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Frontiers of Computer Science 2023年第3期17卷 29-44页

作者： sedigheh KHOSHNEVIS Department of Computer Engineering Shahr-e-Qods BranchIslamic Azad UniversityTehran ***Iran

Recently,SaaS applications are developed as a composition of microservices that serve diverse tenants having similar but different requirements,and hence,can be developed as variability-intensive *** identification of these microservices is difficult,time-consuming,and costly,since,they have to satisfy a set of quality metrics for several SaaS architecture configurations at the same *** this paper,we tackle the multi-objective optimization problem of identifying variable microservices aiming optimal granularity(new metric proposed),commonality,and data convergence,with a search-based approach employing the MOEA/D *** empirically and experimentally evaluated the proposed method following the Goal-Question-Metric *** results show that the method is promising in identifying fully consistent,highly reusable,variable microservices with an acceptable multi-tenancy ***,the identified microservices,although not structurally very similar to those identified by the expert architects,provide design quality measures(granularity,etc.)close to(and even better than)the experts.

关键词： SaaS cloud computing microservice searchbased software engineering MOEA/D

Automating identification of services and their variability for product lines using NSGA-II

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Frontiers of Computer Science 2017年第3期11卷 444-464页

作者： sedigheh KHOSHNEVIS Fereidoon SHAMS Software Engineering Department Shahid Beheshti University Tehran 19836 Iran

Architecture-level business services are identi- fied based on business processes; and likewise, in service- oriented product lines, identifying the domain architecture- level business services and their variability is preferred to be based on business processes and their variability. Identifica- tion of business services for a product line satisfying a set of given design metrics （such as cohesion and coupling） is ex- tremely difficult for a domain architect, since there are many product configurations for which the services must be proper at the same time. This means that the identified services must have proper values for n metrics in m different configura- tions at the same time. The problem becomes more serious when there are high degrees of variability and complexity embedded in the business processes that are the basis for ser- vice identification. We contribute to solve the multi-objective optimization problem of identifying business services for a product line by partitioning the graph of a business process variability model utilizing Non-dominated Sorting Genetic Algorithm-II. The service specification is achieved based on the results of the partitioning. The variability of the services is then determined in terms of mandatory and optional services as well as variability relationships, which are all represented in a Service Variability Model. The method was empirically evaluated through experimentation, and showed proper lev- els of reusability and variability. Furthermore, the resulting models were fully consistent.

关键词： software product model business process genetic line service variability algorithm

Advanced development in upstream of petroleum industry using nanotechnology

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Chinese Journal of Chemical Engineering 2020年第6期28卷 1483-1491页

作者： sedigheh Sadegh Hassani Maryam Daraee Zahra Sobat Catalysis research Division Research Institute of Petroleum Industry(RIPI)West Entrance Blvd.Olympic VillageP.O.Box 14857-33111TehranIran Nanotechnology Research Center Research Institute of Petroleum Industry(RIPI)West Entrance Blvd.Olympic VillageP.O.Box 14857-33111TehranIran

Nowadays,energy supply is one of the most important issues due to limitation of oil,gas and coal *** of rapid population,civilization and energy consumption growth,the improved technologies to make optimal use of the sources,solving related problems and finding new energy sources are *** than 10 years ago,nanotechnology as one of the most important technologies has also been applied to progress in the oil and gas industry(upstream,midstream and downstream).The experience of these years has shown that application of nanotechnology in the oil industry improves the exploration of crude oil and natural gas(underground or deep water),drilling and bringing the crude oil or raw natural gas to the surface,as well as transportation,storage,processing and purifying *** with high specific surface area,pore volume and small size show unique physical and chemical properties,which could be applied in several *** this regard,many researchers have been focused on various nanoparticles for upstream industries and studied their potential in oil exploration,drilling,production and enhanced oil recovery(EOR).Also,in downstream and midstream which involve refining of crude oil,processing and purifying of raw natural gas,transportation and storage of crude or refined petroleum products,the nanomaterials have been used to improve the quality of oil and make it appropriate for the *** sulfur gasoline,enhancing the octane number and coating the transportation system are among the goals that have been achieved successfully using *** this work,various types of nanoparticles such as metallic,metal oxide,hybrid nanoparticles,carbon nanomaterials,nano-composites and their applications in oil upstream industry are ***,their usage in different types of oil upstream processes is discussed.

关键词： Nanotechnology Oil exploration Oil drilling Nanoparticles Enhanced oil recovery

SBR COMPOSITES REINFORCED WITH N-ISOPROPYL-N'PHENYL-P-PHENYLENEDIAMINE-MODIFIED CLAY

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Chinese Journal of Polymer Science 2011年第2期29卷 191-196页

作者： Habibollah Baharvand Ghasem Naderi sedigheh Soltani Iran Polymer & Petrochemical Institute TehranP.O.Box 14965/115Iran

SBR compounds including the N-isopropyl-N＇-phenyl-p-phenylenediamine-modified clay（organoclay） were *** of modified clay and antioxidant（IPPD） contents on mechanical and rheological properties of SBR composites were *** results confirmed that the clay was chemically modified by IPPD and changed into an organoclay.X-ray diffraction（XRD） results confirmed the increase in interlayer distance of the clay due to the insertion of *** and cure characteristics of SBR compounds were determined using RPA（Rubber Process Analyzer） and *** time and cure time of SBR compounds decreased with introduction of the *** properties and heat aging resistance of the SBR composites were improved significantly by incorporation of the organoclay.

