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Spatial and spectral measurement of laser-driven protons through radioactivation

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Nuclear Science and Techniques 2023年第12期34卷 30-39页

作者： Yin‑Ren Shou Xue‑Zhi Wu Gwang‑Eun Ahn Seung Yeon Kim seong Hoon Kim hwang Woon Lee Jin Woo Yoon Jae Hee Sung seong Ku Lee Xue‑Qing Yan Il Woo Choi Chang Hee Nam Center for Relativistic Laser Science Institute for Basic ScienceGwangju 61005Republic of Korea School of Physics Peking UniversityBeijing 100871China Advanced Photonics Research Institute Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea Department of Physics and Photon Science Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea

The simultaneous measurement of the spatial profile and spectrum of laser-accelerated protons is important for further optimization of the beam qualities and *** report a detailed study regarding the underlying physics and regular procedure of such a measurement through the radioactivation of a stack composed of aluminum,copper,and CR-39 plates as well as radiochromic films(RCFs).After being radioactivated,the copper plates are placed on imaging plates(IPs)to detect the positrons emitted by the reaction products through contact *** spectrum and energy-dependent spatial profile of the protons are then obtained from the IPs and confirmed by the measured ones from the RCFs and CR-39 *** also discuss the detection range,influence of electrons,radiation safety,and spatial resolution of this ***,insights regarding the extension of the current method to online measurements and dynamic proton imaging are also provided.

关键词： Laser-driven proton acceleration Proton-induced nuclear reaction Radioactivation measurement Contact imaging

Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge

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Chinese Journal of Integrative Medicine 2020年第7期26卷 533-538页

作者： Woong Jin Bae Jin Bong Choi Kang Sup Kim U Syn ha Sung Hoo Hong Ji Youl Lee Tae-Kon hwang Sung Yeoun hwang WANG Zhi-ping Sae Woong Kim Department of Urology The Catholic University of KoreaCollege of MedicineSeoul(06591)Republic of Korea Catholic Integrative Medicine Research Institute College of MedicineThe Catholic University of KoreaSeoul(06591)Republic of Korea Korea Bio-Medical Science Institute Seoul(06106)Republic of Korea Department of Urology Second Hospital of Lanzhou UniversityLanzhou(730030)China

Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in ***:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative *** laddering analysis was performed to investigate the apoptosis of DU-145 *** mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 *** volumes were ***:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with *** laddering analysis indicated the apoptosis of DU-145 *** with SM increased the expression of p53 and reduced the expression of Bcl-2 *** levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in *** the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour ***:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells.

关键词： apoptosis prostate cancer Salvia miltiorrhiza Bunge Chinese medicine

Mutation of MED12 is not a frequent occurrence in prostate cancer of Korean patients

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Asian Journal of Andrology 2017年第3期19卷 346-349页

作者： Nara Yoon Sharon Lim So Young Kang Ghee Young Kwon hwang Gyun Jeon Byong Chang Jeong seong Il Seo seong Soo Jeon Hyun Moo Lee han Yong Choi Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea

Prostate cancer is one of the major health care problems, but the molecular pathogenesis has been relatively insufficiently elucidated. Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one subsequent study by Sanger sequencing. Thus, we investigated mutation status of MED12 in exons 2 and 26 by Sanger sequencing in 102 radical prostatectomy cases from Korean patients. The analysis found the mutation in none of the cases. Therefore, MED12 mutation does not appear to represent a significant molecular alteration in this cohort of patients according to the analysis by the traditional ＂gold standard.＂

关键词： mediator complex subunit 12 mutation analysis prostate cancer prostate neoplasms

Associations between Wildfire Risk and Socio-Economic-Demographic Characteristics Using GIS Technology

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Journal of Geographic Information System 2022年第5期14卷 365-388页

作者： seong Nam hwang Kayla Meier Environmental Science Program Department of Biology Southeast Missouri State University Cape Girardeau Missouri United States

Wildfire is a natural hazard caused mostly by the interaction of human systems and natural phenomena. This research aims to investigate how extreme wildfire events and disasters that occurred in California in the recent three decades are related to socio-economic-demographic characteristics at the levels of census tracts and counties. In addition, this research will use the data of historic wildfires to show counties and census tracts vulnerable to the natural hazard as well as the cyclical changes such as seasonal and annual fluctuations in the wildfire occurrences in the state. To decide how those variables correlate, this research used a Geographic Information System (GIS) designed to collect, analyze, query, and display geographical information. Two types of secondary data were used to conduct the research. One is the geospatial data showing each location of wildfires. The other is the data about such sociodemographic characteristics as race, ethnicity, level of education, and income, which can be collected through the Bureau of Census. In particular, the research employing GIS-based spatial analysis created maps that represent information on the geographic locations of the wildfires at the different geographic levels as well as demographic and socioeconomic factors influenced by the potential risk of wildfires. There are several researching findings. First, this research showed the wildfire-prone communities have comparatively higher level of representation for the populations such as the White and Native Americans. Second, it reveals that Asian people would prefer to reside in communities with a lower level of wildfire risk. In contrast with previous research reporting the Black, Hispanic or Native American people are more vulnerable to wildfire, this research showed only the census tracts with the higher number of the Native Americans are more exposed to the wildfire risk, compared with other census tracts. Third, it revealed that people with a higher level o

关键词： Environmental hazard Wildfire Risk GIS Disaster Emergency Management Risk Analysis

Tornado Impacts in the US from 1950-2015: A GIS-Based Analysis of Vulnerability and Evolving Risk Zones for Human Casualties

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Journal of Geographic Information System 2023年第5期15卷 563-579页

