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The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells

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Chinese Journal of Traumatology 2024年第1期27卷 1-10页

作者： Zhuo Chen meng-Wei yao Xiang Ao Qing-Jia Gong Yi Yang Jin-Xia Liu Qi-Zhou Lian Xiang Xu Ling-Jing Zuo Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing400042China College of Basic Medical Sciences Army Medical UniversityChongqing400038China Department of Orthopedics 953 Hospital of PLAShigatse Branch of Xinqiao HospitalArmy Medical UniversityShigatse857000Tibet Autonomous RegionChina Department of Rheumatology and Immunology Daping HospitalArmy Medical UniversityChongqing400042China Department of Obstetrics and Gynecology Chongqing People's HospitalChongqing401121China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Nuclear Medicine The First People's Hospital of Yunnan provinceAffiliated Hospital of Kunming University of Science and TechnologyKunming650034China

Programmed cell death 1 ligand 1(PD-L1)is an important immunosuppressive molecule,which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell *** PD-L1 expression disorder plays an important role in the occurrence,development,and treatment of sepsis or other inflammatory diseases,and has become an important target for the treatment of these *** stem cells(MSCs)are a kind of pluripotent stem cells with multiple differentiation *** recent years,MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune ***,PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various *** this review,we will summarize the main regulatory mechanism of PD-L1 expression,and discuss various biological functions of PD-L1 in the immune regulation of MSCs.

关键词： PD-L1 MSCs Immunomodulation

Combining genome-wide association study and transcriptome analysis to identify molecular markers and genetic basis of population-asynchronous ovarian development in Coilia nasus

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Zoological Research 2024年第3期45卷 491-505页

作者： Yue Yu Shi-Ming Wan Cheng-You Huang Shuang-meng Zhang Ai-Li Sun Jun-Qi Liu Shun-yao Li Yong-Fu Zhu Shu-Xin Gu Ze-Xia Gao College of Fisheries Hubei Hongshan Laboratory/Key Lab of Freshwater Animal BreedingMinistry of Agriculture and Rural Affairs/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic BeltMinistry of EducationHuazhong Agricultural UniversityWuhanHubei 430070China Laboratory for Marine Biology and Biotechnology Qingdao Marine Science and Technology CenterQingdaoShandong 266237China Wuhan Hengyuxin Technology Breeding Professional Cooperative WuhanHubei 430117China Hubei Provincial Aquatic Science Research Institute WuhanHubei 430208China Zhenjiang Jiangzhiyuan Fishery Technology Co. Ltd.ZhenjiangJiangsu 212213China

Coilia nasus,a migratory fish species found in the middle and lower reaches of the Yangtze River and along offshore areas of China,possesses considerable aquacultural and economic ***,the species faces challenges due to significant variation in the gonadal development rate among females,resulting in inconsistent ovarian maturation times at the population level,an extended reproductive period,and limitations on fish growth rate due to ovarian *** the present study,we combined genome-wide association study(GWAS)and comparative transcriptome analysis to investigate the potential single nucleotide polymorphisms(SNPs)and candidate genes associated with population-asynchronous ovarian development in *** of the female population based on whole-genome resequencing yielded 2120695 high-quality SNPs,39 of which were suggestively associated with ovarian *** note,a significant SNP peak on LG21 containing 30 suggestively associated SNPs was identified,with cpne5a determined as the causal gene of the ***,single-marker and haplotype association analyses were performed on cpne5a,revealing four genetic markers(P0.9)significantly associated with the *** transcriptome analysis of precociously and normally maturing individuals screened out 29 and 426 overlapping differentially expressed genes in the brain and ovary,respectively,between individuals of different body *** the GWAS and transcriptome analysis results,this study identified genes and pathways related to hypothalamic-pituitary-gonadal axis hormone secretion,extracellular matrix,angiogenesis,and gap junctions involved in population-asynchronous ovarian *** insights gained from this study provide a basis for a deeper understanding of the molecular mechanisms underlying ovarian development in fish and may facilitate the genetic breeding of *** strains exhibiting population-synchronous ovarian

关键词： Coilia nasus GWAS Transcriptome Ovarian development SNP

Compound Product of Hypermatrices

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Journal of Systems Science & Complexity 2024年第1期37卷 169-183页

作者： CHENG Daizhan meng Min ZHANG Xiao JI Zhengping Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China Department of Control Science and Engineering School of Electronics and Information EngineeringTongji UniversityShanghai 201210China National Center for Mathematics and Interdisciplinary Sciences Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100149China.

The semi-tensor product(STP)of matrices is generalized to multidimensional arrays,called the compound product of *** product is first defined for three-dimensional hypermatrices with compatible orders and then extended to general *** different types of hyperdeterminants are introduced and certain properties are *** Lie groups and Lie algebras corresponding to the hypermatrix products are ***,these results are applied to dynamical systems.

