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Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 864-870页

作者： Sa-Rang Oh seon ok Tae-Sung Jung Sang-ok Jeon Ji-Min Park Ji-wook Jung Deok-seon Ryu Department of Wellbeing Products Co. LtdGimhaeGyeongnam 50969Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaeguHaany UniversityKyungsanRepublic of Korea Department of Biomedical Laboratory Science College of Medical SciencesSoonchunhyang UniversityAsanRepublic of Korea

Objective: To investigate the anti-inflammatory effects of decursin and decursinol angelate-rich Angelica gigas Nakai(AGNE) on dextran sulfate sodium(DSS)-induced murine ulcerative colitis(UC).Methods: The therapeutic effect of an AGNE was analyzed in a mouse model of UC induced by DSS. Disease activity index values were measured by clinical signs such as a weight loss, stool consistency, rectal bleeding and colon length. A histological analysis was performed using hematoxylin and eosin staining. Key inflammatory cytokines and mediators including IL-6, TNF-a, PGE2, COX-2 and HIF-1 a were assayed by enzymelinked immunosorbent assay or western ***: Treatment with the AGNE at 10, 20, and 40 mg/kg alleviated weight loss,decreased disease activity index scores, and reduced colon shortening in mice with DSSinduced UC. AGNE inhibited the production of IL-6 and TNF-a in serum and colon tissue. Moreover, AGNE suppressed the increased expression of COX-2 and HIF-1 a and the increased production of PGE2 in colon tissue were observed in mice with DSSinduced UC. Additionally, histological damage was also alleviated by AGNE ***: The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC.

关键词： Angelica gigas Nakai Ulcerative colitis Dextran sulfate sodium Anti-inflammatory effects Cytokine

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Ischemic colitis after enema administration: Incidence, timing, and clinical features

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World Journal of Gastroenterology 2020年第41期26卷 6442-6454页

作者： Yura Ahn Gil-Sun Hong Ju Hee Lee Choong Wook Lee seon-ok Kim Department of Radiology and Research Institute of Radiology University of Ulsan College of Medicine&Asan Medical CenterSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Enema administration is a common procedure in the emergency department(ED). However, several published case reports on enema-related ischemic colitis(IC) have raised the concerns regarding the safety of enema agents. Nevertheless, information on its true incidence and characteristics are still *** To investigate the incidence, timing, and risk factors of IC in patients receiving *** We consecutively collected the data of all adult patients receiving various enema administrations in the ED from January 2010 to December 2018 and identified patients confirmed with IC following enema. Of 8320 patients receiving glycerin enema, 19 diagnosed of IC were compared with an age-matched control group without *** The incidence of IC was 0.23% among 8320 patients receiving glycerin enema;however, there was no occurrence of IC among those who used other enema agents. The mean age ± standard deviation(SD) of patients with glycerin enemarelated IC was 70.2 ± 11.7. The mean time interval ± SD from glycerin enema administration to IC occurrence was 5.5 h ± 3.9 h(range 1-15 h). Of the 19 glycerin enema-related IC cases, 15(79.0%) were diagnosed within 8 h. The independent risk factors for glycerin-related IC were the constipation score [Odds ratio(OR), 2.0;95% confidence interval(CI): 1.1-3.5, P = 0.017] and leukocytosis(OR, 4.5;95%CI: 1.4-14.7, P = 0.012).CONCLUSION The incidence of glycerin enema-related IC was 0.23% and occurred mostly in the elderly in the early period following enema administration. Glycerin enemarelated IC was associated with the constipation score and leukocytosis.

关键词： Enema Glycerin Ischemic colitis Incidence Timing Risk factors

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Temporal trends in the misdiagnosis rates between Crohn's disease and intestinal tuberculosis

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World Journal of Gastroenterology 2017年第34期23卷 6306-6314页

作者： Hyungil Seo Seohyun Lee Hoonsub So Donghoi Kim seon-ok Kim Jae Seung Soh Jung Ho Bae Sun-Ho Lee Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Kyung-Jo Kim Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Byong Duk Ye Department of Gastroenterology University of Ulsan College of MedicineAsan Medical Center Division of Gastroenterology Department of Internal MedicineCenter for Health PromotionSeoul National University Hospital Department of Clinical Epidemiology and Biostatistics University of Ulsan College of MedicineAsan Medical Center Division of Gastroenterology Department of Internal MedicineHallym University College of Medicine Hallym University Sacred Heart Hospital Department of Gastroenterology Seoul National University College of MedicineSeoul National University Hospital Gangnam Center Inflammatory Bowel Disease Center University of Ulsan College of MedicineAsan Medical Center

