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Cancer Communications 2024年第8期44卷 884-888页

作者： Sung Hee Choi Jay Thomas Myers Suzanne Louise Tomchuck Melissa Bonner Saada Eid Daniel Tyler Kingsley Kristen Ashley Van Heyst seong-jin kim Byung-Gyu kim Alex Yee-Chen Huang Department of Pediatrics CaseWestern Reserve University School of MedicineClevelandOhioUSA Case Comprehensive Cancer Center CaseWestern Reserve University School of MedicineClevelandOhioUSA Department of Pathology CaseWestern Reserve University School of MedicineClevelandOhioUSA MedPacto Inc. SeoulRepublic of Korea Center for Pediatric Immunotherapy Angie Fowler AYA Cancer InstituteUH Rainbow Babies and Children’s HospitalClevelandOhioUSA

Osteosarcoma is an aggressive malignant bone sarcoma common among children,adolescents,and young *** 20%of patients present with pulmonary metastasis,and an additional 40%develop pulmonary osteosarcoma *** survival ou... 详细信息

关键词： osteosarcoma immunity patients

Connection between inflammation and carcinogenesis in gastrointestinal tract: Focus on TGF-β signaling

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World Journal of Gastroenterology 2010年第17期16卷 2080-2093页

作者： Suntaek Hong Ho-Jae Lee seong jin kim Ki-Baik Hahm Laboratory of Cancer Cell Biology Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Chemoprevention Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Cell Regulation and Carcinogenesis Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Laboratory of Translational Medicine Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheon 406-840South Korea Department of Gastroenterology Gachon Graduate School of MedicineIncheon 406-840South Korea

Inflammation is a primary defense process against various extracellular stimuli,such as viruses,pathogens,foods,and environmental *** cells respond to stimuli for short periods of time,it results in acute or physiological ***,if the stimulation is sustained for longer time or a pathological state occurs,it is known as chronic or pathological *** studies have shown that tumorigenesis in the gastrointestinal (GI) tract is closely associated with chronic inflammation,for which abnormal cellular alterations that accompany chronic inflammation such as oxidative stresses,gene mutations,epigenetic changes,and inflammatory cytokines,are shared with carcinogenic processes,which forms a critical cross-link between chronic inflammation and *** growth factor (TGF)-β is a multi-potent cytokine that plays an important role in regulation of cell growth,apoptosis and *** importantly,TGF-β is a strong anti-inflammatory cytokine that regulates the development of effector ***-β has a suppressive effect on carcinogenesis under normal conditions by inhibiting abnormal cell growth,but on the other hand,many GI cancers originate from uncontrolled cell growth and differentiation by genetic loss of TGF-β signaling molecules or perturbation of TGF-β *** a tumor has developed,TGF-β exerts a promoting effect on the tumor itself and stromal cells to enhance cell growth,alter the responsiveness of tumor cells to stimulate invasion and metastasis,and inhibited immune ***,novel development of therapeutic agents to inhibit TGF-β-induced progression of tumor and to retain its growth inhibitory activities,in addition to anti-inflammatory actions,could be useful in *** this review,we discuss the role of TGF-β in inflammation and carcinogenesis of the GI tract related to abnormal TGF-β signaling.

关键词： Inflammation Carcinogenesis Transforming growth factor-β Gastrointestinal tract

Vitamin A supplementation downregulates ADH1C and ALDH1A1 mRNA expression in weaned beef calves

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Animal Nutrition 2022年第3期10卷 372-381页

作者： Xue Cheng jin Dong Qiao Peng seong jin kim Na Yeon kim Jalil Ghassemi Nejad Danil kim Stephen B.Smith Hong Gu Lee Department of Animal Science and Technology Sanghvi College of Life SciencesKonkuk UniversitySeoul 05029Republic of Korea Asia Pacific Ruminant Institute Icheon 17385Republic of Korea Farm Animal Clinical Training and Research Center Institute of Green-Bio Science and TechnologySeoul National UniversityPyeongchang 25354Republic of Korea Department of Animal Science Texas A&M UniversityCollege StationTX 77843USA

