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Effect of Aqueous Extract of Boscia senegalensis on Hyperglycemia, Hyperlipidemia and Oxidative Stress Induced in Rats

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Journal of Diabetes Mellitus 2024年第1期14卷 49-68页

作者： Faustin dongmo Elie Baudelaire Djantou Alcherif Hamid Mahamat selestin sokeng dongmo Nicolas Njintang Yanou Department of Biological Sciences Faculty of Science University of Ngaoundere Ngaoundere Cameroon Department of Food Science and Nutrition ENSAI University of Ngaoundere Ngaoundere Cameroon Department of Biomedical and Pharmacetical Sciences National Higher Institute of Science and Techniques of Abeche Abeche Chad

Boscia aqueous extract. senegalensis on hyperglycemia, hyperlipidemia and oxidative stress induced in rats. The aqueous extract was prepared from B. senegalensis seed powders under the extraction conditions: time (10 min), temperature (55˚C) and the ratio of mass of flour/volume of water (3/10 g/mL). Male wistar rats aged 6 to 8 weeks were acclimated and divided into 8 groups of 5 rats each: two normal control groups which received a normal standard diet (3810 kcal/kg), and six test groups which were subjected to a hyperlipidemic diet (5310 Kcal/kg). All groups of animals were fed in this manner for 8 weeks to induce hyperglycemia, hyperlipidemia and oxidative stress. After induction the animals were treated either with distilled water for the normal and negative control groups or with atorvastatin for the positive control group or with the extract of B. senegalensis. (125, 250 and 500 mg/kg) for the test groups. Fasting blood glucose was taken every 7 days during induction. After sacrifice, biochemical and oxidative stress parameters were measured. The aqueous extract of B. senegalensis significantly decreased (p B. senegalensis at a dose of 500 mg/kg has the capacity to reduce blood sugar, improve the quality of the lipid profile and reduce oxidative stress. Thus, the results reveal that the aqueous extract of B. senegalensis has powerful hypoglycemic, hypolipidemic and antioxidant properties.

关键词： Boscia Senegalensis Hypoglycemic Hypolipidemic Hyperlipidemic Diet An-tioxidant

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The antihyperglycemic effect of Bridelia ndellensis ethanol extract and its fractions is mediated by an insulinotropic action

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Journal of Diabetes Mellitus 2013年第3期3卷 111-115页

作者： selestin dongmo sokeng Begum Rokeya Jamadder Mohammed Abdul Hannan Liaquat Ali Pierre Kamtchouing Department of Biological Sciences University of Ngaoundéré Ngaoundéré Cameroon Department of Pharmacy North South University Dhaka Bangladesh Laboratory of Animal Physiology Faculty of Science University of Yaounde Yaounde Cameroon Research Division Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorders (BIRDEM) Dhaka Bangladesh

Backgroung: Bridelia ndellensis (Euphorbiaceae) is used as a traditional plant treatment of diabetes. The aim of the present study was to investigate the mechanism involved in the antihyperglycemic effects of this plant. Methods: An intestinal perfusion technique was used to study the effect of the ethanol extract of B. ndellensis on the intestinal absorption of glucose in normal rats fasted for 36 h. The effect of the extract (50 and 100 mg/kg) on Insulin secretion was evaluated using BRIN-BD11 pancreatic cells. Results: In a perfused rat intestinal preparation in situ, the plant extract at a concentration of 5 mg/ml did not show any inhibitory effects on glucose absorption when compared with control animals. Ouabain which is an inhibitor of glucose transport across the small intestine significantly (p < 0.001) decreased the glucose absorption during the whole perfusion period compared with the control group. On the other hand, the plant extract inhibited the gastrointestinal motility induced by Barium sulphate milk in rats. The ethanol extract of B. ndellensis at concentrations of 50 and100mg/ml stimulated in a concentration-dependent manner the insulin secretion from BRIN-BD11 cells in vitro. The induction of insulin release was significantly different when compared to control with the concentration of 100 μg/ml (P < 0.001). Alanine (10 mM) used as positive control, significantly (p < 0.001) stimulated insulin release from BRIN-BD11 cells. Conclusion: The present study has revealed that B. ndellensis ethanol extract stimulates insulin secretion and does not affect the glucose absorption, and it has suggested that the antihyperglycemic effects of B. ndellensis is partly mediated by the stimulation of insulin secretion.

关键词： Bridelia ndellensis Ethanol Extract Intestinal Glucose Absorption Insulin Secretion in Vitro

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Androgenic effect of Mondia whitei roots in male rats

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Asian Journal of Andrology 2004年第3期6卷 269-272页

作者： Pierre Watcho Pierre Kamtchouing selestin D.sokeng Paul F.Moundipa Justine Tantchou Jean L.Essame Noussithe Koueta Animal Physiology and Phytopharmacology Laboratory Faculty of ScienceUniversity of DschangDschangCameroon Animal Physiology Laboratory University of Yaounde IYaoundeCameroon Department of Biochemistry Faculty of SciencesUniversity of Yaounde IYaoundeCameroon 不详 University Hospital Centre YaoundeCameroon

