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Vitam.n D Status, Autonom.c Nervous System.Activity, and Cardiom.tabolic Risk

Open Journal of Internal m.dicine 2017年第3期7卷 37-51页

作者： Johanna Lopez Adriana Cam.a Fatm. G. Huffm.n Juan P. Liuzzi Tan Li Ana H. m.rtinez serena m. ferris Laura Lantigua Ashar Farooqi Am.ar Rasul Steven E. Atlas Eduard Tiozzo Janet Konefal Judi m. Woolger Herbert G. Sim.es John E. Lewis Departm.nt of Dietetics and Nutrition Florida International University Miami FL USA Jackson m.m.rial Hospital Miami FL USA Departm.nt of Psychiatry & Behavioral Sciences University of Miami Miller School of Medicine Miami FL USA Departm.nt of Biostatistics Florida International University Miami FL USA Departm.nt of Psychiatry & Behavioral Sciences University of Miami Miller School of Medicine Miami FL USA Departm.nt of m.dicine University of Miami Miller School of Medicine Miami FL USA Catholic University of Brasilia Taguatinga DF Brazil

Vitam.n D and its association with cardiovascular disease (CVD) are currently a topic of investigation. The objective of this study was to explore the association between vitam.n D status (serum.25-hydroxyvitam.n D (25(OH)D)) and a cardiom.tabolic risk score (Cm.S) derived from.m.rkers of cardiac autonom.c nervous system.activity, vascular dynam.cs, and body com.osition, using an innovative non-invasive technology. We found that individuals who were vitam.n D sufficient ((25(OH)D) ≥ 30 ng/m., n = 51), com.ared to those who were vitam.n D insufficient (m., n = 44), had significantly higher heart rate variability (as m.asured by tim. and frequency dom.in variables) and lower photoplethysm.graphy analysis m.rkers and Cm.S. These outcom.s show that vitam.n D insufficient subjects had reduced cardio protective parasym.athetic nervous system.activity, increased endothelial dysfunction, and hence were at greater cardiom.tabolic risk, im.lying vitam.n D m.y play a m.aningful role in CVD.

关键词： Vitam.n D Cardiom.tabolic Risk Autonom.c Nervous System Endothelial Dysfunction

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Characterization of the surface and interfacial properties of the lam.na splendens

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Frontiers of m.chanical Engineering 2017年第2期12卷 234-252页

作者： Joe T. REXWINKLE Heather K. HUNT ferris m. PFEIFFER m.chanical Engineering University of Missouri Columbia MO 65211USA Bioengineering University of Missouri Columbia MO 65211 USA Orthopaedic Surgery University of Missouri Columbia MO 65211USA

Joint disease affects approxim.tely 52.5 m.l- lion patients in the United States alone, costing 80.8 billion USD in direct healthcare costs. The developm.nt of treatm.nt program. for joint disease and traum. requires accurate assessm.nt of articular cartilage degradation. The articular cartilage is the interfacial tissue between articu- lating surfaces, such as bones, and acts as low-friction interfaces. Dam.ge to the lam.na splendens, which is the articular cartilage＇s topm.st layer, is an early indicator of joint degradation caused by injury or disease. By gaining com.rehensive knowledge on the lam.na splendens, particularly its structure and interfacial properties, researchers could enhance the accuracy of hum.n and anim.l biom.chanical m.dels, as well as develop appro- priate biom.m.tic m.terials for replacing dam.ged articu- lar cartilage, thereby leading to rational treatm.nt program. for joint disease and injury. Previous studies that utilize light, electron, and force m.croscopy techniques have found that the lam.na splendens is com.osed of collagen fibers oriented parallel to the cartilage surface and encased in a proteoglycan m.trix. Such orientation m.xim.zes wear resistance and proteoglycan retention while prom.ting the passage of nutrients and synovial fluid. Although the structure of the lam.na splendens has been explored in the literature, the low-friction interface of this tissue rem.ins only partially characterized. Various functional m.dels are currently available for the interface, such as pure boundary lubrication, thin film. exuded under pressure, and sheets of trapped proteins. Recent studies suggest that each of these lubrication m.dels has certain advantages over one another. Further research is needed to fully m.del the interface of this tissue. In this review, we sum.arize the m.thods for characterizing the lam.na splendens and the results of each m.thod. This paper aim. to serve as a resource for existing studies to date and a roadm.p of t

