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Development of analysis model for geometric error in turning processes

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Journal of Central South University 2011年第3期18卷 711-717页

作者： LEE mun-jae LEE Choon-man Department of Mechanical Design and manufacturing Engineering Changwon National University

A finite element model was established for analyzing the geometric errors in turning operations and a two-step analyzing process was proposed. In the first analyzing step, the cutting force and the cutting heat for the cutting conditions were obtained using the AdvantEdge. Also, the deformation of a workpiece was estimated in the second step using the ANSYS. The deformation was analyzed for a 150 mm-long workpiece at three different measuring points, such as 10, 70 and 130 mm from a reference point, and the amounts of the deformation were compared through experiments. /n the results of the comparison and analysis, the values obtained from these comparison and analysis represent similar tendencies. Also, it is verified that their geometric errors increase with the increase in temperature. In addition, regarding the factors that affect the deformation of a workpiecc, it can be seen that the geometric error in the lathe is about 15%, the error caused by the cutting force is about 10%, and the deformation caused by the heat is about 75%.

关键词： geometric error machining accuracy finite element analysis turning cutting force, cutting temperature

Cathepsin B-responsive prodrugs for cancer-targeted therapy:Recent advances and progress for clinical translation

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Nano Research 2022年第8期15卷 7247-7266页

作者： seong Ik Jeon Suah Yang man Kyu Shim Kwangmeyung Kim Biomedical Research Institute Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

The cathepsin B-responsive prodrugs are promising strategies to reduce the serious adverse effects of anticancer drugs by improving the cancer selectivity that can be specifically activated by overexpressed cathepsin B in targeted cancer ***,clinical translation of such therapeutic approaches has been restricted by low antitumor efficacy that is mainly attributable to undesirable pharmacokinetic profiles and inefficient tumor-targeting of cathepsin B-responsive prodrugs,due to their small-molecule *** recent decades,many researchers have widely investigated the drug delivery system(DDS)to improve the in vivo pharmacokinetic profiles and tumor-targeting efficiency of cathepsin B-responsive prodrugs via the application of polymers,dendrimers,antibodies,lipids,and inorganic nanoparticles as drug *** addition,the potential therapeutic efficacy of DDS for cathepsin B-responsive prodrugs is demonstrated in multiple studies and combinatorial treatment with typical therapeutic modalities can effectively overcome the challenges of tumor heterogeneity and multidrug *** this review,recent advances and progress of new DDS for cathepsin B-responsive prodrugs are outlined,and their clinical trials are ***,potential challenges and the outlooks for clinical translation of cathepsin B-responsive prodrugs are highlighted.

关键词： cathepsin B prodrug chemotherapy drug delivery system targeted cancer therapy

Lightweight design of 45000r/min spindle using full factorial design and extreme vertices design methods

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Journal of Central South University 2011年第1期18卷 153-158页

作者： PARK seong-jin LEE Choon-man HWANG Young-kug Department of Mechanical Design and manufacturing Engineering Changwon National University

Factors for determining the spindle size are the shaft diameter, positions of bearing and motor, and entire length of the spindle. Then, it is important to find the assembling of the optimal design variables, which satisfy the stiffimss and rotational speed required to the spindle. A general full factorial design method was used to verify some factors that affect the natural frequency of a spindle. It is verified that the shorter shaft length and bearing span length represent the higher natural frequency, and there are some effects according to the change in the levels of factors. The detailed spindle dimension is determined by applying an EVD method, which can define the optimal bearing position through considering the limiting condition. Based on the estimated regression model, the optimal spindle size and bearing distance that can improve the primary natural frequency are obtained, and the influence of design factors on the natural frequency is also analyzed.

关键词： high-speed spindle extreme vertices design natural frequency lightweight design full factorial design

Panax ginseng induces the expression of CatSper genes and sperm hyperactivation

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Asian Journal of Andrology 2014年第6期16卷 845-851页

作者： Eun Hwa Park Do Rim Kim Ha Young Kim seong Kyu Park mun Seog Chang Department of Prescriptionology College of Korean Medicine Kyung Hee Unversity Seoul Korea.

The cation channel of sperm （CatSper） protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of Panax ginseng treatment on the expression of CatSper genes and sperm hyperactivation in male mice, sperm motility and CatSper gene expression were assessed using a computer-assisted semen analysis system, a Fluoroskan Ascent microplate fluorometer to assess Ca2＊ influx, *** polymerase chain reaction, Western blotting and immunofluorescence. The results suggested that the Ca2＊ levels of sperm cells treated with P. ginseng were increased significantly compared with the normal group. The P. ginseng-treated groups showed increased sperm motility parameters, such as the curvilinear velocity and amplitude of lateral head displacement. Taken together, the data suggest that CatSper messenger ribonucleic acid levels were increased significantly in mouse testes in the P. ginseng-treated group, as was the protein level, with the exception of CatSper2. In conclusion, P. ginseng plays an important role in improving sperm hyperactivation via CatSper gene expression.

