A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses

作     者：Seon Hee Chang 

作者机构：Unit 906 Houston USA TX 77030 7455 Fannin Department of Immunology MD Anderson Cancer Center 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2007年第17卷第5期

页      面：435-440页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：美国国立卫生研究院(NIH)项目 

主　　题：inflammation IL-17 T cells 

摘      要：CD4+ helper T (TH) cells play crucial roles in immune responses. Recently a novel subset of TH cells, termed TH,TH17 or inflammatory TH (THi), has been identified as critical mediators of tissue inflammation. These cells produceIL-17 (also called IL-17 A) and IL-17F, two most homologous cytokines sharing similar regulations. Here we reportthat when overexpressed in 293T cells, IL-17 and IL-17F form not only homodimers but also heterodimers, which wename as IL-17A/F. Fully differentiated mouse THi cells also naturally secrete IL-17A/F as well as IL-17 and IL-17Fhomodimeric cytokines. Recombinant IL-17A/F protein exhibits intermediate levels of potency in inducing IL-6 andKC (CXCL1) as compared to homodimeric cytokines. IL-17A/F regulation of IL-6 and KC expression is dependent onIL-17RA and TRAF6. Thus, IL-17A/F cytokine represents another mechanism whereby T cells regulate inflammatoryresponses and may serve as a novel target for treating various immune-mediated diseases.