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Limited, local, extracolonic spread of mucinous appendiceal adenocarcinoma after perforation with formation of a malignant appendix-to-sigmoid fistula: Case report and literature review

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World Journal of Gastroenterology 2016年第38期22卷 8624-8630页

作者： seifeldin hakim Mitual Amin Mitchell S Cappell Division of Gastro-enterology and Hepatology Department of Internal MedicineWilliam Beaumont Hospital Royal Oak MI 48073 Unites States Department of Pathology William Beaumont Hospital Royal Oak MI 48073 Unites States Oakland University William Beaumont School of Medicine Royal Oak MI 48073 Unites States

A 68-year-old man presented with progressive right lower quadrant abdominal pain and tenderness without rebound tenderness, and with constipation during the prior 9 mo. Abdomino-pelvic computed tomography and magnetic resonance imaging demonstrated a dilated appendix forming a fistula to the sigmoid colon. Open laparotomy revealed a bulky abdominal tumor involving appendix, cecum, and sigmoid, and extending up to adjacent viscera, without ascites or peritoneal implants. The abdominal mass was removed en bloc, including resection of sigmoid colon, cecum(with preservation of ileocecal valve), appendix, right vas deferens, testicular vessels, and minimal amounts of anterior abdominal wall; and shaving off of small parts of the walls of the urinary bladder and small bowel. Gross and microscopic pathologic examination revealed an appendix-to-sigmoid malignant fistula secondary to perforation of mucinous adenocarcinoma of the appendix with minimal local spread(stage T4). However, the surgical margins were clear, all 13 resected lymph nodes were cancer-free, and pseudomyxoma peritonei or peritoneal implants were not present. The patient did well during 1 year of follow-up with no clinical or radiologic evidence of local recurrence, metastases, or pseudomyxoma peritonei despite presenting with extensive stage T4 cancer that was debulked without administering chemotherapy, and despite presenting with malignant appendiceal perforation. This case illustrates the non-aggressive biologic behavior of this low-grade malignancy. The fistula may have prevented free spillage of cancerous cells and consequent distant metastases by containing the appendiceal contents largely within the colon.

关键词： Mucinous adenocarcinoma Appendicitis Appendix Malignant fistula Pseudomyxoma peritonei Colon cancer Metastases

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Two case reports of acute upper gastrointestinal bleeding from duodenal ulcers after Roux-en-Y gastric bypass surgery: Endoscopic diagnosis and therapy by single balloon or push enteroscopy after missed diagnosis by standard esophagogastroduodenoscopy

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World Journal of Gastrointestinal Endoscopy 2017年第10期9卷 521-528页

作者： seifeldin hakim Srinivas R Rami Reddy Mihaela Batke Gregg Polidori Mitchell S Cappell Division of Gastroenterology and Hepatology Department of MedicineWilliam Beaumont Hospital Oakland University William Beaumont School of Medicine

The diagnosis and opportunity for endoscopic therapy of gastric or duodenal lesions may be missed at esophagogastroduodenoscopy(EGD) because of technical difficulty in intubating at EGD the postoperatively excluded stomach and proximal duodenum in patients status post Roux-en-Y gastric bypass(RYGB). Two cases are reported of acute upper gastrointestinal bleeding 10 or 11 years status postRYGB, performed for morbid obesity, in which the EGD was non-diagnostic due to failure to intubate the excluded stomach and proximal duodenum, whereas subsequent push enteroscopy or single balloon enteroscopy were diagnostic and revealed 4-cm-wide or 5-mm-wide bulbar ulcers and even permitted application of endoscopic therapy. These case reports suggest consideration of push enteroscopy, or single balloon enteroscopy, where available, in the endoscopic evaluation of acute UGI bleeding in patients status post RYGB surgery when the EGD was non-diagnostic because of failure to intubate these excluded segments.

