作者： Anatoly G.Korepin Natalia m.Glushakova David B.Lempert Anatoly I.Kazakov Gennady V.Shilov Denis V.Korchagin Vadim m.Volokhov Elena S.Amosova sergey m.Aldoshin Institute of Problems of Chemical Physics Ac.Semenov Avenue 1Chernogolovka142432Russian Federation

The work addresses to the study of the molecular and crystal structure and properties of a new energyintensive compound 3,6-bis(2,2,2-trinitroethylnitramino)-1,2,4,5-tetrazine(NBTAT),first obtained by the authors in *** compound crystallizes in the monoclinic system,space group P2(1)/n,density at room temperature 1.939 g/cm^(3).The energies of crystal packing and pairwise intermolecular interactions in NBTAT and its unnitrated analogue BTAT were calculated,and their comparative analysis was carried *** enthalpy of formation of NBTAT molecules was calculated by quantum-chemical methods using Gaussian 09,and the enthalpy of formation of NBTAT in the solid phase(618 kJ/mol)was *** energy capabilities of NBTAT as an oxidizer of solid composite propellants are *** is shown that in metal-free compositions NBTAT is significantly superior to ammonium perchlorate(AP),dinitramide ammonium salt(ADN),HmX,BTAT at all stages of rocket systems,and is comparable to the superdense CL-20 yielding to the latter at the lower stages and slightly winning at the upper stages.

关键词： Nitrogen heterocycles Quantum chemistry Enthalpy of formation 3,6-bis(2,2,2-trinitroethylnitramino)-1,2,4,5-tetrazine Crystal structure Energetic ability

A novel technique for unilateral dissection of the penile neurovascular bundle to prevent loss of penile sensation during treatment of Peyronie's disease-Initial results of a pilot study

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Current Urology 2023年第4期17卷 299-302页

作者： Alexandr m.Pinkhasov matthew Beamer Daniel Shulman Rachel Yakubov Esther Pinkhasov sergey Kravchick Department of Urology SUNY Upstate Medical University HospitalSyracuseNY 13202USA

Background:Plaque incision/excision and grafting are surgical techniques used to treat patients with Peyronie's disease who are refractory to less invasive interventions,have severe penile curvature,or have an hourglass ***,the procedure carries the risk of penile sensory loss because of the need for dissection of the neurovascular bundle(NVB).The aim of this study was to assess the feasibility of a novel technique for unilateral NVB dissection and its ability to preserve penile sensitivity while maintaining adequate correction of the penile *** and methods:Charts of patients who underwent unilateral NVB dissection during Peyronie's plaque incision/excision and grafting were retrospectively *** patients received preprocedural intracavernosal injections of Trimix,and the curvature was measured to be>70 *** 3 cases,an incision and minimal excision of the plaque were performed at the point of maximum curvature on the concave side of the *** 3 cases,Tutoplast allografts(Coloplast US,minneapolis,mN)were used,whereas autografts were used in 2 other *** patients were examined at 1,3,and 6 months after the procedure when curvature and penile sensation were ***:Five patients underwent this *** mean age of patients was 55 years(45-70 years).All plaques were dorsally *** mean preoperative curvature was 78 degrees(75-90 degrees).At the 6-month follow-up,all patients hadmetic *** 1 patient continued with phosphodiesterase-5 inhibitors to improve potency at the 6-month *** patients reported normal penile glans *** patients experienced decreased sensation at the site of NVB dissection,but this was only detected when compared with the contralateral *** 2 patients reported a difference after 6 months,and only a minor area of involvement was ***:Unilateral NVB dissection is a feasi

关键词： Peyronie's disease Neurovascular bundle dissection

Dielectric barrier discharge plasma synthesis of Ag/γ-Al_(2)O_(3) catalysts for catalytic oxidation of CO

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Plasma Science and Technology 2023年第8期25卷 113-121页

作者：陶云明胥月兵常宽陈美玲 sergey A STAROSTIN 许虎君林良良 Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122People's Republic of China FUJIFILm manufacturing Europe Tilburg Research LabsTilburg 5047 TKNetherlands