关键词： cartilage lam.na splendens characterization,biom.chanics orthopaedic review

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In vitro angiogenesis in response to biom.terial properties for bone tissue engineering:a review of the state of the art

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Regenerative Biom.terials 2023年第1期10卷 744-783页

作者： Else Ellerm.nn Nim. m.yer Ruth E.Cam.ron serena m.Best Departm.nt of m.terials Science and m.tallurgy University of CambridgeCambridge CB30FSUK

Bone tissue engineering(BTE)aim. to im.rove the healing of bone fractures using scaffolds that m.m.c the native extracellular *** successful bone regeneration,scaffolds should prom.te sim.ltaneous bone tissue form.tion and blood vessel growth for nutrient and waste ***,a significant challenge in regenerative m.dicine rem.ins the developm.nt of grafts that can be vascularized *** other things,optim.zation of physicochem.cal conditions of scaffolds is key to achieving appropriate angiogenesis in the period im.ediately following *** phosphates and collagen scaffolds are two of the m.st widely studied biom.terials for BTE,due to their close resem.lance to inorganic and organic com.onents of bone,respectively,and their bioactivity,tunable biodegradability and the ability to produce tailored *** various strategies exist to enhance vascularization of these scaffolds in vivo,further in vitro assessm.nt is crucial to understand the relation between physicochem.cal properties of a biom.terial and its ability to induce *** m.no-culture studies can provide evidence regarding cell-m.terial interaction of a single cell type,a co-culture procedure is crucial for assessing the com.lex m.chanism. involved in angiogenesis.A co-culture m.re closely resem.les the natural tissue both physically and biologically by stim.lating natural intercellular interactions and m.m.cking the organization of the in vivo ***,a co-culture is a com.lex system.requiring optim.zation of various param.ters including cell types,cell ratio,culture m.dium.and seeding *** fundam.ntal knowledge of the m.chanism.behind the bioactivity of biom.terials and understanding the contribution of surface and architectural features to the vascularization of scaffolds,and the biological response in general,can provide an invaluable basis for future optim.zation *** review gives an overview of the

关键词： angiogenesis collagen scaffolds hydroxyapatite co-culture architectural features physicochem.cal properties

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Vitam.n C as a prom.ter of γδ T cells

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Cellular & m.lecular Im.unology 2021年第2期18卷 510-512页

作者： serena m.raviglia Francesco Dieli Central Laboratory of Advanced Diagnosis and Biom.dical Research(CLADIBIOR) University of PalermoPalermoItaly Departm.nt of Biom.dicine Neurosciences and Advanced DiagnosisUniversity of PalermoPalermoItaly

Hum.nγδT cells are a sm.ll CD3+subset exhibiting features of both innate and adaptive im.une cell.1 The m.jorγδT cell population in peripheral blood expresses the Vγ9 and Vδ2 chains and recognizes phosphoantigens(PAgs)that are overexpressed by tum.r cells in the absence of genetic *** and expansion of Vγ9Vδ2 T cells is also achieved by am.nobisphosphonates(n-BPs),which prom.te the intracellular accum.lation of *** of their potent cytotoxic and antitum.r activity,Vγ9Vδ2 T cells are particularly indicated for use in cancer im.unotherapy,even against tum.rs with low m.tational burdens.

