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Pain Efficacy of a Home-Based Low-Intensity Continuous Ultrasound Stimulator for Knee Arthritis: A Single-Arm, Open-Label, Prospective Clinical Trial

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Health 2024年第7期16卷 703-716页

作者： Md. Habibur Rahman Yeon-Gyu Jang Johny Bajgai Subham Sharma Kchorng Vira Abdul-Nasir Sofian seong hoon goh Yundeok Kim Cheol-Su Kim Doo-Sup Kim Kyu-Jae Lee Department of Convergence Medicine Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Neurosurgery Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Global Medical Science Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Internal Medicine Division of Hematology-Oncology Wonju Severance Christian Hospital Wonju Republic of Korea Department of Orthopaedic Surgery Wonju College of Medicine Yonsei University Wonju Republic of Korea

1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.

关键词： Knee Osteoarthritis Low-Intensity Continuous Ultrasound Stimulator Clinical Trial Visual Analogue Scale Western Ontario and McMaster Universities Osteoarthritis Index

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Pain Efficacy of a Home-Based Low-Intensity Continuous Ultrasound Stimulator for Knee Arthritis: A Single-Arm, Open-Label, Prospective Clinical Trial

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Health（健康） 2024年第7期 703页

作者： Md.Habibur Rahman Yeon-Gyu Jang Johny Bajgai Subham Sharma Kchorng Vira Abdul-Nasir Sofian seong hoon goh Yundeok Kim Cheol-Su Kim Doo-Sup Kim Kyu-Jae Lee

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Effect of pre-twinning and heat treatment on formability of AZX311 Mg alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 1154-1169页

作者： Mahesh Panchal Lalit Kaushik Min-seong Kim Ravi Kottan Renganayagalu Shi-hoon Choi Jaiveer Singh Department of Mechanical Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Department of Metallurgical and Materials Engineering Indian Institute of Technology JodhpurKarwarJodhpur 342030RajasthanIndia Energy Materials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang-roSeongbuk-guSeoul 02792Republic of Korea Department of Advanced Components and Materials Engineering Sunchon National University255 Jungang-roSuncheonJeonnam 57922Republic of Korea

In this study,the effects of pre-strain-induced tensile twins(TTWs)and controlled heat treatment on the formability behavior of AZX311 Mg alloy sheets were investigated.A 4%compressive strain was applied to pre-strain the sheets using the in-plane compression(IPC)technique along the rolling direction(RD)to introduce *** pre-strained(PS)samples were subsequently heat-treated at 250℃,350℃,and 400℃ independently for 1 hr,and are termed as PSA1,PSA2,and PSA3,*** cupping tests were conducted to assess the formability of the sheet samples under different initial *** results showed that the PS sample heat-treated at 250℃ for 1hr exhibited a decrease in the Erichsen index(IE)compared to the as-rolled sample,whereas PSA2 and PSA3 samples showed an increase in IE *** analysis revealed that most of the TTWs generated through pre-twinning were stable at 250℃;however,the twin volume fraction reduced to 41%at 350℃ compared to the PS samples due to enhanced thermal activity at that ***,PSA2 samples showed severe grain coarsening in some areas of the sample,and the fraction of such grains increased in the PSA3 *** stretch formability(IE value)of PSA2 samples showed a 32.3%increase compared to the as-rolled ***,the analysis of the deformed specimen at failure under the Erichsen test indicated that considerable detwinning occurs in the PS and PSA1 samples,whereas dislocation slip activity dominates in the PSA2 and PSA3 samples during stretch *** from detwinning and dislocation slip,deformation twins were also observed in all samples after the Erichsen ***,this work highlights the importance of texture control and its underlying mechanisms via pre-twinning followed by heat treatment and their impact on the room temperature(RT)stretch formability of AZX311 Mg alloy sheets.

关键词： Mg alloys Pre-twinning Texture Formability EBSD.

