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Femtosecond laser-mediated anchoring of polymer layers on the surface of a biodegradable metal

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Journal of Magnesium and Alloys 2021年第4期9卷 1380-1388页

作者： Jaeho park Bo-In park Young ju Son Sun Hee Lee Seung-Hoon Um Yu-Chan Kim Myoung-Ryul Ok Jeong-Yun Sun Hyung-Seop Han Hojeong Jeon Center for Biomaterials Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Materials science and Engineering Seoul National University(SNU)Seoul 08826Republic of Korea Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea

Mg has received much attention as a next-generation implantable material owing to its biocompatibility,bone-like mechanical properties,and biodegradability in physiological *** application of various polymer coatings has been conducted in the past to reduce the rapid formation of hydrogen gas and the local change in pH during the initial phase of the chemical reaction with the body ***,we propose femtosecond(fs)laser-mediated Mg surface patterning for significant enhancement of the binding strength of the coating material,which eventually reduces the corrosion *** of the structural,physical,crystallographic,and chemical properties of the Mg surface have been conducted in order to understand the mechanism by which the surface adhesion increases between Mg and the polymer coating *** on the fs laser conditions,the surface structure becomes rough owing to the presence of several microscaled pits and grooves of nanoporous MgO,resulting in a tightly bonded poly(lactic-co-glycolic acid)(PLGA)*** corrosion rate of the PLGA-coated,fs laser-treated Mg is considerably slow compared with the non-treated Mg;the treated Mg is also more biocompatible compared with the non-treated *** fs laser-based surface modification technique offers a simple and quick method for introducing a rough coating on Mg;further,it does not require any chemical treatment,thereby overcoming a potential obstacle for its clinical use.

关键词： Femtosecond laser Biodegradable metal Polymer coating Surface modification Surface adhesion

Comparative effects of artemisia vulgaris and charcoal moxa stimulating Zhongwan(CV 12) on body temperature in healthy participants:a cross-over single-blind randomized study

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Journal of Traditional Chinese Medicine 2015年第5期35卷 551-557页

作者： Ho-Yeon Go ju Ah Lee Sunyoung park Sunju.park Jeong-Su park Chunhoo Cheon seong-Gyu Ko Kyung-Hwan Kong Chan-yong jun Jong-hyeong park Mi-Ran Shin Se-Hoon Lee Department of Internal Medicine College of Korean MedicineSemyung University Department of Public Health The Catholic University of Korea Medical Research Division Korea Institute of Oriental Medicine Department of Physiology College of Korean MedicineSemyung University Department of Preventive Medicine College of Korean MedicineDaejeon University Center for Clin ical Research and Genomics College of Oriental Medicine and Institu te of Oriental MedicineKyung Hee University Department of Internal Medicine College of Korean MedicineGachon University Department of Sasang Constitutional Medicine College of Korean MedicineSemyung University

OBJECTIVE:To evaluate the efficacy,safety,satisfaction,discomfort and patient preference of moxa cones of artemisia vulgaris and charcoal ***:This comparative study of moxibustion treatment with Artemisia vulgaris and charcoal moxa cone stimulating Zhongwan(CV 12) is a cross-over single-blinded,randomized clinical trial.A total of 40 healthy subjects(24 males and 16females) participated in this *** subjects dropped out of the ***-eight subjects were treated with Artemisia vulgaris and charcoal moxa cones for 30 min in a cross-over *** treatment,the patients underwent a 30 minute waiting period,and then the temperatures at Tanzhong(CV 17),Zhongwan(CV 12) and Guanyuan(CV 4) were measured using digital infrared thermal ***:After the use of Artemisia vulgaris moxa,the patients' body temperatures were slightly lowered at Tanzhong(CV 17),Zhongwan(CV 12)and Guanyuan(CV 4),but the changes were not statistically *** the use of charcoal moxa,the patients' body temperatures were somewhat increased at Zhongwan(CV 12) and Guanyuan(CV 4),but the changes were not statistically *** Artemisia vulgaris moxa use,the body temperature difference between Zhongwan(CV 12) and Guanyuan(CV 4)was significantly *** charcoal moxa use,the body temperature difference between Tanzhong(CV 17) and Zhongwan(CV 12) was significantly decreased in males and in the whole *** change was caused by the difference in the moxibustion type and by gender ***:This pilot study found that moxibustion did not raise the body temperature,but temperature differences between acupoints were *** large-scale randomized controlled trials are needed for the effect of moxibustion on body temperature.

