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Elevated fluid and glycosaminoglycan content in the Achilles tendon contribute to higher intratendinous pressures:Implications for Achilles tendinopathy

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Journal of Sport and Health Science 2024年第6期13卷 863-871页

作者： Lauren pringels Gert-Jan Van Valckenborgh patrick segers Amelie Chevalier Hedwig Stepman Evi Wezenbeek Arne Burssens Luc Vanden Bossche Department of physical and Rehabilitation Medicine Ghent University HospitalGhent 9000Belgium Department of Rehabilitation Sciences and physiotherapy Ghent UniversityGhent 9000Belgium Department of Electronics and Information Systems Ghent UniversityGhent 9000Belgium Department of Electromechanics University of AntwerpAntwerp 2020Belgium Department of Laboratory Medicine Ghent University HospitalGhent 9000Belgium Department of Orthopedic Surgery Ghent University HospitalGhent 9000Belgium

Background:Tendinopathy alters the compositional properties of the Achilles tendon by increasing fluid and glycosaminoglycan *** has been speculated that these changes may affect intratendinous pressure,but the extent of this relationship remains ***,we aimed to investigate the impact of elevated fluid and glycosaminoglycan content on Achilles tendon intratendinous pressure and to determine whether hyaluronidase(HYAL) therapy can intervene in this potential ***:Twenty paired fresh-frozen cadaveric Achilles tendons were mounted in a tensile-testing machine and loaded up to 5% *** resting(at 0% strain) and dynamic pressure(at 5% strain) were assessed using the microcapillary infusion ***,intratendinous pressure was measured under native conditions before and after infusion of 2 mL physiological ***,80 mg of glycosaminoglycans were administered bilaterally to the paired *** right tendons were additionally treated with 1500 units of ***,both groups were retested,and the glycosaminoglycan content was ***:It was found that both elevated fluid and glycosaminoglycan content resulted in higher intratendinous resting and dynamic pressures(p p=0.002) and restored intratendinous ***:The results of this study demonstrated that elevated fluid and glycosaminoglycan content in Achilles tendinopathy contribute to increased intratendinous re sting and dynamic pressures,which can be explained by the associated increased volume and reduced permeability of the tendon matrix,*** degrades glycosaminoglycans sufficiently to lower intratendinous pressures and may,therefore,serve as a promising treatment.

关键词： Achilles tendon Achilles tendinopathy Intratendinous pressure Glycosaminoglycans Tendon fluid

脉搏波反射幅度对死亡率的预测作用:动脉粥样硬化多种族研究

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中华高血压杂志 2014年第11期22卷 1042-1042页

作者：刘莉叶鹏 Zamani p Jacobs DR Jr segers p Duprez DA Brumback L Kronmal RA Lilly SM Townsend RR Budoff M Lima JA Hannan p Chirinos JA

研究表明,纯亚裔人群中脉搏波反射与死亡率相关。但是,多种族人群中是否存在这样的关系,以及其是否独立于亚临床动脉粥样硬化,尚未确定。该研究人员假设,以社区为基础的多种族成人样本中,脉搏波反射幅度（定义为后向波振幅pb与前向波振... 详细信息

研究表明,纯亚裔人群中脉搏波反射与死亡率相关。但是,多种族人群中是否存在这样的关系,以及其是否独立于亚临床动脉粥样硬化,尚未确定。该研究人员假设,以社区为基础的多种族成人样本中,脉搏波反射幅度（定义为后向波振幅pb与前向波振幅pf的比值）与全因死亡率相关。方法与结果：纳入多种族动脉粥样硬化研究中,行动脉张力波形分析的5984名受试者作为研究对象。

关键词：亚临床动脉粥样硬化全因死亡率种族人群波反射预测作用脉搏社区为基础研究人员

严重急性营养不良幸存者成年后心血管结构和功能受损

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中华高血压杂志 2014年第8期22卷 758-758页

作者：刘莉叶鹏 Tennant IA Barnett AT Thompson DS Kips J Boyne M Chung EE Chung Ap Osmond C Hanson MA Gluckman pD segers p Cruickshank JK Forrester TE

儿童严重急性营养不良（severe acute malnutrition,SAM）分为水肿（恶性营养不良）或非水肿（消瘦）两种形式,两者对心血管的长期影响尚不清楚。研究人员假设,SAM幸存者成年后的心血管结构和功能较儿童期无营养不良者差。方法：纳入11... 详细信息

