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Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis

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World Journal of Gastroenterology 2022年第44期28卷 6294-6309页

作者： Kang Nyeong Lee Oh Young Lee Hoon Jai Chun Jin Il Kim Sung Kook Kim Sang Woo Lee Kyung Sik park Kook Lae Lee Suck Chei Choi Jae-Young Jang Gwang Ha Kim In-kyung Sung Moo In park Joong Goo Kwon Nayoung Kim Jae Jun Kim Soo Teik Lee Hyun Soo Kim Ki Bae Kim Yong chan Lee Myung-Gyu Choi Joon seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-Hyun Kim Hyunsoo Chung Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Korea University Anam HospitalSeoul 02841South Korea Department of Internal Medicine The Catholic University of KoreaYeouido ST.Mary’s HospitalSeoul 07260South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine Korea University Ansan HospitalAnsan-si 15355South Korea Department of Internal Medicine Keimyung University Dongsan HospitalDaegu 42601South Korea Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Internal Medicine Wonkwang University HospitalIksan 54538South Korea Department of Internal Medicine KyungHee University Medical CenterSeoul 02447South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 47241South Korea Department of Internal Medicine KKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Kosin University Gaspel HospitalBusan 49267South Korea Department of Internal Medicine Daegu Catholic University Medical CenterDaegu 42471South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam-si 13620Gyeonggi-doSouth Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju-si 54907South Korea Department of Internal Medicine Chonnam National University HospitalGwangju 61469South Korea Department of Internal medicine Chungbuk National University School of MedicineCheong Ju 28644South Korea Department of Internal Medicine Severance HospitalSeoul 03722South Korea Department of Internal Medicine The Catholic University of KoreaSeoul ST.Mary’s HospitalSeoul 06591South Korea Digestive Disease Center Soon

BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal ***’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent *** To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight *** primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week *** secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life *** profiles and serum gastrin levels were compared between the *** Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life ***,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the *** Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week *** suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE.

关键词： Gastroesophageal reflux Esophagitis Proton pump inhibitors Heartburn Quality of life

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Statistics of oxidation resistance of Ni-(0-15)Co-(8-15)Cr-(0-5)Mo-(0-10)W-(3-8)Al-(0-5)Ti-(0-10)Ta-0.1C-0.01B superalloys at 1000℃ by compositional variations

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Rare Metals 2020年第8期39卷 918-927页

作者： Si-Jun park Kyu-Hyuk Lee seong-Moon Seo Hi-Won Jeong Young-Soo Yoo HeeJin Jang Multi-Material Research Center Gwangju-Jeonnam DivisionKorea Automotive Technology InstituteGwangju 62207Republic of Korea Department of Advanced Materials Engineering Chosun UniversityGwangju 61452Republic of Korea High Temperature Materials Group Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea

The effects of alloying elements(Co,Cr,Mo,W,Al,Ti,and Ta)on the oxidation resistance of Ni-(0-15)Co-(8-15)Cr-(0-5)Mo-(0-10)W-(3-8)Al-(0-5)Ti-(0-10)Ta-0.1 C-0.01 B alloys were *** sample compositions were designed by the Box-Behnken method of design of experiments(DOE).The alloying elements show complicated effects on the mass gain due to oxidation,depending on the alloy *** reduces the mass gain *** other elements except Al do not appear to exert a strong effect on the oxidation rate on average,but their influences are shown clearly in the alloys with a low Al ***,W,and Ta reduce the oxidation rate,while Cr,Mo,and Ti promote *** is the most effective element in reducing the oxidation rate of the alloy with a low Al *** is confirmed that a continuous Al2O3 layer is essentially required for high oxidation *** oxide scale of easily oxidized alloys has various oxides such as NiCr2O4,NiAl2O4,NiO,Cr2O3,CrTaO4,and TiO2.

