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Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists

World Journal of Gastroenterology 2011年第21期17卷 2602-2610页

作者： Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists Department of Pathology Inha University Hospital Department of Pathology Yonsei University Wonju College of Medicine Wonju Christian Hospital Department of Pathology Sungkyunkwan University School of MedicineKangbuk Samsung Medical Center Department of Pathology Chungnam National University College of Medicine Department of Pathology Sungkyunkwan University School of MedicineSamsung Medical Center Department of Pathology Seoul National University College of Medicine Department of Pathology Soonchunhyang University Hospital Department of Pathology Kosin University College of Medicine Department of Pathology University of Ulsan College of MedicineAsan Medical Center Department of Pathology The Catholic University of KoreaSeoul St.Mary's Hospital Department of Pathology Seoul National University Boramae Hospital Department of Pathology Eulji General Hospital Department of Pathology Inje University Ilsan Paik Hospital Department of Pathology Kyunghee University College of Medicine Department of Pathology Pusan National University College of Medicine Department of Pathology Inje University Seoul Paik Hospital Department of Pathology Korea Cancer Center Hospital Department of Pathology Konkuk University Medical Center Department of Pathology Ajou University School of Medicine Department of Pathology Chonbuk National University Medical School Department of Pathology Korea University College of Medicine Department of Pathology Bundang Jesaeng Hospital Department of Pathology National Cancer Center The Korean Society of Pathologists 4FThe Korean Medical Association BuildingSeoul 140-721South Korea

The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of *** the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic *** pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western *** is geographically close to Korea,and academic exchanges are ***,Korean doctors are familiar with Western style medical *** a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in *** solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss

关键词： Intraepithelial neoplasia Stomach Dysplasia Adenoma Carcinoma Japanese Western Consensus Vienna

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Electrostatic spraying for flne-tuning particle dimensions to enhance oral bioavailability of poorly water-soluble drugs

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Asian Journal of Pharmaceutical Sciences 2024年第5期 141-153页

作者： Jung Suk Kim Seunghyun Cheon Mi Ran woo Sanghyun woo Jee-Eun Chung Yu seok Youn Kyung Taek Oh Soo-Jeong Lim Sae Kwang Ku Bao Loc Nguyen Jong Oh Kim Sung Giu Jin Han-Gon Choi College of Pharmacy Hanyang University School of Pharmacy Sungkyunkwan University College of Pharmacy Chung-Ang University Department of Bioscience and biotechnology Sejong University Department of Anatomy and Histology College of Korean Medicine Daegu Haany University College of Pharmacy Yeungnam University Department of Pharmaceutical Engineering Dankook University

While spray-drying has been widely utilized to improve the bioavailability of poorly water-soluble drugs, the outcomes often exhibit suboptimal particle size distribution and large particle sizes, limiting their effectiveness. In this study, we introduce electrostatic spraying as an advanced technology tailored for poorly water-soluble drugs, enabling the fabrication of nanoparticles with flne and uniform particle size distribution. Regorafenib(1 g), as a model drug, copovidone(5 g), and sodium dodecyl sulfate(0.1 g) were dissolved in 200 ml ethanol and subjected to conventional-spray-dryer and electrostatic spray dryer. The electrostatic spray-dried nanoparticles(ESDN) showed smaller particle sizes with better uniformity compared to conventional spray-dried nanoparticles(CSDN). ESDN demonstrated signiflcantly enhanced solubility and rapid release in water. In vitro studies revealed that ESDN induced apoptosis in HCT-116 cells to a greater extent, exhibiting superior cytotoxicity compared to CSDN. Furthermore, ESDN substantially improved oral bioavailability and antitumor efflcacy compared to CSDN. These flndings suggest that ESD shows potential in developing enhanced drug delivery systems for poorly water-soluble drugs, effectively addressing the limitations associated with CSD methods.

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卵巢恶性肿瘤患者治疗后FDGPET/CT显像的临床意义

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中华核医学与分子影像杂志 2017年第6期37卷 382-382页

作者：唐军 Eun Ji Han Hye Lim Park Yong seok Lee Eun Kyung Park Min Jong song Ie Ryung Yoo Sung Hoon Kim woo Hee Choi 苏州大学附属第二医院核医学科 Department of Radiology Daejeon St.Mary's HospitalCollege of MedicineThe Catholic University of Korea

目的评价卵巢恶性肿瘤患者治疗后;F-FDG PET/CT显像的诊断和预后价值。方法回顾性分析卵巢恶性肿瘤患者治疗后的FDG PET/CT显像结果,计算PET/CT诊断肿瘤复发或第二原发肿瘤的准确性,并评价其对患者诊疗过程的影响。用Cox回归分析PET/CT... 详细信息

