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World Journal of Clinical Cases 2018年第16期6卷 1094-1100页

作者： Masatoshi Nakagawa Kazuyuki kojima Mikito Inokuchi Kenta Kobayashi Toshiro Tanioka Keisuke Okuno Kentaro Gokita Department of Gastric Surgery Tokyo Medical and Dental University Center for Minimally Invasive Surgery Tokyo Medical and Dental University

AIM To investigate safety and oncological feasibility of laparoscopic total gastrectomy(LTG) in overweight(OW) *** Patients who underwent total gastrectomy(110 laparoscopic, 211 open) for gastric cancer between January 1999 and July 2016 were included. Propensity score matching selected 152 patients(76 laparoscopic, 76 open), which were subsequently divided into the OW(≥ 25) or non-OW(< 25) group by body mass index. Postoperative outcomes of laparoscopic versus open approaches were compared between OW and non-OW groups. RESULTS In the propensity-matched population, baseline characteristics were comparable between the OW and nonOW groups for the laparoscopy and open groups. In the laparoscopy group, operative time was longer(P = 0.01) in the OW group, however, other perioperative results including complication rates were comparable between the non-OW and OW groups. In the open group, number of retrieved lymph nodes were less(P = 0.03) and local complication rate was more frequent(P = 0.03) in the OW group. CONCLUSION LTG in OW patients remains technically challenging but can be performed safely. Our findings imply that OW has a lesser effect on the laparoscopic versus open approach to total gastrectomy.

关键词： Gastric cancer Laparoscopy Overweight Total gastrectomy

Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients

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World Journal of Gastroenterology 2011年第7期17卷 914-921页

作者： Takumi Akiyama Toshihiko Mizuta seiji Kawazoe Yuichiro Eguchi Yasunori Kawaguchi Hirokazu Takahashi Iwata Ozaki Kazuma Fujimoto Department of Internal Medicine Saga Medical School Department of Hepatology Saga Prefectural Hospital Department of Hepatology Saga Prefectural Hospital Saga 8408571 Japan

AIM: To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS: Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-nafive HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups according to age at HCC onset: 60 years old were lower and mean BMI values of female patients 25 kg/m2 [hazard ratio (HR), 1.8, P = 0.045], excessive alcohol consumption (HR, 2.5, P = 0.024), male sex (HR, 3.6, P = 0.002), and GGT levels > 50 IU/L (HR, 2.4, P = 0.014) were independently associated with HCC onset in patients < 60 years. Low ALT level was the only factor associated with HCC onset in patients aged ≥ 80 years. CONCLUSION: Increased BMI is associated with increased risk for early HCC development in HCV-infected patients. Achieving recommended BMI and reducing alcohol intake could help prevent hepatic carcinogenesis.

关键词： Age-at-onset Hepatocellular carcinoma Hepatitis C virus Body mass index Alcohol consumption Sex difference

Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer

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World Journal of Gastroenterology 2006年第47期12卷 7585-7590页

作者： Kenji Koishi Reigetsu Yoshikawa Tohru Tsujimura Tomoko Hashimoto-Tamaoki Syoudou kojima Hidenori Yanagi Takehira Yamamura Yoshinori Fujiwara Second Department of Surgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Second Department of Surgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Second Department of Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Genetics Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan

AIM: To study the effect of CXC chemokine receptor-4 (CXCR4) expression on disease progression and prognosis in esophageal cancer. METHODS: CXCR4 expression was evaluated in 37 patients with histologically confirmed esophageal squamous carcinomas (ESCC) undergoing preoperative chemoradiotherapy (CRT) by immunohistochemical staining. RESULTS: Eleven out of 37 ESCC patients showed a pathological complete response (CR) after CRT. CXCR4 protein expression was observed in cell cytoplasms of 13 tumors, and null expression was seen in 13 tumors. Distant recurrence was significantly more common in patients with positive CXCR4 expression (P = 0.0318). After a median follow-up time of 31.6 mo, 19 patients progressed (12 of 19 expressed positive CXCR4) and 11 died (10 of 11 expressed positive CXCR4). Overall survival was significantly correlated with lymph node metastasis (952.1 ± 53.8 d in negative group vs 475.1 ± 56.2 d in positive group, P = 0.023), distant metastasis (874.0 ± 60.4 d in negative group vs 434.9 ± 75.2 d in positive group, P = 0.014) and CRT (811.5 ± 51.2 d in responder group vs 459.6 ± 94.0 d in non-responder group, P = 0.00038) and further with an absence ofCXCR4 expression or no residual tumor (959.8 ± 51.0 d in null expression or no tumor group vs 412.0 ± 57.1 d in positive expression group, P = 0.0001). CONCLUSION: Persistent positive CXCR4 expression is implicated in tumor aggressiveness and poor prognosis in ESCC after CRT, and preoperative CRT may improve the prognosis of ESCC via CXCL12-CXCR4 signaling pathway.

关键词： CXC chemokine receptor-4 Metastasis Chemoradiotherapy Esophageal cancer

Rescue of white egg 1 mutant by introduction of the wildtype Bombyx kynurenine 3-monooxygenase gene

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Insect Science 2007年第2期14卷 85-92页

作者： GUO-XING QUAN ISAO KOBAYASHI KATSURA kojima KEIRO UCHINO TOSHIO KANDA HIDEKI SEZUTSU TORU SHIMADA TOSHIKI TAMURA Transgenic Silkworm Research Center National Institute of Agrobiological Sciences Tsukuba Ibaraki 305-8634 Japan Biomimetic Laboratory National Institute of Agrobiological Sciences Tsukuba Ibaraki 305-8634 Japan Department of Agricultural and Environmental Biology Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan

In silkworms, the white egg 1 （w-1） mutant, which is characterized by white eyes and white eggs, is deficient in Bombyx kynurenine 3-monooxygenase （KMO） activity. To investigate whether the w-1 mutant phenotype is rescued by introducing the wild-type KMO gene, we constructed transgenic silkworms with the wild-type Bombyx KMO gene under the control of either the cytoplasmic actin gene promoter （A3KMO） or the native KMO gene promoter （KKMO）. We created two transgenic lines with A3KMO and one line with KKMO constructs. The eyes of adults in these lines were brown, and the eggs laid by the transgenic females were also brown. Reverse transcription-polymerase chain reaction（RT-PCR） analysis showed that the A3KMO silkworm lines expressed the transcript in the mid-gut, fat bodies, and Malpighian tubules. The KKMO line expressed the transcript only in the fat bodies and Malpighian tubules. The intensity of eye and egg color in the transgenic lines was proportional to the KMO expression level. Interestingly, transgenic larvae with the A3KMO construct had a light brown larval cuticle, but the KKMO line did not. These results indicate that the wild-type KMO gene can be used as a marker gene for visually screening transgenic silkworms.

关键词： Bombyx mori KMO marker gene transgenic w-1

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大功率光纤激光焊熔池形态及焊接稳定性分析

焊接学报 2011年第9期32卷 13-16,113页

作者：高向东张勇游德勇 Katayama seiji 广东工业大学机电工程学院广州510006 日本大阪大学接合科学研究所

在大功率光纤激光焊接过程中,熔池热辐射含有丰富的焊接质量信息,熔池形态及其变化特征与焊接稳定性密切相关.研究一种基于红外热像的大功率光纤激光深熔焊熔池形态分析及焊缝质量稳定性评价的方法.以10 kW大功率光纤连续激光焊接304不... 详细信息

在大功率光纤激光焊接过程中,熔池热辐射含有丰富的焊接质量信息,熔池形态及其变化特征与焊接稳定性密切相关.研究一种基于红外热像的大功率光纤激光深熔焊熔池形态分析及焊缝质量稳定性评价的方法.以10 kW大功率光纤连续激光焊接304不锈钢为试验对象,应用近红外传感高速摄像机摄取熔池动态热像,通过动态自动阈值和数学形态学方法重点分析熔池和匙孔形态以及对应的焊缝宽度变化,以熔池宽度、匙孔面积和匙孔宽度作为熔池形态参数,焊缝宽度作为衡量焊接过程稳定性的参数,研究熔池形态参数与焊接稳定性的关联.结果表明,通过熔池形态参数能够较准确地反映大功率光纤激光焊接过程的稳定性.