关键词： Ca2+ CatSper hyperactivation panax Einseng

Role of transcription factor acetylation n the regulation of metabolic homeostasis

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Protein & Cell 2015年第11期6卷 804-813页

作者： Joo-man Park seong-Ho Jo Mi-Young Kim Tae-Hyun Kim Yong-Ho Ahn Department of Biochemistry and Molecular Biology Yonsei University College of Medicine 50-1 Yonsei-ro Seodaemun-gu Seoul 120-752 Republic of Korea Brain Korea 21 PLUS Project for Medical Sciences Yonsei University College of Medicine 50-1 Yonsei-ro Seodaemun-gu Seoul 120-752 Republic of Korea

Post-translational modifications （PTMs） of transcription factors play a crucial role in regulating metabolic homeostasis. These modifications include phosphory- lation, methylation, acetylation, ubiqulUnation, SUMOy- lation, and O-GIcNAcylation. Recent studies have shed light on the importance of lysine acetylation at nonhis- tone proteins including transcription factors. Acetyla- tion of transcription factors affects subcellular distribution, DNA affinity, stability, transcriptional activity, and current investigations are aiming to further expand our understanding of the role of lysine acetyla- tion of transcription factors. In this review, we summarize recent studies that provide new insights into the role of protein lysine-acetylation in the transcriptional regulation of metabolic homeostasis.

关键词： metabolic homeostasis transcriptionfactor post-translational modification type 2 diabetesmellitus

Assimilating OSTIA SST into regional modeling systems for the Yellow Sea using ensemble methods

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Acta Oceanologica Sinica 2017年第3期36卷 37-51页

作者： JI Xuanliang KWON Kyung man CHOI Byoung-Ju LIU Guimei PARK Kwang-Soon WANG Hui BYUN Do-seong LI Yun JI Qiyan ZHU Xueming National Marine Environmental Forecasting Center State Oceanic AdminstrationBeijing 100081China Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CenterState Oceanic AdminstrationBeijing 100081China Department of Oceanography Kunsan National UniversityGunsan 54150Republic of Korea Department of Oceanography Chonnam National UniversityGwangju 61186Republic of Korea Korea Institute of Ocean Science and Technology Ansan 15627Republic of Korea Korea Hydrographic and Oceanographic Agency Busan 49111Republic of Korea Marine Acoustics and Remote Sensing Laboratory Zhejiang Ocean UniversityZhoushan 316000China

The effects of sea surface temperature（SST） data assimilation in two regional ocean modeling systems were examined for the Yellow Sea（YS）. The SST data from the Operational Sea Surface Temperature and Sea Ice Analysis（OSTIA） were assimilated. The National Marine Environmental Forecasting Center（NMEFC） modeling system uses the ensemble optimal interpolation method for ocean data assimilation and the Kunsan National University（KNU） modeling system uses the ensemble Kalman filter. Without data assimilation, the NMEFC modeling system was better in simulating the subsurface temperature while the KNU modeling system was better in simulating SST. The disparity between both modeling systems might be related to differences in calculating the surface heat flux, horizontal grid spacing, and atmospheric forcing data. The data assimilation reduced the root mean square error（RMSE） of the SST from 1.78°C（1.46°C） to 1.30°C（1.21°C） for the NMEFC（KNU） modeling system when the simulated temperature was compared to Optimum Interpolation Sea Surface Temperature（OISST） SST dataset. A comparison with the buoy SST data indicated a 41%（31%） decrease in the SST error for the NMEFC（KNU） modeling system by the data assimilation. In both data assimilative systems, the RMSE of the temperature was less than 1.5°C in the upper 20 m and approximately 3.1°C in the lower layer in October. In contrast, it was less than 1.0°C throughout the water column in February. This study suggests that assimilations of the observed temperature profiles are necessary in order to correct the lower layer temperature during the stratified season and an ocean modeling system with small grid spacing and optimal data assimilation method is preferable to ensure accurate predictions of the coastal ocean in the YS.

