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Ink-st.uct.ng t.e fut.re of vascular t.ssue engineering:a review of t.e physiological bioink design

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Bio-Design and Manufact.ring 2024年第2期7卷 181-205页

作者： Judit. Synofzik sebastian Heene Rebecca Jonczyk Cornelia Blume Inst.t.t. for t.chnical Chemist.y Leibniz University Hannover30167 HannoverGermany

t.ree-dimensional(3D)print.ng and bioprint.ng have come int. view for a plannable and st.ndardizable generat.on of implant.ble t.ssue-engineered const.uct. t.at.can subst.t.t. nat.ve t.ssues and *** t.ssue-engineered st.uct.res are int.nded t. int.grat. wit. t.e pat.ent.s *** t.ssue engineering(t.)is relevant.in t. because it.support. t.e sust.ined oxygenizat.on and nut.it.on of all t.ssue-engineered *** have a specific role,represent.ngt.enecessarymedium for print.bilit. and vascular cell *** review aims t. underst.nd t.e requirement. for t.e design of vascular ***,an in-dept. analysis of vascular cell int.ract.on wit. t.eir nat.ve environment.must.be gained.A physiological bioink suit.ble for a t.ssue-engineered vascular graft.t.VG)must.not.only ensure good print.bilit. but.also induce cells t. behave like in a nat.ve vascular vessel,including self-regenerat.ve and growt. *** review describes t.e general st.uct.re of vascular walls wit. wall-speciﬁc cell and ext.acellular mat.ix(ECM)component. and biomechanical propert.es and ***,t.e physiological role of vascular ECM component. for t.eir int.ract.on wit. vascular cells and t.e mode of int.ract.on is *** current.y available or imaginable bioinks are described from physiological mat.ix prot.ins t. nonphysiologically occurring but.nat.ral chemical compounds useful for vascular *** physiological performance of t.ese bioinks is evaluat.d wit. regard t. biomechanical propert.es post.rint.ng,wit. a view t. current.animal st.dies of 3D print.d vascular ***,t.e main challenges for furt.er bioink development.suit.ble bioink component. t. creat. a self-assembly bioink concept.and fut.re bioprint.ng st.at.gies are *** concept. are discussed in t.rms of t.eir suit.bilit. t. be part.of a t.VG wit. a high pot.nt.al for lat.r clinical use.

关键词： Vascular wall hist.logy Vascular cells Microenvironment Ext.acellular mat.ix Cell–mat.ix int.ract.on Bioink Print.bilit.

Beyond net.ork cent.alit.: individual-level behavioral t.ait. for predict.ng informat.on superspreaders in social media

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Nat.onal Science Review 2024年第7期11卷 148-157页

作者： Fang Zhou Linyuan Lü Jianguo Liu Manuel sebastian Mariani Inst.t.t. of Fundament.l and Front.er Sciences University of Electronic Science and Technology of China Yangt.e Delt. Region Inst.t.t.(Huzhou) University of Electronic Science and Technology of China School of Cyber Science and t.chnology University of Science and Technology of China Depart.ent.of Digit.l Economics Shanghai University of Finance and Economics URPP Social Net.orks Universit?t Zürich

Underst.nding t.e het.rogeneous role of individuals in large-scale informat.on spreading is essent.al t. manage online behavior as well as it. pot.nt.al offline consequences. t. t.is end, most.exist.ng st.dies from diverse research domains focus on t.e disproport.onat. role played by highly connect.d ‘hub’ ***, we demonst.at. here t.at.informat.on superspreaders in online social media are best.underst.od and predict.d by simult.neously considering t.o individual-level behavioral t.ait.: influence and suscept.bilit.. Specifically, we derive a nonlinear net.ork-based algorit.m t. quant.fy individuals' influence and suscept.bilit. from mult.ple spreading event.dat.. By applying t.e algorit.m t. large-scale dat. from t.it.er and Weibo, we demonst.at. t.at.individuals' est.mat.d influence and suscept.bilit. scores enable predict.ons of fut.re superspreaders above and beyond net.ork cent.alit., and reveal new insight. int. t.e net.ork posit.ons of t.e superspreaders.

关键词： complex net.orks social net.orks social media informat.on spreading superspreaders

Int.grat.on of bio-inspired limb-like st.uct.re damping int. mot.r suspension of high-speed t.ains t. enhance bogie hunt.ng st.bilit.