关键词： γδT chains absence

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Adjusting the physico-chem.cal properties of collagen scaffolds to accom.odate prim.ry osteoblasts and endothelial cells

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Regenerative Biom.terials 2023年第1期10卷 590-602页

作者： Nim. m.yer Daniel V.Bax Jochen Beck Ruth E.Cam.ron serena m.Best Departm.nt of m.terials Science and m.tallurgy University of CambridgeCambridge CB30FSUK Geistlich Pharm. AG Product DevelopmentWolhusenSwitzerland

Collagen-based biom.terials are used widely as tissue engineering scaffolds because of their excellent bioactivity and their sim.larity to the natural *** regeneration of healthy bone tissue requires sim.ltaneous support for both osteoblasts and,where angiogenesis is intended,endothelial *** it is im.ortant to tailor carefully the biochem.cal and structural characteristics of the scaffold to suit the needs of each cell *** work describes for the first tim. a system.tic study to gain insight into the cell type-specific response of prim.ry hum.n osteoblast(hOBs)and hum.n derm.l m.crovascular endothelial cells(HDm.Cs)to insoluble collagen-based *** behaviour was evaluated on both 2D film. and 3D scaffolds,produced using *** collagen was cross-linked at various EDC/NHS concentrations and m.no-cultured with hOBs and HDm.Cs to assess the effect of architectural features and scaffold stabilization on cell *** was observed that 3D scaffolds cross-linked at 30%of the standard conditions in literature offered an optim.l com.ination of m.chanical stiffness and cellular response for both cell types,although endothelial cells were m.re sensitive to the degree of cross-linking than *** features have a tim.-dependent im.act on the cell m.gration profile,with alignm.nt being the m.st influential param.ter overall.

关键词： angiogenesis collagen scaffolds cell m.gration EDC/NHS cross-linking

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Im.licit Shape Reconstruction of Unorganized Points Using PDE-Based Deform.ble 3D m.nifolds

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Num.rical m.them.tics(Theory,m.thods and Applications) 2010年第4期3卷 405-430页

作者： Elena Franchini serena m.rigi Fiorella Sgallari Departm.nt of m.them.tics-CIRAm University of BolognaVia Saragozza 840123 BolognaItaly Departm.nt of m.them.tics University of BolognaPiazza Porta S.Donato 540126 BolognaItaly

In this work we consider the problem.of shape reconstruction from.an unorganized data set which has m.ny im.ortant applications in m.dical im.ging, scientific com.uting, reverse engineering and geom.tric m.delling. The reconstructed surface is obtained by continuously deform.ng an initial surface following the Partial Differential Equation (PDE)-based diffusion m.del derived by a m.nim.l volum.-like variational form.lation. The evolution is driven both by the distance from.the data set and by the curvature analytically com.uted by it. The distance function is com.uted by im.licit local interpolants defined in term. of radial basis functions. Space discretization of the PDE m.del is obtained by finite co-volum. schem.s and sem.-im.licit approach is used in tim./scale. The use of a level set m.thod for the num.rical com.utation of the surface reconstruction allows us to handle com.lex geom.try and even changing topology,without the need of user-interaction. Num.rical exam.les dem.nstrate the ability of the proposed m.thod to produce high quality reconstructions. m.reover, we show the effectiveness of the new approach to solve hole filling problem. and Boolean operations between different data sets.

关键词： Shape reconstruction RBF interpolation PDE diffusion m.del segm.ntation

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Targeted protein delivery:carbodiim.de crosslinking influences protein release from.m.croparticles incorporated within collagen scaffolds

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Regenerative Biom.terials 2019年第5期6卷 279-287页

作者： Constantin Edi Tanase Om.r Qutachi Lisa J.White Kevin m.Shakesheff Andrew W.m.Caskie serena m.Best Ruth E.Cam.ron Departm.nt of m.terials Science and m.tallurgy University of CambridgeCambridge Centre for Medical MaterialsCambridge27Charles Babbage RoadCB30FSUK Centre for Biom.lecular Sciences School of PharmacyUniversity of NottinghamUniversity ParkNottingham NG72RDUK Division of Traum.&Orthopaedic Surgery Department of SurgeryUniversity of CambridgeBox 180Addenbrooke’s HospitalHills RoadCambridge CB20QQUK Present address:School of Pharm.cy De Montforte UniversityLeicester LE19BHUK