关键词： High temperature oxidation Alloy composition Ni-based superalloy Oxidation resistance Design of experiments

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Driving characteristics of octagon-type ultrasonic motor

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Journal of Central South University 2013年第1期20卷 71-75页

作者： KIM Jong-Wook park Choong-Hyo LIM Jung-Hoon JEONG seong-Su park Jong-Kyu park Tae-Gone changwon National University Sarim-dongChangwon-siGyeongsangnam-do641-773Korea

Structure of the octagon-type ultrasonic motor was proposed and designed so as to allow the motor to drive small actuator. The stator of the motor consisted of the octagon shape elastic body and four rectangular plate ceramics. The four ceramics were attached to outer surfaces of the octagon elastic body. The same phase voltages were applied to the ceramics on horizontal surfaces, and 90° phase difference voltages were applied to the ceramics on vertical surfaces. When the AC voltage with 90° phase difference was applied in ceramics, the elliptical displacement of unimorph bars was generated by generating bending vibration. To find the maximum displacement model that generates elliptical displacement at the centers of the inner surfaces, the finite element analysis program ATILA was used. The analyzed results were compared to the experimental results. As a result, the speed and torque are increased linearly by increasing the input voltage and the speed of motors can be controlled by changing the applied voltages.

关键词：超声波马达驾驶特性超声波电动机有限元分析程序陶瓷连接输入电压外表面相位差

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A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1093-1109页

作者： Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye Choi Yoon Pyo Choi seong Wook Seo Hyuk Woo Lee Chong Hak Chae Woo-Kyu park Hyun Young Kim Daeyoung Jeong Tran Quang De chang-Seon Myung Heeyeong Cho Therapeutics&Biotechnology Division Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea Department of Pharmacology Chungnam National University College of PharmacyYuseong-guDaejeon 34134Republic of Korea Future Medicine Co. Ltd.Rm616 LH-Business Growth CenterSeongnamGyeonggido 13449Republic of Korea Department of Chemistry College of Natural SciencesCan Tho UniversityCan Tho city 9000Viet Nam

Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of ***,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib *** developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in *** rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and ***-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in *** addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 *** results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.

关键词： Drug discovery IRAK4 PIM1 NF-κB pathway Rheumatoid arthritis ABC-DLBCL Ibrutinib resistance Dual inhibitor

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New approach of medicinal herbs and sulfasalazine mixture on ulcerative colitis induced by dextran sodium sulfate

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World Journal of Gastroenterology 2020年第35期26卷 5272-5286页

作者： Mi-Rae Shin Hae-Jin park Bu-Il Seo seong-Soo Roh Department of Herbology Korean Medicine CollegeDaegu Haany UniversitySuseong-guDeagu 42158South Korea DHU Bio Convergence Testing Center Gyeongsan-siGyeongsangbuk-do 38610South Korea

BACKGROUND Sulfasalazine has been used as a standard-of-care in ulcerative colitis for decades,however,it results in severe adverse symptoms,such as hepatotoxicity,blood disorders,male infertility,and ***,the new treatment strategy has to enhance pharmacological efficacy and stimultaneously minimize side *** To compare the anti-inflammatory action of sulfasalazine alone or in combination with herbal medicine for ulcerative colitis in a dextran sodium sulfate(DSS)-induced colitis mouse *** To induce ulcerative colitis,mice received 5%DSS in drinking water for 7 *** were divided into five groups(n=9 each)for use as normal(non-DSS),DSS controls,DSS+sulfasalazine(30 mg/kg)-treatment experimentals,DSS+sulfasalazine(60 mg/kg)-treatment experimentals,DSS+sulfasalazine(30 mg/kg)+Citrus unshiu peel and Bupleuri radix mixture(30 mg/kg)(SCPB)-treatment *** The SCPB treatment showed an outstanding effectiveness in counteracting the ulcerative colitis,as evidenced by reduction in body weight,improvement in crypt morphology,increase in antioxidant defenses,down-regulation of proinflammatory proteins and cytokines,and inhibition of proteins related to *** may represent a promising alternative therapeutic against ulcerative colitis,without inducing adverse effects.