关键词： Morbid obesity Bariatric surgery Roux-en-Y gastric bypass surgery Upper gastrointestinal bleeding Esophagogastroduodenoscopy Push enteroscopy Single balloon enteroscopy Therapeutic endoscopy Double balloon enteroscopy

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History, current status, and prospects of soybean production and research in sub-Saharan Africa

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The Crop Journal 2018年第3期6卷 226-235页

作者： Dalia Mohamedkheir Khojely seifeldin Elrayah Ibrahim Enoch Sapey Tianfu Han MOA Key Lab of Soybean Biology (Beijing) Institute of Crop SciencesChinese Academy of Agricultural Sciences Gezira Research Station Agricultural Research Corporation (ARC) Oil Palm Breeding and Genetics CSIR-Oil Palm Research Institute

Soybean(Glycine max(L.) Merr.) is a non-native and non-staple crop in sub-Saharan Africa(SSA) with potential to be a commercial crop owing to its wide range of uses as food, feed,and industrial raw material. Soybean was first introduced to SSA by Chinese traders in the19 th century and was cultivated as an economic crop as early as 1903 in South Africa. In the past four decades, soybean cultivation area and production in SSA has increased exponentially, from about 20,000 ha and 13,000 t in the early 1970 s to 1,500,000 ha and2,300,000 t in 2016. Soybean yield has been stagnant in SSA for decades at about 1.1 t ha^(-1),much lower than the world average, representing one of the most challenging issues in the soybean industry in SSA. The low soybean yield in SSA can be attributed to the use of poorperforming varieties and to the limited application of fertilizers and rhizobial inoculants in soils with no history of soybean production. South Africa, Nigeria, Zambia, and Uganda are the leading soybean producers in SSA. Soybean research in SSA is conducted by international and national research institutions, including IITA, national soybean improvement programs, universities, and the private sector. Between 1970 and 2011, 195 soybean varieties were released by IITA, private breeders, and national soybean improvement programs in SSA. This paper reviews the history and current state of soybean production and of the utilization and adoption of tropical varieties in SSA, addresses the major soybean yield-limiting factors across the region, and discusses the potential of the soybean industry in SSA. It also highlights soybean improvement efforts and lessons learned from previous soybean improvement efforts and the current progress of some national soybean improvement programs in SSA. Opportunities for scaling up tropical soybean as a major crop across SSA countries are promising.

关键词： Soybean Sub-Saharan Africa(SSA) History Current status Prospects

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Sediment balances in the Blue Nile River Basin

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International Journal of Sediment Research 2014年第3期29卷 316-328页

作者： Yasir S.A.ALI Alessandra CROSATO Yasir A.MOHAMED seifeldin H.ABDALLA Nigel G.WRIGHT UNESCO-IHE Westvest 72601 DA Delftthe Netherlands and Hydraulics Research CenterMinistry of Water Resources and ElectricityP.O.Box 318Wad MedaniSudan UNESCO-IHE Westvest 72601 DA Delft and Profat Hydraulics Research CenterMinistry of Water Resources and Electricity School of Civil Engineering University of LeedsFaculty of EngineeringLeeds LS2 9JT.United Kingdom Water Resources Technical Organ Ministry of Water Resources and ElectricityKhartoumSudan UNESCO-IHE Westvest 72601 DA Delft and Research Associate at Civil Engineering and Geosciences Delft University of TechnologyStevin weg 12628 CN Delftthe Netherlands