Our previous studies demonstrated that oral vitamin A supplementation during late-stage pregnancy and the neonatal stage enhances birth weight,growth performance,and mRNA expression related to muscle and preadipocyte development in beef *** alcohol dehydrogenase 1C(ADH1C)c.-64T>C genotype also correlated with vitamin A concentration in beef *** study aimed to investigate the effects of vitamin A supplementation on the muscle development and vitamin A metabolism in weaned beef calves with different ADH1C *** male calves(90 d of age;initial BW:89.03 kg[SD 8.60])were stratified according to ADH1C genotype and vitamin A treatment(duration:3 months)and randomly assigned to 4 groups with a 22 factorial *** A treatments included the following:control(10,000 IU/kg of as-fed,*** type;*** type);treatment(40,000 IU/kg of as-fed,*** type;and *** type).Parameters including BW,FI,blood,longissimus dorsi muscle,and liver status during the experimental period were analyzed using the generalized linear model(GLM)procedure and Tukey's test by SAS 9.4 *** vitamin A was significantly increased(P<0.05)in the vitamin A treatment group at 4 and 6 months of *** type calves showed higher serum vitamin A concentration(P<0.05)than the TC type *** triglyceride and non-esterified fatty acid(NEFA)levels increased(P<0.05)in the treatment group compared with the control at 6 months of ***,BW,ADG and FI showed no differences between the *** addition,mRNA expression in longissimus dorsi muscle revealed upregulation of paired box 7(PAX7)(P<0.05)after the vitamin A treatment period based on biopsy *** ADH1C and aldehyde dehydrogenase(ALDH)1A1 mRNA expression was downregulated(P<0.01)by vitamin A *** TC type of ADH1C showed higher mRNA expression than the TT ***,no effect was observed on adipogenic mRNA expression(preadipocyte factor-1[PREF-1],peroxisome proliferator-activated rece

关键词： Vitamin A ADH1C genotype Muscle development Korean native calves

Plasma transforming growth factor-β_1 levels in patients with erectile dysfunction

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Asian Journal of Andrology 2004年第4期6卷 349-353页

作者： Ji-Kan Ryu Sun U.Song Hyung-Ki Choi Do-Hwan seong Sang-Min Yoon seong-jin kim Jun-Kyu Suh Department of Urology Clinical Research CenterDepartment of UrologyDepartment of UrologyDepartment of UrologyNational Cancer InstituteDepartment of Urology Inha University School of Medicine Incheon Korea Yonsei University School of Medicine Seoul Korea National Institutes of Health Bethesda MD USA

Aim: To evaluate the plasma TGF-β1 level in erectile dysfunction (ED) patients of various causes. Methods: Sixty-two patients with ED and 26 potent men were subjected to the study. Based on multidisciplinary work-ups, including medical history, physical examinations, blood tests with lipid profile and hormones, penile duplex Doppler ultrasonogram and neurophysiological tests, causes for ED were classified as psychogenic (n=15), neurogenic (n=16) and vasculogenic (n=31). The plasma TGF-β1 level was measured by the ELISA method. Results: The plasma TGF-β1 level was significantly increased in the ED group (6.7 ± 4.9 ng/mL), compared to the control (4.0±2.1 ng/mL) (P <0.01). In the ED groups, there was a significant increase in the vasculogenic group (9.0 ± 5.5 ng/mL), compared to the psychogenic (3.8 ± 1.8 ng/mL) and neurogenic groups (4.8 ± 3.2 ng/mL) (P<0.01). Of the vascular risk factors, both the smoking (7.5 ± 4.7 ng/mL) and dyslipidemia groups (7.4 ± 4.4 ng/mL) showed significantly increased plasma TGF-β1 levels, compared to the non-smokers (5.5 ± 2.8 ng/mL), and those without dyslipidemia (4.8 ?2.8 ng/mL) (P<0.05). Conclusion: Vascular risk factors are associated with an elevated plasma TGF-β1 level, which may contribute to cavernous fibrosis and ED.

关键词： erectile dysfunction transforming growth factor fibrosis diagnosis

Dragonfly Interaction Algorithm for Optimization of Queuing Delay in Industrial Wireless Networks

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Journal of Bionic Engineering 2024年第1期21卷 447-485页

作者： Sanjay Bhardwaj Da-Hye kim Dong-seong kim Department of IT Convergence Engineering ICT Convergence Research CenterKumoh National Institute of TechnologyGumiSouth Korea

