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2002 3rd International Conference on Microwave and Millimeter Wave Technology

作者： A.K.Rastogi seema hardikar Department of Physics Govt.M.V.M.Bhopal(M.P.) India-462008

This paper describes the work involved in designing a microstrip-to-slotline transition[1]&[2].Two of these transitions would be required in order to meet the specifications of obtaining a maximum insertion loss(S) of -0.5 dB with a minimum return loss of-20 dB throughout the 8-10 GHz range.A CAD package for the design of RF/microwave circuit have been used to analyze and optimize the transition *** transmission line circuit models were used to optimize the *** transition would be fabricated on 1.27 mm thick RT-Duroid 6010.2 substrate and the S-parameters would be measured using standard SMA connectors and a HP-8501A Network Analyzer.A spectral domain Galerkin’s method is used to compute the characteristic impedance of wide slotline on the substrate.

关键词： Microstrip Design optimization Microwave theory and techniques Insertion loss Design automation Packaging Radio frequency Microwave circuits Performance analysis Distributed parameter circuits

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Author Correction:Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24

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Cellular & Molecular Immunology 2024年第1期21卷 100-100页

作者： Zhengzhou Ying Swanand hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M.McBride Taiping Chen Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Houston TX 77030 USA

In the sentence beginning‘To trace cell proliferation,FO and MZ B cells’and the sentence beginning‘For cell activation,naïve B cells or CH12F3 cells’in this article,the[10 ng/ml]‘F(ab’)_(2)fragment goat anti-mouse IgM’should have read‘10μg/ml F(ab’)_(2)fragment goat anti-mouse IgM’.The original article has been corrected.

关键词： immunodeficiency CD19 deficient

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Intrahepatic cholestasis of pregnancy:When should you look further?

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World Journal of Gastroenterology 2009年第9期15卷 1126-1129页

作者： Winita hardikar Shivani Kansal Ronald P J Oude Elferink Peter Angus Victorian Liver Transplant Unit Austin HospitalMelbourne 3084Australia Department of Gastro-enterology&Clinical Nutrition Royal Children's HospitalMelbourne 3052Australia Department of Paediatrics University of MelbourneMelbourne 3052Australia Murdoch Children's Research Institute Melbourne 3052Australia AMC Liver Centre Academic Medical CentreAmsterdam 1105AZThe Netherlands

Pruritis with abnormal liver function tests is the classical presentation of intrahepatic cholestasis of pregnancy(ICP),a condition associated with significant fetal *** the etiology of ICP is unclear in many cases,certain features of the clinical presentation should alert the practitioner to the possibility of an underlying metabolic defect, which may not only affect subsequent pregnancies, but may be an indicator of more serious subsequent liver *** report a kindred of Anglo-Celtic descent,among whom many members present with ICP,gallstones or cholestasis related to use of oral *** studies revealed a novel mutation in the ABCB4 gene,which codes for a phospholipid transport *** clinical significance of this mutation and the importance of identifying such patients are discussed.

关键词： ABCB4 gene ABCB4 transporter Phospholipids Cholestasis of pregnancy Gallstones

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The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation

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Protein & Cell 2020年第3期11卷 214-218页

作者： Swanand hardikar Zhengzhou Ying Yang Zeng Hongbo Zhao Bigang Liu Nicolas Veland Kevin McBride Xiaodong Cheng Taiping Chen Taiping Chen11 Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer CenterSmithvilleTX 78957USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical SciencesHoustonTX 77030USA Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Obstetrics and Gynecology HospitalFudan UniversityShanghai 200011China

Dear Editor,Immunodeficiency,centromeric instability,and facial anomalies(ICF)syndrome is a rare autosomal recessive disorder characterized by antibody deficiency,facial dysmorphism,failure to thrive,and mental *** with ICF syndrome suffer from recurrent and often fatal infections in early childhood.A hallmark of ICF syndrome is loss of DNA methylation in special genomic regions,most notably satellite repeats at centromeric regions,which leads to heterochromatin decondensation and chromosomal abnormalities in lymphocytes(Ehrlich et al.,2008).