Rapid population growth in the upper Blue Nile basin has led to fast land-use changes from natural forest to agricultural *** resulted in speeding up the soil erosion process in the highlands and increasing sedimentation further downstream in reservoirs and irrigation *** present,several dams are planned across the Blue Nile River in Ethiopia and the Grand Ethiopian Renaissance Dam is currently under construction near the border with *** will be the largest hydroelectric power plant in *** objective of this paper is to quantify the river flows and sediment loads along the Blue Nile River *** Soil and Water Assessment Tool was used to estimate the water flows from un-gauged *** assess model performance,the estimated sediment loads were compared to the measured ones at selected *** the gauged sub-basins,water flows and sediment loads were derived from the available flow and sediment *** fill in knowledge gaps,this study included a field survey in which new data on suspended solids and flow discharge were collected along the Blue Nile and on a number of *** comparison between the results of this study and previous estimates of the sediment load of the Blue Nile River at El Deim,near the Ethiopian Sudanese border,show that the sediment budgets have the right order of magnitude,although some uncertainties *** gives confidence in the results of this study providing the first sediment balance of the entire Blue Nile catchment at the sub-basin scale.

关键词： Blue Nile basin Sediment balance Field data Rating curve SWAT model

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Age distribution,polyps and rectal cancer in the Egyptian population-based cancer registry

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World Journal of Gastroenterology 2012年第30期18卷 3997-4003页

作者： Darlene Veruttipong Amr S Soliman Samuel F Gilbert Taylor S Blachley Ahmed Hablas Mohamed Ramadan Laura S Rozek Ibrahim A seifeldin Department of Epidemiology University of Michigan School of Public HealthAnn ArborMI 48109United States Department of Biostatistics University of Michigan School of Public HealthAnn ArborMI 48109United States Tanta Cancer Center and the Gharbiah Population-Based Cancer Registry Tanta 31512Egypt Department of Environmental Health Science University of Michigan School of Public HealthAnn ArborMI 48109United States

AIM:To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based ***:The Gharbiah cancer registry is the only population-based cancer registry in Egypt since *** analyzed the data of all colorectal cancer patients included in the registry for the period of *** medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted:age,residence,diagnosis date,grade,stage,topology,clinical characteristics,and histology *** census data for 1996 and 2006 were used to provide the general population's statistics on age,sex,residence and other related demographic *** addition to age-and sex-specific incidence rate analyses,we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the *** also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results(SEER) data of the United ***:Over the 9 year-period,1364 colorectal cancer cases were *** disease incidence under age 40 years was relatively high(1.3/10 5) while the incidence in the age groups 40 and over was very low(12.0/10 5,19.4/10 5 and 21.2/10 5 in the age groups 40-59 years,60-69 years and > 70 years,respectively).The vast majority of tumors(97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the *** cancer was more common in patients from urban(55%) than rural(45%) *** differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this *** registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 *** results also shows significantly lower incidence of colorectal cancer in subjects over age

关键词： Colorectal cancer Young-onset Polyps Developing countries Egypt

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A new early maturing soybean varieties for irrigated and rainfed farming in Sudan

A new early maturing soybean varieties for irrigated and rai...

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第十届全国大豆学术讨论会

作者： seifeldin Elrayah Ibrahim Amin Elsir Ahmed Mohamed Ahmed Elzaki Han Tian-fu Gezira Research Station Agricultural Research Corporation(ARC) MOA Key Laboratory of Soybean Biology Institute of Crop ScienceChinese Academy of Agricultural Sciences