In this study,Ag/γ-Al_(2)O_(3)catalysts were synthesized by an Ar dielectric barrier discharge plasma using silver nitrate as the Ag source andγ-alumina(γ-Al_(2)O_(3))as the *** is revealed that plasma can reduce silver ions to generate crystalline silver nanoparticles(Ag NPs)of good dispersion and uniformity on the alumina surface,leading to the formation of Ag/γ-Al_(2)O_(3)catalysts in a green manner without traditional chemical ***/γ-Al_(2)O_(3)exhibited good catalytic activity and stability in CO oxidation reactions,and the activity increased with increase in the Ag *** catalysts with more than 2 wt%Ag,100%CO conversion can be achieved at 300°*** catalytic activity of the Ag/γ-Al_(2)O_(3)catalysts is also closely related to the size of theγ-alumina,where Ag/nano-γ-Al_(2)O_(3)catalysts demonstrate better performance than Ag/micro-γ-Al_(2)O_(3)catalysts with the same Ag *** addition,the catalytic properties of plasma-generated Ag/nano-γ-Al_(2)O_(3)(Ag/γ-Al_(2)O_(3)-P)catalysts were compared with those of Ag/nano-γ-Al_(2)O_(3)catalysts prepared by the traditional calcination approach(Ag/γ-Al_(2)O_(3)-C),with the plasma-generated samples demonstrating better overall *** simple,rapid and green plasma process is considered to be applicable for the synthesis of diverse noble metal-based catalysts.

关键词： DBD plasma plasma nanofabrication noble metal nanoparticles CO oxidation Ag/-Al2O3 catalysts

Simulation of thermal processes in metamaterial millimeter-wave to infrared converter for millimeter-wave imager

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International Journal of modeling, Simulation, and Scientific Computing 2014年第S01期5卷 120-128页

作者： Peter S.Zagubisalo Andrey G.Paulish sergey A.Kuznetsov Novosibirsk Branch of the Institute of Semiconductor Physics Siberian Branch of Russian Academy of Sciences 2/1 pr.Akademika LavrentyevaNovosibirsk 630090Russian Federation Novosibirsk State University 2 ul.PirogovaNovosibirsk 630090Russian Federation

The main characteristics of millimeter-wave(mm-wave)image detector were simulated by means of accurate numerical modeling of thermophysical processes in a metamaterial mm-to-IR *** converter represents a multilayer structure consisting of an ultra thin resonant metamaterial absorber and a perfect emissive *** absorber consists of a dielectric self-supporting film that is metallized from both sides.A micropattern is fabricated from one *** absorption of the mm waves induces the converter heating that yields enhancement of IR emission from the emissive *** emission is detected by IR *** this contribution an accurate numerical model for simulation of the thermal processes in the converter structure was created by using COmSOL multiphysics *** simulation results are in a good agreement with experimental results that validates the *** simulation shows that the real-time operation is provided for the converter thickness less than 3µm and time response can be improved by decreasing of the converter *** energy conversion efficiency of mm waves into IR radiation is over 80%.The converter temperature increase is a linear function of a mm-wave radiation power within three orders of the dynamic *** blooming effect and ways of its reducing are also *** model allows us to choose the ways of converter structure optimization and improvement of image detector parameters.

关键词： metamaterials subterahertz waves terahertz waves millimeter waves highimpedance surface ultra-thin absorber focal plane array detector bolometric detectors thermodynamic modeling optical readout system

Characterization and Electrochemical Properties of Nanostructured Zr-Doped Anatase TiO_2 Tubes Synthesized by Sol–Gel Template Route

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Journal of materials Science & Technology 2017年第6期33卷 527-534页

作者： Denis P.Opra sergey V.Gnedenkov sergey L.Sinebryukhov Elena I.Voit Alexander A.Sokolov Evgeny B.modin Anatoly B.Podgorbunsky Yury V.Sushkov Veniamin V.Zheleznov Institute of Chemistry Far Eastern Branch of Russian Academy of Sciences Far Eastern Federal University National Research Centre "Kurchatov Institute"