In industrial wireless networks,data transmitted from source to destination are highly *** often leads to the queuing of the data,and poor management of the queued data results in excessive delays,increased energy consumption,and packet ***,a nature-inspired-based Dragonfly Interaction Optimization Algorithm(DMOA)is proposed for optimization of the queue delay in industrial wireless *** term“interaction”herein used is the characterization of the“flying movement”of the dragonfly towards damselflies(female dragonflies)for *** a result,interaction is represented as the flow of transmitted data packets,or traffic,from the source to the base *** includes each and every feature of dragonfly movement as well as awareness of the rival dragonflies,predators,and damselflies for the desired optimization of the queue *** features are juxtaposed as noise and interference,which are further used in the calculation of industrial wireless metrics:latency,error rate(reliability),throughput,energy efficiency,and fairness for the optimization of the queue *** analysis,convergence analysis,the Wilcoxon test,the Friedman test,and the classical as well as the 2014 IEEE Congress of Evolutionary Computation(CEC)on the benchmark functions are also used for the evaluation of DMOA in terms of its robustness and *** results demonstrate the robustness of the proposed algorithm for both classical and benchmarking functions of the IEEE CEC ***,the accuracy and efficacy of DMOA were demonstrated by means of the convergence rate,Wilcoxon testing,and ***,fairness using Jain’s index in queue delay optimization in terms of throughput and latency,along with computational complexity,is also evaluated and compared with other *** results show that DMOA exceeds other bio-inspired optimization algorithms in terms of fairness in queue delay management and average packet *** proposed a

关键词： Dragonfly Damselfly Interaction Queuing delay Optimization Industrial wireless networks

Random pinhole attenuator for high-power laser beams

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High Power Laser Science and Engineering 2024年第3期12卷 116-121页

作者： seong Cheol Park Hyeok Yun jin Woo Yoon seong Ku Lee Jae Hee Sung Il Woo Choi Chang Hee Nam Kyung Taec kim Department of Physics and Photon Science Gwangju Institute of Science and TechnologyGwangjuRepublic of Korea Center for Relativistic Laser Science Institute for Basic ScienceGwangjuRepublic of Korea Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangjuRepublic of Korea

The intensity attenuation of a high-power laser is a frequent task in the measurements of optical *** intensity can be attenuated by inserting an optical element,such as a partial reflector,polarizer or absorption *** devices are,however,not always easily applicable,especially in the case of ultra-high-power lasers,because they can alter the characteristics of a laser beam or become easily *** this study,we demonstrated that the intensity of a laser beam could be effectively attenuated using a random pinhole attenuator(RPA),a device with randomly distributed pinholes,without changing the beam *** this device,a multi-PW laser beam was successfully attenuated and the focused beam profile was measured without any alterations of its *** addition,it was confirmed that the temporal profile of a laser pulse,including the spectral phase,was ***,the RPA possesses significant potential for a wide range of applications.

关键词： high-power laser intensity attenuation laser diagnostics

Tracking of horizontal alignment of the long and large diameter uncharged hole in NATM tunnel

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Underground Space 2024年第3期16卷 18-28页

作者： Min-seong kim Sean Seungwon Lee Department of Energy and Resources Engineering Chonnam National UniversityGwangju 61186Republic of Korea Department of Earth Resources and Environmental Engineering Hanyang UniversitySeoul 04763Republic of Korea

The long and large diameter uncharged hole boring(LLB)method is a cut blasting method that minimizes blast-induced vibrations by creating long and large diameter uncharged holes at the excavation face of tunnels prior to tunnel *** in this method typically uses a 50 m long with a 382 mm diameter hammer bit in the horizontal direction at the tunnel ***,the significant weight and uni-directional rotation of the rod head,as well as variables such as geological characteristics,machine conditions,and inexperienced operators result in significant deviation from the target borehole alignment that hinders the vibration-dampening effect of the uncharged ***,since there is no method to verify the alignment of the boreholes until main tunnel construction,borehole misalignment is often not discovered until weeks after construction,which requires tunnel construction to cease until the equipment can be remobilized and an additional borehole be created,causing significant delays and increased costs for the entire tunnel *** this study,the borehole alignment tracking and ground exploration system(BGS)is developed to predict and monitor the quality and alignment of boreholes for cut blasting methods such as the LLB methods immediately after *** BGS was subsequently tested at a subway construction site to evaluate its performance in the *** measurements yielded by the BGS were compared with manually measured boring positions at every 5 m along the *** the BGS showed a maximum deviation of approximately 12%at a local point where the hole surface was relatively rough,the accuracy for the final boring position was approximately 97%,demonstrating excellent precision of the alignment tracking *** BGS demonstrates excellent performance in predicting ground conditions and the boring quality of a cut hole immediately after drilling,and shows promise in various other applications for monitoring borehole alignment.