AIM To investigate the temporal trends in the misdiagnosis rate between Crohn's disease(CD) and intestinal tuberculosis(ITB) in South Korea. METHODS We retrospectively reviewed the medical records of patients managed for CD or ITB at Asan Medical Center, a tertiary referral hospital, Seoul, Korea between 1996 and 2014. The temporal trends in the misdiagnosis rates between the two diseases were analyzed. The demographic and clinical characteristics were compared between CD patients who were initially misdiagnosed as ITB(final CD group) and vice versa(final ITB group). Final diagnostic criteria for ITB and medication for CD before definite diagnosis of TB were also analyzed in final ITB *** In total, 2760 patients were managed for CD and 772 patients for ITB between 1996 and 2014. As well, 494 of the 2760 CD patients(17.9%) were initially misdiagnosed as ITB and 83 of the 772 ITB patients(10.8%) as CD. The temporal trend in misdiagnosing CD as ITB showed a decrease(OR = 0.89, 95%CI: 0.87-0.91, P < 0.001), whereas the temporal trend in misdiagnosing ITB as CD showed an increase(OR = 1.06, 95%CI: 1.01-1.11, P = 0.013). Age at diagnosis, presenting symptoms, and proportion of patients with active/past perianal fistula and active/inactive pulmonary tuberculosis(TB) were significantly different between final CD group and final ITB group. Forty patients(48.2%) in final ITB group were diagnosed by favorable response to empirical anti-TB treatment. Seventeen patients(20.5%) in final ITB group had inappropriately received corticosteroids and/or thiopurines due to misdiagnosis as CD. However, there were no mortalities in both groups. CONCLUSION Cases of CD misdiagnosed as ITB have been decreasing, whereas cases of ITB misdiagnosed as CD have been increasing over the past two decades.

关键词： Crohn’s disease Intestinal tuberculosis Misdiagnosis

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Humulus japonicus extract alleviates oxidative stress and apoptosis in 6-hydroxydopamine-induced PC12 cells

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Asian Pacific Journal of Tropical Biomedicine 2022年第5期12卷 197-206页

作者： Feng Wang Byoung ok Cho Jae Young Shin Suping Hao seon Il Jang Department of Health Management Jeonju UniversityJeonju 55069Korea Research Institute Ato Q&A CoLTDCheonjam-roWansan-guJeonju 55069Korea Department of Life Sciences Yuncheng UniversityYunchengShanxi Province 044000PR China Institute of Health&Science Jeonju UniversityJeonju 55069Korea

Objective:To explore the possible neuroprotective activities of Humulus japonicus extract against Parkinson's disease(PD)in a cellular ***:PD was modeled in PC12 cells using 6-hydroxydopamine(6-OHDA).The cell activity,intracellular levels of reactive oxygen species(ROS),anti-oxidative and anti-apoptotic effects,and other related indicators and related signaling pathways were evaluated to elucidate the neuroprotective effects of Humulus japonicus ***:Humulus japonicus extract exhibited anti-oxidative and anti-apoptotic effects in 6-OHDA-stimulated PC12 *** also reduced oxidative stress-induced ROS accumulation;upregulated antioxidant enzymes,such as glutathione,catalase,heme oxidase-1,and 8-oxguanine glycosylase 1;promoted cell survival by decreasing BAX and increasing Bcl-2 and sirtuin 1 expression via the MAPK and/or Nrf2 signaling ***:Humulus japonicus extract has antioxidative and anti-apoptotic effects and could be developed as a promising candidate for preventing and treating oxidative stress-related neurodegenerative diseases.