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Atomically Adjustable Rhodium Catalyst Synthesis with Outstanding Mass Activity via Surface-Li mi ted Cation Exchange

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Energy & Environmental Materials 2024年第2期7卷 83-92页

作者： Hak Hyeon Lee Dong Su Kim Swagotom Sarker Ji hoon Choi Ho seong Lee Hyung Koun Cho Department of Advanced Materials Science&Engineering Sungkyunkwan University2066Seobu-roJangan-guSuwon-siGyeonggi-doSeoul 16419Korea Department of Advanced Materials Science&Engineering Kyungpook National University80Daehak-roBuk-guDaegu 41566Korea

Rh has been widely studied as a catalyst for the promising hydrazine oxidation reaction that can replace oxygen evolution reactions for boosting hydrogen production from hydrazine-containing *** Rh being expensive,only a few studies have examined its electrocatalytic mass ***,surface-limited cation exchange and electrochemical activation processes are designed to remarkably enhance the mass activity of *** atoms were readily replaced at the Ni sites on the surface of NiOOH electrodes by cation exchange,and the resulting RhOOH compounds were activated by the electrochemical reduction *** cation exchange-derived Rh catalysts exhibited particle sizes not exceeding 2 nm without agglomeration,indicating a decrease in the number of inactive inner Rh ***,an improved mass activity of 30 A mg_(Rh)^(-1)was achieved at 0.4 V versus reversible hydrogen ***,the two-electrode system employing the same CE-derived Rh electrodes achieved overall hydrazine splitting over 36 h at a stable low *** proposed surface-limited CE process is an effective method for reducing inactive atoms of expensive noble metal catalysts.

关键词： cation exchange synthesis electrochemical metallization hydrazine oxidation reaction mass activity rhodium catalyst

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Functionally graded structure of a nitride-strengthened Mg_(2)Si-based hybrid composite

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Journal of Magnesium and Alloys 2024年第3期12卷 1239-1256页

作者： Jeongho Yang Woongbeom Heogh Hogi Ju Sukhyun Kang Tae-Sik Jang Hyun-Do Jung Mohammad Jahazi Seung Chul Han seong Je Park Hyoung Seop Kim Susmita Bose Amit Bandyopadhyay Martin Byung-Guk Jun Young Won Kim Dae-kyeom Kim Rigoberto CAdvincula Clodualdo Aranas Jr Sang hoon Kim School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Mechanical Design Engineering Hanyang UniversitySeoul 04763Republic of Korea Process Research 3 Team LG Display Co.Ltd.PajuGyeonggi-do 10845Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangju 61452Republic of Korea Institute of Well-Aging Medicare&Chosun University LAMP Center Chosun UniversityGwangju 61452Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul 04763Republic of Korea Department of Mechanical Engineering École de Technologie SupérieureMontrealQuebec H3C 1K3Canada Material&Component Convergence R&D Center Korea Construction Equipment Technology InstituteGunsanJeollabuk-do 54002Republic of Korea School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Graduate Institute of Ferrous&Eco Materials Technology Pohang University of Science and TechnologyPohangGyeongsangbuk-do 37673Republic of Korea Advanced Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Institute for Convergence Research and Education in Advanced Technology Yonsei UniversitySeoul 03722Republic of Korea School of Mechanical and Materials Engineering Washington State UniversityPullmanWashington 99164USA School of Mechanical Engineering Purdue UniversityWest LafayetteIndiana 47907USA Research Institute of Advanced Manufacturing Technology Korea Institute of Industrial TechnologyIncheon 21999Republic of Korea Department of Macromolecular Science and Engineering Case Western Reserve UniversityClevelandOhio 44106USA Department of Chemical and Biomolecular Engineering and Joint Institute for Advanced Materials University of TennesseeKnoxvilleTennessee 37996USA Center for Nanophase Materials and Sciences Oak Ridge National LaboratoryOak RidgeTennessee 37830USA Department of Mechanical Engineering University of New BrunswickFrederictonNew Brunswick E3B 5A3Cana

The ex-situ incorporation of the secondary SiC reinforcement,along with the in-situ incorporation of the tertiary and quaternary Mg_(3)N_(2) and Si_(3)N_(4) phases,in the primary matrix of Mg_(2)Si is employed in order to provide ultimate wear resistance based on the laser-irradiation-induced inclusion of N_(2) gas during laser powder bed *** is substantialized based on both the thermal diffusion-and chemical reactionbased metallurgy of the Mg_(2)Si–SiC/nitride hybrid *** study also proposes a functional platform for systematically modulating a functionally graded structure and modeling build-direction-dependent architectonics during additive *** strategy enables the development of a compositional gradient from the center to the edge of each melt pool of the Mg_(2)Si–SiC/nitride hybrid ***,the coefficient of friction of the hybrid composite exhibits a 309.3%decrease to–1.67 compared to–0.54 for the conventional nonreinforced Mg_(2)Si structure,while the tensile strength exhibits a 171.3%increase to 831.5 MPa compared to 485.3 MPa for the conventional *** outstanding mechanical behavior is due to the(1)the complementary and synergistic reinforcement effects of the SiC and nitride compounds,each of which possesses an intrinsically high hardness,and(2)the strong adhesion of these compounds to the Mg_(2)Si matrix despite their small sizes and low concentrations.