儿童严重急性营养不良（severe acute malnutrition,SAM）分为水肿（恶性营养不良）或非水肿（消瘦）两种形式,两者对心血管的长期影响尚不清楚。研究人员假设,SAM幸存者成年后的心血管结构和功能较儿童期无营养不良者差。方法：纳入116名已成年的SAM幸存者,其中54名为非水肿型,62名为水肿型,同时纳入45名年龄、性别、体质量指数相匹配的儿童期无营养不良的成人作为对照组。所有受试者均接受标准化人体学测量、血压测量、超声心动图和动脉张力测量。同时测定左心室质量指数、流出道内径、颈动脉参数和脉搏波传导速度,计算全身血管阻力。结果：受试者平均年龄为（28.8±7.8）岁,55%为男性。调整年龄、性别、身高、体质量后,与对照组相比,SAM幸存者左心室流出道内径、每搏输出量、心输出量、

关键词：心血管结构营养不良幸存者功能受损成年急性左心室流出道体质量指数

Effects of Sodium Citrate plus Sodium Diacetate and Buffered Vinegar on Quality Attributes of Enhanced Beef Top Rounds

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Food and Nutrition Sciences 2012年第3期3卷 354-362页

作者： Amudhan ponrajan Mark A. Harrison Timothy D. pringle Jacob R. segers Bradley K. Lowe Russell O. McKeith Alexander M. Stelzleni 1Department of Animal and Dairy Sciences Meat Science Technology Center University of Georgia Athens USA 2Department of Food Science and Technology University of Georgia Athens USA. Department of Animal and Dairy Sciences Meat Science Technology Center University of Georgia Athens USA Department of Food Science and Technology University of Georgia Athens USA.

The effect of two antimicrobials in the enhancement solution was investigated in this study. Sensory and shelf-life characteristics were measured for beef top rounds enhanced to 110% with 0.5% sodium chloride and 0.4% sodium tripolyphosphate (CNT);CNT with a 1% solution of 80% sodium citrate plus 20% sodium diacetate (SC + D);or CNT with 2% buffered vinegar (VIN) in the final product. SC + D and VIN had less (p 0.05). However, SC + D had lower (p 0.05) for all enhancement solutions within each day. After 7 days of retail display, SC + D retarded (p pid oxidation to a greater extent than VIN or CNT samples. Sodium citrate plus sodium diacetate or buffered vinegar may be included in enhancement solutions without having a large influence on subjective color, and may aid in improving sensory tenderness.

关键词： Beef Enhancement Quality Sensory Shelf-Life

用免疫缺陷雄性F_1代小鼠制备抗问号钩端螺旋体外膜蛋白的单克隆抗体

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北京实验动物科学 1992年第3期9卷 40-41页

作者： Ruud p. A. M. segers Arne De Nijs peter J. S. VanKooten 步恒富陈娟北京太平路27号军事医科院实验动物中心 100039

单克隆抗体(McAbs)已成为人们研究细菌蛋白在致病机制及抗体反应中之作用的一种重要工具。问号钩端螺旋体(Leptospira interrogans)是引起Weil氏病和“牛乳热”(Dairy Fever)的病原体,由糖、脂和至少9种蛋白构成的外膜所包绕。钩体外膜... 详细信息

单克隆抗体(McAbs)已成为人们研究细菌蛋白在致病机制及抗体反应中之作用的一种重要工具。问号钩端螺旋体(Leptospira interrogans)是引起Weil氏病和“牛乳热”(Dairy Fever)的病原体,由糖、脂和至少9种蛋白构成的外膜所包绕。钩体外膜与纯化脂多糖(LpS)一样也可诱发免疫保护反应,

关键词：单克隆抗体钩端螺旋体免疫缺陷鼠

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妊娠诱发的拉莫三嗪药代动力学改变

世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 59-59页

作者： De Haan G.-J. Edelbroek p. segers J. 高中宝 SEIN P.O. Box 21 2100 AA Heemstede Netherlands Dr.

The authors describe 12 pregnancies in women with epilepsy using lamotrigine (LTG) monotherapy. A seizure increase in nine pregnancies was probably related to a gradual decline of LTG level to dose ratio to 40% of baseline. After delivery, LTG kinetics returned swiftly to baseline, causing toxic side effects in some women. Frequent LTG level monitoring and appropriate dose adjust ents are advised in the period before and during pregnancy and after delivery, especially in women on LTG monotherapy.

关键词：拉莫三嗪药代动力学血药浓度监测抗癫痫药物剂量比毒副作用基础水平