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Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons

Neural Regeneration Research 2013年第18期8卷 1714-1720页

作者： Haluk Kelestimur Emine Kacar Aysegul Uzun Mete Ozcan selim kutlu Department of Physiology Medical School Firat University Department of Biochemistry Medical School Karadeniz Technical University Department of Biophysics Medical School Firat University

The hypothalamic Arg-Phe-amide-related peptides, gonadotropin-inhibitory hormone and orthologous mammalian peptides of Arg-Phe-amide, may be important regulators of the hypothalamus-pituitary-gonadal reproductive axis. These peptides may modulate the effects of kisspeptins because they are presently recognized as the most potent activators of the hypothalamus-pituitary-gonadal axis. However, their effects on gonadotropin-releasing hormone neurons have not been investigated. In the current study, the GT1-7 cell line-expressing gonadotropin-releasing hormone was used as a model to explore the effects of Arg-Phe- amide-related peptides on kisspeptin activation. Intracellular calcium concentration was quantified using the calcium-sensitive dye, fura-2 acetoxymethyl ester. Gonadotropin-releasing hormone released into the medium was detected via enzyme-linked immunosorbent assay. Results showed that 100 nmol/L kisspeptin-10 significantly increased gonadotropin-releasing hormone levels （at 120 minutes of exposure） and intracellular calcium concentrations. Co-treatment of kisspeptin with 1 μmol/L gonadotropin-inhibitory hormone or 1 μmol/L Arg-Phe-amide-related peptide-1 significantly attenuated levels of kisspeptin-induced gonadotropin-releasing hormone but did not affect kisspeptin-induced elevations of intracellular calcium concentration. Overall, the results suggest that gonadotropin-inhibitory hormone and Arg-Phe-amide-related peptide-1 may have inhibitory effects on kisspeptin-activated gonadotropin-releasing hormone neurons independent of the calcium signaling pathway.

关键词： neural regeneration hypothalamus gonadotropin-inhibitory hormone Arg-Phe-amide-relatedpeptide-1 kisspeptin gonadotropin-releasing hormone calcium signaling GT1-7 cells neuroregeneration

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Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 309-318页

作者： Ayşe E.ÖZSOYÖZBAY Işıl SANRI KARAPINAR Zehra N.kutlu İsmail E.KILIÇ Department of Civil Engineering Maltepe UniversityIstanbul 34857Turkey School of Engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

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Critical Exponents for the Re-entrant Phase Transitions in the Three-Dimensional Blume-Emery-Grifilths Model on the Cellular Automaton

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Chinese Physics Letters 2007年第7期24卷 2040-2043页

作者： N. Seferoglu B. kutlu GaziUfniversitesi Fen Bilimleri Enstitfisfi Fizik Anabilim Dah Ankara Turkey GaziUniversitesi Fen-Edebiyat Fakiiltesi Fizik Boliumfi 06500 Teknikokullar Ankara Turkey

The critical behaviour of the three-dimensional Blume-Emery-Griffiths （BEG） model ＆ investigated at D/ J = O, -0.25 and -1 in the range of-1 ≤ K/J ≤ 0 for J -- 100. The simulations are carried out on a simple cubic lattice using the heating algorithm improved from the Creutz cellular automaton （CCA ） under periodic boundary conditions. The universality of the model are obtained for re-entrant and double re-entrant phase transitions which occur at certain D/J and K/J parameters, with J and K representing the nearest-neighbour bilinear and biquadratic interactions, and D being the single-ion anisotropy parameter. The values of static critical exponents β, γ and v are estimated within the framework of the finite-size scaling theory. The results are compatible with the universal Ising critical behaviour for all continuous phase transitions in these ranges.

关键词： Three-Dimensional Blume-Emery-Griffiths BEG CCA

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Critical Finite Size Scaling Relation of the Order-Parameter Probability Distribution for the Three-Dimensional Ising Model on the Creutz Cellular Automaton

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Chinese Physics Letters 2006年第10期23卷 2670-2673页

作者： B.kutlu M.Civi Department of Physics Gazi University 06500 Ankara Turkey

We study the order parameter probability distribution at the critical point for the three-dimensional spin-1/2 and spin-1 Ising models on the simple cubic lattice under periodic boundary conditions. The finite size scaling relation for the order parameter probability distribution is tested and verified numerically by microcanonical Creutz cellular automata simulations. The state critical exponent δ, which characterizes the far tail regime of the scaling order parameter probability distribution, is estimated for three-dimensional Ising models using the cellular automaton simulations at the critical temperature. The results are in good agreement with the Monte Carlo calculations.