A series of nanostructured Zr-doped anatase TiO_2 tubes with the Zr/Ti molar ratio of 0.01, 0.02, 0.03, and0.09 were prepared by a sol–gel technology on a carbon fiber template. The electrochemical performance of Zr-doped anatase TiO_2 as anodes for rechargeable lithium batteries was investigated and compared with undoped titania. Tests represented that after 35-fold charge/discharge cycling at C/10 the reversible capacity of Zr-doped titania（Zr/Ti = 0.03） reaches 135 m A h g^（-1）, while the capacity of undoped titania（Zr/Ti = 0） yielded only 50 m A h g^（-1）. Based on the results of the physicochemical investigation, three reasons of improving electrochemical performance of Zr-doped titania were suggested. According to the scanning electron microscopy and transmission electron microscopy, Zr^（4＋） doping induces a decrease in nanoparticle size, which facilitates the Li＋diffusion. The Raman investigations show the more open structure of Zr-doped TiO_2 as compared to undoped titania due to changing of the unit cell parameters, that significantly affects on the reversibility of the insertion/extraction process. The electrochemical impedance spectroscopy results indicate that substitution of Zr^（4＋） for Ti^（4＋） into anatase TiO_2 has favorable effects on the conductivity.

关键词： Li-ion batteries Anatase titania Nanostructured materials Sol–gel template process Doping Electrochemical performance

New insights into substrate folding preference of plant OSCs

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Science Bulletin 2016年第18期61卷 1407-1412页

作者： Yongshuo ma Yuan Zhou sergey Ovchinnikov Per Jr.Greisen Sanwen Huang Yi Shang Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture Sino-Dutch Joint Laboratory of Horticultural Genomics Department of Biochemistry University of Washington Department of modelling Novo Nordisk A/S 2760 Ml?vDenmark Agricultural Genomic Institute at Shenzhen Chinese Academy of Agricultural Sciences

Sterols and triterpenes are structurally diverse bioactive molecules generated through cyclization of linear 2,3-oxidosqualene. Based on carbocationic intermediates generated during initial substrate preorganization step, oxidosqualene cyclases （OSCs） are roughly segregated into protosteryl cation group that mainly catalyzes tetracyclic products and dammarenyl cation group which mostly generates pentacyclic products. However, in contrast to well-studied cascade of ring-forming reactions, little is known about the mechanism underlying the initial sub- strate folding process. Previously, we have identified a cucurbitadienol synthase （Bi） and its null allele bi （C393Y） from cucumber. By integration of homology modeling, residue coevolution and site-directed mutagenesis, we discover that four covarying amino acids including C393 constitute a dynamic domain that may be involved in substrate folding process for Bi. We also reveal a group of co-conserved residues that closely associated with the segregation of plant OSCs. These residues may act col- laboratively in choice of specific substrate folding inter- mediate for OSCs. Thus, engineer plant OSCs from into five-ringed producer. our findings open a door to four-ringed skeleton catalysts

关键词： Oxidosqualene cyclase Homologymodeling Residue coevolution Substrate folding

On the correctness of orbital solutions obtained from a small set of *** of HIP 53731

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Research in Astronomy and Astrophysics 2020年第11期20卷 321-324页

作者： Arina mitrofanova Vladimir Dyachenko Anatoly Beskakotov Yury Balega Alexander maksimov Denis Rastegaev sergey Komarinsky Special Astrophysical Observatory of the Russian Academy of Sciences Nizhnij ArkhyzRussia 369167

HIP 53731 is a binary consisting of stars of the spectral types K0 and *** orbit of this object was constructed previously by Cvetkovic et *** improved by *** should be noted that there is a 180°ambiguity in the position angles of some published *** interferometric observations were obtained in 2007–2020(21 measurements)at the 6-m telescope of the SAO RAS(BTA)by the authors of this *** analysis of new data together with previously published ones made it possible to construct an accurate orbit of HIP 53731 and to halve the already known values of the orbital period of the *** a result of the study,the mass sum,the masses of each component and their spectral types were determined by two independent *** to the qualitative classification of orbits,the orbital solution has grade 2–"good"(observations cover more than half of the orbital period and correspond to different phases).

关键词： techniques high angular resolution,speckle interferometry stars low-mass,fundamental parameters stars binaries spectroscopic stars individual HIP 53731