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Journal of Materials Science & Technology 2013年第2期29卷 142-148页

作者： sebastian Wiegand Stefan Flege Olaf Baake Wolfgang Ensinger Materials Analysis Group Department of Materials and Geosciences Technische Universitt Darmstadt Petersenstrasse 23 64287 Darmstadt Germany

（Na0.5K0.5）NbO3 （NKN） lead free thin films were synthesized by means of an acetic acid based sol-gel process on Pt/Ti/SiO2/Si substrates. Na-acetate, K-acetate and Nb-pentaethoxide were used as metal precursors and acetic acid as the solvent. The effect of different calcination temperatures on the properties of the NKN films was investigated by X-ray diffraction, scanning electron microscopy, leakage current and hysteresis measurements. Low calcination temperatures led to low currents at high electric fields whereas high calcination temperatures led to low currents at low electric fields. Based on these findings calcination at low temperature was combined with a post annealing treatment. Low leakage currents of 4×10^-4 A/cm2 at 150 kV/cm and 2pr and 2Ec values of 28 μC/cm2 and 150 kV/cm, respectively, could be obtained. All films were single phase NKN with random crystal orientations and no crack or pore formation was visible on the surface.

关键词： Sol-gel process (Na0.5K0.5)NbO3 Thin film Perovskite Lead-free Piezo material

Optical prediction of single muscle fiber force production using a combined biomechatronics and second harmonic generation imaging approach

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Light(Science & Applications) 2018年第1期7卷 289-302页

作者： Dominik Schneidereit Stefanie Nübler Gerhard prölß Barbara Reischl sebastian Schürmann Oliver J Müller Oliver Friedrich Institute of Medical Biotechnology Friedrich-Alexander-University(FAU)Erlangen-NürnbergPaul-Gordan-Str.391052 ErlangenGermany Erlangen Graduate School in Advanced Optical Technologies(SAOT) FAU Erlangen-NürnbergPaul-Gordan-Str.791052 ErlangenGermany Muscle Research Center Erlangen(MURCE) Friedrich-Alexander-University Erlangen-NürnbergErlangenGermany Department of Internal Medicine III University of KielArnold-Heller-Str.324105 KielGermany DZHK(German Center for Cardiovascular Research)Partner Site Hamburg/Kiel/Lübeck KielGermany

Skeletal muscle is an archetypal organ whose structure is tuned to match *** magnitude of order in muscle fibers and myofibrils containing motor protein polymers determines the directed force output of the summed force vectors and,therefore,the muscle’s power performance on the structural *** and function can change dramatically during disease states involving chronic *** remodeling of the cytoarchitecture has been pursued using noninvasive and label-free multiphoton second harmonic generation(SHG)***,structure parameters can be extracted as a measure of myofibrillar order and thus are suggestive of the force output that a remodeled structure can still ***,to date,the parameters have only been an indirect measure,and a precise calibration of optical SHG assessment for an exerted force has been elusive as no technology in existence correlates these *** engineered a novel,automated,high-precision biomechatronics system into a multiphoton microscope allows simultaneous isometric Ca2+-graded force or passive viscoelasticity measurements and SHG *** this MechaMorph system,we studied force and SHG in single EDL muscle fibers from wt and mdx mice;the latter serves as a model for compromised force and abnormal myofibrillar *** present Ca2+-graded isometric force,pCa-force curves,passive viscoelastic parameters and 3D structure in the same fiber for the first ***,we provide a direct calibration of isometric force to morphology,which allows noninvasive prediction of the force output of single fibers from only multiphoton images,suggesting a potential application in the diagnosis of myopathies.

关键词： structure harmonic fibers

Diabetes and cognitive function:An evidence-based current perspective

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World Journal of Diabetes 2023年第2期14卷 92-109页

作者： Meghna Julian sebastian Shahanas KA Khan Joseph M Pappachan Mohammad Sadiq Jeeyavudeen School of Life Sciences Keele UniversityStoke-on-Trent ST55BGUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Endocrinology and Metabolism University Hospitals of EdinburghEdinburgh EH164SAUnited Kingdom

