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Neuritogenic function of microglia in maternal immune activation and autism spectrum disorders

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Neural Regeneration Research 2021年第7期16卷 1436-1437页

作者： Srinidhi Venkatesan Kalavai seiko Ikezu Department of Pharmacology&Experimental Therapeutics Boston University School of MedicineBostonMAUSA

Autism spectrum disorder and maternal immune activation: Environmental factors during pregnancy, such as infections, maternal stress or autoimmune disorders, are closely associated with the prevalence of neurodevelopmental disorders including autism spectrum disorder(ASD), bipolar disorder and *** has been shown that severe infections during pregnancy cause maternal immune activation(MIA) and significantly increase the risk of ASD in the offspring although the mechanisms are poorly *** rodent MIA studies support this causal link by showing that offspring of dams administered with polyinosinic:polycytidylic acid(poly I:C), a viral mimetic Toll-like receptor 3 agonist, exhibit longlasting ASD-like behavioral abnormalities such as increased repetitive behavior, impaired social interaction and ***, MIA alters inflammatory cytokine expressions persisting through development and adulthood in the brain of the offspring, suggesting that chronic neuroimmune dysfunction plays a role in mediating the deleterious effects of MIA on neurodevelopment(Garay et al., 2013).

关键词： disorders impaired activation

Molecular Functions of Oxygen-Evolving Complex Family Proteins in Photosynthetic Electron Flow

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Journal of Integrative Plant Biology 2010年第8期52卷 723-734页

作者： Kentaro Ifuku seiko Ishihara Fumihiko Sato Graduate School of Biostudies Kyoto University

Oxygen-evolving complex （OEC） protein is the original name for membrane-peripheral subunits of photosystem （PS） II. Recently, multiple isoforms and homologs for OEC proteins have been iden- tified in the chloroplast thylakoid lumen, indicating that functional diversification has occurred in the OEC family. Gene expression profiles suggest that the Arabidopsis OEC proteins are roughly categorized into three groups： the authentic OEC group, the stressresponsive group, and the group including proteins related to the chloroplast NAD（P）H dehydrogenase （NDH） complex involved in cyclic electron transport around PSI. Based on the above gene expression profiles, molecular functions of the OEC family proteins are discussed together with our current knowledge about their functions.

关键词： NDH Molecular Functions of Oxygen-Evolving Complex Family Proteins in Photosynthetic Electron Flow OEC PSII PPL

Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

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Acta Pharmaceutica Sinica B 2014年第2期4卷 141-145页

作者： Ryuji Uchida seiko Ishikawa Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato UniversityTokyo 108-8641Japan School of Pharmacy Kitasato UniversityTokyo 108-8641Japan

2-Hydroxytyrosol(2-HT),originally reported as a synthetic compound,was isolated for the first time as a fungal metabolite.2-HT was found to inhibit mushroom tyrosinase with an IC_(50) value of 13.0 mmol/***,2-HT dose-dependently inhibited tyrosinase activity(IC_(50),32.5 mmol/L)in the cell-free extract of B16 melanoma cells andα-melanocyte stimulating hormone(α-MSH)-stimulated melanin formation in intact B16 melanoma cells.

关键词： 2-Hydroxytyrosol Metarhizium sp. Tyrosinase inhibitor Melanine formation B16 melanoma cells

A new scorpion polypeptide enhances the binding of radiolabeled-ryanodine on ryanodine receptor in sarcoplasmic reticulum of rabbit skeletal muscle

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Chinese Science Bulletin 1997年第2期42卷 147-151页

作者： seiko Kawano Yoshiyuki Hirayama Masayasu Hiraoka Akihiko Kuniyasu Hitoshi Nakayama Department of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanFaculty of Pharmaceutical Science Hokkaido University Japan Faculty of Pharmaceutical Science Kumamoto University Japan

RYANODINE is a toxic alkaloid from the plant Ryania speciosa Vahl. It selectively binds to the Ca2+ release channel on skeletal and cardiac heavy sarcoplasmic reticulum （HSR） and has

关键词： scorpion Buthus martensi Karsch ryanodine receptor toxic polypeptide.