关键词： Laser powder bed fusion Mg_(2)Si-SiC/nitride hybrid composite Both the thermal diffusion-and chemical reaction-based metallurgy Functionally graded structure Compositional gradient Wear resistance.

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Successful living donor liver transplantation with a graft-to-recipient weight ratio of 0.41 without portal flow modulation:A case report

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World Journal of Clinical Cases 2022年第16期10卷 5414-5419页

作者： seong hoon Kim Center for Liver Cancer National Cancer CenterGoyang 10408GyeonggidoSouth Korea

BACKGROUND There have been numerous efforts to lower the limit of minimum graft size to meet the metabolic demand of recipients in adult-to-adult living donor liver transplantation(LDLT).We experienced a successful case of LDLT using a verysmall-for-size graft without portal flow modulation such as splenectomy or portocaval *** SUMMARY A 49-year-old man(weighing 91 kg)suffering hepatocellular carcinoma accompanied with hepatitis B virus related cirrhosis underwent *** one and only voluntary donor was his 17-year-old daughter whose body weight was 50 kg with a body mass index(BMI)of *** procured right liver graft was 411 g with a real graft-to-recipient weight ratio(GRWR)of 0.41%,the smallest to be reported in the *** the recipient and donor had an uneventful recovery and were discharged on days 15 and 8,respectively,with normal liver *** father and daughter have had no complication so far and are still in good health with normal liver function 81 mo after *** Satisfactory outcomes can be achieved in LDLT with a GRWR as low as 0.41%even without using portal flow modulation in highly selected patients.

关键词： Small-for-size graft Living donor liver transplantation Graft-to-recipient weight ratio Case report

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Electrophoretic deposition of a supercapacitor electrode of activated carbon onto an indium-tin-oxide substrate using ethyl cellulose as a binder

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Journal of Materials Science & Technology 2020年第23期58卷 188-196页

作者： Taeuk Kim seong-hoon Yi Sang-Eun Chun School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

A transparent energy storage device is an essential component for transparent *** increasing demand for high-power devices stimulates the development of transparent supercapacitors with high power density.A transparent electrode for such supercapacitors can be assembled via the electrophoretic deposition of an active material powder with a binder onto a transparent *** properties of the binder critically influence the electrochemical behavior and performance of the resulting *** cellulose(EC)is known as an eco-friendly,transparent,flexible,and inexpensive ***,we fabricated an electrode film with EC binder via electrophoretic deposition on an indium tin oxide(ITO)substrate instead of using the conventional polytetrafluoroethylene(PTFE)*** assembled electrodes with EC and PTFE were compared to investigate the feasibility of EC as a binder from different perspectives,including homogeneity,wettability,electrochemical behavior,and mechanical *** EC enabled the formation of a homogeneous film composed of smaller particles and with a higher specific capacitance compared with films prepared with *** annealing improved the adhesion strength of the EC because of its glass transition;however,its hydrophobic nature limited utilization of the active material for charge *** electrochemical activation improved the wettability of the electrode,resulting in an increased capacitance of 60 F g^(-1).Furthermore,even with the lower wettability of EC compared with that of PTFE,better rate performance was possible with the EC *** increased mechanical stability after the annealing process ensured an excellent cycle life of 95%capacitance retention for 15,000 cycles.

关键词： Electrophoretic deposition Transparent electrode Activated carbon Ethyl cellulose Indium tin oxide

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Enhanced stability and rate performance of zinc-doped cobalt hexacyanoferrate (CoZnHCF) by the limited crystal growth and reduced distortion

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Journal of Energy Chemistry 2022年第6期31卷 649-658,I0018页

作者： Jihwan Kim seong-hoon Yi Li Li Sang-Eun Chun School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina School of Industrial Technology Advances Kyungpook National UniversityDaegu 41566Republic of Korea