关键词： Moxibustion Point CV12(Zhongwan) Artemisia Body temperature Cross-over studies Single-blind method Randomized controlled trial

Plant-based,adjuvant-free,potent multivalent vaccines for avian influenza virus via Lactococcus surface display

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Journal of Integrative Plant Biology 2021年第8期63卷 1505-1520页

作者： Shi-Jian Song Gyeong-Im Shin Jinyong Noh Jiho Lee Deok-Hwan Kim Gyeongryul Ryu Gyeongik Ahn Hyungmin Jeon Hai-Ping Diao Youngmin park Min Gab Kim Woe-Yeon Kim Young-Jin Kim Eun-ju Sohn Chang seon Song Inhwan Hwang Department of Life Science Pohang University of Science and TechnologyPohang37673 Korea College of Pharmacy and Research Institute of Pharmaceutical Science Gyeongsang National UniversityJinju660-701 Korea KCAV Inc. Gwangjin-gu05029 Korea Avian Disease Laboratory College of Veterinary MedicineKonkuk UniversitySeoul05029 Korea Division of Applied Life Science(BK21 PLUS) Institute of Agriculture&Life SciencesGyeongsang National UniversityJinju52828 Korea Bioapp Inc.Pohang Technopark ComplexPohang37668 Korea

Influenza epidemics frequently and unpredictably break out all over the world,and seriously affect the breeding industry and human *** and live attenuated viruses have been used as protective vaccines but exhibit high risks for *** vaccines enjoy high biosafety and specificity but have a few weak points compared to inactivated virus or live attenuated virus vaccines,especially in low *** this study,we developed a new subunit vaccine platform for a potent,adjuvant-free,and multivalent *** ectodomains of hemagglutinins(HAs)of influenza viruses were expressed in plants as trimers(tHAs)to mimic their native *** in plant extracts were directly used without purification for binding to inactivated Lactococcus(iLact)to produce iLact-tHAs,an antigen-carrying bacteria-like particle(BLP).tHAs BLP showed strong immune responses in mice and chickens without ***,simultaneous injection of two different antigens by two different formulas,t^(HAH5N6+H9N2) BLP or a combination of t^(HAH5N6) BLP and t^(HAH9N2) BLP,led to strong immune responses to both *** on these results,we propose combinations of plant-based antigen production and BLP-based delivery as a highly potent and cost-effective platform for multivalent vaccination for subunit vaccines.

关键词： bacteria-like particle(BLP) H5N6 H9N2 Lactococcus lactis multi-valent vaccine plant-based vaccine trimeric HA

Effects of Chairside Polishing and Brushing on SurfaceRoughness of Acrylic Denture Base Resins

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Journal of Wuhan University of Technology(Materials Science) 2009年第1期24卷 100-105页

作者： Seung-Kyun Kim ju-Mi park Min-Ho Lee Jae-Youn jung Shipu Li Xinyu Wang Department of Prosthodontics and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Department of Dental Biomaterials and Institute of Oral Bioscience School of Dentistry Chonbuk National University Jeonju Republic of Korea Division of Mechanical & Aerospace System Engineering and RCIT Chonbuk National University Jeonju Republic of Korea Biomedical Materials and Engineering Research Center Wuhan University of Technology Wuhan 430070 China

The effects of 3 chairside polishing kits and mechanical brushing on the surface roughness of 3 different acrylic denture base resins were compared. Acrylic denture base resins （auto-polymerizing, heat-polymerizing, injected heat-polymerizing resins） were examined after a tungsten carbide bur, and after chairside polishing using 3 polishing kits and pumice. The specimens were subjected to mechanical brushing using a wear tester to simulate 30 000 strokes of brushing. The surface roughness of the acrylic denture base resin specimens was measured using a contact pro-filometer. After the test, the random polished acrylic resins were evaluated by scanning electron mi-croscopy （SEM） and atomic force microscopy （AFM）. Acrylic denture base resins polished using the 3 types of polishing kits had a smoother surface than those finished with the tungsten carbide bur （p〈0.05）. The surface of the resin polished by a TC cutter exceeded the Ra of 0.2 μm （p〈0.05）. The auto-polymerizing resin showed a significantly higher surface roughness than the heat-polymerizing resin and injected heat-polymerizing resin （p〉0.05）. In the case of polishing step wise, there was almost no change in surface roughness after brushing （p〉0.05）.

关键词： acrylic denture base resin polishing brushing surface roughness

The H_∞ synchronization of nonlinear Bloch systems via dynamic feedback control approach

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Chinese Physics B 2011年第7期20卷 101-106页

作者： D.H. Ji J.H. Koo S.C. Won ju H. park Mobile Communication Division Digital Media and Communications Samsung Electronics Co. Ltd 416-2 Maetan-Dong Suwon 443-803 Republic of Korea Department of Electronic and Electrical Engineering Pohang University of Science and Technology San 31 Hyoja-Dong Pohang 790-784 Republic of Korea Department of Electrical Engineering Yeungnam University 214-1 Dae-Dong Kyongsan 712-749 Republic of Korea

We consider an H∞ synchronization problem in nonlinear Bloch systems. Based on Lyapunov stability theory and linear matrix inequality formulation, a dynamic feedback controller is designed to guarantee asymptotic stability of the master-slave synchronization. Moreover, this controller reduces the effect of an external disturbance to the H∞ norm constraint. A numerical example is given to validate the proposed synchronization scheme.