关键词： ensemble optimal interpolation ensemble Kalman filter SST Yellow Sea assimilation

Atraumatic splenic rupture after cocaine use and acute Epstein-Barr virus infection: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2019年第12期11卷 433-442页

作者： Allan mun Fai Kwok Department of Surgery Wollongong Hospital

BACKGROUND Atraumatic splenic rupture(ASR)accounts for just over 3%of all cases of splenic rupture and is associated with a high mortality *** most common culprit is acute infection with Epstein-Barr virus(EBV)but other documented aetiologies include neoplasia,other viral/bacterial infections,acute and chronic pancreatitis,amyloidosis and anticoagulant *** are four previous reports of cocaine-associated ASR but never before has it been documented in combination with concurrent acute EBV *** SUMMARY A 21-year-old man presented to hospital with acute left shoulder pain which radiated to the right shoulder and upper *** denied any history of recent trauma and had no relevant past medical *** took no regular prescription medications but had used cocaine within the previous 24 *** revealed splenomegaly,a Grade 3 subcapsular splenic haematoma,moderate haemoperitoneum and an incidental 9 mm splenic artery *** was also serological evidence of acute EBV *** endovascular embolisation of the pseudoaneurysm was performed and the splenic rupture was managed *** patient remained admitted in hospital for seven days and did not require any transfusion of blood *** imaging showed complete resolution of the haemoperitoneum after 5 *** importance of abstinence from illicit drug use was emphasised to the patient but it is unknown whether or not he remains *** This case demonstrates that ASR is a rare condition that can result from acute EBV infection and cocaine ingestion and requires a high index of suspicion to diagnose clinically.

关键词： Atraumatic Spontaneous Splenic rupture Cocaine Epstein-Barr virus Splenic artery pseudoaneurysm Case report

Successful living donor liver transplantation with a graft-to-recipient weight ratio of 0.41 without portal flow modulation:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5414-5419页

作者： seong Hoon Kim Center for Liver Cancer National Cancer CenterGoyang 10408GyeonggidoSouth Korea

BACKGROUND There have been numerous efforts to lower the limit of minimum graft size to meet the metabolic demand of recipients in adult-to-adult living donor liver transplantation(LDLT).We experienced a successful case of LDLT using a verysmall-for-size graft without portal flow modulation such as splenectomy or portocaval *** SUMMARY A 49-year-old man(weighing 91 kg)suffering hepatocellular carcinoma accompanied with hepatitis B virus related cirrhosis underwent *** one and only voluntary donor was his 17-year-old daughter whose body weight was 50 kg with a body mass index(BMI)of *** procured right liver graft was 411 g with a real graft-to-recipient weight ratio(GRWR)of 0.41%,the smallest to be reported in the *** the recipient and donor had an uneventful recovery and were discharged on days 15 and 8,respectively,with normal liver *** father and daughter have had no complication so far and are still in good health with normal liver function 81 mo after *** Satisfactory outcomes can be achieved in LDLT with a GRWR as low as 0.41%even without using portal flow modulation in highly selected patients.

关键词： Small-for-size graft Living donor liver transplantation Graft-to-recipient weight ratio Case report

Cytoprotective effects of Morinda offucinalis against hydrogen peroxide-induced oxidative stress in Leydig TM3 cells

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Asian Journal of Andrology 2008年第4期10卷 667-674页

作者： mun-Seog Chang Won-Nam Kim Woong-Mo Yang Hyu-Young Kim Ji-Hoon Oh seong-Kyu Park Department of Prescriptionology College of Oriental Medicine Kyung Hee University Seoul 130-701 Korea

Aim： To investigate the antioxidant effects of Morinda officinalis （Morindae radix, MR） on H2O2-induced oxidative stress in cultured mouse TM3 Leydig cells. Methods： We carried out 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide, lipid peroxidation, testosterone enzyme immunoassay, superoxide dismutase （SOD）, and catalase （CAT） assays in Leydig TM3 cells. Results： MR showed a 47.8% 2,2-diphenyl-1-picrylhydrazyl radical scavenging effect in TM3 cells with no significant cytotoxicity. Oxidative stress was induced in TM3 cells with 100 μmol H2O2, and treatment of the cells with 250 μg/mL MR showed the most significant protective effect （64%, P 〈 0.001） in the cell viability assay with a decreased lipid peroxidation level （1.75 nmol/mg protein, P 〈 0.05）, increased testosterone production （43.5 pg/mL）, and improvements in SOD activity （7.49 units of SOD/mg protein, P 〈 0.001） and CAT activity （74.6 units of CAT/mg protein, P 〈 0.001）. Conclusion： These findings indicate that MR, as an antioxidant, protects functions of cultured mouse TM3 Leydig cells from H2O2-induced oxidative stress.

关键词： Morindae radix Leydig cell testosterone hydrogen peroxide antioxidant