Several epidemiological studies have clearly identified diabetes mellitus(DM)as a major risk factor for cognitive dysfunction,and it is going to be a major public health issue in the coming years because of the alarming rise in diabetes prevalence across the *** and neural tissues predominantly depend on glucose as energy substrate and hence,any alterations in carbohydrate metabolism can directly impact on cerebral functional output including cognition,executive capacity,and *** affects neuronal function and mental capacity in several ways,some of which include hypoperfusion of the brain tissues from cerebrovascular disease,diabetes-related alterations of glucose transporters causing abnormalities in neuronal glucose uptake and metabolism,local hyper-and hypometabolism of brain areas from insulin resistance,and recurrent hypoglycemic episodes inherent to pharmacotherapy of diabetes resulting in neuronal *** decline can further worsen diabetes care as DM is a disease largely self-managed by ***,it is crucial to understand the pathobiology of cognitive dysfunction in relation to DM and its management for optimal long-term care plan for patients.A thorough appraisal of normal metabolic characteristics of the brain,how alterations in neural metabolism affects cognition,the diagnostic algorithm for patients with diabetes and dementia,and the management and prognosis of patients when they have this dangerous combination of illnesses is imperative in this *** evidence-based narrative with the backup of latest clinical trial reviews elaborates the current understanding on diabetes and cognitive function to empower physicians to manage their patients in day-to-day clinical practice.

关键词： Diabetes mellitus Dementia Cognitive function Antidiabetic medications Hyperglycemia Hypoglycemia

Stability of computed tomography densitometry in patients with otosclerosis:a two-year follow-up

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Journal of Otology 2022年第1期17卷 39-45页

作者： Yanqing Fang Wei Chen Liu-Jie Ren sebastian Kiehn Yilai Shu Bing Chen ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai200031China NHC Key Laboratory of Hearing Medicine Fudan UniversityShanghai200031PR China Department of Radiology Eye and ENT HospitalFudan UniversityShanghai200031China Laryngeal Physiology Laboratory University of Wisconsin e MadisonMadisonWIUnited States Institutes of Biomedical Sciences Fudan UniversityNO.83 Fenyang RoadXuhui DistrictShanghai200031China

Objectives:To quantify the progression of otosclerosis in the unoperated ear between two stapedotomy procedures for patients with bilateral otosclerosis which can help to determine whether a HRCT scan should be re-performed before the second surgery for patients who already received HRCT imaging before the initial ***:35 patients who underwent bilateral stapedotomy were *** rounds of HRCT examination and audiometry were performed at the time of the first surgery and second surgery on the ear that was not operated on during the initial *** relationship between the changes in HRCT densitometry and audiometry over time was ***:The second round of HRCT did not add significant information about the changes to the otosclerosis lesions in either the imaging diagnosis or the HRCT density values except for small changes in the HRCT densitometry readings at the area anterior to the inner auditory(P=0.01).While the changes in HRCT manifestation are small,changes near the fissula ante fenestram(FAF)were still positively correlated with the air bone gap(ABG)of patients(p=0.031,r=0.388).Conclusions:The progression of lesions in otosclerosis is slow resulting in small and insignificant changes to the HRCT ***,a repeat HRCT evaluations prior to surgery is not necessary for patients who have had a previous HRCT evaluation within 2 years of the *** small changes in HRCT manifestation near the FAF were still correlated with negative effects on the ABG which could cause worsened hearing thresholds over this timeframe。

关键词： Otosclerosis Fissula ante fenestram(FAF) High reconstruction-computed tomography (HRCT) Auditory CT densitometry

Modelling the daily reference evapotranspiration in semi-arid region of South India: A case study comparing ANFIS and empirical models

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Information processing in Agriculture 2021年第1期8卷 173-184页

作者： Ramiro T.Gonzalez del Cerro M.S.P Subathra Nallapaneni Manoj Kumar sebastian Verrastro S.Thomas George Departamento de Ingenieria Electronica Facultad Regional Buenos AiresUniversidad Tecnologica NacionalBuenos AiresArgentina Department of Electrical Sciences Karunya Institute of Technology and SciencesCoimbatore 641114Tamil NaduIndia School of Energy and Environment City University of Hong KongKowloonHong KongChina Sustainable Solutionz T NagarChennai-600017Tamil NaduIndia

The estimation of evapotranspiration(eto)is one of the main tools for the control of crop growth and to make a rational use of water *** estimate this parameter accurately,it is necessary to have a daily measurement of four meteorological variables,these are:temperature,solar radiation,relative humidity and wind *** is not always possible to count on all the variables,that is why there are empirical methods that use a limited number of variables that make an approximate estimate of the eto *** of these models are applicable to different regions with completely different *** this paper,a study has been carried out to define the model of eto estimation that best adapts to the semi-arid region in South *** different datasets for the same period from different meteorological stations were *** addition to the empirical methods for estimating eto,computer models ANFIS(Adaptive Neuro-Fuzzy Inference System)were *** models consist in the future estimation of a certain parameter by using current variables and a history of variables and past *** results of this work show that ANFIS 11 model makes the best estimate with RMSD=0.002 and r=*** RITCHIE method is the most suitable empirical model for this region,which reaches RMSD=0.507 and r=*** addition,ranking of equations is elaborated for both datasets for daily estimates of ***,comparison is made with the results for each case and thus confirm or reject the convenience of one model over the *** achieve this,a series of statistical indicators were used:Index of agreement(d),MAE(Mean absolute error),SEE(Standard error of estimate)and RMSD(Root mean square difference).Moreover,a sensitivity analysis was performed in order to compare and show the stability of the best models when an error is introduced within the input *** this case,the empirical models demonstrate a better performance than the ANFIS *** work demonstrates that th