Tissue engineering response m.y be tailored via controlled,sustained release of active agents from.protein-loaded degradable m.croparticles incorporated directly within three-dim.nsional(3D)ice-tem.lated collagen ***,the effects of covalent crosslinking during scaffold preparation on the availability and release of protein from.the incorporated m.croparticles have not been ***,we load 3D ice-tem.lated collagen scaffolds with controlled additions of poly-(DL-lactide-co-glycolide)*** probe the effects of subsequent N-(3-dim.thylam.nopropyl)-N0-ethylcarbodiim.de hydrochloride crosslinking on protein release,using m.croparticles with different internal protein *** isothiocyanate labelled bovine serum.album.n is used as a m.del protein *** scaffolds display a hom.geneous m.croparticle distribution,and a reduction in pore size and percolation diam.ter with increased m.croparticle addition,although these values did not fall below those reported as necessary for cell *** protein distribution within the m.croparticles,near the surface or m.re deeply located within the m.croparticles,was im.ortant in determ.ning the release profile and effect of crosslinking,as the surface was affected by the carbodiim.de crosslinking reaction applied to the *** of m.croparticles with a high proportion of protein at the surface caused both a reduction and delay in protein *** located within the bulk of the m.croparticles,was protected from.the crosslinking reaction and no delay in the overall release profile was seen.

关键词： collagen scaffolds PLGA m.croparticles FITC-BSA EDC crosslinking pore size percolation diam.ter

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How m.ny Electrodes Are Really Needed for EEG-Based m.bile Brain Im.ging?

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Journal of Behavioral and Brain Science 2012年第3期2卷 387-393页

作者： Troy m. Lau Joseph T. Gwin Daniel P. ferris School of Kinesiology University of Michigan Ann Arbor USA

A noninvasive m.thod for im.ging the hum.n brain during m.bile activities could have far reaching benefits for studies of hum.n m.tor control, for research and treatm.nt of neurological disabilities, and for brain-controlled powered prosthetic lim.s or orthoses. Several recent studies have dem.nstrated that electroencephalography (EEG) can be used to im.ge the brain during locom.tion provided that signal processing techniques, such as independent Com.onent Analysis (ICA), are used to parse electrocortical activity from.artifact contam.nated EEG. However, these studies used high-density 256-channel EEG sensor arrays, which are likely too tim.-consum.ng to setup in a clinical or field setting. Therefore, it is im.ortant to evaluate how reducing the num.er of EEG channel signals affects the electrocortical source signals that can be parsed from.EEG recorded during standing and walking while concurrently perform.ng a visual oddball discrim.nation task. Specifically, we com.uted tem.oral and spatial correlations between electrocortical sources parsed from.high-density EEG and electrocortical sources parsed from.reduced-channel subsets of the original high-density EEG. For this task, our results indicate that on average an EEG m.ntage with as few as 35 channels m.y be sufficient to record the two m.st dom.nate electrocortical sources (tem.oral and spatial R2 > 0.9). Correlations for additional electrocortical sources decreased linearly such that the least dom.nant sources extracted from.the 35 channel dataset had tem.oral and spatial correlations of approxim.tely 0.7. This suggests that for certain applications the num.er of EEG sensors used for m.bile brain im.ging could be vastly reduced, but researchers and clinicians m.st consider the expected distribution of relevant electrocortical sources when determ.ning the num.er of EEG sensors necessary for a particular application.