关键词： BLUME-CAPEL MODEL MONTE-CARLO RENORMALIZATION-GROUP TRICRITICAL BEHAVIOR FREE-ENERGY MAGNETIZATION UNIVERSALITY SIMULATION DIMENSIONS EXPONENTS

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Finite-Size Scaling Analysis of a Three-Dimensional Blume-Capel Model in the Presence of External Magnetic Field

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Chinese Physics Letters 2008年第7期25卷 2599-2602页

作者： H. Demirel A. Ozkan B. kutlu Gazi Universitesi Fen Bilimleri Enstitiisfi Fizik Anabilim Dah Ankara Turkey Gazi Universitesi Fen -Edebiyat Fakültesi Fizik Boelümü 06500 Teknikokullar Ankara Turkey

The Blume-Capel model in the presence of external magnetic field H has been simulated using a cellular automaton algorithm improved from the Creutz cellular automaton in three-dimension lattice. The field critical exponent 5 is estimated using the power law relations and the finite size scaling functions for the magnetization and the susceptibility in the range -0.1≤ h = H/J ≤0. The estimated value of the field critical exponent 5 is in good agreement with the universal value （δ = 5） in three dimensions. The simulations are carried out on a simple cubic lattice under periodic boundary conditions.

关键词： 2-DIMENSIONAL ISING-MODEL CREUTZ CELLULAR-AUTOMATON EMERY-GRIFFITHS MODEL TRICRITICAL BEHAVIOR MONTE-CARLO CRITICAL EXPONENTS PHASE-TRANSITIONS O(4) MODEL SIMULATION ANISOTROPY

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Finite Size Effect for the First-Order Phase Transition of the Three-Dimensional Blume-Capel Model on a Cellular Automaton

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Chinese Physics Letters 2006年第9期23卷 2526-2529页

作者： N. Seferoglu A. Oezkan B. kutlu Gazi Universitesi Fen Bilimleri Enstitiisfi Fizik Anabilim Dah Ankara Turkey Gazi Universitesi Fen Edebiyat Fakiiltesi Fizik B61iimii 06500 Teknikokullar Ankara Turkey

The first-order phase transition of the three-dimensional Blume-Capel model is investigated using the cooling algorithm which is improved from Creutz Cellular Automaton at D/J = 2.9, i.e. a ratio of single-ion anisotropy constant to bilinear interaction energy. We test the efficiency of the algorithm and obtain the finite-size effects at the first-order phase transition point. The transition temperature is estimated using the probability distributions of the order parameter and the energy. The analysis of data at the transition point indicates that the magnetic susceptibility and the specific heat maxima increase with the system value （L^d）.

关键词： TRICRITICAL BEHAVIOR MONTE-CARLO APPROXIMATION SIMULATION ANISOTROPY SYSTEMS

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Asian Journal of Andrology 2013年第2期15卷 269-274,I0009页

作者： Orcun Celik Omer kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal Department of Urology Faculty of Medicine Akdeniz University Antalya 07070 Turkey Department of Urology Faculty of Medicine Karadeniz Technical University Trabzon 61080 Turkey Department of Histology and Embryology Faculty of Medicine Akdeniz University Antatya 07070 Turkey

The higher frequency of varicocele in men with infertility has drawn attention and resulted in increased research at the molecular level towards treatments. The aim of this study was to investigate the role of tumor necrosis factor （TNF）-related apoptosis-inducing ligand （TRAIL） and its receptors in varicocele-induced testicular dysfunction in an experimental rat model. The rats were divided into three groups： control, sham and varicocele. Varicoceles in rats were induced by partial ligation of the left renal vein and left testes. The rats were analyzed 13 weeks after surgery. The degree of DNA fragmentation within cells in the testis was determined using terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling （TUNEL） assay. Tubule degeneration was evaluated using the Johnsen score. The expression of TRAIL and its receptors was detected by immunohistochemical and Western blotting techniques. The apoptotic index, Johnsen score and the expression of TRAIL and TRAIL receptors were examined. The data are presented as the mean-.＋s.d, and were analyzed using computer software. The KruskaI-Wallis and Dunn＇s multiple comparison tests were used in the statistical analyses. The germ cell apoptotic index was increased in rats with varicoceles when compared with the sham and control groups （P=0.0031）. The Johnsen score was significantly decreased in the varicocele group when compared with the sham and control groups （P〈O.O001）. Immunohistochemical and Western blotting analyses showed that after varicocele induction, the expression of TRAIL-R1 and TRAIL-R4 in germ cells was increased and the expression of TRAIL-R2 was decreased. There are no significant differences among the groups in terms of TRAIL and TRAIL-R3 receptor expression. The results of this study indicate that TRAIL and its receptors may have a potential role in the pathogenesis of varicocele-induced testicular dysfunction.