关键词： Evapotranspiration ANFIS ANN Semi-arid regions in India Coimbatore RITCHIE method

An automated, 0.5 Hz nano-foil target positioning system for intense laser plasma experiments

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High Power Laser Science and Engineering 2017年第2期5卷 52-56页

作者： Ying Gao Jianhui Bin Daniel Haffa Christian Kreuzer Jens Hartmann Martin Speicher Florian H.Lindner Tobias M.Ostermayr Peter Hilz Thomas F.Rsch sebastian Lehrack Franz Englbrecht sebastian Seuferling Max Gilljohann Hao Ding Wenjun Ma Katia Parodi Jorg Schreiber Lehrstuhl fur Medizinphysik Fakultat fUr PhysikLudwig-Maximilians-Universitat MiinchenAm Coulombwall 1D-85748GarchingGermany Max-Planck-lnstitut fur Quantenoptik D-85748 GarchingGermany peking University Beijing 100871PR China

We report on a target system supporting automated positioning of nano-targets with a precision resolution of 4 μm in three dimensions. It relies on a confocal distance sensor and a microscope. The system has been commissioned to position nanometer targets with 1 Hz repetition rate. Integrating our prototype into the table-top ATLAS 300 TW-laser system at the Laboratory for Extreme Photonics in Garching, we demonstrate the operation of a 0.5 Hz laser-driven proton source with a shot-to-shot variation of the maximum energy about 27% for a level of confidence of 0.95. The reason of laser shooting experiments operated at 0.5 Hz rather than 1 Hz is because the synchronization between the nano-foil target positioning system and the laser trigger needs to improve.

关键词： high intense laser nm thick target positioning system repetition rated laser-driven ion source

Optimizing the oxide support composition in pr-doped CeO_(2) towards highly active and selective Ni-based CO_(2) methanation catalysts

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Journal of Energy Chemistry 2022年第8期31卷 547-561,I0015页

作者： Anastasios I.Tsiotsias Nikolaos D.Charisiou Ayesha AlKhoori Safa Gaber Vlad Stolojan Victor sebastian Bart van der Linden Atul Bansode Steven J.Hinder Mark A.Baker Kyriaki Polychronopoulou Maria A.Goula Laboratory of Alternative Fuels and Environmental Catalysis(LAFEC) Department of Chemical EngineeringUniversity of Western MacedoniaGR-50100Greece Department of Mechanical Engineering Khalifa University of Science and TechnologyAbu DhabiP.O.Box 127788United Arab Emirates Center for Catalysis and Separations Khalifa University of Science and TechnologyAbu DhabiP.O.Box 127788United Arab Emirates Advanced Technology Institute Department of Electrical and Electronic EngineeringUniversity of SurreyGuildford GU24DLUK Department of Chemical Engineering and Environmental Technology Universidad de ZaragozaCampus Río Ebro-Edificio I+D50018 ZaragozaSpain Instituto de Nanociencia y Materiales de Aragón(INMA) Universidad de Zaragoza-CSICc/María de Luna 350018 ZaragozaSpain Networking Research Center on Bioengineering Biomaterials and NanomedicineCIBERBBN28029 MadridSpain Department of Chemical Engineering Delft University of TechnologyVan der Massweg 92629 HZ DelftThe Netherlands The Surface Analysis Laboratory Faculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU24DLUK

In this study,Ni catalysts supported on pr-doped Ce O_(2) are studied for the CO_(2) methanation reaction and the effect of pr doping on the physicochemical properties and the catalytic performance is thoroughly *** is shown,that pr^(3+)ions can substitute Ce^(4+)ones in the support lattice,thereby introducing a high population of oxygen vacancies,which act as active sites for CO_(2) *** doping can also act to reduce the crystallite size of metallic Ni,thus promoting the active metal *** performance evaluation evidences the promoting effect of low pr loadings(5 at%and 10 at%)towards a higher catalytic activity and lower CO_(2) activation *** the other hand,higher pr contents negate the positive effects on the catalytic activity by decreasing the oxygen vacancy population,thereby creating a volcano-type trend towards an optimum amount of aliovalent substitution.

