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Prognostic relevance of ventricular arrhythmias in surgical patients with gastrointestinal tumors

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1787-1795页

作者： Jiao-Jie xue Su-Tian Hu Chong-Chong Wang Zhi-Chong Chen Shi-Yao Cheng Shu-Qi Yu Hua-Jing Peng Yi-Tao Zhang Wei-Jie Zeng Department of Cardiovascular Internal Medicine Sun Yat-sen University Sixth Affiliated HospitalGuangzhou 510655Guangdong ProvinceChina Department of Cardiovascular Internal Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700Guangdong ProvinceChina Department of Ultrasound Fuwai HospitalChinese Academy of Medical Sciences ShenzhenShenzhen 518052Guangdong ProvinceChina Department of Kidney Internal Medicine Sun Yat-sen University First Affiliated HospitalGuangzhou 510062Guangdong ProvinceChina

BACKGROUND Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular diseases.Among which,ventricular arrhythmia is a prevalent clinical concern.This suggests that ventricular arrhythmias may have predictive value in the prognosis of patients with gastrointestinal tumors.AIM To explore the prognostic value of ventricular arrhythmias in patients with gastrointestinal tumors receiving surgery.METHODS We retrospectively analyzed data from 130 patients undergoing gastrointestinal tumor resection.These patients were evaluated by a 24-h ambulatory electrocardiogram(ECG)at the Sixth Affiliated Hospital of Sun Yat-sen University from January 2018 to June 2020.Additionally,41 general healthy age-matched and sexmatched controls were included.Patients were categorized into survival and non-survival groups.The primary endpoint was all-cause mortality,and secondary endpoints included major adverse cardiovascular events(MACEs).RESULTS Colorectal tumors comprised 90%of cases.Preoperative ambulatory ECG monitoring revealed that among the 130 patients with gastrointestinal tumors,100(76.92%)exhibited varying degrees of premature ventricular contractions(PVCs).Ten patients(7.69%)manifested non-sustained ventricular tachycardia(NSVT).The patients with gastrointestinal tumors exhibited higher PVCs compared to the healthy controls on both conventional ECG[27(21.3)vs 1(2.5),P=0.012]and 24-h ambulatory ECG[14(1.0,405)vs 1(0,6.5),P35/24 h to all-cause mortality,and NSVT was associated with MACE.However,neither PVC burden nor NSVT independently predicted outcomes according to multivariate analysis.CONCLUSION Patients with gastrointestinal tumors exhibited elevated PVCs.PVCs>35/24 h and NSVT detected by 24-h ambulatory ECG were prognostically significant but were not found to be ind

关键词： Ventricular arrhythmia Gastrointestinal tumor Major adverse cardiovascular events Prognostic Surgery

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变动格局下的中国与世界——第四届山东青年史学家论坛会议综述

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聊城大学学报（社会科学版） 2024年第1期 151-156页

作者：吕俊昌李东青聊城大学历史文化与旅游学院山东聊城252000

2023年11月3-5日,由山东省社会科学界联合会、山东省历史学会、聊城大学主办,聊城大学历史文化与旅游学院、聊城大学太平洋岛国研究中心、区域国别研究院承办的“变动格局下的中国与世界--第四届山东青年史学家论坛”在聊城大学召开。... 详细信息

2023年11月3-5日,由山东省社会科学界联合会、山东省历史学会、聊城大学主办,聊城大学历史文化与旅游学院、聊城大学太平洋岛国研究中心、区域国别研究院承办的“变动格局下的中国与世界--第四届山东青年史学家论坛”在聊城大学召开。来自北京师范大学、复旦大学、东北师范大学、华中师范大学、河北师范大学等高校的知名学者,以及山东大学、山东师范大学、曲阜师范大学、青岛大学、济南大学、泰山学院等省内兄弟院校的近百位学者参加论坛。聊城大学党委书记关延平、校长王昭风、副书记房增福出席开幕式。

关键词：山东师范大学东北师范大学聊城大学青岛大学曲阜师范大学太平洋岛国济南大学山东省历史学会

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Visible-light degradation of azo dyes by imine-linked covalent organic frameworks

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Green Energy & Environment 2023年第1期8卷 194-199页

作者： Hongbo xue sen Xiong Kai Mi Yong Wang State Key Laboratory of Materials-Oriented Chemical Engineering And College of Chemical EngineeringNanjing Tech UniversityNanjing211816JiangsuChina