关键词： Humulus japonicus Parkinson’s disease Oxidative stress Apoptosis MAPK PC12 cells Nrf2

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Microstructural evolution and mechanical properties of binary Mg-xBi(x=2,5,and 8 wt%)alloys

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Journal of Magnesium and Alloys 2021年第3期9卷 983-994页

作者： Hui Yu Shaoda Fan Shuaiju Meng Jae ok Choi Zhongjie Li Yohan Go Young Min Kim Weimin Zhao Bong Sun You Kwang seon Shin School of Materials Science and Engineering Hebei University of TechnologyXiping Road 5340Tianjin 300130China

The microstructures and mechanical properties of Mg-x Bi(x=2,5,and 8 wt%)were investigated compared with pure *** ascast Mg-Bi billets consist of dendriticα-Mg grain matrix,divorced eutectic Mg_(3)Bi_(2) phase and secondary precipitated Mg_(3)Bi_(2) *** homogenization,secondary precipitated Mg_(3)Bi_(2) particles were all dissolved into the matrix,while most of the divorced eutectic Mg_(3)Bi_(2) intermetallic compounds *** the as-extruded samples exhibit fully dynamic recrystallization(DRX)and the average grain size decreases and the amount of nano-scale Mg_(3)Bi_(2) precipitates increases with increasing Bi ***,Bi alloying has little influence on the texture of the as-extruded pure Mg,with all the samples showing typical basal *** the results of grain refinement and precipitation hardening,the strengths of the as-extruded samples increase under both tensile and compressive ***,the yield asymmetry significantly decreases with Bi ***,all the as-extruded samples represent similar ductility under compression,while the tensile elongation first increases and then decreases with more Bi *** as-extruded Mg-5Bi alloy demonstrates good combination of strength and ***,Mg-8Bi alloy displays lower tensile ductility than that of Mg-5Bi alloy due to the presence of abundant undissolved coarse Mg_(3)Bi_(2) particles,which act as cracking sources during tensile ***,the strain hardening rate,strain hardening exponent n,and hardening capacity Hc are greatly reduced by Bi addition,mainly owing to the enhanced synergy effects of grain refinement and numerous Mg_(3)Bi_(2) precipitates.

关键词： Mg-Bi Mechanical properties Microstructure Strain hardening

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Plasma Wall Potentials with Secondary Electron Emissions up to the Stable Space-Charge-Limited Condition

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Plasma Science and Technology 2013年第11期15卷 1093-1099页

作者： Jongho seon Ensang LEE School of Space Research Kyung Hee University Seocheon-dong Giheung-gu Yongin-si

Numerical solutions to floating plasma potentials for walls emitting secondary elec- trons are obtained for various surface materials. The calculations are made with plasma moment equations and the secondary electron emission coefficients, which were determined from recent laboratory experiments. The results estimate the wall potentials up to the physical conditions that allow stable plasma sheaths under the space-charge-limited condition. The materials often used in the laboratory, such as aluminum, silicon, boron, molybdenum, silicon dioxide, and alumina, are considered. The minimum wall potential before the onset of space-charge-limited emission is determined by the electron temperatures at which the effective secondary electron emission coefficient integrated over the velocity distributions is about 0.62. The corresponding potential is given by -eφ0 ,- 1.87kBT. The condition for space-charge-limited emission is newly found by numerically searching for all the stable sheaths. The new condition is -eφ0 - 0.95kBT, and this predicts a wall potential that is less negative than the previously found one. Calculation of the power dissipated to the wall for hydrogen plasmas shows that there is a large difference in terms of power dissipation among the considered materials in the temperature range 20-50 eV.

关键词： secondary electrons plasma sheath wall potential space-charge-limited emission

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A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses

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Cell Research 2007年第5期17卷 435-440页

作者： seon Hee Chang Unit 906 Houston USA TX 77030 7455 Fannin Department of Immunology MD Anderson Cancer Center

CD4+ helper T (TH) cells play crucial roles in immune responses. Recently a novel subset of TH cells, termed TH,TH17 or inflammatory TH (THi), has been identified as critical mediators of tissue inflammation. These cells produceIL-17 (also called IL-17 A) and IL-17F, two most homologous cytokines sharing similar regulations. Here we reportthat when overexpressed in 293T cells, IL-17 and IL-17F form not only homodimers but also heterodimers, which wename as IL-17A/F. Fully differentiated mouse THi cells also naturally secrete IL-17A/F as well as IL-17 and IL-17Fhomodimeric cytokines. Recombinant IL-17A/F protein exhibits intermediate levels of potency in inducing IL-6 andKC (CXCL1) as compared to homodimeric cytokines. IL-17A/F regulation of IL-6 and KC expression is dependent onIL-17RA and TRAF6. Thus, IL-17A/F cytokine represents another mechanism whereby T cells regulate inflammatoryresponses and may serve as a novel target for treating various immune-mediated diseases.

