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Modeling the gene delivery process of the needle array-based tissue nanotransfection

Nano Research 2022年第4期15卷 3409-3421页

作者： Zhigang Li Yi xuan Subhadip Ghatak Poornachander RGuda Sashwati Roy Chandan K.sen Indiana Center for Regenerative Medicine and Engineering Indiana University Health Comprehensive Wound CenterDepartment of SurgeryIndiana University School of MedicineIndianapolisIN 46202USA Birck Nanotechnology Center and Weldon School of Biomedical Engineering Purdue UniversityWest LafayetteIN 47907USA

Hollow needle array-based tissue nanotransfection(TNT)presents an in vivo transfection approach that directly translocate exogeneous genes to target tissues by using electric *** this work,the gene delivery process of TNT was simulated and experimentally *** adopted the asymptotic method and cell-array-based model to investigate the electroporation behaviors of cells within the skin *** distribution of nonuniform electric field across the skin results in various electroporation behavior for each *** underneath the hollow microchannels of the needle exhibited the highest total pore numbers compared to others due to the stronger localized electric *** percentage of electroporated cells within the skin structure,with pore radius over 10 nm,increases from 25%to 82%as the applied voltage increases from 100 to 150 V/***,the gene delivery behavior across the skin tissue was investigated through the multilayer-stack-based *** delivery distance increased nonlinearly as the applied voltage and pulse number increased,which mainly depends on the diffusion characteristics and electric conductivity of each *** was also found that the skin is required to be exfoliated prior to the TNT procedure to enhance the delivery *** work provides the foundation for transition from the study of murine skin to translation use in large animals and human settings.

关键词： tissue nanotransfection silicon needle array hollow needle array electroporation electrophoresis gene delivery

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Parallelizing maximum likelihood classification (MLC) for supervised image classification by pipelined thread approach through high-level synthesis (HLS) on FPGA cluster

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Big Earth Data 2018年第2期2卷 144-158页

作者： sen Ma xuan Shi David Andrews Micron Technology Inc.SeattleWAUSA Department of Geosciences University of ArkansasFayettevilleARUSA Department of CSCE University of ArkansasFayettevilleARUSA

High spectral,spatial,vertical and temporal resolution data are increasingly available and result in the serious challenge to pro-cess big remote-sensing images effectively and *** article introduced how to conduct supervised image classification by implementing maximum likelihood classification(MLC)over big image data on a field programmable gate array(FPGA)*** comparing our prior work of implementing MLC on conventional cluster of multicore computers and graphics processing unit,it can be concluded that FPGAs can achieve the best performance in comparison to conventional CPU cluster and K40 GPU,and are more energy *** proposed pipelined thread approach can be extended to other image-processing solutions to handle big data in the future.

关键词： FPGA maximum likelihood classification parallel computing

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One-Pot Synthesis of Spiro[fluorene-9,9'-xanthene]Derivatives

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Chinese Journal of Chemistry 2021年第3期39卷 701-709页

作者： Hao-xuan Yuan Ying wei Ling-Hai Xie wei Huang Centre for Molecular Systems and Organic Devices(CMSOD)&Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced Materials(IAM)&Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjingJiangsu 210023China Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University127 West Youyi RoadXi'anShaanxi 710072China

As a novel class of spirofluorenes,spirobifluorene(SBF)and spiro[fluo-rene-9,9'-xanthene]derivatives(SFXs)have orthogonal geometric config-uration,spiro-conjugation effect,and rigid steric hindrance,which can be widely used in the fields of synthetic chemistry,materials chemistry and supramolecular *** to their facile one-pot synthetic route,and to the variety of molecular designs,SFXs are expected to become new spiro functional materials that replace *** this review,we present the history,development and expansion of SFXs synthesis in one-pot methods,and the advantages and limitations of one-pot synthesis are also dis-cussed.

关键词： Spirofluorenes Spiro[fluorene 9,9'-xanthene]s(SFXs) One pot synthesis Synthetic methods Heterocycles Cyclization

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Intelligent Reflecting Surface Assisted Transmission Optimization Strategies in Wireless Networks

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China Communications 2024年第4期21卷 120-135页

作者： He Xinxin Qi xuan Meng wei Liu wei Yin Changchuan School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

Wireless Power Transfer(WPT)technology can provide real-time power for many terminal devices in Internet of Things(IoT)through millimeterWave(mmWave)to support applications with large capacity and low *** the intelligent reflecting surface(IRS)can be adopted to create effective virtual links to address the mmWave blockage problem,the conventional solutions only adopt IRS in the downlink from the Base Station(BS)to the users to enhance the received signal *** practice,the reflection of IRS is also applicable to the uplink to improve the spectral *** is a challenging to jointly optimize IRS beamforming and system resource allocation for wireless energy acquisition and information *** this paper,we first design a Low-Energy Adaptive Clustering Hierarchy(LEACH)clustering protocol for clustering and data ***,the problem of maximizing the minimum system spectral efficiency is constructed by jointly optimizing the transmit power of sensor devices,the uplink and downlink transmission times,the active beamforming at the BS,and the IRS dynamic *** solve this non-convex optimization problem,we propose an alternating optimization(AO)-based joint solution *** results show that the use of IRS dynamic beamforming can significantly improve the spectral efficiency of the system,and ensure the reliability of equipment communication and the sustainability of energy supply under NLOS link.