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Railway Engineering Science 2024年第3期32卷 324-343页

作者： Heng Zhang Liang Ling sebastian St.chel Wanming Zhai St.t. Key Laborat.ry of Rail t.ansit.Vehicle Syst.m Southwest Jiaotong UniversityChengdu 610031China Depart.ent.of Engineering Mechanics KTH Royal Institute of TechnologyStockholmSweden

Hunt.ng st.bilit. is an import.nt.performance crit.rion in railway *** st.dy proposes an incorporat.on of a bio-inspired limb-like st.uct.re(LLS)-based nonlinear damping int. t.e mot.r suspension syst.m for t.act.on unit. t. improve t.e nonlinear crit.cal speed and hunt.ng st.bilit. of high-speed t.ains(HSt.).Init.ally,a vibrat.on t.ansmission analysis is conduct.d on a HSt.vehicle and a met.o vehicle t.at.suffered from hunt.ng mot.on t. explore t.e effect.of different.mot.r suspension syst.ms from on-t.ack ***,a simplified lat.ral dynamics model of an HSt.bogie is est.blished t. invest.gat. t.e influence of t.e mot.r suspension on t.e bogie hunt.ng *** bifurcat.on analysis is applied t. opt.mize t.e mot.r suspension paramet.rs for high crit.cal ***,t.e nonlinear damping of t.e bio-inspired LLS,which has a posit.ve correlat.on wit. t.e relat.ve displacement.can furt.er improve t.e modal damping of hunt.ng mot.on and nonlinear crit.cal speed compared wit. t.e linear mot.r suspension ***,a comprehensive numerical model of a high-speed t.ain,considering all nonlinearit.es,is est.blished t. invest.gat. t.e influence of different.t.pes of mot.r *** simulat.on result. are well consist.nt.wit. t.e t.eoret.cal *** benefit. of employing nonlinear damping of t.e bio-inspired LLS int. t.e mot.r suspension of HSt. t. enhance bogie hunt.ng st.bilit. are t.oroughly validat.d.

关键词： High-speed t.ain Hunt.ng st.bilit. Bio-inspired limb-like st.uct.re Mot.r suspension Nonlinear damping

Opt.cal probing of ult.afast.laser-induced solid-t.-overdense-plasma t.ansit.ons

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Light.Science & Applicat.ons) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg Alexander Becker sebastian Keppler Guillaume Duchat.au St.fan Skupin Mickael Grech Fabrice Cat.ire sebastian Hell Issa t.mer Marco Hornung Marco Hellwing Alexander Kessler Franck Schorcht.Malt. Christ.ph Kaluza GSI Helmholt.zent.um für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholt. Inst.t.t. Jena Fröbelstieg 307743 JenaGermany. Inst.t.t. of Opt.cs and Quant.m Elect.onics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESt. 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Inst.t.t.Lumière Mat.ère UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universit.de Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Underst.nding t.e solid t.rget.dynamics result.ng from t.e int.ract.on wit. an ult.ashort.laser pulse is a challenging fundament.l mult.-physics problem involving at.mic and solid-st.t. physics,plasma physics,and laser *** of t.e init.al int.rplay of t.e underlying processes is essent.al t. many applicat.ons ranging from lowpower laser regimes like laser-induced ablat.on t. high-power laser regimes like laser-driven ion *** t.e propert.es of t.e so-called pre-plasma formed as t.e laser pulse’s rising edge ionizes t.e t.rget.is complicat.d from t.e t.eoret.cal and experiment.l point.of view,and many aspect. of t.is laser-induced t.ansit.on from solid t. overdense plasma over picosecond t.mescales are st.ll open *** t.e one hand,laser-driven ion accelerat.on requires precise cont.ol of t.e pre-plasma because t.e efficiency of t.e accelerat.on process crucially depends on t.e t.rget.propert.es at.t.e arrival of t.e relat.vist.c int.nsit. peak of t.e *** t.e ot.er hand,efficient.laser ablat.on requires,for example,prevent.ng t.e so-called“plasma shielding”.By capt.ring t.e dynamics of t.e init.al st.ge of t.e int.ract.on,we report.on a det.iled visualizat.on of t.e pre-plasma format.on and ***-t.in diamond-like carbon foils are shown t. t.ansit.on from solid t. plasma during t.e laser rising edge wit. int.nsit.est.near-infrared probe t.ansmission measurement. evidence sub-picosecond dynamics of an expanding plasma wit. densit.es above 10^(23)cm^(−3)(about.100 t.mes t.e crit.cal plasma densit.).t.e complement.rit. of a solid-st.t. int.ract.on model and kinet.c plasma descript.on provides deep insight.int. t.e int.rplay of init.al ionizat.on,collisions,and expansion.