关键词： inflammation IL-17 T cells

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Hydrodynamics and modeling of a ventilated supercavitating body in transition phase

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Journal of Hydrodynamics 2015年第5期27卷 763-772页

作者： KIM seon-Hong KIM Nakwan Department of Naval Architecture and Ocean Engineering Seoul National University

Compared to other underwater vehicles, supercavitating vehicles can attain a high speed because they eliminate drag by creating a large cavity, thus establishing the so-called ＂supercavitating condition.＂ Such a cavity is difficult to develop under normal conditions, hence, ventilation is used to attain the supercavitating condition in the initial phase of flight. In this paper, we focus on the hydrodynamic characteristics of a ventilated supercavitating vehicle. First, dynamic modeling of the supercavitating vehicle is performed to calculate the hydrodynamic force/moment acting on the vehicle for a given size of cavity. We then define the relationship between the ventilation rate and the cavitation number based on an air entrainment model of the ventilated cavity. Numerical simulations were performed to analyze the physical feasibility and characteristics of the modeling. The results show that the cavity length/radius increases with the ventilation rate, proving that ventilation can be used to attain the supercavitating condition.

关键词： entilated supercavity hydrodynamical modeling supercavitating body transition phase cavity closure mode dynamics modeling

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Learning feature alignment and dual correlation for few‐shot image classification

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 303-318页

作者： Xilang Huang seon Han Choi Department of Electronic and Electrical Engineering Ewha Womans UniversitySeoulSouth Korea Graduate Program in Smart Factory Ewha Womans UniversitySeoulSouth Korea

Few‐shot image classification is the task of classifying novel classes using extremely limited labelled *** perform classification using the limited samples,one solution is to learn the feature alignment(FA)information between the labelled and unlabelled sample *** FA methods use the feature mean as the class prototype and calculate the correlation between prototype and unlabelled features to learn an alignment ***,mean prototypes tend to degenerate informative features because spatial features at the same position may not be equally important for the final classification,leading to inaccurate correlation ***,the authors propose an effective intraclass FA strategy that aggregates semantically similar spatial features from an adaptive reference prototype in low‐dimensional feature space to obtain an informative prototype feature map for precise correlation ***,a dual correlation module to learn the hard and soft correlations was developed by the *** module combines the correlation information between the prototype and unlabelled features in both the original and learnable feature spaces,aiming to produce a comprehensive cross‐correlation between the prototypes and unlabelled *** both FA and cross‐attention modules,our model can maintain informative class features and capture important shared features for *** results on three few‐shot classification benchmarks show that the proposed method outperformed related methods and resulted in a 3%performance boost in the 1‐shot setting by inserting the proposed module into the related methods.

关键词： image classification machine learning metric learning

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Expression and regulation of IL-22 in the *** CD4+T lymphocytes

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Cell Research 2006年第11期16卷 902-907页

作者： Yeonseok Chung seon Hee Chang Department of lmmunology MD Anderson Cancer CenterHoustonTX 77030USA

IL-22 is a novel cytokine in the IL-10 family that functions to promote innate immunity of tissues against *** CD4+helper T lymphocytes(TH)were found as a source of IL-22,the regulation of this cytokine has beenpoorly ***,we show that IL-22 is expressed at both mRNA and protein levels by a novel subset of THcells that also makes ***-22 and IL-17 were found to be coordinately regulated by TGFβ and IL-6 during TH dif-ferentiation by real-time PCR as well as ELISA ***,IL-22 does not regulate TH differentiation; exogenousIL-22 or an IL-22 antagonist had no effect on TH *** data demonstrate a novel cytokine expressed byIL-17-producing T cells,and suggest interaction and synergy of IL-22 and IL-17 signaling pathways in tissue inflam-mation and autoimmune diseases.

关键词： cytokines helper T cells T cell activation gene regulation

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