关键词： Compound semi-tensor product hyperdeterminants hypereigenvalues and hypereigenvectors hypergeneral linear groups hypermatrices.

Covariate-Assisted Matrix Completion with Multiple Structural Breaks

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Journal of Systems Science & Complexity 2024年第2期37卷 692-728页

作者： meng Jing FENG Long ZOU Changliang WANG Zhaojun School of Statistics and Data Science KLMDASRLEBPSand LPMCNankai UniversityTianjin 300071China

In matrix completion,additional covariates often provide valuable information for completing the unobserved entries of a high-dimensional low-rank matrix *** this paper,the authors consider the matrix recovery problem when there are multiple structural breaks in the coefficient matrix β under the column-space-decomposition model A=Xβ+B.A cumulative sum(CUSUM)statistic is constructed based on the penalized estimation of β.Then the CUSUM is incorporated into the Wild Binary Segmentation(WBS)algorithm to consistently estimate the location of ***,a nearly-optimal recovery of A is *** findings are further corroborated via numerical experiments and a real-data application.

关键词： Additional covariates matrix completion multiple structural breaks wild Binary Segmentation

Experimental Study on the Variation of Optical Imaging Characteristics with Zenith Angle due to Internal Solitary Waves in Sunglint

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Journal of Ocean University of China 2024年第4期23卷 943-952页

作者： LIU Tengfei SUN Lina CHANG Zhe ZHANG meng LIANG Keda meng Junmin WANG Jing School of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

Internal solitary waves(ISWs)change the roughness of the sea surface,thus producing dark and bright bands in optical ***,reasons for changes in imaging characteristics with the solar zenith angle remain *** this paper,the optical imaging pattern of ISWs in sunglint under different zenith angles of the light source is investigated by collecting optical images of ISWs through physical *** experiment involves setting 10 zenith angles of the light source,which are divided into area a the optical images of ISWs in the three areas show dark-bright mode,single bright band,and bright-dark mode,which are consistent with those observed by optical remote *** addition,this study analyzed the percentage of the dark and bright areas of the bands and the change in the relative gray difference and found changes in both areas under different zenith angles of the light *** MODIS and ASAR images display a similar brightness-darkness distance of the same ***,the relationship between the brightness-darkness distance and the characteristic half-width of ISWs is determined in accordance with the eKdV theory and the imaging mechanism of ISWs of the SAR ***,the relationship between them in the experiment is almost consistent with the theoretical result.

关键词： internal solitary waves optical imaging characteristic laboratory simulation zenith angle sunglint

Modeling Long- and Short-Term Service Recommendations with a Deep Multi-Interest Network for Edge Computing

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Tsinghua Science and Technology 2024年第1期29卷 86-98页

作者： Rui Yuan Shunmei meng Ruihan Dou Xinna Wang Department of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210056China Faculty of Mathematics University of WaterlooWaterloo N2L 3G1Canada

Edge computing platforms enable application developers and content providers to provide context-aware services(such as service recommendations)using real-time wireless access network *** to recommend the most suitable candidate from these numerous available services is an urgent ***-through rate(CTR)prediction is a core task of traditional service ***,many existing service recommender systems do not exploit user mobility for prediction,particularly in an edge computing *** this paper,we propose a model named long and short-term user preferences modeling with a multi-interest network based on user *** uses a logarithmic network to capture multiple interests in different fields,enriching the representations of user short-term *** terms of long-term preferences,users'comprehensive preferences are extracted in different periods and are fused using a nonlocal *** experiments on three datasets demonstrate that our model relying on user mobility can substantially improve the accuracy of service recommendation in edge computing compared with the state-of-the-art models.

关键词： recommender system logarithmic network nonlocal network

Experimental study on the variation of optical remote sensing imaging characteristics of internal solitary waves with wind speed

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Journal of Oceanology and Limnology 2024年第2期42卷 408-420页

作者： Zhe CHANG Lina SUN Tengfei LIU meng ZHANG Keda LIANG Junmin meng Jing WANG School of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

Optical remote sensing has been widely used to study internal solitary waves(ISWs).Wind speed has an important effect on ISW imaging of optical remote *** light and dark bands of ISWs cannot be observed by optical remote sensing when the wind is too *** relationship between the characteristics of ISWs bands in optical remote sensing images and the wind speed is still *** influence of wind speeds on the characteristics of the ISWs bands is investigated based on the physical simulation experiments with the wind speeds of 1.6,3.1,3.5,3.8,and 3.9 m/*** experimental results show that when the wind speed is 3.9 m/s,the ISWs bands cannot be observed in optical remote sensing images with the stratification of h_(1)∶h_(2)=7∶58,ρ_(1)∶ρ_(2)=1∶*** the wind speeds are 3.1,3.5,and 3.8 m/s,which is lower than 3.9 m/s,the ISWs bands can be obtained in the simulated optical remote sensing *** location of the band’s dark and light extremum and the band’s peak-to-peak spacing are almost not affected by wind ***-significant wind speeds can cause a greater gray difference of the light-dark *** provided a scientific basis for further understanding of ISW optical remote sensing imaging.