关键词： Dextran sulfate sodium Ulcerative colitis Anti-inflammatory Sulfasalazine Citrus unshiu peel and Bupleuri radix mixture Apoptosis

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Pretransplant locoregional therapy for hepatocellular carcinoma:encouraging but insufficient

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Hepatobiliary Surgery and Nutrition 2018年第2期7卷 136-137页

作者： seong Hoon Kim Eung chang Lee Sang Jae park Organ Transplantation Center/Center for Liver Cancer National Cancer CenterGoyang-siGyeonggi-doRepublic of Korea

Despite in the era of liver transplantation(LT)widely performed as an established curative treatment for hepatocellular carcinoma(HCC),the scarcity of liver donors has still been a well-nigh insurmountable barrier to access of ***,the bridging locoregional therapy(LRT)that treats HCC during the waiting time prior to LT emerged as an attractive strategy to reduce the risk of tumor progression and waitlist dropout,which came to an international consensus statement regarding the waitlist management of HCC patients(1).However,the actual advantage for LRT has not been clearly demonstrated in terms of recurrence and survival.

关键词： hepatocellular statement attractive

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Microfluidic dual loops reactor for conducting a multistep reaction

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Frontiers of Chemical Science and Engineering 2018年第2期12卷 239-246页

作者： Si Hyung Jin Jae-Hoon Jung seong-Geun Jeong Jongmin Kim Tae Jung park chang-Soo Lee Department of Chemical Engineering Chungnam National University Daejeon 34134 Korea Lotte Chemical R&D Center Daejeon 34110 Korea Department of Chemistry Chung-Ang University Seoul 06974 Korea

Precise control of each individual reaction that constitutes a multistep reaction must be performed to obtain the desired reaction product efficiently. In this work, we present a microfluidic dual loops reactor that enables multistep reaction by integrating two identical loop reactors. Specifically, reactants A and B are synthesized in the first loop reactor and transferred to the second loop reactor to synthesize with reactant C to form the final product. These individual reactions have nano-liter volumes and are carded out in a stepwise manner in each reactor without any cross-contamination issue. To pre- cisely control the mixing efficiency in each loop reactor, we investigate the operating pressure and the operating frequency on the mixing valves for rotary mixing. This microfluidic dual loops reactor is integrated with several valves to realize the fully automated unit operation of a multistep reaction, such as metering the reactants, rotary mixing, transportation, and collecting the product. For proof of concept, CdSeZn nanopartieles are successfully synthesized in a microfluidic dual loops reactor through a fully automated mukistep reaction. Taking all of these features together, this microfluidic dual loops reactor is a general microfluidic screening platform that can synthesize various materials through a multistep reaction.

关键词： microfluidics multistep reaction rotary mixing nanoparticle

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Influence of different nitrogen application on flour properties,gluten properties by HPLC and end-use quality of Korean wheat

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Journal of Integrative Agriculture 2018年第5期17卷 982-993页

作者： seong-Woo Cho Chon-Sik Kang Taek-Gyu Kang Kwang-Min Cho Chul Soo park Department of Crop Science and Biotechnology Chonbuk National University National Institute of Crop Science Rural Development Administration Research Center of Bioactive Materials Chonbuk National University

This study was performed to identify how the different levels of nitrogen application affected the variances of gluten properties and end-use qualities and the differences of variances among Korean wheat cultivars. Protein and dry gluten content, SDS sedimentation volume and water absorption of Mixolab increased as nitrogen application increased. This ratio of the increase was higher in Korean wheat cultivars for bread than in Korean wheat cultivars for noodles and cookies. The proportion of（α＋β）-gliadin measured by reversed-phase high-performance liquid chromatography（RP-HPLC） increased, but the proportion of ω-and γ-gliadin decreased as the protein content increased. The Korean wheat cultivars for bread showed a high proportion of（α＋β）-gliadin increase, the Korean cultivars for noodles had a high proportion of γ-gliadin decrease and the Korean wheat cultivars for cookies had a high proportion of ω-gliadin decrease. However, there was no variation of the component in the proportion of glutenin component measured by RP-HPLC, even though the protein content was increased, but all of the protein fractions measured by size exclusion（SE）-HPLC were increased. The soluble monomeric protein showed a high proportion of Korean wheat cultivars for bread by the increase of protein content. Bread loaf volume increased by the increase of protein content but there were no variances in the ratio of increase among Korean wheat cultivars. The cookie diameter decreased with the increase of protein content, and this ratio of decrease was the highest in Korean wheat cultivars for cookies. The hardness of cooked noodles also increased by the increase of protein content but there were no variations in springiness and cohesiveness. The decrease proportion of ω-gliadin affected the increase of bread loaf volume, the hardness of cooked noodles, and the decrease of cookie diameter.