目的评价卵巢恶性肿瘤患者治疗后;F-FDG PET/CT显像的诊断和预后价值。方法回顾性分析卵巢恶性肿瘤患者治疗后的FDG PET/CT显像结果,计算PET/CT诊断肿瘤复发或第二原发肿瘤的准确性,并评价其对患者诊疗过程的影响。用Cox回归分析PET/CT显像结果与患者总体生存率的关系。结果 268例卵巢恶性肿瘤患者[平均年龄（50±13）岁]共行416次PET/CT显像,其中87次（21%）结果阳性,329次结果阴性;灵敏度、特异性、准确性、阳性预测值和阴性预测值分别为98.8%、98.2%、98.3%、93.1%和99.7%。362次随访显像中,38次（11%）的显像结果使患者治疗决策发生了改变;54次因临床有可疑征象而进行的PET/CT显像中,9次（17%）显像排除了肿瘤复发。PET/CT显像后进行了中位时间26.7个月的随访,24例（9%）患者在随访期内死亡。单因素分析结果发现,患者年龄、国际妇产科联盟（FIGO）分期、复发病史和PET/CT显像结果均与患者的总体生存率相关。多因素分析结果显示,PET/CT显像结果与患者的总体生存率相关（P<0.05）。结论卵巢恶性肿瘤治疗后FDG PET/CT是诊断复发和第二原发肿瘤的有效方法,其便于对患者采用更合适的治疗手段,并能帮助预测预后。

关键词： FDG PET/CT 复发性卵巢恶性肿瘤诊断准确性预后

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麻醉前给予晶体或胶体负荷液对等比重蛛网膜下隙麻醉药椎管内扩散及脑脊液运动影响的比较研究

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麻醉与镇痛 2012年第2期8卷 48-55页

作者： Byung Seop Shin Chung Su Kim, MD woo seok Sire, MD Chul Joong Lee, MD Sung Tae Kim, MD Gunn Hee Kim Si Ra Bang, MD Sang Hyun Lee, MD Sun Ji Hyun, MD Gaab Soo Kim, MD 潘鹏（译）李文志（校） Department of Anesthesiology and Pain Medicine Radiology and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine Seoul department of An-esthesiology and Pain Medicine National Medical Center Seoul Department of Anesthesiolo-gy and Pain Medicine Haeundae Paik Hospital Inje University School of Medicine Busan Korea

背景脑脊液（cerebrospinalfluid，CSF）运动是影响等比重蛛网膜下隙麻醉药椎管内扩散的重要因素。由于各自特性的不同，麻醉前给予晶体或胶体负荷液对CSF脉冲式运动的影响不完全相同。因此，本研究观察了麻醉前预充晶体或胶体负荷液是... 详细信息

背景脑脊液（cerebrospinalfluid，CSF）运动是影响等比重蛛网膜下隙麻醉药椎管内扩散的重要因素。由于各自特性的不同，麻醉前给予晶体或胶体负荷液对CSF脉冲式运动的影响不完全相同。因此，本研究观察了麻醉前预充晶体或胶体负荷液是否对CSF动力学（脉冲式运动）引起的等比重蛛网膜下隙麻醉药椎管内扩散有不同影响。方法等比重蛛网膜下隙麻醉药的临床研究中，患者随机分为两组：晶体液负荷组（η=30）及胶体液负荷组（η=30）。等比重蛛网膜下隙麻醉药为0．5％丁卡因。同时．通过MRI对23名健康志愿者讲行研究．分别观察给予品体及及胶体负荷液0、30分钟、60分钟后．CSF在L2-3节殿强中脑水管中部的运动。结果临床研究中，与胶体负荷液组（13．9±7．0分钟）相比，晶体负荷液组（27．1±17．8分钟）达感觉阻滞峰值时间明显延长（P〈0．01）。15分钟及20分钟时，晶体负荷液组平均感觉阻滞平面（15分钟：T10；20分钟：T9．5）显著低于胶体负荷液组（15分钟：T8；20分钟：T7）（P〈0．05）。MRI志愿者研究中，晶体负荷液组在30分钟时，直接来自头侧的CSF脉冲式运动在L2—3节段降低，而胶体负荷液组未出现显著变化。与基础值（448μl/min）相比，晶体负荷液组30分钟时CSF生成速度显著增加（637μl/min，P〈0．05），而在60分钟时轻微下降（609μl/min）。与基础值相比，胶体负荷液组30分钟及60分钟时CSF生成率没有统计学差异（基础值：464μl/min；30分钟：512μl/min；60分钟：542μl/min）。结论麻醉前给予胶体负荷液与无液体预充情形类似，而给予晶体负荷液，由于CSF生成增加，减弱了CSF脉冲式运动，进而延长等比重蛛网膜下隙麻醉药椎管内阻滞的感觉阻滞峰值时间。