关键词：大功率光纤激光焊红外热像熔池稳定性

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焊缝偏差RBF神经网络预测算法

焊接学报 2012年第4期33卷 1-4,113页

作者：高向东莫玲游德勇 Katayama seiji 广东工业大学机电工程学院广州510006 大阪大学接合科学研究所

以10 kW大功率光纤激光焊接304奥氏体不锈钢板为试验对象,研究一种焊缝偏差预测算法.利用红外摄像机摄取焊接过程中的熔池红外图像,提取匙孔质心、匙孔形状参数和热堆积效应参数等反映激光束与焊缝位置偏差的特征量作为径向基函数RBF神... 详细信息

以10 kW大功率光纤激光焊接304奥氏体不锈钢板为试验对象,研究一种焊缝偏差预测算法.利用红外摄像机摄取焊接过程中的熔池红外图像,提取匙孔质心、匙孔形状参数和热堆积效应参数等反映激光束与焊缝位置偏差的特征量作为径向基函数RBF神经网络预测模型的输入量,建立焊缝偏差RBF神经网络预测模型.选择焊缝偏差特征量作为训练样本并对预测模型进行训练,建立焊缝偏差预测模型.结果表明,该模型能够对大功率光纤激光焊接过程中的激光束与焊缝位置之间的偏差进行有效预测.

关键词：大功率光纤激光焊 RBF神经网络焊缝偏差预测

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Severe hypercholesterolemia associated with primary biliary cirrhosis in a 44-year-old Japanese woman

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World Journal of Gastroenterology 2004年第17期10卷 2607-2608页

作者： Tatsuo Kanda Osamu Yokosuka Hiroshige kojima Fumio Imazeki Keiich Nagao Ichiro Tatsuno Yasushi Saito Hiromitsu Saisho First Department of Medicine Chiba University School of MedicineChiba 260-8670Japan Health Sciences CenterChiba UniversityChiba 260-8670Japan Health Sciences Center Chiba UniversityChiba 260-8670Japan Second Department of Medicine Chiba University School of MedicineChiba 260-8670Japan

A 44-year-old woman developed jaundice and was diagnosed as stage Ⅱ of primary biliary cirrhosis(PBC).She showed a severely high total cholesterol *** article focuses on atypical presentations of PBC and the need to ... 详细信息

关键词： Adult Cholesterol Female Humans Hypercholesterolemia Japan Liver Cirrhosis, Biliary Severity of Illness Index

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色噪声下卡尔曼滤波焊缝跟踪算法与试验研究

控制理论与应用 2011年第7期28卷 931-935页

作者：高向东仲训杲游德勇 KATAYAMA seiji 广东工业大学机电工程学院广东广州510006 大阪大学接合科学研究所

精确控制激光束使其始终对中并跟踪焊缝是保证激光焊接质量的前提.以大功率光纤激光焊接Type304不锈钢为试验对象,研究一种有色噪声环境下应用卡尔曼滤波最优状态估计预测激光束与焊缝路径偏差的方法.使用高速红外视觉传感器摄取焊接区... 详细信息

精确控制激光束使其始终对中并跟踪焊缝是保证激光焊接质量的前提.以大功率光纤激光焊接Type304不锈钢为试验对象,研究一种有色噪声环境下应用卡尔曼滤波最优状态估计预测激光束与焊缝路径偏差的方法.使用高速红外视觉传感器摄取焊接区红外热像,提取焊缝位置参数并构成状态向量,建立基于焊缝位置参数的系统状态方程和焊缝位置测量方程.针对系统动态噪声为有色噪声,通过扩展状态变量的方法建立有色噪声环境下的卡尔曼滤波算法,对焊缝位置进行最优状态估计并得到最小均方差条件下的焊缝偏差最优预测值,消除系统噪声对焊缝偏差测量的影响.焊接试验结果表明新方法可有效抑制有色噪声干扰并提高焊缝跟踪精度.