关键词： apoptosis infertility testis TNF-related apoptosis inducing ligand (TRAIL) varicocele

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Values of high-resolution computed tomography and pulmonary function tests in managements of patients with chronic hepatitis C virus infection

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World Journal of Gastroenterology 2004年第3期10卷 381-384页

作者： Oguzhan Okutan Zafer Kartaloglu Ahmet Ilvan Ali kutlu Erkan Bozkanat Emir Silit GATA Haydarpasa Training Hospital Department of Pulmonary DiseasesIstanbulTurkey Gumussuyu Military Hospital Department of Pulmonary DiseasesIstanbulTurkey GATA Haydarpasa Training Hospital Department of RadiologyIstanbulTurkey

AIM:To investigate pulmonary involvement via pulmonary function tests (PFT) and high-resolution computed tomocjraphy (HRCT) in patients with chronic hepatitis C virus (HCV) infection. METHODS:Thirty-four patients with chronic HCV infection without diagnosis of any pulmonary diseases and 10 healthy cases were enrolled in the study,PFT and HRCT were performed in all cases. RESULTS:A decrease lower than 80% of the predicted value was detected in vital capacity in 9/34 patients,in forced expiratory volume in one second in 8/34 patients,and in forced expiratory flow 25-75 in 15/34 patients,*** monoxide diffusing capacity (DLCO) was decreased in 26/34 *** of interstitial pulmonary involvement were detected in the HRCT of 16/34 *** difference was found between controls and patients with HCV infection in findings of HRCT (X^2=4.7,P=0.003).Knodell histological activity index (KHAI) of 28/34 patients in whom liver biopsy was applied was 9.0±*** findings,PFT values and DLCO were not affected by KHAI in patients with HCV *** these patients,all the parameters were related with age. CONCLUSION:We suggest that chronic hepatitis C virus infection may cause pulmonary interstitial involvement without evident respiratory symptoms.

关键词： Respiratory Function Tests Tomography, X-Ray Computed Adult Aged Female Hepatitis C, Chronic Humans Lung Diseases Male Middle Aged

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Effects of obstructive sleep apnea on retinal microvasculature

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国际眼科杂志:英文版 2023年第10期16卷 1670-1675页

作者： Müjdat Karabulut Semai Bek Sinem Karabulut Aylin Karalezli Gülnihal kutlu Ophthalmology Department Mugla Sitki Kocman University Training and Research HospitalMugla 48300Türkiye Neurology Department Mugla Sitki Kocman University Faculty of MedicineMugla 48300Türkiye Ophthalmology Department Mugla Sitki Kocman University Faculty of MedicineMugla 48300Türkiye

AIM:To detect retinal microvascular variations in obstructive sleep apnea syndrome ***:This prospective,observational case-control study included healthy controls and patients with mild,moderate,and severe obstructive sleep apnea *** parameters,foveal avascular area,and flow areas in macula-centered,6.00×6.00 mm2 scan size optical coherence tomography angiography images were ***:The control group had the highest whole image,parafoveal,and perifoveal vessel density among the groups in both superficial and the deep capillary plexus(all P<0.05).Rapid eye movement sleep apnoea-hypopnoea index was reversely correlated with whole(Rho=-0.195,P=0.034),parafoveal(Rho=-0.242,P=0.008),perifoveal(Rho=-0.187,P=0.045)vessel density in the superficial capillary plexus,and whole(Rho=-0.186,P=0.046),parafoveal(Rho=-0.260,P=0.004),perifoveal(Rho=-0.189,P=0.043)vessel density in the deep capillary plexus,though the mean and non-rapid eye movement sleep apnoeahypopnoea index related with only parafoveal vessel density in the superficial capillary plexus(Rho=-0.213,P=0.020;Rho=-0.191,P=0.038)and the deep capillary plexus(Rho=-0.254,P=0.005;Rho=-0.194,P=0.035).CONCLUSION:This study shows decreased vessel density and its reverse correlation with the apnoea-hypopnoea index in patients with obstructive sleep apnea syndrome.

关键词： apnoea-hypopnoea index deep capillary plexus obstructive sleep apnea superficial capillary plexus vessel density retinal microvasculature

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Medical management of ischemic stuttering priapism： a ：ontemporary review of the literature

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Asian Journal of Andrology 2012年第1期14卷 156-163,180页

作者： Helen R Levey Omer kutlu Trinity J Bivalacqua The Arthur Smith Institute for Urology North Shore- Long Island Jewish Health System New Hyde Park NY 11010 USA The James Buchanan Brady Urological Institute Department of Urology Johns Hopkins Hospital Baltimore MD 21287 USA

Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder. Complications from this disorder are devastating due to the irreversible erectile damage and resultant erectile dysfunction （ED）. Stuttering priapism, though relatively rare, affects a high prevalence of men with sickle-cell disease （SCD） and presents a challenging problem with guidelines for treatment lacking or resulting in permanent ED. The mechanisms involved in the development of priapism in this cohort are poorly characterized; therefore, medical management of priapism represents a therapeutic challenge to urologists. Additional research is warranted, so we can effectively target treatments for these patients with prevention as the goal. This review gives an introduction to stuttering priapism and its clinical significance, specifically with regards to the patient with SCD. Additionally, the proposed mechanisms behind its pathophysiology and a summary of the current and future targets for medical management are discussed.

关键词： erectile dysfunction ischemic priapism medical management recurrent priapism sickle cell disease stuttering priapism therapy treatment

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