关键词： H∞ synchronization Bloch system dynamic control linear matrix inequality

Crypto primitive of MOCVD MoS_(2) transistors for highly secured physical unclonable functions

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Nano Research 2021年第6期14卷 1784-1788页

作者： Bangjie Shao Tsz Hin Choy Feichi Zhou Jiewei Chen Cong Wang Yong ju.park Jong-Hyun Ahn Yang Chai Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina School of Electrical and Electronic Engineering Yonsei UniversitySeoul03722Republic of Korea

Physically unclonable crypto primitives have potential applications for anti-counterfeiting,identification,and authentication,which are clone proof and resistant to variously physical *** physical unclonable function(PUF)based on Si complementary metal-oxide-semiconductor(CMOS)technologies greatly suffers from entropy loss and bit instability due to noise *** we grow atomically thick MoS2 thin film and fabricate field-effect transistors(FETs).The inherently physical randomness of MoS2 transistors from materials growth and device fabrication process makes it appropriate for the application of PUF *** perform electrical characterizations of MoS2 FETs,collect the data from 448 devices,and generate PUF keys by splitting drain current at specific levels to evaluate the response *** selection of splitting threshold enables to generate binary,ternary,and double binary *** generated PUF keys exhibit good randomness and uniqueness,providing a possibility for harvesting highly secured PUF devices with two-dimensional materials.

关键词： transition metal dichalcogenides two-dimensional materials physical unclonable function metal-organic chemical vapor deposition field-effect transistor

Fabrication of cast carbon steel with ultrafine TiC particles

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 54-57页

作者： Sang-Hoon LEE Jin-ju.park Sung-Mo HONG Byoung-Sun HAN Min-Ku LEE Chang-Kyu RHEE Nuclear Materials Research Division Korea Atomic Energy Research Institute Daejeon 305-353 Korea

The carbon steels dispersed with ultrafine TiC particles were fabricated by conventional casting method. The casting process is more economical than other available routes for metal matrix composite production, and the large sized components to be fabricated in short processing time. However, it is extremely difficult to obtain uniform dispersion of ultrafine ceramic particles in liquid metals due to the poor wettability and the specific gravity difference between the ceramic particle and metal matrix. In order to solve these problems, the mechanical milling (MM) and surface-active processes were introduced. As a result, Cu coated ultrafine TiC powders made by MM process using high energy ball milling machine were mixed with Sn powders as a surfactant to get better wettability by lowering the surface tension of carbon steel melt. The microstructural investigations by OM show that ultrafine TiC particles are distributed uniformly in carbon steel matrix. The grain sizes of the cast matrix with ultrafine TiC particles are much smaller than those without ultrafine TiC particles. This is probably due to the fact that TiC particles act as nucleation sites during solidification. The wear resistance of cast carbon steel composites added with MMed TiC/Cu-Sn powders is improved due to grain size refinement.

关键词： TiC particles mechanical milling carbon steel casting dispersion wettability

Spontaneous rupture of hepatic metastasis from a thymoma: A case report

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World Journal of Gastroenterology 2016年第44期22卷 9860-9864页

作者： Ho Jae Kim Yong Eun park Min Seo Ki Se ju Lee Seung Hun Beom Dai Hoon Han Young Nyun park jun Yong park Department of Internal Medicine Yonsei University College of Medicine Department of Surgery Yonsei University College of Medicine Department of Pathology Yonsei University College of Medicine

Bleeding resulting from spontaneous rupture of the liver is an infrequent but potentially life threatening complication that may be associated with an underlying liver disease. A hepatocellular carcinoma or hepatic adenoma is frequently reported is such cases. However, hemoperitoneum resulting from a hepatic metastatic thymoma is extremely rare. Here, we present a case of a 62-year-old man with hypovolemic shock induced by ruptured hepatic metastasis from a thymoma. At the first hospital admission, the patient had a 45-mm anterior mediastinal mass that was eventually diagnosed as a type A thymoma. The mass was excised, and the patient was disease-free for 6 years. He experienced sudden-onset right upper quadrant pain and was again admitted to our hospital. We noted large hemoperitoneum with a 10-cm encapsulated mass in S5/8 and a 2.3-cm nodular lesion in the right upper quadrant of the abdomen. He was diagnosed with hepatic metastasis from the thymoma, and he underwent chemotherapy and surgical excision.

关键词： Spontaneous rupture Hemoperitoneum Transarterial chemoembolization Hepatic metastasis Thymoma

Bile acid increases expression of the histamine-producing enzyme,histidine decarboxylase,in gastric cells

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World Journal of Gastroenterology 2014年第1期20卷 175-182页

作者： Hye Jin Ku Hye Young Kim Hyeong Hoe Kim Hee ju.park Jae Hun Cheong Department of Pediatrics College of MedicinePusan National UniversityBusan 601-721South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 609-735South Korea Department of Experimental Medicine College of MedicinePusan National UniversityBusan 601-721South Korea

AIM: To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon coope... 详细信息

关键词： Histamine Histidine decarboxylase Bile acid Farnesoid X receptor