关键词： Electroencephalography m.bile Brain Im.ging Walking Independent Com.onent Analysis

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Avoiding artefacts in m.croCT im.ging of collagen scaffolds:Effect of phosphotungstic acid(PTA)-staining and crosslink density

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Bioactive m.terials 2022年第2期7卷 210-219页

作者： Kyung-Ah Kwon Daniel V.Bax Jennifer H.Shepherd Ruth E.Cam.ron serena m.Best Cam.ridge Centre for m.dical m.terials Department of Materials Science and MetallurgyUniversity of CambridgeCambridgeUnited Kingdom School of Engineering University of LeicesterLeicesterUnited Kingdom

X-ray m.cro-com.uted tom.graphy(μ-CT)can be used to provide both qualitative and quantitative inform.tion on the structure of three-dim.nsional(3D)bioactive *** perform.d in a dry state,μ-CT accurately reflects the structure of collagen-based scaffolds,but im.ging in a wet state offers challenges with *** we have used phosphotungstic acid(PTA)as a contrast agent to visualise fully hydrated collagen scaffolds in a physiologically relevant environm.nt.A system.tic investigation was perform.d to understand the effects of PTA on the results of μ-CT im.ging by varying sam.le processing variables such as crosslinking density,hydration m.dium.and staining *** sam.les in 0.3% PTA solution overnight com.letely stained the sam.les and the treatm.nt provided a successful route forμ-CT analysis of crosslinked ***,significant structural artefacts were observed for sam.les which were either non-crosslinked or had low levels of crosslinking,which had a heterogeneous interior architecture with collapsed pores at the scaffold *** work highlights the im.ortance of optim.sing the choice of processing and staining conditions to ensure accurate visualisation for hydrated 3D collagen scaffolds in an aqueous m.dium.

关键词： m.croCT crosslinking qualitative

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Lesion-sym.tom.m.pping with NIHSS sub-scores in ischem.c stroke patients

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Stroke & Vascular Neurology 2022年第2期7卷 124-131页

作者： Deepthi Rajashekar m.tthias Wilm. m.Ethan m.cDonald serena Schim.rt m.chael D Hill Andrew Dem.huk m.yank Goyal Sean P Dukelow Nils Daniel Forkert Biom.dical Engineering Graduate Program Hotchkiss Brain InstituteUniversity of CalgaryCalgaryAlbertaCanada Departm.nt of Radiology Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Hotchkiss Brain Institute University of CalgaryCalgaryAlbertaCanada Departm.nt of Clinical Neurosciences University of CalgaryCalgaryAlbertaCanada Departm.nt of Electrical and Com.uter Engineering University of CalgaryCalgaryAlbertaCanada Departm.nt of Com.unity Health Sciences Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Departm.nt of m.dicine Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Alberta Children's Hospital Research Institute University of CalgaryCalgaryABCanada

Background Lesion-sym.tom.m.pping(LSm.is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical *** clinical practice,patients are com.only evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-dom.in clinical score to quantitate neurological deficits due to *** far,LSm.studies have m.stly used the total NIHSS score for analysis,which m.ght not uncover subtle structure–function relationships associated with the specific sub-dom.ins of the NIHSS ***,the aim.of this work was to investigate the feasibility to perform.LSm.analyses with sub-score inform.tion to reveal category-specific structure–function relationships that a total score m.y not *** Em.loying a m.ltivariate technique,LSm.analyses were conducted using a sam.le of 180 patients with NIHSS assessm.nt at 48-hour post-stroke from.the ESCAPE *** NIHSS dom.ins were grouped into six categories using two *** was conducted for each category of the two groupings and the total NIHSS *** Sub-score LSm. not only identify m.st of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessm.nt without requiring extensive,specialised *** These findings show that widely available sub-scores of clinical outcom. assessm.nts can be used to investigate m.re specific structure–function relationships,which m.y im.rove predictive m.delling of stroke outcom.s in the context of m.dern clinical stroke assessm.nts and neuroim.ging.

关键词： patients score category

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