关键词： laser accelerat.on solid

Numerical st.dy of novel OME_(1-6) combust.on mechanism and spray combust.on at.changed ambient.environment.

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Front.ers in Energy 2024年第4期18卷 483-505页

作者： Frederik WIESMANN Zeyan QIU Dong HAN Lukas St.AUβ sebastian RIEβ Michael WENSING t.omas LAUER Inst.t.t. of Powert.ains and Aut.mot.ve t.chnology TU Wien1060 ViennaAustria Key Laborat.ry for Power Machinery and Engineering of Minist.y of Educat.on Shanghai Jiao Tong UniversityShanghai 200240China Professorship for Fluid Syst.ms t.chnology Friedrich-AlexanderUniversität Erlangen-Nürnberg91058 ErlangenGermany

For a climat.-neut.al fut.re mobilit.,t.e socalled e-fuels can play an essent.al ***,oxygenat.d e-fuels cont.ining oxygen in t.eir chemical formula have t.e addit.onal pot.nt.al t. burn wit. significant.y lower soot.*** part.cular,polyoxymet.ylene dimet.yl et.ers or oxymet.ylene et.ers(PODEs or OMEs)do not.cont.in carbon-carbon bonds,prohibit.ng t.e product.on of soot.precursors like acet.lene(C_(2)H_(2)).t.ese propert.es make OMEs a highly int.rest.ng candidat. for fut.re climat.-neut.al compression-ignit.on ***,t. fully leverage t.eir pot.nt.al,t.e aut.-ignit.on process,flame propagat.on,and mixing regimes of t.e combust.on need t. be *** achieve t.is,efficient.oxidat.on mechanisms suit.ble for comput.t.onal fluid dynamics(CFD)calculat.ons must.be developed and *** present.work aims t. highlight.t.e improvement. made by developing an adapt.d oxidat.on mechanism for OME1-6 and int.oducing it.int. a validat.d spray combust.on CFD model for *** simulat.ons were conduct.d for single-and mult.-inject.on pat.erns,changing ambient.t.mperat.res,and oxygen *** result. were validat.d against.high-pressure and high-t.mperat.re const.nt.ressure chamber ****-chemiluminescence measurement. accomplished t.e charact.rizat.on of t.e aut.-ignit.on *** experiment. and simulat.ons were conduct.d for t.o different.*** improvement. concerning t.e predict.on of t.e ignit.on delay t.me were accomplished while also ret.ining an excellent.agreement.for t.e flame lift.off *** spat.al zones of high-t.mperat.re react.on act.vit. were also affect.d by t.e adapt.on of t.e react.on *** showed a great.r t.ndency t. form OH^(*) radicals wit.in t.e cent.r of t.e spray in accordance wit. t.e experiment..

关键词： oxygenat.d fuels react.on kinet.cs oxidat.on mechanisms comput.t.onal fluid dynamics(CFD) oxymet.ylene et.ers(OME) e-fuels mult.inject.on spray-combust.on

Ab init.o densit. response and local field fact.r of warm dense hydrogen

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Mat.er and Radiat.on at.Ext.emes 2024年第5期9卷 48-67页

作者： t.bias Dornheim sebastian Schwalbe Panagiot.s t.lias Maximilian P.Böhme Zhandos A.Moldabekov Jan Vorberger Cent.r for Advanced Syst.ms Underst.nding(CASUS) D-02826 GörlitzGermany Helmholt.-Zent.um Dresden-Rossendorf(HZDR) D-01328 DresdenGermany Space and Plasma Physics Royal Institute of Technology(KTH)Stockholm SE-10044Sweden t.chnische Universit.t.Dresden D-01062 DresdenGermany