Cardiac biomarkers in children with congenital heart disease

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World Journal of Pediatrics 2015年第4期11卷 309-315页

作者： Masaya Sugimoto seiko Kuwata Clara Kurishima Jeong Hye Kim Yoich Iwamoto Hideaki Senzaki Department of Pediatrics Asahikawa Medical UniversityAsahikawaJapan Department of Pediatric Cardiology Saitama Medical CenterSaitama Medical UniversityKawagoeJapan

Background:Most congenital heart diseases(CHDs)have specific hemodynamics,including volume and pressure overload,as well as cyanosis and pulmonary hypertension,associated with anatomical *** hemodynamic abnormalities can cause activation of neurohormones,inflammatory cytokines,fibroblasts,and vascular endothelial cells,which in turn contribute to the development of pathologic conditions such as cardiac hypertrophy,fi brosis,and cardiac cell damages and *** biomarker levels facilitates the prediction of these pathological changes,and provides information about the stress placed on the myocardial cells,the severity of the damage,the responses of neurohumoral factors,and the remodeling of the *** to the ample information on cardiac biomarkers in adult heart diseases,data from children with CHD are still *** sources:We reviewed cardiac biomarkers-specifi cally focusing on troponin as a biomarker of myocardial damage,amino-terminal procollagen type III peptide(PIIIP)as a biomarker of myocardialfi brosis and stromal remodeling,and B-type natriuretic peptide(BNP)/N-terminal proBNP as biomarkers of cardiac load and heart failure,by introducing relevant publications,including our own,on pediatric CHD patients as well as ***:Levels of highly sensitive troponin I are elevated in patients with atrial septal defects(ASDs)and ventricular septal defects(VSDs).PIIIP levels are also elevated in patients with ASD,VSD,pulmonary stenosis,and Tetralogy of *** of BNP and N-terminal proBNP levels shows good correlation with heart failure score in ***:In the treatment of children with CHD requiring delicate care,it is vital to know the specifi c degree of myocardial damage and severity of heart *** biomarkers are useful tools for ascertaining the condition of CHDs with ease and are likely to be useful in determining the appropriate care of pediatric cardiology patients.

关键词： biomarker B-type natriuretic peptide congenital heart disease procollagen type III peptide troponin

Korean Wave： Towards Regional Cultural Diffusion？

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Journal of Literature and Art Studies 2013年第2期3卷 101-112页

作者： seiko Yasumoto The University of Sydney Sydney Australia

The aim of this paper is firstly to determine if the Korean television drama Winter Sonata and its spinoffs are contributing to contemporary cross-cultural diffusion in Japan. Secondly, if cross-cultural diffusion is occurring, is it contributing to a loss of local identity？ Winter Sonata is a small but significant part of the Korean Wave and in the vanguard of Korean television drama content viewed in Japan. There have been macro political changes in East Asia, largely driven by Korea, resulting in an easing of restrictions on cross-border media trade. These in turn have progressively created a new dynamic in content and volume. The methodology used for the study is triangulation including document analysis, audience analysis, and commercial outcomes. The convergent validation derived from the three parameters advances the proposition that Winter Sonata has contributed to cultural diffusion from a Japanese perspective but not to a loss of local identity. Arguably, the process is an enriching one in East Asia reinforced by multi-lateral media trade.

关键词： popular culture Korean Wave cross-cultural diffusion cultural hybridity triangulation

Japanese Media Strategy： The Recognition of Economic Value Chains

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Journalism and Mass Communication 2012年第10期2卷 998-1011页

作者： seiko Yasumoto University of Sydney Sydney Australia

This paper examines, as a case study, Japanese media production, remaking, and transferences of media content derived from the manga Janguru Taitei （Jungle Emperor） and contemporary Japanese government strategies to protect and promote Japanese cultural and economic value within the content business. The study utilizes methodological triangulation inclusive of textual, document, and value chain analysis. The Japanese government has progressively appreciated the intrinsic value of the media content from both a commercial and cultural context and the loss of value in unregulated segments of the regional market. In 2003, they established an Intellectual Property Strategy Group to support and promote the Japanese media content business. There has been a continuum of policy development since then to protect and amplify the financial value of Japanese media products. All of the developments in media industry are fuelled not only by government regulations, the imagination of talented artists and writers, and the growing regionalization and internationalization of the industry but also the ＂bottom line＂ emerging from the value chain. The recognition of the need for sustaining profit growth to continue the viability of original and remade content in Japan is paramount for Japan.