关键词： SBR Organoclay Mechanical properties Cure characteristics Antioxidant

In vitro anti-plasmodial activity of new synthetic derivatives of 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine

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Asian Pacific Journal of Tropical Medicine 2021年第3期14卷 128-138页

作者： Azar Tahghighi Akram Abouie Mehrizi sedigheh Zakeri Malaria and Vector Research Group Biotechnology Research CenterPasteur Institute of IranTehranIran Department of Clinical Research Pasteur Institute of IranTehranIran

Objective:To evaluate new compounds synthesized by integrating quinoline,quinazoline,and acridine rings with the active moiety of(5-nitroheteroaryl)methylene ***:A new series of compounds(1a,1b,2a,2b,3a,and 3b)were synthesized and evaluated for cytotoxicity against COS-7 cells using the MTT *** vitro anti-plasmodial activity of the compounds was measured against CQ-sensitive(3D7)and CQ-resistant(K1)Plasmodium(P.)falciparum strains.β-hematin assay was performed to assess the inhibitory effects ofβ-hematin formation for new ***:The synthetic compounds had anti-plasmodial activity against blood-stage of 3D7[IC50=(0.328-5.483)μM]and K1[IC50=(0.622-7.746)μM]strains of ***,with no cytotoxicity against COS-7 cells in effective *** 1a,1b,and 2b were the most effective derivatives against *** 3D7 and K1 *** on theβ-hematin assay,the inhibition ofβ-hematin formation is the main mechanism of the inhibitory effect of these ***:The synthetic compounds could inhibit the erythrocytic stages of CQ-sensitive and resistant *** strains without toxicity towards mammalian *** 1b,2a,and 2b had comparable anti-plasmodial activity against both CQ-sensitive(3D7)and resistant(K1)*** *** compounds may be promising lead structures for the development of new anti-malarial drugs.

关键词： Plasmodium 5-nitroheteroaryl Hydrazine Quinoline Quinazoline Acridine

Efficacy of the herbal formula of Foeniculum vulgare and Rosa damascena on elderly patients with functional constipation:A double-blind randomized controlled trial

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Journal of Integrative Medicine 2022年第3期20卷 230-236页

作者： Maryam Azimi Hanieh Niayesh Mahboobeh Raeiszadeh sedigheh Khodabandeh-shahraki Gastroenterology and Hepatology Research Center Kerman University of Medical SciencesKerman ***Iran Department of Traditional Medicine School of Persian MedicineKerman University of Medical SciencesKerman ***Iran Student Research Committee Afzalipour Faculty of MedicineKerman University of Medical SciencesKerman ***Iran Herbal and Traditional Medicines Research Center Kerman University of Medical SciencesKerman ***Iran Department of Community Health Nursing Razi Faculty of Nursing and MidwiferyKerman University of Medical SciencesKerman ***Iran

Background:Constipation is a common chronic bowel disorder with an incidence of more than 50%in the elderly *** and alternative medicine is a cost-effective and satisfactory treatment for constipation used widely by the ***:This study evaluates the efficacy of an herbal formula made from Foeniculum vulgare *** Rosa damascena for the treatment of constipation in an elderly population and consequent changes to their quality of ***,setting,participants and intervention:This double-blind randomized active controlled clinical trial,with parallel group allocation ratio of 1:1,was conducted in a referral clinic in Afzalipour Hospital,affiliated to Kerman University of Medical Sciences in Kerman,Southeastern *** over 60 years of age,diagnosed with functional constipation(based on the RomeⅣcriteria),were included in this *** received a sachet of 10 g *** and ***(herbal formula group)or polyethylene glycol 4000(PEG 4000 group)with a glass of warm water two times a day for 4 weeks and were followed up for 4 additional *** outcome measures:Constipation severity,stool consistency,and the quality of life were used as the primary *** side effects were used as a secondary *** outcomes were assessed using the Constipation Assessment Scale,the Bristol Stool Form Scale,and the Patient Assessment of Constipation Quality of Life ***:A total of 25 participants in each group completed the four-week treatment cycle and the eightweek *** the end of the four-week treatment cycle,all clinical outcomes had significant improvements in both groups(P<0.05).The analysis of constipation severity(P<0.001),stool consistency(P<0.001),and the quality of life(P<0.001)showed significant improvements with fewer side effects(mild diarrhea)and a longer duration of symptom relief in the herbal formula group compared to the PEG 4000 ***:Although both interv

关键词： Elderly Constipation Foeniculum vulgare Mill. Rosa damascena Persian medicine Randomized controlled trial