作者： seong Nam hwang Kayla Meier Environmental Science Program Department of Biology Southeast Missouri State University Cape Girardeau Missouri USA

The United States is one of the major countries in the world that faces a numerous number of tornadoes every year, directly and indirectly experiencing extensive property damage and human casualties as well as a variety of demographic, socioeconomic, and environmental impacts. This research provides a GIS-based examination of the ways past tornadoes that occurred in the US in the period 1950-2015 have played out in the context of bodily injuries and loss of human life. To this end, the research collected major secondary data (i.e., georeferenced tornado point data) from the Storm Prediction Center (SPC) tornado database and conducted raster-based spatial analysis, utilizing techniques like point density analysis and map algebra to locate areas that have a high risk of tornadoes and to create maps that show relationships between the past tornado events and human casualties. One of the major research findings shown by the spatial analysis was that the geographic areas or regions impacted by tornadoes varied over time. In addition, the statistical results showed a trend that the tornado-prone regions extend from “Tornado Alley” to the states of Illinois, Mississippi, Tennessee, Alabama, and Florida, indicating that the communities in those states that are newly considered to be vulnerable to tornadoes should step up to develop their own tornado mitigation plan to help protect the public and its property from tornadoes. Such plans can play a crucial role in safeguarding the public and protecting property from tornadoes’ potential impact. Additionally, urban planners and policymakers can use this information to make informed decisions about building codes and infrastructure development in tornado-prone areas, potentially reducing the impact of future tornado events on human lives and property.

关键词： Tornadoes Emergency Management Spatial Analysis Environmental hazard Natural hazard

Gastric per-oral endoscopic myotomy: Current status and future directions

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World Journal of Gastroenterology 2019年第21期25卷 2581-2590页

作者： Alexander Podboy Joo ha hwang Linda A Nguyen Patricia Garcia Thomas A Zikos Afrin Kamal George Triadafilopoulos John O Clarke Division of Gastroenterology and Hepatology Stanford University School of Medicine

Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field.

关键词： Gastroparesis Gastric per-oral endoscopic myotomy Per-oral endoscopic pyloromyotomy Myotomy Endoscopic myotomy Peroral endoscopic myotomy Gastric emptying

Quantum-Dot Spin-Based Secret Sharing in an Optical Microcavity

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Communications in Theoretical Physics 2010年第12期 1049-1053页

作者：张英俏张寿 YEON Kyu-hwang YU seong-Cho Department of Physics College of ScienceYanbian University BK21 Physics Program and Department of Physics College of Natural SciencesChungbuk National University BK21 Physics Program and Department of Physics College of Natural SciencesChungbuk National UniversityCheongju

Two schemes of quantum secret sharing are proposed via single electron spin confined in charged QDs inside a single-sided microcavity and a double-sided microcavity, respectively. Both schemes rely on coherent photons... 详细信息

关键词： secret sharing quantum-dot spin single-sided microcavity double-sided microcavity

Choroidal and skin metastases from colorectal cancer

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World Journal of Gastroenterology 2016年第43期22卷 9650-9653页

作者： Joo Young ha Edward Hynseung Oh Moon Ki Jung Song Ee Park Ji Tak Kim In Gyu hwang Department of Internal Medicine Chung-Ang University College of Medicine Department of Internal Medicine Division of Hemato-oncology Chung-Ang University College of Medicine Department of Ophthalmology Chung-Ang University College of Medicine

Choroidal and skin metastasis of colon cancer is rare. In women, the frequency of cutaneous metastasis from colon cancer as the primary lesion in is 9% and skin metastasis occurs in 0.81% of all colorectal cancers. We report a patient with colonic adenocarcinoma who presented with visual disorder in her right eye and scalp pain as her initial symptoms. Contrast-enhance orbital magnetic resonance imaging with fat suppression revealed an infrabulbar mass, and skin biopsy of the posterior parietal scalp confirmed adenocarcinoma. These symptoms were diagnosed as being caused by choroidal and skin metastases of colonic adenocarcinoma. We started palliative chemotherapy with oral capecitabine(1000 mg/m2, twice a day, on days 1-14) every 3 wk, which was effective at shrinking the brain masses and improving the visual disorder. This is the first report that capecitabine is effective at reducing a choroidal and cutaneous metastatic lesion from rightsided colorectal cancer.

关键词： Colon cancer Choroid cancer Skin cancer Capecitabine

DISTINIT:Data poISoning atTacks dectectIon usiNg optIized jaCcard disTance

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Computers, Materials & Continua 2022年第12期 4559-4576页

作者： Maria Sameen seong Oun hwang Department of IT Convergence Engineering Gachon UniversitySeongnam-si13120Korea Department of Computer Engineering Gachon UniversitySeongnam-si13120Korea

Machine Learning(ML)systems often involve a re-training process to make better predictions and *** re-training process creates a loophole and poses a security threat for ML *** leverage this loophole and design data poisoning attacks against ML *** poisoning attacks are a type of attack in which an adversary manipulates the training dataset to degrade the ML system’s *** poisoning attacks are challenging to detect,and even more difficult to respond to,particularly in the Internet of Things(IoT)*** address this problem,we proposed DISTINIT,the first proactive data poisoning attack detection framework using *** found that Jaccard Distance(JD)can be used in the DISTINIT(among other distance measures)and we finally improved the JD to attain an Optimized JD(OJD)with lower time and space *** security analysis shows that the DISTINIT is secure against data poisoning attacks by considering key features of adversarial *** conclude that the proposed OJD-based DISTINIT is effective and efficient against data poisoning attacks where in-time detection is critical for IoT applications with large volumes of streaming data.

关键词： Data poisoning attacks detection framework jaccard distance(JD) optimized jaccard distance(OJD) security analysis