The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation

作     者：Swanand Hardikar Zhengzhou Ying Yang Zeng Hongbo Zhao Bigang Liu Nicolas Veland Kevin McBride Xiaodong Cheng Taiping Chen Swanand Hardikar;Zhengzhou Ying;Yang Zeng;Hongbo Zhao;Bigang Liu;Nicolas Veland;Kevin McBride;Xiaodong Cheng;Taiping Chen

作者机构：Taiping Chen11 Department of Epigenetics and Molecular CarcinogenesisThe University of Texas MD Anderson Cancer CenterSmithvilleTX 78957USA Program in Genetics and EpigeneticsThe University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical SciencesHoustonTX 77030USA Shanghai Key Laboratory of Female Reproductive Endocrine Related DiseasesObstetrics and Gynecology HospitalFudan UniversityShanghai 200011China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2020年第11卷第3期

页      面：214-218页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：This work was supported by grants(1R01AI1214030A1 to T.C.and CA16672 to the CCSG Cores at MDACC)from U.S.National Institutes of Health(NIH)and Core Facility Support Awards to MDACC(RP170628 to FCCIC and RP190507 to RAPC)from the Cancer Prevention and Research Institute of Texas(CPRIT).Z.Y.received a fellowship from the Sam Freda Davis Fund.Y.Z.received a fellowship from the Thomas Endowment.N.V.was supported by a CPRIT Research Training Grant Award(RP170067) received a fellowship from the Center for Cancer Epigenetics(CCE)at MDACC and a scholarship from the Andrew Sowell-Wade Huggins Scholarship Fund 

主　　题：Ehrlich facial lymphocytes 

摘      要：Dear Editor,Immunodeficiency,centromeric instability,and facial anomalies(ICF)syndrome is a rare autosomal recessive disorder characterized by antibody deficiency,facial dysmorphism,failure to thrive,and mental *** with ICF syndrome suffer from recurrent and often fatal infections in early childhood.A hallmark of ICF syndrome is loss of DNA methylation in special genomic regions,most notably satellite repeats at centromeric regions,which leads to heterochromatin decondensation and chromosomal abnormalities in lymphocytes(Ehrlich et al.,2008).