关键词：蛛网膜下隙椎管内阻滞体负荷麻醉药等比重麻醉前内扩散脑脊液

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International consensus on natural orifice specimen extraction surgery(NOSES)for gastric cancer(2019)

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Gastroenterology Report 2020年第1期8卷 5-10,I0001页

作者： Xu Guan Zheng Liu Amjad Parvaiz Antonio Longo Avanish Saklani Ali AShafik Jian-Chun Cai Charles Ternent Lin Chen Cuneyt Kayaalp Fatih Sumer Fernanda Nogueira Feng Gao Fang-Hai Han Qing-Si He Ho-Kyung Chun Chang-Ming Huang Hai-Yang Huang Rui Huang Zhi-Wei Jiang Jim S Khan Joaquim Manuel da Costa Pereira JosephWNunoo-Mensah Jung Tack son Liang Kang Keisuke Uehara Ping Lan Le-Ping Li Han Liang Bing-Rong Liu Juan Liu Dan Ma Ming-Yin Shen Mohammad Rashidul Islam Narimantas Evaldas Samalavicius Kai Pan Petr Tsarkov Xin-Yu Qin Ricardo Escalante Sergey Efetov Seung Kyu Jeong Suk-Hwan Lee Dong-Hui Sun Li Sun Tatiana Garmanova Yan-Tao Tian Gui-Yu Wang Guo-Jun Wang Guo-Rong Wang Xiao-Qiang Wang William Tzu-Liang Chen woo Yong Lee Su Yan Zu-Li Yang Gang Yu Pei-Wu Yu Dan Zhao Yun-Shi Zhong Jian-Ping Wang Xi-Shan Wang The International Alliance of NOSES Department of Colorectal Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Poole Hospital NHS Trust PooleUK European Center of Coloproctology and Pelvic Diseases-Multimedica Hospital MilanItaly Department of GI Surgical Oncology Tata Memorial HospitalMumbaiIndia Department of Colorectal Surgery Cairo UniversityCairoEgypt Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamenFujianP.R.China Section of Colon and Rectal Surgery Creighton University School of MedicineOmahaNEUSA Department of General Surgery Chinese People’s Liberation Army General HospitalBeijingP.R.China Department of Gastrointestinal Surgery Inonu UniversityMalatyaTurkey Department of Surgery Hospital de BragaBragaPortugal Department of Colorectal Cancer Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangP.R.China Department of Gastroenterological Surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of General Surgery Shandong University Qilu HospitalJinanShandongP.R.China Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea Department of Gastric Surgery Fujian Medical University Union HospitalFuzhouFujianP.R.China Department of General Surgery Jiangsu Province Hospital of Traditional Chinese MedicineNanjingJiangsuP.R.China Department of Colorectal Surgery PortsmouthHospitals NHSTrustQueen Alexandra HospitalPortsmouthUK King’s College Hospital LondonUK Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Division of Surgical Oncology Department of SurgeryNagoya University School of MedicineNagoyaJapan Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong UniversityJinanShandongP.R.China Department of Gastric Cancer

At present,natural orifice specimen extraction surgery(NOSES)has attracted more and more attention worldwide,because of its great advantages including minimal cutaneous trauma and post-operative pain,fast post-operative recovery,short hospital stay,and positive psychological ***,NOSES for the treatment of gastric cancer(GC)is still in its infancy,and there is great potential to improve its theoretical system and clinical ***,several key points including oncological outcomes,bacteriological concerns,indication selection,and standardized surgical procedures are raised with this innovative ***,it is necessary to achieve an international consensus to regulate the implementation of GC-NOSES,which is of great significance for healthy and orderly development of NOSES worldwide.

关键词： gastric cancer natural orifice specimen extraction surgery transanal specimen extraction transvaginal specimen extraction transoral specimen extraction consensus

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Endothelial progenitor cell differentiation using cryopreserved,umbilical cord blood-derived mononuclear cells

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Acta Pharmacologica Sinica 2007年第3期28卷 367-374页

作者： Jun-ho JANG~(2,5) Sun-kyung KIM~(3,5) Jeong-eun CHOI~3 Young-jin KIM~3 Hyun-woo LEE~2 seok-yun KANG~2 Joon-seong PARK~2 Jin-hyuk CHOI~2 Ho-yeong LIM~4 Hugh C KIM~(2,6)2 Department of Hematalogy-Oncology,Ajou University,School of Medicine,Suwon 442749,Korea 3 Biomedical Research Institute,LifeCord,Suwon 442749,Korea 4 Division of Hematology-Ontology,Department of Medicine,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul 135710,Korea DepartmentofHematology-Oncology AjouUniversitySchoolofMedicineSuwon442749Korea BiomedicalResearchInstitute LifeCordSuwon442749Korea SamsungMedicalCenter SungkyunkwanUniversitySchoolofMedicineSeoul135710Korea