关键词： Japanese media strategy economic value chains adaptation

Helicobacter heilmannii sensu stricto-related gastric ulcers:A case report

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World Journal of Gastroenterology 2014年第12期20卷 3376-3382页

作者： Takehisa Matsumoto Masatomo Kawakubo Taiji Akamatsu Naohiko Koide Naoko Ogiwara seiko Kubota Mitsutoshi Sugano Yoshiyuki Kawakami Tsutomu Katsuyama Hiroyoshi Ota Departments of Laboratory Medicine Shinshu University Hospital Endoscopy Center Suzaka HospitalNagano Prefectural Hospital Organization Department of Surgery Nagano Prefectural Kiso Hospital Department of Health and Medical Sciences Shinshu University Graduate School of Medicine Maruko Central Hospital

A spiral bacterium (SH9), morphologically different from Helicobacter pylori (H. pylori), was found in a 62-year-old woman’s gastric mucosa. Gastroscopic examination revealed multiple gastric ulcers near the pyloric ring; mapping gastric biopsy showed mild mononuclear infiltration with large lymphoid follicles in the antrum, without corpus atrophy. Urea breath test and H. pylori culture were negative, but Giemsa staining of biopsies revealed tightly coiled bacteria that immunostained with anti-H. pylori antibody. Sequencing of SH9 16S rRNA and the partial urease A and B subunit genes showed that the former sequence had highest similarity (99%; 1302/1315 bp) to Helicobacter heilmannii (H. heilmannii) sensu stricto (H. heilmannii s.s.) BC1 obtained from a bobcat, while the latter sequence confirmed highest similarity (98.3%; 1467/1493 bp) to H. heilmannii s.s. HU2 obtained from a human. The patient was diagnosed with multiple gastric ulcers associated with H. heilmannii s.s. infection. After triple therapy (amoxicillin, clarithromycin, and lansoprazole) with regimen for eradicating H. pylori, gastroscopy showed ulcer improvement and no H. heilmannii s.s. upon biopsy.

关键词： Helicobacter heilmannii sensu stricto, “ Helicobacter heilmannii” type 2, Gastric ulcers, Urease gene, Non-Helicobacter pylori helicobacters

Survey of Bereavement Care Provided by Home-Visit Nurses for Bereaved Families in Japan

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Health 2021年第6期13卷 660-676页

作者： Ozawa Miwa Sei Jungetsu Uchino seiko Department of Nursing School of Nursing University of Tsukuba Ibaraki Japan Department of Nursing Faculty of Nursing Gifu University of Medical Science Gifu Japan

Purpose: This study aims to investigate the implementation conditions of bereavement care for bereaved families and the relationship between demographics of home-visit nurses and rates of provision of bereavement care. Methods: A self-rating anonymous questionnaire survey was conducted with 2200 facilities randomly selected from among the members of the Home-visit Nursing Stations of the National Nursing Business Association. Calculating the rates of provision of each pre- and post-bereavement care item of the survey, we performed a multiple logistic regression analysis to investigate the relationship between the demographics of home-visit nurses and rates of provision of care. Statistical processing employed SPSS ver. 21.0 with the significance level set at 5%. Results: A total of 688 responses were collected (collection rate, 31.3%), and 649 were included in the analysis. “Approval of the care that the family has provided” and “Involvement in the care together with the family and listening to their thoughts” were frequently provided in both pre- and post-bereavement care;however, the rate of provision of “Provided continued support/life planning until the family fully recovers social life” was low. More care services were provided by home-visit nurses working in facilities with 24-hour services in pre-bereavement, and by those with longer home-visit nursing experience in post-bereavement. Conclusions: Home-visit nurses provide many post-bereavement care services. However, continued care that helps bereaved families fully recover their social life, including life planning, is less frequently provided. Bereavement care provision rates vary depending on the facility type, whether the facility offers 24-hour services, and the length of home-visit nursing experience.

关键词： Continued Nursing Bereavement Care Home-Visit Nurses Family Caregivers Bereaved Families