Cathepsin B-responsive prodrugs for cancer-targeted therapy:Recent advances and progress for clinical translation
作者机构：Biomedical Research InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and TechnologyKorea UniversitySeoul 02841Republic of Korea
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第8期
页 面：7247-7266页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the National Research Foundation of Korea(NRF)grant funded by the Korea government(Nos.NRF2019R1A2C3006283 and NRF-2021R1C1C2005460) the KUKIST Graduate School of Converging Science and Technology(Korea University&KIST) the Intramural Research Program of KIST
主 题：cathepsin B prodrug chemotherapy drug delivery system targeted cancer therapy
摘 要：The cathepsin B-responsive prodrugs are promising strategies to reduce the serious adverse effects of anticancer drugs by improving the cancer selectivity that can be specifically activated by overexpressed cathepsin B in targeted cancer ***,clinical translation of such therapeutic approaches has been restricted by low antitumor efficacy that is mainly attributable to undesirable pharmacokinetic profiles and inefficient tumor-targeting of cathepsin B-responsive prodrugs,due to their small-molecule *** recent decades,many researchers have widely investigated the drug delivery system(DDS)to improve the in vivo pharmacokinetic profiles and tumor-targeting efficiency of cathepsin B-responsive prodrugs via the application of polymers,dendrimers,antibodies,lipids,and inorganic nanoparticles as drug *** addition,the potential therapeutic efficacy of DDS for cathepsin B-responsive prodrugs is demonstrated in multiple studies and combinatorial treatment with typical therapeutic modalities can effectively overcome the challenges of tumor heterogeneity and multidrug *** this review,recent advances and progress of new DDS for cathepsin B-responsive prodrugs are outlined,and their clinical trials are ***,potential challenges and the outlooks for clinical translation of cathepsin B-responsive prodrugs are highlighted.
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