关键词： Tunnel blasting LLB method Drilling deviation Vertical sagging Horizontal alignment tracking BGS

Incorporation of Ionic Conductive Polymers into Sulfide Electrolyte-Based Solid-State Batteries to Enhance Electrochemical Stability and Cycle Life

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Energy & Environmental Materials 2024年第6期7卷 4-12页

作者： Juhyoung kim Woonghee Choi seong-Ju Hwang Dong Wook kim Advanced Materials Division Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea Department of Material Science and Engineering Yonsei UniversitySeoul 03722Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Korea Advanced Materials and Chemical Engineering University of Science and Technology(UST)Daejeon 34113Korea

Sulfide-based inorganic solid electrolytes are promising materials for high-performance safe solid-state *** high ion conductivity,mechanical characteristics,and good processability of sulfide-based inorganic solid electrolytes are desirable properties for realizing high-performance safe solid-state batteries by replacing conventional liquid ***,the low chemical and electrochemical stability of sulfide-based inorganic solid electrolytes hinder the commercialization of sulfide-based safe solid-state ***,the instability of sulfide-based inorganic solid electrolytes is intensified in the cathode,comprising various *** this study,carbonate-based ionic conductive polymers are introduced to the cathode to protect cathode materials and suppress the reactivity of sulfide *** instruments,including electrochemical spectroscopy,X-ray photoelectron spectroscopy,and scanning electron microscopy,confirm the chemical and electrochemical stability of the polymer electrolytes in contact with sulfide-based inorganic solid ***-based solid-state cells show stable electrochemical performance over 100 cycles when the ionic conductive polymers were applied to the cathode.

关键词： composite cathode electrochemical stability ionic conductive polymer solid-state battery sulfide solid electrolyte

Liquid crystal-integrated metasurfaces for an active photonic platform

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Opto-Electronic Advances 2024年第6期7卷 5-29页

作者： Dohyun Kang Hyeonsu Heo Younghwan Yang Junhwa seong Hongyoon kim Joohoon kim Junsuk Rho Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of Electrical Engineering Pohang University of Science and Technology(POSTECH)Pohang 36763Republic of Korea POSCOPOSTECH-RIST Convergence Research Center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea National Institute of Nanomaterials Technology(NINT) Pohang 37673Republic of Korea

Metasurfaces have opened the door to next-generation optical devices due to their ability to dramatically modulate electromagnetic waves at will using periodically arranged ***,metasurfaces typically have static optical responses with fixed geometries of nanostructures,which poses challenges for implementing transition to technology by replacing conventional optical *** solve this problem,liquid crystals(LCs)have been actively employed for designing tunable metasurfaces using their adjustable birefringent in real ***,we review recent studies on LCpowered tunable metasurfaces,which are categorized as wavefront tuning and spectral *** to numerous reviews on tunable metasurfaces,this review intensively explores recent development of LC-integrated *** the end of this review,we briefly introduce the latest research trends on LC-powered metasurfaces and suggest further directions for improving *** hope that this review will accelerate the development of new and innovative LC-powered devices.

关键词： tunable metasurface liquid crystal active metasurface electrically tunable optical system

Boosted Lithium-Ion Transport Kinetics in n-Type Siloxene Anodes Enabled by Selective Nucleophilic Substitution of Phosphorus

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Nano-Micro Letters 2024年第10期16卷 618-637页

作者： Se In kim Woong-Ju kim jin Gu Kang Dong-Wan kim School of Civil Environmental and Architectural EngineeringKorea University02841 SeoulSouth Korea Nanophotonics Research Center Korea Institute of Science and Technology02792 SeoulSouth Korea

Doped two-dimensional(2D)materials hold significant promise for advancing many technologies,such as microelectronics,optoelectronics,and energy ***,n-type 2D oxidized Si nanosheets,namely n-type siloxene(n-SX),are employed as Li-ion battery *** thermal evaporation of sodium hypophosphite at 275℃,P atoms are effectively incorporated into siloxene(SX)without compromising its 2D layered morphology and unique Kautsky-type crystal ***,selective nucleophilic substitution occurs,with only Si atoms being replaced by P atoms in the O_(3)≡Si-H *** resulting n-SX possesses two delocalized electrons arising from the presence of two electron donor types:(i)P atoms residing in Si sites and(ii)H *** doping concentrations are varied by controlling the amount of precursors or their mean free *** at 2000 mA g^(-1),the n-SX electrode with the optimized doping concentration(6.7×10^(19) atoms cm^(-3))delivers a capacity of 594 mAh g^(-1) with a 73%capacity retention after 500 *** improvements originate from the enhanced kinetics of charge transport processes,including electronic conduction,charge transfer,and solid-state *** approach proposed herein offers an unprecedented route for engineering SX anodes to boost Li-ion storage.

关键词： Li-ion battery Two-dimensional N-type siloxene Doping mechanism Kinetics