Assessment of electrostatic discharge sensitivity of nitrogen-rich heterocyclic energetic compounds and their salts as high energy-density dangerous compounds:A study of structural variables

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Defence Technology（防务技术） 2024年第9期39卷 15-22页

作者： Mohammad Hossein Keshavarz sedigheh Heydari Bani Reza Bakhtiari Seyyed Hesamodin Hosseini Faculty of Applied Sciences Malek Ashtar University of TechnologyIsfahan 177415875Iran

Nitrogen-rich heterocyclic energetic compounds(NRHECs)and their salts have witnessed widespread synthesis in recent *** substantial energy-density content within these compounds can lead to potentially dangerous explosive reactions when subjected to external stimuli such as electrical ***,developing a reliable model for predicting their electrostatic discharge sensitivity(ESD)becomes *** study proposes a novel and straightforward model based on the presence of specific groups(-NH_(2) or-NH-,-N=N^(+)-O^(-)and-NNO_(2),-ONO_(2) or-NO_(2))under certain conditions to assess the ESD of NRHECs and their salts,employing interpretable structural *** a comprehensive dataset comprising 54 ESD measurements of NRHECs and their salts,divided into 49/5 training/test sets,the model achieves promising *** Root Mean Square Error(RMSE),Mean Absolute Error(MAE),and Maximum Error for the training set are reported as 0.16 J,0.12 J,and 0.5 J,***,the ratios RMSE(training)/RMSE(test),MAE(training)/MAE(test),and Max Error(training)/Max Error(test)are all greater than 1.0,indicating the robust predictive capabilities of the *** presented model demonstrates its efficacy in providing a reliable assessment of ESD for the targeted NRHECs and their salts,without the need for intricate computer codes or expert involvement.

关键词： Electrostatic discharge sensitivity Heterocyclic energetic compounds containing azole compound Interpretable structural parameter Safety

Therapeutic applications of collagenase(metalloproteases): A review

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Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 975-981页

作者： Hamzeh Alipour Abbasali Raz sedigheh Zakeri Navid Dinparast Djadid Malaria and Vector Research Group Biotechnology Research Center Pasteur Institute of Iran Department of Medical Entomology School of Health Research Center for Health Sciences Shiraz University of Medical Sciences

Non-invasive therapeutic methods have recently been used in medical sciences. Enzymes have shown high activity at very low concentrations in laboratories and pharmaceutical,enabling them to play crucial roles in different biological phenomena related to living organism, especially human medicine. Recently, using the therapeutic methods based on non-invasive approaches has been emphasized in medical society. Researchers have focused on producing medicines and tools reducing invasive procedures in *** are proteins which catalyze chemical processes and break the peptide bonds in collagen. Collagen may be generated more than the required amount or produced in unsuitable sites or may not degrade after a certain time. In such cases, using an injectable collagenase or its ointment can be helpful in collagen degradation. In both in vitro and in vivo tests, it has been revealed that collagenases have several therapeutic properties in wound healing, burns, nipple pain and some diseases including intervertebral disc herniation, keloid, cellulite, lipoma among others. This review describes the therapeutic application of collagenase in medical sciences and the process for its production using novel methods, paving the way for more effective and safe applications of collagenases.

关键词： Enzyme Therapeutic application Collagenase Non-invasive Metalloproteinase

Psychometric evaluation of Iranian version of nursing faculty’s incivility questionnaire

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Frontiers of Nursing 2023年第2期10卷 249-254页

作者： Zahra Abedini sedigheh Khanjari Sima Hashemi Department of Nursing School of Nursing and MidwiferyIran University of Medical SciencesTehran ***Iran bDepartment of NursingShoushtar Faculty of Medical SciencesShoushtar 64517-73865Iran

Objective:Faculty incivility is a growing problem in nursing schools that disrupts the learning process and affects nursing care of *** and managing faculty incivility requires knowing this problem using a valid and reliable *** purpose of this research was to evaluate the validity and reliability of the faculty’s perceived incivility questionnaire in the Iranian ***:In this methodological study,the participants involved were 357 nursing *** were selected between October and December *** faculty’s perceived incivility questionnaire was evaluated in terms of content and construct ***’s omega and Cronbach’s alpha coefficients were *** and confirmatory factor analyses were conducted to evaluate the construct validity of the ***:The content validity index(CVI)was 0.86-0.91 for the items and 0.87 for the whole *** factor analysis,two factors of violent and irresponsible behaviors were *** factors explained>41.769%of the *** fit indices(Parsimonious Comparative Fit Index[PCFI]=0.783,Parsimonious Normed Fit Index[PNFI]=0.756,root mean square error of approximation[RMSEA]=0.051,Goodness-of-Fit Index[GFI]=0.955,Adjusted Goodness-of-Fit Index[AGFI]=0.932,Comparative Fit Index[CFI]=0.955,χ^(2)/df=2.26)indicated the proportion of *** consistency was ***:Faculty’s perceived incivility questionnaire is a valid and reliable tool with two factors that can be used to evaluate the incivility in Iranian faculty members.

关键词： education evaluation faculty incivility nursing reliability validity