关键词： intelligent reflecting surface(IRS) joint optimization millimeter wave wireless information transmission(WIT) wireless power transfer(WPT)

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A Novel Synthesis of Dimethyl Malonate by Carbonylation of Methyl Chloroacetate Catalyzed by Cobalt Complex

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Chinese Chemical Letters 2001年第3期12卷 207-210页

作者： wei Hong SONG xuan Zhen JIANG Department of Chemistry Zhejiang UniversityHangzhou 310027

A novel method of preparing dimethyl malonate by carbonylation of methyl chloroacetate catalyzed by Na[Co(CO)(4)] was proposed. Na[Co(CO)(4)] was synthesized in situ in the presence of Na2S2O3 and iron powder. The effects of some reaction parameters such as temperature. CO pressure and the concentrations of catalyst on the yields of dimethyl malonate were discussed. The kinetic data were studied and a possible reaction mechanism was proposed.

关键词： Dimethyl malonate cobalt complex carbonylation reaction mechanism

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Investigation on plasma structure evolution and discharge characteristics of a single-stage planar-pulsed-inductive accelerator under ambient fill condition

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Chinese Physics B 2020年第11期29卷 398-405页

作者： Xiao-Kang Li Bi-xuan Che Mou-sen Cheng Da-wei Guo Mo-Ge Wang Yun-Tian Yang College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

The physical process of a single-stage planar-pulsed-inductive accelerator is *** include the waveforms of circuit current,capacitor voltage,plasma radiation intensity,and temporal plasma structure photos captured by a high-speed *** are conducted under static ambient fill condition using argon as *** values of capacitor voltage and gas pressure are *** discussions quantify the EM interaction between circuit and plasma,as well as their energy deposition and current sheet *** on the results of experiments,physical mechanisms of the initial ionization phase and the following acceleration phase are analyzed theoretically.

关键词： electric propulsion pulsed-inductive thruster discharge characteristics plasma structure

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Discussing the development of domestic and foreign fire protection technical regulation and fire protection technical standard systems

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Journal of Safety Science and Resilience 2023年第1期4卷 26-29页

作者： xuan Sun Na Cai wei Zhang CABR Fire Safety Science&Technology Co. LtdBeijing 100013China

This paper reviews the composition, development, and operation mechanism of domestic and foreign fire protection technical regulations and standards. Considering the development and problems of China's fire protection standard system and fire protection technical standards, this paper recommends fire safety professional engineering design specialization, suggests key research fields pertaining to fire protection technical standards, and elucidates how a performance-based fire protection technical standard system can be established.

关键词： Fire protection standard Standard system Specialization of fire safety design

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Homologous layered InFeO3(ZnO)m:new promising abradable seal coating materials

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Rare Metals 2018年第2期37卷 79-94页

作者： wei-wei Qu Xiao-xuan Zhang Bi-Fei Yuan Li-Dong Zhao School of Materials Science and Engineering BeihangUniversityBeijing 100191China China National Petroleum Corporation Greatwall Drilling Company Beijing 100101China

As promising abradable seal coating materials used in high temperature range, the homologous layered InFeO3（ZnO）m （m = 1, 2, 3...20） have attracted great attention. In this short review, we summary the research progress in InFeO3（ZnO）m that were developed in our group. We first introduced a series of conventional abradable seal coating materials as a research motivation. Second, the phase composition and crystal structures of lnFeO3（ZnO）m system were presented. Then, their thermophysical properties, as the most important part, were introduced in detail. At last, the mechanical properties such as hardness, friction coefficient, erosion wear resistance of InFeO3（ZnO）m system were also described. Our summary indicates that InFeO3（ZnO）m sys- tems are promising abradable seal coating materials.

关键词： Abradable seal coating InFeO3(ZnO)m Thermal conductivity Thermal expansion coefficient Mechanical properties

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Quantum computation with surface-state electrons by rapid population passages

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Science China(Physics,Mechanics & Astronomy) 2014年第9期57卷 1718-1724页

作者： SHI xuan wei LianFu OH Choo Hiap Quantum Optoelectronics Laboratory School of Physics and Technology Southwest Jiaotong University Centre for Quantum Technologies and Department of Physics National University of Singapore State Key Laboratory of Optoelectronic Materials and Technologies School of Physics Science and Engineering Sun Yet-sen University

Quantum computation requires coherently controlling the evolutions of ***,these manipulations are implemented by precisely designing the durations(such as theπ-pulses)of the Rabi oscillations and tunable interbit *** this requirement,herein we show that the desired population transfers between the logic states can be deterministically realized(and thus quantum computation could be implemented)both adiabatically and non-adiabatically,by performing the duration-insensitive quantum *** proposal is specifically demonstrated with the surface-state of electrons floating on the liquid helium,but could also be applied to the other artificially controllable systems for quantum computing.

关键词： quantum computation surface-state electrons rapid population passages

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Segmentation by Elastica Energy with L^(1) and L^(2) Curvatures: a Performance Comparison

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Numerical Mathematics(Theory,Methods and Applications) 2019年第1期12卷 285-311页

作者： xuan He wei Zhu Xue-Cheng Tai Department of Mathematics University of AlabamaBox 870350TuscaloosaAL 35487USA Department of Mathematics Hong Kong Baptist UniversityKowloonTong KowloonHong Kong

In this paper,we propose an algorithm based on augmented Lagrangian method and give a performance comparison for two segmentation models that use the L^(1)-and L^(2)-Euler’s elastica energy respectively as the regularization for image *** capture contour curvature more reliably,we develop novel augmented Lagrangian functionals that ensure the segmentation level set function to be signed dis-tance functions,which avoids the reinitialization of segmentation function during the iterative *** the proposed algorithm and with the same initial contours,we compare the performance of these two high-order segmentation models and numerically verify the different properties of the two models.

关键词： Augmented Lagrangian method Euler’s elastica image segmentation

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