Androgenic effect of Mondia whitei roots in male rats

作     者：Pierre Watcho Pierre Kamtchouing Selestin D.Sokeng Paul F.Moundipa Justine Tantchou Jean L.Essame Noussithe Koueta PIERRE WATCHO;PIERRE KAMTCHOUING;SELESTIN D.SOKENG;PAUL F.MOUNDIPA;JUSTINE TANTCHOU;JEAN L.ESSAME;NOUSSITHE KOUETAANIMAL PHYSIOLOGY AND PHYTOPHARMACOLOGY LABORATORY;FACULTY OF SCIENCE;UNIVERSITY OF DSCHANG;DSCHANG;CAMEROON ANIMAL PHYSIOLOGY LABORATORY;DEPARTMENT OF BIOCHEMISTRY;FACULTY OF SCIENCES;UNIVERSITY OF YAOUNDE I;YAOUNDE;CAMEROONDEPARTMENT OF ANIMAL BIOLOGY;UNIVERSITY OF NGAOUNDERE;NGAOUNDERE;CAMEROONUNIVERSITY HOSPITAL CENTRE;CAMEROON

作者机构：Animal Physiology and Phytopharmacology LaboratoryFaculty of ScienceUniversity of DschangDschangCameroon Animal Physiology LaboratoryUniversity of Yaounde IYaoundeCameroon Department of BiochemistryFaculty of SciencesUniversity of Yaounde IYaoundeCameroon 不详 University Hospital CentreYaoundeCameroon 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志(英文版))

年 卷 期：2004年第6卷第3期

页      面：269-272页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Mondia whitei testosterone sperm density fertility 

摘      要：Aim: To determine the effect of the aqueous extract of Mondia whitei (Periplocaceae) roots on testosterone production and fertility of male rats. Methods: Adult male Wistar rats were used. In the acute study, 20 rats were randomly divided into 5 groups of 4 animals each. Four treated groups were administered orally a single dose of Mondia whitei (400 mg/kg) and the controls received a similar amount of distilled water. One group of animals were sacrificed by cervical dislocation 1,2,4 and 6 h after treatment, respectively. The controls were sacrificed at 6 h. Testicular testosterone was determined by radioimmunoassay. In the chronic study, 28 rats were divided at random into 4 groups of 7 animals each: Groups 1, 2 and 3 were given orally the plant extract (400 mg·kg-1·day-1) for 2, 4 and 8 days, respectively. The animals of Groups 1 and 2 were sacrificed 24 hours after the last dosing. The controls (Group 4) received the same amount of distilled water for 8 days. The fertility was assessed only in Groups 3 and 4 and after that, the animals were sacrificed and the epididymal sperm density, the serum testosterone and the testicular testosterone and 17β-estradiol were assayed. The serum, testicular and epidydimal protein contents were also determined. Results: In the acute treatment groups, the serum and testicular concentrations of testosterone remained unchanged at all the time points. Chronic treatment for 8 days induced a significant increase in the testicular weight, the serum and testicular testosterone, the testicular protein content and the sperm density (P0.05-0.01), but did not affect the accessory gland weights, the serum protein contents, the testicular concentration of 17β-estradiol and the fertility compared to the controls. Conclusion: Mondia whitei root extract possesses an androgenic property.