关键词： Ehrlich facial lymphocytes

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Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24

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Cellular & Molecular Immunology 2023年第12期20卷 1487-1498页

作者： Zhengzhou Ying Swanand hardikar Joshua B.Plummer Tewfik Hamidi Bin Liu Yueping Chen Jianjun Shen Yunxiang Mu Kevin M.McBride Taiping Chen Department of Epigenetics and Molecular Carcinogenesis The University of Texas MD Anderson Cancer CenterHoustonTX77030USA Program in Genetics and Epigenetics The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical SciencesHoustonTX77030USA

Immunodeficiency,centromeric instability,and facial anomalies(ICF)syndrome is a rare autosomal recessive disorder characterized by DNA hypomethylation and antibody *** is caused by mutations in DNMT3B,ZBTB24,CDCA7,or *** progress has been made in elucidating the roles of these genes in regulating DNA methylation,little is known about the pathogenesis of the life-threatening hypogammaglobulinemia ***,we show that mice deficient in Zbtb24 in the hematopoietic lineage recapitulate the major clinical features of patients with ICF ***,Vav-Cre-mediated ablation of Zbtb24 does not affect lymphocyte development but results in reduced plasma cells and low levels of IgM,IgG1,and ***24-deficient mice are hyper and hypo-responsive to T-dependent and T-independent type 2 antigens,respectively,and marginal zone B-cell activation is ***,Zbtb24-deficient B cells show severe loss of DNA methylation in the promoter region of Il5ra(interleukin-5 receptor subunit alpha),and Il5ra derepression leads to elevated CD19 *** disruption of Cd19 can revert the hypogammaglobulinemia phenotype of Zbtb24-deficient *** results suggest the potential role of enhanced CD19 activity in immunodeficiency in ICF syndrome.

关键词： ICF syndrome ZBTB24 CD19 IL-5Ra hypogammaglobulinemia

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光伏制造中冷喷涂溅射靶的力学性能表征方法

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热喷涂技术 2015年第4期7卷 53-60页

作者： Johannes Vlcek Kedar hardikar Daniel R Juliano 周小彬 MiaSole高科技公司汉能公司不详

本文中巴西圆盘试验被应用于冷喷涂Cu-In-Ga涂层的力学性能测试。这个实验的主要优势在于材料可以最终产品形态来测试,同时自然的可以通过选择合适的材料尺寸大小来观察微观相和缺陷的分布。试样的应力状态可以通过闭合分析获得,并且测... 详细信息

本文中巴西圆盘试验被应用于冷喷涂Cu-In-Ga涂层的力学性能测试。这个实验的主要优势在于材料可以最终产品形态来测试,同时自然的可以通过选择合适的材料尺寸大小来观察微观相和缺陷的分布。试样的应力状态可以通过闭合分析获得,并且测试也可以直接扩展获得应力-应变曲线。尽管由于其典型的脆性,受限于低延展性材料,巴西圆盘仍然是获得冷喷涂涂层理想的性能测试手段。

关键词：冷喷涂溅射靶材力学性能巴西圆盘

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12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染患者时安全有效

12周的来迪派韦/索磷布韦用于3至<6岁的慢性丙型肝炎病毒儿童感染...

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第十届全国疑难及重症肝病大会

作者： Kathleen B.Schwarz Philip Rosenthal Karen F.Murray Jonathan Robert Honegger Winita hardikar Rosemary Hague Naveen Mittal Benedetta Massetto Diana Brainard Rebecca Begley Bandita Parhy Jiang Shao Michael R.Narkewicz Girish S.Rao Suzanne Whitworth Sanjay Bansal William F.Balistreri Johns Hopkins Hospital University of California San Francisco University of Washington School of Medicine and Seattle Children's Hospital The Ohio State University Medical Center The Royal Children's Hospital

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOF FDC...

背景基于索磷布韦的治疗方案已被批准用于12至<18岁的青少年患者,但对于年龄更小的儿童患者而言,标准治疗方案仍然是长达48周的聚乙二醇化干扰素+利巴韦林。之前,我们报告了有关12周或24周的来迪派韦/索磷布韦固定剂量组合(LDV/SOF FDC)用于6至<12岁的患者中时的数据,其SVR12率分别为99%-100%。本研究评估了全口服LDV/SOF FDC疗法用于3至<6岁

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