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Human urine metabolome in response to Fermentum rubrum(Hongqu Capsules)by HILIC-UHPLC-QTOF

中国药理学与毒理学杂志 2015年第S1期29卷 106-106页

作者： HongYANG EdmundJ.D.LEE seokhweekoo FengTIAN School of Applied Science Temasek Polytechnic Singapore 529757 Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Clinical Trials & Research Unit Changi General Hospital Singapore 529889

OBJECTIVE ″-omics″study represents an unbiased perspective to examine the bio-system to discover the novel biomarker(s)which might be overlooked when targeted analysis is performed ***,due to its ease of collection,minimal invasion involved and rich information of the downstream metabolites,has been extensively *** rubrum(Hongqu,HQ capsules)is a well-known traditional medicine with the claimed slimming effect which could be related to the reduction in the deposition of total cholesterol and *** in sufficient clinical evidence is always one of the leading reasons that hamper traditional medicines from gaining world-wide *** our pursuit of scientific support for HQ capsules in managing obesity,we aim to examine the alteration of urinary metabolites in this small-scale human clinical *** 6 Chinese subjects were included and exposed to short-term administration of HQ capsules for 3d,twice daily,two capsules each *** urine samples were collected for three days prior to the dosing and on the day following the last *** total,96 urine samples were collected and then separated on hydrophilic interaction chromatography(HILIC)and analyzed by Agilent 6550 ESI-Quadrupoletime-of-flight(QTOF)mass *** Under positive mode,two compounds were found to be present only in post-dosing urine,and one compound was significantly lowered in post-dosing *** two compounds might be associated with the administered HQ capsules,which is formulated with multiherbal *** Further elucidation on the structures of these compounds is needed to enable better understanding of the mechanism of HQ capsules in managing obesity.

关键词： urine metabolome Fermentum rubrum HILIC-UHPLC-QTOF

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