Covalent organic frameworks(COFs)are nanoporous crystalline polymers with densely conjugated structures.This work discovers that imine-linked COFs exhibit remarkable photodegradation efficiency to azo dyes dissolved in water.Visible light generates different types of radicals from COFs,and superoxide radicals break N=N bonds in dye molecules,resulting in 100%degradation of azo dyes within 1 h.In contrast,these dyes cannot be degraded by conventionally used photocatalysts,for example,TiO2.Importantly,the COF photocatalysts can be recovered from the dye solutions and re-used to degrade azo dyes for multiple times without loss of degradation efficiency.This work provides an efficient strategy to degrade synthetic dyes,and we expect that COFs with designable structures may use as new photocatalysts for other important applications.

关键词： Covalent organic frameworks Dyes Photocatalytic degradation Porous polymer Water pollution

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NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-Mao xue Zhi-Jie Xiao Pui-Chi Tin Hiu-Ling Fung Hoi-Tang Ma Jing-Ping Yun Judy Wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted pathways.The success of cell entry determines the effect of sEV on recipient cells.Here,we aimed to delineate the mechanisms underlying the uptake of sEV in HCC.Abbreviations:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene 101.Yue Yao and Yi Xu contributed equally to this work.Methods

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

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不同温度条件下天然胶乳海绵热氧老化行为

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科学技术与工程 2024年第6期24卷 2462-2468页

作者：何森黄冬梅陈晨张雪键孔哲中国计量大学质量与安全工程学院杭州310018 浙江省特种设备检验研究院杭州310012

为了分析温度对胶乳海绵在热氧老化过程中形貌与内部结构变化的影响,胶乳海绵老化后的形貌与结构变化直接影响其产品使用价值,其老化行为与温度密切相关。本文研究不局限于力学性能,通过测量70℃与120℃温度条件下胶乳海绵的白度指数、... 详细信息

为了分析温度对胶乳海绵在热氧老化过程中形貌与内部结构变化的影响,胶乳海绵老化后的形貌与结构变化直接影响其产品使用价值,其老化行为与温度密切相关。本文研究不局限于力学性能,通过测量70℃与120℃温度条件下胶乳海绵的白度指数、黄度指数、交联密度、压陷硬度的变化,分析了不同温度条件下材料热氧老化行为的规律。实验结果表明,120℃条件下黄度指数于86 h达到峰值,孔结构消失,表面生成残渣粉末,交联密度先升后降,同时压陷硬度短时间内急剧上升;70℃条件下材料白度指数缓慢下降,其余指标均呈缓升趋势,且孔结构完整保留。可见120℃条件下胶乳海绵形貌和结构在老化过程中的变化过程和最终形态与相对低温条件下存在明显差异,其产品价值因热氧老化行为极快丧失,80NR胶乳海绵抗热氧老化能力有待提高。

关键词：胶乳海绵热氧老化交联密度压陷硬度黄度指数

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基于STM32的雷达波流速仪辅助定位系统

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机械设计与制造 2024年第4期398卷 220-224页

作者：薛森杰武利生张金柱太原理工大学机械与运载工程学院山西太原030024

针对雷达波流速仪测流过程中不能获取流速仪地理空间位置的问题,提出一种基于STM32的雷达波流速仪定位系统。该系统基于STM32实时采集GPS导航系统、INS惯导系统的速度和位置信息,通过组合导航实现流速仪的定位功能。在软件中使用抗野值... 详细信息

针对雷达波流速仪测流过程中不能获取流速仪地理空间位置的问题,提出一种基于STM32的雷达波流速仪定位系统。该系统基于STM32实时采集GPS导航系统、INS惯导系统的速度和位置信息,通过组合导航实现流速仪的定位功能。在软件中使用抗野值卡尔曼滤波对GPS收到的经纬度信息进行过滤剔除,通过自适应卡尔曼滤波对GPS/INS信息融合,提高系统的实用性、精确性。实验结果表明,该系统可以获得流速仪的地理位置,输出位置信息较好的贴近真实轨迹,定位精度在0.5m以内,可以满足流速仪定位要求。

关键词： STM32 松耦合 GPS/INS组合导航野值过滤自适应卡尔曼滤波

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基于干冰微粒喷射冷却的高速列车IGBT散热器设计

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制冷学报 2024年第2期45卷 143-151页

作者：宁静红任子亮宋志朋祝森孙璐瑶高雪天津商业大学天津市制冷技术重点实验室天津300134

针对高速列车IGBT模块的高效散热问题,设计了一种应用于干冰微粒喷射冷却的针肋散热器。建立了3组不同针肋参数模型,通过数值模拟研究分析了针肋数量、直径、高度对散热效果的影响,得出最优针肋散热器的针肋数量为64、直径为12 mm、高度... 详细信息