Aim: To determine the effect of the aqueous extract of Mondia whitei (Periplocaceae) roots on testosterone production and fertility of male rats. Methods: Adult male Wistar rats were used. In the acute study, 20 rats were randomly divided into 5 groups of 4 animals each. Four treated groups were administered orally a single dose of Mondia whitei (400 mg/kg) and the controls received a similar amount of distilled water. One group of animals were sacrificed by cervical dislocation 1,2,4 and 6 h after treatment, respectively. The controls were sacrificed at 6 h. Testicular testosterone was determined by radioimmunoassay. In the chronic study, 28 rats were divided at random into 4 groups of 7 animals each: Groups 1, 2 and 3 were given orally the plant extract (400 mg·kg-1·day-1) for 2, 4 and 8 days, respectively. The animals of Groups 1 and 2 were sacrificed 24 hours after the last dosing. The controls (Group 4) received the same amount of distilled water for 8 days. The fertility was assessed only in Groups 3 and 4 and after that, the animals were sacrificed and the epididymal sperm density, the serum testosterone and the testicular testosterone and 17β-estradiol were assayed. The serum, testicular and epidydimal protein contents were also determined. Results: In the acute treatment groups, the serum and testicular concentrations of testosterone remained unchanged at all the time points. Chronic treatment for 8 days induced a significant increase in the testicular weight, the serum and testicular testosterone, the testicular protein content and the sperm density (P<0.05-0.01), but did not affect the accessory gland weights, the serum protein contents, the testicular concentration of 17β-estradiol and the fertility compared to the controls. Conclusion: Mondia whitei root extract possesses an androgenic property.

关键词： Mondia whitei testosterone sperm density fertility

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Particle Size Effects on Antioxydant and Hepatoprotective Potential of Essential Oil from Eucalyptus camaldulensis Leaves against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

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Pharmacology & Pharmacy 2022年第8期13卷 253-272页

作者： Venant Donald Noumi Markusse Deli Richard Marcel Nguimbou Elie Baudelaire Sandrine Rup-Jacques Dicko Amadou selestin sokeng Nicolas Yanou Njintang Department of Biological Sciences Faculty of Sciences University of Ngaoundere Ngaoundere Cameroon Department of Biological Sciences Faculty of Sciences University of Maroua Maroua Cameroon Department of Food Sciences and Nutrition ENSAI University of Ngaoundere Ngaoundere Cameroon AGRITECH Nancy France Université de Lorraine ICPM Metz Cedex France Université de Lorraine UR-AFPA Metz Cedex France

Particle size fractionation by sieving is used to optimize antioxydant potential of natural substances. The aim of the present study was to evaluate particle size effects on antioxidant and hepatoprotective potential of Eucalyptus camaldulensis essential oils (EO) on CCl4-induced hepatic damage in Wistar rats. Animals were daily orally treated with the EOs extracted by hydrodistillation from powder sieved at four particle sizes (≥355, 200 - 355, 100 - 200, ≤100 μm) and those of the unsieved powder at dose of 50 mg/Kg for 7 days. Compounds that are evaluated for these activities are hydrocarbons and oxygenated terpenes that were identified and quantified by GC/MS. Activities of enzymes markers of hepatocellular damage in serum and antioxidant enzymes in the liver homogenates were measured. In this research, EOs significantly prevented the increase in serum ALT and AST (p 4 and significant increase level of plasma HDL-cholesterol. Also, significantly (p < 0.05) decreased the extent of malondialdehyde (MDA) formation and elevated the activities of superoxide dismutase (SOD) and catalase (CAT) liver in comparison to negative control group. The best antioxidant and hepatoprotective activities were those of EOs from two fine powder fractions (≤100 μm and 100 - 200 μm) was correlated to their high concentration in oxygenated terpenes (70.9% and 46.4%, respectively), when compared to the large particles (200 - 355 μm and ≥355 μm, with 33.3% and 41.8%, respectively) and unsieved powder (37.4%).

关键词： Eucalyptus camaldulensis Powder Particle Size Essential Oils Hepatoprotection Oxidative Stress

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Phytochemical Profile and <i>In Vitro</i>Antioxidant Properties of Essential Oils from Powder Fractions of <i>Eucalyptus camaldulensis</i>Leaves

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American Journal of Plant Sciences 2021年第3期12卷 329-346页

作者： Venant Donald Noumi Richard Marcel Nguimbou Marthe Valentine Tsague Markusse Deli Sandrine Rup-Jacques Dicko Amadou Elie Njantou Baudelaire selestin sokeng Nicolas Yanou Njintang Department of Biological Sciences Faculty of Sciences University of Ngaoundere Ngaoundere Cameroon Department of Food Sciences and Nutrition ENSAI University of Ngaoundere Ngaoundere Cameroon Department of Biomedical Sciences Faculty of Sciences University of Ngaoundere Ngaoundere Cameroon Université de Lorraine ICPM Metz France Université de Lorraine UR-AFPA Metz France

Dried leaves of Eucalyptus camaldulensis were finely grinded and fractionated by sieving into four granulometric classes (355 μm). The obtained powder fractions were used for essential oil (EO) extraction by hydrodistillation and their phytochemical profile and in vitro antioxidant activities were evaluated. The mother powder (unsieved powder) was used for comparison. Particle size exerted a significant influence (p in vitro antioxidant properties of the EOs. Comparatively, the mother powder had the highest contents of α-pinene (55.6%), camphene (3.4%) and limonene (3.7%), while 1,8-cineole (26.6% and 22.4%), exo-fenchol (5.6% and 3.5%), α-campholenol (4.2% and 3.4%), L-trans-pinocarveol (5.5% and 2.7%), L-borneol (12.6% and 6.8%) and α-terpineol (16.4% and 7.6%) are the main compounds of EOs from the <100 μm and 100 - 200 μm fractions, respectively. The antioxidant activities of the EOs revealed higher radical-scavenging activities DPPH (90.62% and 7

关键词： Eucalyptus camaldulensis Powder Fraction Essential Oil Chemical Composition Antioxidant Activity

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