关键词： internal solitary wave(ISW) optical remote sensing wind speed characteristics of ISWs bands

Dynamic performance and parameter optimization of a half-vehicle system coupled with an inerter-based X-structure nonlinear energy sink

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 85-110页

作者： Yong WANG Peili WANG Haodong meng Liqun CHEN .Automotive Engineering Research Institute Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina Guangxi Key Laboratory of Automobile Components and Vehicle Technology Guangxi University of Science and TechnologyLiuzhou 545006Guangxi Zhuang Autonomous RegionChina School of Automotive Engineering Changzhou Institute of TechnologyChangzhou 213032Jiangsu ProvinceChina Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China

Inspired by the demand of improving the riding comfort and meeting the lightweight design of the vehicle, an inerter-based X-structure nonlinear energy sink(IXNES) is proposed and applied in the half-vehicle system to enhance the dynamic performance. The X-structure is used as a mechanism to realize the nonlinear stiffness characteristic of the NES, which can realize the flexibility, adjustability, high efficiency, and easy operation of nonlinear stiffness, and is convenient to apply in the vehicle suspension, and the inerter is applied to replacing the mass of the NES based on the mass amplification characteristic. The dynamic model of the half-vehicle system coupled with the IX-NES is established with the Lagrange theory, and the harmonic balance method(HBM) and the pseudo-arc-length method(PALM) are used to obtain the dynamic response under road harmonic excitation. The corresponding dynamic performance under road harmonic and random excitation is evaluated by six performance indices, and compared with that of the original half-vehicle system to show the benefits of the IX-NES. Furthermore, the structural parameters of the IX-NES are optimized with the genetic algorithm. The results show that for road harmonic and random excitation, using the IX-NES can greatly reduce the resonance peaks and root mean square(RMS) values of the front and rear suspension deflections and the front and rear dynamic tire loads, while the resonance peaks and RMS values of the vehicle body vertical and pitching accelerations are slightly *** the structural parameters of the IX-NES are optimized, the vehicle body vertical and pitching accelerations of the half-vehicle system could reduce by 2.41% and 1.16%,respectively, and the other dynamic performance indices are within the reasonable ***, the IX-NES combines the advantages of the inerter, X-structure, and NES, which improves the dynamic performance of the half-vehicle system and provides an effective option for vibrati

关键词： inerter X-structure nonlinear energy sink(NES) half-vehicle system dynamic performance

Simplified design of nonlinear damper parameters and seismic responses for long-span cable-stayed bridges with nonlinear viscous dampers

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1103-1116页

作者： Huihui LI Lifeng LI Rui HU meng YE College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060China Guangdong Provincial Key Laboratory of Durability for Marine Civil Engineering Shenzhen UniversityShenzhen 518060China College of Civil Engineering Hunan UniversityChangsha 410082China

Viscous dampers are widely used as passive energy dissipation devices for long-span cable-stayed bridges for mitigation of seismic load-induced ***,complicated finite element(FE)modeling,together with repetitive and computationally intensive nonlinear time-history analyses(NTHAs)are generally required in conventional design *** streamline the preliminary design process,this paper developed a simplified longitudinal double degree of freedom model(DDFM)for single and symmetric twin-tower cable-stayed *** on the proposed simplified longitudinal DDFM,the analytical equations for the relevant mass-and stiffness-related parameters and longitudinal natural frequencies of the structure were derived by using analytical and energy *** of the relationship between the nonlinear viscous damper parameters and the equivalent damping ratio was achieved through the equivalent linearization ***,the analytical equations of longitudinal seismic responses for long-span cable-stayed bridges with nonlinear viscous dampers were *** on the developed simplified DDFM and suggested analytical equations,this paper proposed a simplified calculation framework to achieve a simplified design method of nonlinear viscous damper ***,the effectiveness and applicability of the developed simplified longitudinal DDFM and the proposed calculation framework were further validated through numerical analysis of a practical cable-stayed ***,the results indicated the following.1)For the obtained fundamental period and longitudinal stiffness,the differences between results of the simplified longitudinal DDFM and numerical analysis were only 2.05%and 1.5%,respectively.2)Relative calculation errors of the longitudinal girder-end displacement and bending moment of the bottom tower section of the bridge obtained from the simplified longitudinal DDFM were limited to less than 25%.3)The equivalent damping ratio of nonline

关键词： cable-stayed bridges viscous dampers simplified analytical model equivalent damping ratio seismic mitigation