Cobalt hexacyanoferrate (CoHCF) is a potential cathode for aqueous Na-ion batteries due to its high theoretical specific capacity (170 m Ah g^(-1));however,its lower rate capability and cyclability limit its *** distortion at a weak N-coordinated crystal field during cycling disintegrates Co,yielding an irreversible *** Zn amounts ranging 0–1 were added to the Co site to suppress the structural irreversibility of CoHCF,yielding Co_(1-x)Zn_(x)HCF powder;this Zn (x≤0.09) addition reduced the powder’s dimension because the lower four coordination of Zn–N,not the six coordination of Co–N,limits the powder ***,a small lattice parameter and interaxial angle (~90°) are obtained,implying that a narrower Co_(1-x)Zn_(x)HCF inner structure is formed to accommodate Na ***,the electronic conductivity of Co_(1-x)Zn_(x)HCF gradually increased within 0–0.09 range.A smaller particle size with a high surface area leads to a near-surface-limited redox process,similar to a capacitive *** the surface-limited reaction and electronic conductivity enhances the reversibility due to the smaller charge transfer resistance at the electrode/electrolyte interface caused by Zn *** redox-active Co with non-active Zn amount of 0.07 (Co_(1-x)Zn_(x)HCF) slightly reduces the specific capacity from 127 to 119 mAh g^(-1)at 0.1 A g^(-1)due to the shrunken Co charging *** performance is enhanced by compromising the capacity and reduced distortion,resulting in 81%retention at a 20-times-faster charging ***,the Co_(1-x)Zn_(x)HCF sample exhibited the good stability while preserving 74%of the initial capacity at 0.5 A g^(-1)after 200 cycles.

关键词： Cobalt hexacyanoferrate Rate capability Stability Growth limitation Structural distortion Near-surface-limited redox process

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Does antiviral therapy reduce complications of cirrhosis?

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World Journal of Gastroenterology 2014年第23期20卷 7306-7311页

作者： goh Eun Chung Jeong-hoon Lee Yoon Jun Kim Department of Internal Medicine Healthcare Research InstituteGangnam Healthcare CenterSeoul National University HospitalSeoul 135-984South Korea Department of Internal Medicine and Liver Research Institute Seoul National College of MedicineSeoul 110-744South Korea

Chronic hepatitis B infection is associated with the development of cirrhosis, hepatocellular carcinoma, and finally liver-related mortality. Each year, approximately, 2%-5% of patients with hepatitis B virus (HBV)-related compensated cirrhosis develop decompensation, with additional clinical manifestations, such as ascites, jaundice, hepatic encephalopathy, and gastrointestinal bleeding. The outcome of decompensated HBV-related cirrhosis is poor, with a 5-year survival of 14%-35% compared to 84% in patients with compensated cirrhosis. Because the risk of disease progression is closely linked to a patient’s serum HBV DNA level, antiviral therapy may suppress viral replication, stabilize liver function and improve survival. This article briefly reviews the role that antiviral therapy plays in cirrhosis complications, particularly, in decompensation and acute-on-chronic liver failure.

关键词： Antiviral therapy Cirrhosis Complication Hepatitis B Decompensation

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Finite element analysis using elasto-visco-plastic self-consistent polycrystal model for E-form Mg sheet subjected to bending

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Journal of Magnesium and Alloys 2023年第4期11卷 1393-1407页

作者： Bohye Jeon Min-seong Kim Shi-hoon Choi Youngung Jeong Department of Materials Convergence and System Engineering Changwon National UniversityChangwon-siGyeongnamRepublic of Korea Center for Energy Materials Research Korea Institute of Science and TechnologySeoulRepublic of Korea Department of Advanced Components and Materials Engineering Sunchon National UniversitySuncheon-siJeollanam-doRepublic of Korea School of Materials Science and Engineering Changwon National UniversityChangwon-siGyeongnamRepublic of Korea

The mechanical behavior of a magnesium alloy E-form under bending was investigated using the elasto-visco-plastic polycrystal model(ΔEVPSC) and its finite element(FE) implementation(ΔEVPSC-FE) developed in Jeong et al. and Jeong and Tomé. The crystallographic orientation distribution(COD) obtained from X-ray diffraction was used to represent the initial texture, and the Voce hardening parameters were calibrated by fitting the uniaxial tension and the compression flow stress curves. A quasi-static FE analysis of a miniaturized V-bending operation was conducted using the ΔEVPSC-FE model. The bending induced an inhomogeneous stress response along the through-thickness and the lateral directions, which was well captured by the model. Moreover, the predictive capability of the model was validated by comparing with various experimental results such as(1) force vs. displacement curves;(2) the through-thickness variations in the twin volume fraction;and(3) the changes in crystallographic texture as a function of displacement. Additional bending simulation was performed using an isotropic texture, the result of which suggests that the potential improvement in bendability of the magnesium alloy is attainable by weakening the initial texture. Moreover, the simulation results imply that the crystallographic texture, which may affect the twin activation across the thickness direction, plays a significant role in the shifting direction of the neutral layer.

关键词： FEM Texture V-bending Polycrystal Magnesium Elasto-visco-plasticity

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