关键词： wheat gluten end-use quality cultivar nitrogen application

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Spectroscopic Understanding of Structural and Electrical Property Variations in Dopant-Free ZnO Films

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Journal of Materials Science & Technology 2017年第6期33卷 523-526页

作者： Hyegyeong Kim JiWoong Kim Dooyong Lee Won-Jae Lee Jong-seong Bae Jaekwang Lee Sungkyun park Department of Physics Pusan National University Department of Nano Engineering & Electronic Research Center Dong-Eui University Busan Center Korea Basic Science Institute

Physical property variation in dopant-free ZnO films was investigated. Film annealing under various environments（O_2, in-Air, N2 and vacuum） resulted in better crystallinity than in the as-grown film. In particular, the film annealed under the N_2 environment showed better crystallinity and electrical properties than films annealed in other environments. Based on spectroscopic analysis, we found a correlation between physical（structural, electrical） and chemical properties： The crystallinity of ZnO films is closely related to ZnO bonding, whereas carrier concentration is associated with VO（oxygen vacancy）.

关键词： ZnO films Annealing Oxygen vacancies Environmental stability

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Comparative study of tensile and high-cycle fatigue properties of extruded AZ91 and AZ91-0.3Ca-0.2Y alloys

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Journal of Materials Science & Technology 2021年第34期93卷 41-52页

作者： Ye Jin Kim Young Min Kim seong-Gu Hong Dae Woong Kim Chong Soo Lee Sung Hyuk park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Division of Industrial Metrology Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Energy Infra Material Measure Team Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Graduate Institute of Ferrous Technology Pohang University of Science and Technology.Pohang 37673Republic of Korea

Mg-Al-Zn-Ca-Y alloys with excellent ignition and corrosion resistances—termed SEN alloys(where the letters"S,""E,"and"N"stand for stainless,environmentally friendly,and non-flammable,respectively)—have been developed *** this study,the microstructure,tensile properties,and high-cycle fatigue properties of an extruded Mg-9.0Al-0.8Zn-0.1Mn-0.3Ca-0.2Y(SEN9)alloy are investigated and compared with those of a commercial Mg-9.0Al-0.8Zn-0.1Mn(AZ91)alloy extruded under the same *** the extruded SEN9 alloy and the extruded AZ91 alloy have a fully recrystallized structure comprising equiaxed grains,but the former has a smaller average grain size owing to the promoted dynamic recrystallization during *** extruded AZ91 alloy contains coarse Mg_(17)Al_(12) discontinuous precipitate(DP)bands parallel to the extrusion direction,which are formed during its cool down after *** contrast,the extruded SEN9 alloy contains relatively fine undissolved Al_(2)Ca,Al_(8)Mn_(4)Y,and Al_(2)Y second-phase particles,which are formed during the solidification stage of the casting *** tensile strength of the extruded SEN9 alloy,which has finer grains and more abundant particles,is slightly higher than that of the extruded AZ91 ***,the difference in their strengths is relatively small because the stronger solid-solution hardening and precipitation hardening effects in the extruded AZ91alloy offset the stronger grain-boundary hardening and dispersion hardening effects in the extruded SEN9alloy to some *** tensile elongation of the extruded AZ91 alloy is significantly lower than that of the extruded SEN9 alloy because the large cracks formed in the DP bands in the former cause its premature *** the extruded SEN9 alloy has higher tensile properties than the extruded AZ91alloy,the high-cycle fatigue life and fatigue strength of the former are shorter and lower,respectively,than those of the *** DP bands in the extruded

关键词： Mg-Al-Zn-Ca-Y alloy Extrusion Tensile properties High-cycle fatigue Crack source

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