Soybean[Glycine max(L.) Merr.]production in Sudan relies on two late maturing released varieties,which may limit the expansion of the crop into irrigated and rainfed *** of early maturing soybean varieties with high-yielding is a target for soybean breeding program in Agricultural Research Corporation(ARC),*** selected promiscuous soybean varieties introduced from International Institute of Tropical Agriculture(IITA) were evaluated in eight environments in Wad Medani,Kenana and Damazin from 2014 to *** 1 and Sudan 2 varieties were used as *** trials were arranged at a randomized complete block design with four ***-row plots,10 m in long and 80 cm apart,were *** were collected on days to 50%flowering,days to maturity,plant height(cm),height to first pod(cm),grain yield(kg/ha),fodder yield(kg/ha),number of pods/plant and 100-seed weight(g).Grain quality analysis was performed for oil and protein *** of variance and stability analysis for grain yield were carried out with SAS version 9.1(SAS Institute 2003).Grain yield(kg/ha) was significantly(P< 0.001) affected by environment,variety and variety x environment *** eight environment days to maturity and grain yield(kg/ha) ranged from 99-121 days and from 1588-2395 kg/ha,*** best grain yield at Wad Medani and Kenana were from the late maturing varieties Sudan 1(3026 and 2938 kg/ha) and Sudan 2(2964 and 2827 kg/ha) followed by TGx-1485-lD(2862 and 2726 kg/ha),*** the best grain yield at Damazin were from the early maturing varieties Soya04 and TGx-1835-10 E(1482 and 1462 kg/ha) followed by the late maturing varieties Sudan 1 and Sudan 2(1403 and 1362 kg/ha),***,Soya04 matured 15 and 14 days earlier than check varieties Sudan 1 and Sudan 2,respectively,while TGx-1835-10 E matured 22 and 21 days earlier than check varieties Sudan 1 and Sudan 2,***,Soya04 and TGx-1835-10 E

关键词： Soybean New variety Early maturity Sudan

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造血干细胞移植患者中抗真菌预防治疗的成本-效果分析

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中国药物经济学 2009年第3期4卷 58-68页

作者： Warren Schonfeld J Wang Cheng Kuo B Tong Raafat seifeldin 杨莉

背景:米卡芬净已经被批准用于对造血干细胞移植患者中念珠菌感染的预防治疗。一项临床Ⅲ期、多中心的随机双盲对比试验入组了882例成年及儿童患者,该试验发现米卡芬净能预防系统性真菌感染使其发生率显著降低,并在经验性抗真菌治疗方面... 详细信息

背景:米卡芬净已经被批准用于对造血干细胞移植患者中念珠菌感染的预防治疗。一项临床Ⅲ期、多中心的随机双盲对比试验入组了882例成年及儿童患者,该试验发现米卡芬净能预防系统性真菌感染使其发生率显著降低,并在经验性抗真菌治疗方面优于氟康唑在造血干细胞移植后的中性粒细胞减少期内作为抗真菌预防治疗的效果。尽管米卡芬净比氟康唑的药品费用高,但它可以降低相关治疗费用。目的:对米卡芬净与氟康唑在接受造血干细胞移植患者中的预防治疗作用进行成本-效果分析。方法:从医院角度出发,费用计算从患者入院开始至出院结束,效果基于临床试验取得的临床转归数据。采用已经发表的文献估算与造血干细胞移植和预防治疗、经验性抗真菌治疗和一次可能或确诊的念珠菌或曲霉感染的治疗相关的费用。每个治疗组都进行了平均成本-效果比的计算。为了检验分析结果的变化采用了重复抽样,还使用Bootstrap法对从每个治疗组随机抽取的100例患者进行了1000次模拟分析。计算了增量成本-效果比,并对不同成本进行了敏感度分析。结果:本研究分析的数据来自882例患者[527例男性,355例女性;使用米卡芬净患者425例,平均年龄43.2岁(年龄0.6～73.0岁);使用氟康唑患者457例,平均年龄41.9岁(年龄0.6～71.0岁)]。米卡芬净治疗组和氟康唑治疗组每例患者的总住院费用分别是121098美元和124957美元,相差3859美元。Bootstrap分析表明米卡芬净预防治疗真菌感染在72.4%的样本中节省了费用,而氟康唑预防治疗仅在9.2%的样本中节省了费用。对住院费用的敏感度分析表明米卡芬净是一种具有良好成本-效果的治疗方法。结论:本研究通过对一项接受造血干细胞移植的成年和儿童患者进行的临床试验获得的数据分析发现,米卡芬净与氟康唑相比能减少抗真菌预防治疗的住院费用和总的相关治疗费用。

关键词：成本-效果分析抗真菌预防治疗米卡芬净氟康唑造血干细胞移植

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