关键词： Power-to-gas CO_(2)methanation Ni-based catalyst pr-doped CeO_(2) Oxygen vacancy Catalytic activity Activation energy

1 H-吡咯-2,5-二酮(马来酰亚胺):油气地球化学中的新生物标志物

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石油学报 2019年第2期40卷 176-181页

作者：王广利 sebastian Naeher 李婧仪师生宝常睿油气资源与探测国家重点实验室中国石油大学(北京)地球科学学院北京102249 GNS Science

1 H-吡咯-2,5-二酮(马来酰亚胺)是发现于石油以及土壤、沉积物和沉积岩中四吡咯色素的降解产物或衍生物,其中2-甲基-3-正丙基(Me,n-pr)和2-甲基-3-异丁基(Me,i-Bu)马来酰亚胺主要来源于光合硫细菌体内的细菌叶绿素。将不同来源和成因的... 详细信息

1 H-吡咯-2,5-二酮(马来酰亚胺)是发现于石油以及土壤、沉积物和沉积岩中四吡咯色素的降解产物或衍生物,其中2-甲基-3-正丙基(Me,n-pr)和2-甲基-3-异丁基(Me,i-Bu)马来酰亚胺主要来源于光合硫细菌体内的细菌叶绿素。将不同来源和成因的石油中分离出马来酰亚胺组分,并运用气相色谱-质谱(GC-MS)和全二维气相色谱-飞行时间质谱(GC×GC-ToFMS)进行分析鉴定,结果表明,在中国湖相原油中发育3类不同系列的马来酰亚胺,且不同成因的原油中马来酰亚胺组成存在显著差别。丰富的Me,npr和Me,i-Bu马来酰亚胺主要分布于咸化、水体存在永久性分层的渤海湾盆地沙河街组四段上部烃源岩生成的原油中,在微咸水或淡水条件下形成的原油中二者均不发育。同时,Me,n-pr和Me,i-Bu马来酰亚胺可以有效地应用于判识透光滞水带(PZE)的出现和进行油源对比。马来酰亚胺有望成为油气地球化学中一类新的非烃类生物标志物。

关键词： 1H-吡咯-2,5-二酮马来酰亚胺光合绿硫菌生物标志物沉积环境油源对比

High-resolution patterns of palaeoenvironmental changes during the Little Ice Age and the Medieval Climate Anomaly in the northwestern Iberian Peninsula

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Geoscience Frontiers 2020年第5期11卷 1461-1475页

作者： Daniel Castro Martin Souto Maria Isabel Fraga Eduardo Garcia-Rodeja sebastian Perez-Diaz Jose Antonio Lopez Saez Xabier Pontevedra-Pombal Dpto.Botanica Fac.BioloxiaUniversidade de Santiago de CompostelaGaliciaSpain Dpto.Edafoloxia e Quimica Agricola Fac.BioloxiaUniversidade de Santiago de CompostelaGaliciaSpain Dpto.Geografia Urbanismo y Ordenacion Del TerritorioETS CaminosCanales y PuertosUniversidad de CantabriaSpain GI Arqueobiologia Instituto de HistoriaCCHS–CSICMadridSpain

to identify plant macrofossils,estimate peat humification and calculate hydroclimatic indices based on current bog species,with the overall aim of determining the climate conditions associated with evolution of the bog during the Medieval Climate Anomaly and the Little Ice *** proxies,together with historical and climate data,proved to be good indicators of the changes in bog surface ***:of the core led to identification of 9 different periods:two corresponding to the so-called Medieval Climate Anomaly(930 to 1345 AD,1075–665 calibrated years before present[*** BP]);four corresponding to the Little Ice Age(1345 to 1905 AD;665–105 cal yr BP);and three corresponding to the last century(1905 to 2000 AD).The findings revealed a generally dry climate that lasted until the 14th century,followed by a transition to a long period with a more humid,but characteristically very variable climate,which ended at the beginning of the 20th century and was followed by a rapid transition to more humid conditions and finally,a change to drier *** Medieval Climate Anomaly was indicated by the abundance of dry-adapted mosses(Leucobryum glaucum,Hypnum cupressiforme)and characterized by warm dry conditions and high levels of peat humification,with alternating wet *** LIA period was dated by a large abundance of Sphagnum species(an indicator of wetness)and a gradual increase in the humification ***,four different climate phases were differentiated in this ***-resolution reconstruction of the evolution of the CVM bog and the multiproxy approach have together enabled a more detailed identification of climatic variations in this area,which are generally consistent with the global models,as well as better definition of the elusive climatic oscillations in the last millennium and confirmation of the importance of local modulation of global *** study provides new information and a detailed chronology of climatic events that will hel

关键词： Last millennium Raised bog Plant macrofossil Humification analysis Southwest Europe Climate change

Wheat transcription factor TaWRKY51 promotes lateral root formation through negatively regulating ethylene biosynthesis in Arabidopsis

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Wheat transcription factor TaWRKY51 promotes lateral root fo...