We present.quasi-exact.ab init.o pat. int.gral Mont. Carlo(PIMC)result. for t.e part.al st.t.c densit. responses and local field fact.rs of hydrogen in t.e warm dense mat.er regime,from solid densit. condit.ons t. t.e st.ongly compressed *** full dynamic t.eat.ent.of elect.ons and prot.ns on t.e same foot.ng allows us t. rigorously quant.fy bot. elect.onic and ionic exchange–correlat.on effect. in t.e syst.m,and t. compare t.e result. wit. t.ose of earlier incomplet. models such as t.e archet.pal uniform elect.on gas or elect.ons in a fixed ion snapshot.pot.nt.al t.at.do not.t.ke int. account.t.e int.rplay bet.een t.e t.o *** full elect.onic densit. response is highly sensit.ve t. elect.onic localizat.on around t.e ions,and our result. const.t.t. unambiguous predict.ons for upcoming X-ray t.omson scat.ering experiment. wit. hydrogen jet. and fusion *** PIMC result. are made freely available and can be used direct.y for a gamut.of applicat.ons,including inert.al confinement.fusion calculat.ons and t.e modeling of dense ast.ophysical ***,t.ey const.t.t. invaluable benchmark dat. for approximat. but.comput.t.onally less demanding approaches such as densit. funct.onal t.eory or PIMC wit.in t.e fixed-node approximat.on.

关键词： local incomplet. rigorous

Mult.t.rget.t.iol-Act.vat.d t.t.apyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer t.erapy

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CCS Chemist.y 2024年第3期6卷 783-797页

作者： Xue-Quan Zhou Selda Abyar Imma Carbo-Bague Lan Wang sebastian t.rck Maxime ASiegler Ut.ara Basu Ingo Ot. Rongfang Liu Adriaan PIJzerman Sylvest.e Bonnet Inst.t.t. of Biopharmaceut.cal and Healt. Engineering Tsinghua Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055 Leiden Inst.t.t. of Chemist.y Leiden University2333 CC Leiden Depart.ent.of Chemist.y Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6 Inst.t.t. of Medicinal and Pharmaceut.cal Chemist.y Technische Universität Braunschweig38106 Braunschweig Depart.ent.of Chemist.y Johns Hopkins UniversityBaltimoreMaryland 21218 Division of Drug Discovery&Safet. Leiden Academic Centre for Drug ResearchLeiden University2333 CC Leiden

Gold complexes have emerged as promising ant.cancer met.llodrugs due t. t.eir efficient.t.ioredoxin reduct.se(t.xR)inhibit.on,which dist.rbs t.e redox balance of cancer ***,in t.is model,t.e role of t.e ligand(s)coordinat.d t. gold is oft.n *** t.is work,we present.a series of t.t.apyridyl Au(Ⅲ)complexes t.at.exhibit.t.iol-induced release of a Au(Ⅰ)ion and a t.t.apyridyl *** format.on of a free Au(Ⅰ)cent.r is responsible for t.e expect.d t.xR ***,t.e released ligand,which was visible in cells due t. it. int.nse blue fluorescence,showed excellent.binding propert.es t. t.e hERG pot.ssium ***,t.ese ligands ended up in t.e lysosomes,result.ng in significant.lysosome ***,t.e Au(Ⅲ)complexes present.d in t.is work showed broad-spect.um ant.cancer propert.es,bot. in hypoxic 2D monolayers and 3D t.mor *** suggest.t.at.t.e int.ract.on of t.e released Au(Ⅰ)cent.r and t.e t.t.apyridyl ligand wit. t.o different.prot.in t.rget. may combine int. prodrugs t.at.overcome hypoxia-induced drug deact.vat.on.

关键词： ant.cancer Au(Ⅲ)complexes enzyme inhibt.on pot.ssium channel affinit. lysosome damage cell imaging prodrug

Adapt.ve-opt.cal 3D microscopy for microfluidic mult.phase flows

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Light.Advanced Manufact.ring) 2024年第3期5卷 105-119页

作者： Clemens Bilsing Erik Nüt.enadel sebastian Burgmann Jürgen Czarske Lars Büt.ner Laborat.ry of Measurement.and Sensor Syst.m t.chniques TUD Dresden University of Technology01069 DresdenGermany Chair of Fluid Mechanics Bergische Universitát Wuppertal42119 WuppertalGermany BIOLAS Laboratory of Measurement and Sensor System Techniques01069 DresdenGermany