关键词：焊缝跟踪色噪声卡尔曼滤波大功率光纤激光焊

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Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome

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World Journal of Gastroenterology 2012年第13期18卷 1508-1516页

作者： Masahide Hamaguchi Noriyuki Takeda Takao kojima Akihiro Ohbora Takahiro Kato Hiroshi Sarui Michiaki Fukui Chisato Nagata Jun Takeda Immunology Frontier Research Center at Osaka University Osaka 5650871Japan Department of Endocrinology and Metabo lism Murakami Memorial HospitalAsahi UniversityGifu 5008523Japan Department of Gastroenterology Murakami Memorial HospitalAsahi UniversityGifu 5008523Japan Department of Endocrinology and Metabolism Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 6028566Japan Department of Epidemiology and Preventive Medicine Graduate School of MedicineGifu UniversityGifu 5008523Japan Department of Diabetes and Endocrinology Division of Molecule and StructureGraduate School of MedicineGifu UniversityGifu 5008523Japan

AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health checkup program including abdominal *** study involved 11 714 apparently healthy Japanese men and women,18 to 83 years of *** was defined by abdominal ultrasonography without an alcohol intake of more than 20 g/d,known liver disease,or current use of *** revised criteria of the National Cholesterol Education Program Adult Treatment PanelⅢ were used to characterize the metabolic ***:NAFLD was detected in 32.2%(95%CI:31.0%-33.5%)of men(n=1874 of 5811)and in 8.7%(95%CI:8.0%-9.5%)of women(n=514 of 5903).Among obese people,the prevalence of NAFLD was as high as 67.3%(95%CI:64.8%-69.7%)in men and 45.8%(95%CI:41.7%-50.0%)in *** NAFLD was thought of as being the liver phenotype of metabolic syndrome,the prevalence of the metabolic syndrome among subjects with NAFLD was low both in men and women.66.8%of men and 70.4%of women with NAFLD were not diagnosed with the metabolic syndrome.48.2%of men with NAFLD and 49.8%of women with NAFLD weren't overweight[body mass index(BMI)≥25 kg/m2].In the same way,68.6%of men with NAFLD and 37.9%of women with NAFLD weren't satisfied with abdominal classification(≥90 cm for men and≥80 cm for women).Next,authors defined it as positive at screening for NAFLD when participants satisfied at least one criterion of metabolic *** sensitivity of the definition"at least 1 criterion"was as good as 84.8%in men and 86.6%in *** subjects by BMI,the sensitivity was higher in obese men and women than in non-obese men and women(92.3%vs 76.8%in men,96.1%vs 77.0%in women,respectively).CONCLUSION:Authors could determine NAFLD effectively in epidemiological study by modifying the usage of the criteria for metabolic syndrome.

关键词： Nonalcoholic fatty liver Metabolic syndrome Population based study Methodology

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中国美术学院博物馆

城市环境设计 2024年第1期147卷 76-81页

作者：藤原徹平寺川奈穂子小岛伸也加纳永一

中国美术学院博物馆位于中国美院杭州象山校区，坐落在一片曾经的茶场上。为了与大地融为一体，创造出能够感受大地的博物馆，沿着山坡的倾斜地面进行了连续的设计。通过以平行四边形为单位的几何分割系统，进行了复杂地形的规划，并通...

中国美术学院博物馆位于中国美院杭州象山校区，坐落在一片曾经的茶场上。为了与大地融为一体，创造出能够感受大地的博物馆，沿着山坡的倾斜地面进行了连续的设计。通过以平行四边形为单位的几何分割系统，进行了复杂地形的规划，并通过为每个单位建造小屋顶，形成了连续的瓦屋顶的“村庄”景观。外墙上覆盖着一道“屏风”，由不锈钢丝外挂瓷砖构成，有助于控制进入房间的阳光。屏风和屋顶的旧瓷砖都来自本地烧的瓦。瓦片尺寸的变化使建筑更好地与大地融合。

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