针对高速列车IGBT模块的高效散热问题,设计了一种应用于干冰微粒喷射冷却的针肋散热器。建立了3组不同针肋参数模型,通过数值模拟研究分析了针肋数量、直径、高度对散热效果的影响,得出最优针肋散热器的针肋数量为64、直径为12 mm、高度为45 mm,相比于无肋散热器其换热基板表面温度降低了10.57℃,散热器内部干冰升华率提高了17.2%。通过实验观测到了干冰微粒冷却流体在管内流动状态以及干冰微粒在散热器内部扰动碰撞过程,验证了模拟结果,干冰微粒喷射冷却使热源功率为1.6 kW的IGBT模块保持在约25℃,满足其散热需要,为深入研究干冰微粒喷射冷却技术提供指导。

关键词：干冰升华散热器相变 IGBT模块

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利用ATR-FTIR研究脂质纳米粒的鼻黏液渗透性

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光谱学与光谱分析 2024年第4期44卷 1052-1060页

作者：王健敏李雪梅马士超李志勇唐华东马凤森浙江工业大学前沿交叉科学研究院浙江杭州310014 浙江工业大学化学工程学院浙江德清313216

鼻黏液是影响疫苗和药物经鼻吸收的首要屏障。由于干扰因素复杂多变,在体评价黏液渗透性较难实施,多采用体外评价。现有的药物鼻黏液渗透性检测方法如细胞模型法、多粒子示踪技术等,存在细胞培养周期长、操作繁琐、成本高、可获得信息... 详细信息

鼻黏液是影响疫苗和药物经鼻吸收的首要屏障。由于干扰因素复杂多变,在体评价黏液渗透性较难实施,多采用体外评价。现有的药物鼻黏液渗透性检测方法如细胞模型法、多粒子示踪技术等,存在细胞培养周期长、操作繁琐、成本高、可获得信息少且需要进行荧光标记等不足,对鼻黏膜制剂的体外评价具有很大的局限性,因此迫切需要建立一种快速、简便、灵敏的鼻黏膜制剂黏液渗透性评价方法。基于衰减全反射-傅里叶红外光谱(ATR-FTIR)对药物结构以及粘蛋白二级结构变化的敏感性,利用其对不同性质(粒径与电荷)脂质体的鼻黏液渗透性进行研究,通过FTIR图谱分析不同脂质纳米粒与黏液中粘蛋白的相互作用,建立了鼻黏膜制剂黏液渗透性的体外评价方法。方法学研究表明,对于聚乙二醇10000(PEG10000)、壳聚糖、海藻酸钠脂质体,该方法线性关系分别为Y=2.3866X+2.154、Y=1.8703X+0.2789、Y=1.13014X+0.0609,线性相关系数分别为0.9958、0.9945、0.9909,精密度RSD值分别为0.62%、0.73%、0.95%;重复性试验中RSD值分别为0.83%、0.97%、0.88%,说明该方法线性关系良好、精密度高、重复性好,可用于体外评价药物制剂在黏液中的渗透性。研究结果表明,利用ATR-FTIR在不同时间内扫描样品可得到不同脂质体制剂样品的强度增加的吸收带。对于不同粒径PEG脂质体而言,粒径越小其黏液渗透性越强;对于不同电荷脂质体而言,壳聚糖脂质体黏液渗透性最弱,海藻酸钠次之,PEG脂质体黏液渗透性最强。进一步研究表明,不同电荷脂质体黏液渗透性的差异源于其与粘蛋白相互作用,该结论可通过分析粘蛋白酰胺Ⅰ带所包含的各二级结构信息得到。综上,基于ATR-FTIR所建立的体外评价方法灵敏简便,可作为多种不同制剂的鼻黏液渗透性的快速测定,经改进后还可用于药物制剂在其他黏液中的渗透性评价,应用前景广阔。

关键词：脂质纳米粒 ATR-FTIR光谱渗透鼻黏液

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K_(3)C_(60)表面量子自旋诱导的YSR多重态和量子相变

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Science Bulletin 2024年第10期69卷 1392-1399页