Measurement. based on opt.cal microscopy can be severely impaired if t.e access exhibit. variat.ons of t.e refract.ve *** t.e case of fluct.at.ng liquid-gas boundaries,refract.on int.oduces dynamical aberrat.ons t.at.increase t.e measurement.*** is prevalent.at.mult.phase flows(***,film flows)t.at.occur in many t.chnical applicat.ons as for example in coat.ng and cleaning processes and t.e wat.r management.in fuel *** t.is paper,we present.a novel approach based on adapt.ve opt.cs for correct.ng t.e dynamical aberrat.ons in real t.me and t.us reducing t.e measurement.*** shape of t.e fluct.at.ng wat.r-air int.rface is sampled wit. a reflect.ng light.beam(Fresnel Guide St.r)and a Hart.ann-Shack sensor which makes it.possible t. correct.it. influence wit. a deformable mirror in a closed ***-dimensional flow measurement. are achieved by using a double-helix point.spread *** measure t.e flow inside a sessile,oscillat.ng 50-μl droplet.on an opaque gas diffusion layer for fuel cells and show t.at.t.e t.mporally varying refract.on at.t.e droplet.surface causes a syst.mat.c underest.mat.on of t.e flow field magnit.de corresponding t. t.e first.droplet.eigenmode which plays a major role in t.eir det.chment.*** demonst.at. t.at.t.e adapt.ve opt.cs correct.on is able t. reduce t.is syst.mat.c ***,t.e adapt.ve opt.cs syst.m can pave t.e way t. a deeper underst.nding of wat.r droplet.format.on and det.chment.which can help t. improve t.e efficiency of fuels cells.

关键词： Double-Helix point.spread funct.on Adapt.ve opt.cs Part.cle t.acking velocimet.y Aberrat.on correct.on Dept.-resolving microscopy Closed-loop cont.ol

Dormancy het.rogeneit. among Arabidopsis t.aliana seeds is linked t. individual seed size

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Plant.Communicat.ons 2024年第2期5卷 215-227页

作者： Michal Krzyszt.n sebastian P.Sacharowski Veena Halale Manjunat. Kat.rzyna Mut.r Grzegorz Bokot. Ce Wang Dariusz Plewczynski t.reza Dobisova Szymon Swiezewski Laborat.ry of Seeds Molecular Biology Institute of Biochemistry and BiophysicsPAS02-106 WarsawPoland Laborat.ry of Funct.onal and St.uct.ral Genomics Centre of New TechnologiesUniversity of WarsawWarsawPoland Laborat.ry of Bioinformat.cs and Comput.t.onal Genomics Faculty of Mathematics and Information ScienceWarsaw University of TechnologyWarsawPoland Labdeers Lt.. 680-01 BoskoviceCzech Republic

Product.on of morphologically and physiologically variable seeds is an import.nt.st.at.gy t.at.helps plant. t. survive in unpredict.ble nat.ral ***,t.e model plant.Arabidopsis t.aliana and most.agronomically essent.al crops produce visually homogenous *** aut.mat.d phenot.pe analysis,we observed t.at.small seeds in Arabidopsis t.nd t. have higher primary and secondary dormancy levels t.an large *** analysis revealed dist.nct.gene expression profiles bet.een large and small *** seeds have higher expression of t.anslat.on-relat.d genes implicat.d in germinat.on *** cont.ast.small seeds have elevat.d expression of many posit.ve regulat.rs of dormancy,including a key regulat.r of t.is process,t.e DOG1 *** in DOG1 expression are associat.d wit. different.al product.on of it. alt.rnat.ve cleavage and polyadenylat.on isoforms;in small seeds,t.e proximal poly(A)sit. is select.d,result.ng in a short.mRNA ***,single-seed RNA sequencing analysis demonst.at.d t.at.large seeds resemble DOG1 knockout.mut.nt.***,on t.e single-seed level,expression of genes affect.d by seed size is correlat.d wit. expression of genes t.at.posit.on seeds on t.e pat. t.ward *** result. demonst.at. an unexpect.d link bet.een seed size and dormancy phenot.pes in a species t.at.produces highly homogenous seed pools,suggest.ng t.at.t.e correlat.on bet.een seed morphology and physiology is more widespread t.an init.ally assumed.

关键词： seed size dormancy DOG1 Arabidopsis