Aim:To investigate the endothelial differentiation potentiality of umbilical cordblood(UCB),we induced the differentiation of endothelial progenitor cells(EPC)from cryopreserved UCB-derived mononuclear cells(MNC).Methods:MNC fromcryopreserved UCB and peripheral blood(PB)were cultured in M199 medium withendothelial cell growth supplements for 14 *** were characterized by RT-PCR,flow cytometry,and immunocytochemistry *** proliferation of differen-tiated EPC was studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide(MTT)assay,and vascular endothelial growth factor(VEGF)concentra-tion was measured using an ELISA *** of UCB-derived EPC werecompared with those of PB-derived ***:A number of round-shapedcells were loosely attached to the bottom after 24 h culture,and numerous spindle-shaped cells began to appear from the round-shaped ones on d *** cellsexpressed endothelial markers such as,Flt-1/VEGFR-1,ecNOS,VE-cadherin,vonWillebrand factor,and secreted VEGE The patterns of endothelial markers of EPCfrom PB and UCB did not show striking *** results of the prolifera-tion and secretion of VEGF were also ***:We successfully cul-tured UCB cells stored at -196℃ into cells with the quality of endothelial *** EPC could be used for angiogenic therapeutics by activating adjacentendothelial cells and enhancing angiogenesis.

关键词： cord blood endothelial cells cryopreserved

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Induction of murine interleukin-1 beta expression by water-soluble components from Hericium erinaceum

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Acta Pharmacologica Sinica 2006年第8期27卷 1058-1064页

作者： Chang-gue son~2 Jang-woo SHIN~2 Jung-hyo CHO~2 Chong-kwan CHO~2 Cheol-heui YUN~3 Seung-hyun HAN~(4,5,6) ~2East-West Cancer Center,Dunsan Oriental Hospital of Daejon University,Daejon,301-724,Republic of Korea ~3School of Agricultural Biotechnology,Seoul National University,Seoul 151-742,Korea ~4Department of Oromaxillofacial Infection and Immunity and Dental Research Institute,School of Dentistry,Seoul National University.Seoul 110-749,Korea ~5Laboratory Sciences Division,International Vaccine Institute.Seoul 151-818.Korea East-West Cancer Center Dunsan Oriental Hospital of Daejon University Daejon 301-724 Republic of Korea

Aim:To investigate the inductive effect of water extract from Hericium erinaceum(WEHE)on interleukin-1β(IL-1β)***:A murine macrophagecell-line,RAW 264.7 was stimulated with 1 to 10 mg/L WEHE and inductions of IL-1β protein and its steady state mRNA were examined using a bioassay,Westernblotting,and reverse transcription-polymerase chain reaction(RT-PCR)*** inductive effect of WEHE on IL-1β gene expression was further investigatedby a chloramphenicol acetyltransferase(CAT)reporter gene assay using a tran-sient transfection with pIL-1(870 bp)-CAT where the expression of the CAT genewas regulated by a IL-1β *** electrophoretic mobility shift assay(EMSA)was also performed to examine transcription factors,nuclear factor-kappa B(NF-kB),activator protein 1(AP-1),nuclear factor interleukin-6(NF-IL6),and cAMPresponse element(CRE)/activating transcription factor(ATF).Results:WEHEinduced IL-1β production in both its mRNA and protein expression in a dose-dependent *** inductive effect of WEHE on IL-1β gene expression wasdue to the augmentation of the IL- 1β ***,EMSA showedthat WEHE markedly increased the binding activities of NF-kB,and to a lesserextent,those of AP-1 and NF-IL6 to their cognate DNA recognition sites,whereasCRE/ATF binding remained constant,all of which are known to be involved in theregulation of IL-1β gene ***:WEHE induces IL-1β expres-sion in macrophages at a transcriptional level by enhancing the activation oftranscription factors,NF-kB,NF-IL6,and AP-1.

关键词： Hericium erinaceum interleukin-1 lipopolysaccharide

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基于辣椒基因组测序探究辣味在种群中的进化

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辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh Chungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon Chanseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-woo Lee Hyung-Taeg Cho Hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-seok Park Allen van Deynze Hamid Ashrafi Theresa Hill woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young Choi Beom-Soon Choi Jong-Sung Lim Yong-Hwan Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation Korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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