作者：王树泽于雪晴韦力瑄王利程强军彭坤程方君刘宇李坊森马旭村薛其坤宋灿立 State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Vacuum Interconnected Nanotech Workstation Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Frontier Science Center for Quantum Information Beijing 100084China Beijing Academy of Quantum Information Sciences Beijing 100193China Southern University of Science and Technology Shenzhen 518055China

Magnetic impurities in superconductors are of increasing interest due to emergent Yu-Shiba-Rusinov(YSR)states and Majorana zero modes for fault-tolerant quantum computation.However,a direct relationship between the YSR multiple states and magnetic anisotropy splitting of quantum impurity spins remains poorly characterized.By using scanning tunneling microscopy,we systematically resolve individual transition-metal(Fe,Cr,and Ni)impurities induced YSR multiplets as well as their Zeeman effects in the K_(3)C_(60)superconductor.The YSR multiplets show identical d orbital-like wave functions that are symmetry-mismatched to the threefold K_(3)C_(60)(111)host surface,breaking point-group symmetries of the spatial distribution of YSR bound states in real space.Remarkably,we identify an unprecedented fermion-parity-preserving quantum phase transition between ground states with opposite signs of the uniaxial magnetic anisotropy that can be manipulated by an external magnetic field.These findings can be readily understood in terms of anisotropy splitting of quantum impurity spins,and thus elucidate the intricate interplay between the magnetic anisotropy and YSR multiplets.

关键词： Magnetic anisotropy YSR multiplets Quantum spin Quantum phase transition Identical wave functions Zeeman effects

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Littoral landforms of Lake Hulun and Lake Buir(China and Mongolia):Wind-driven hydro-sedimentary dynamics and resulting clastics distribution

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Journal of Palaeogeography 2024年第2期13卷 309-326页

作者： Li Wang Mathieu Schuster Shi-Wei Xin Florin Zainescu Xin-Yu xue Joep Storms Jan-Hendrik May Alexis Nutz Helena van der Vegt Guilherme Bozetti Zai-Xing Jiang School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Universite de Strasbourg CNRSENGEESInstitut Terre et Environnement de StrasbourgUMR 70635 Rue DescartesStrasbourgFrance Tamsag Mongolia(XIX)Ltd. PetroChinaDaqing 163000China CEREGE Aix-Marseille UniversitéCNESIRDCollege de FranceINRAAix en ProvenceFrance School of Marine Science Sun Yat-sen UniversityZhuhai 519083China Delft University of Technology Department of Geoscience and EngineeringDelfthe Netherlands School of Geography Earth and Atmospheric SciencesUniversity of Melbourne253 Elgin St.CarltonVIC 3053Australia Deltares Delfthe Netherlands SCMF Faculty of GeographyUniversity of Bucharest1 N.Balcescu Blv.BucharestRomania

Two rectangular-shaped lakes,Lake Hulun and Lake Buir,located at the boundary between China and Mongolia,only c.75 km apart and therefore experiencing similar wind fields,have been studied based on satellite images and field surveys in order to compare their geomorphological and sedimentological characteristics.The wind-driven hydrodynamics,which have a significant effect on the development of littoral landforms and on sediment distribution,have been discussed for the two similar lakes that experienced a prevailing wind perpendicular to their long axis.A conceptual model related to wind-driven water bodies and sediment distribution is proposed.Wave-influenced to wave-dominated deltas,beaches,spits,and eolian dune deposits develop around these two lakes,with a strikingly similar distribution pattern.These features locally inform the longshore drift and help reconstruct the water circulation induced by wind forcing.Under the NW prevailing wind regime,the spits developed on the SW coast with a NW—SE extension,which was influenced by the NW—SE longshore currents.The same influence was observed in the delta extension in the NE area.The differences lie in the presence of fan deltas in the NW region of Lake Hulun,but not in Lake Buir.Additionally,the width of the beach and eolian deposits on the downwind coast of Lake Hulun is three times greater than that of Lake Buir which were caused by the differences in sediment supply and wind fetch between the two lakes.Lake Hulun and Lake Buir provide two reliable examples to understand the relationship among the wind field,provenance,hydrodynamics,landforms,and asymmetrical distribution of clastics in elongated lakes.They also represent relevant modern analogs,which may also be of guiding significance to wind-driven sand body prediction in lacustrine basins.

关键词： Wind-driven lakes Fetch Sedimentary facies Hydrodynamics Geomorphology Spits Shoreline Lake Hulun Lake Buir

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