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Olfactory immune response to SARS-CoV-2

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Cellular & Molecular Immunology 2024年第2期21卷 134-143页

作者： sebastian A.Wellford e.Ashley Moseman Department of Integrative Immunobiology Duke University School of MedicineDurhamNCUSA

Numerous pathogens can infect the olfactory tract,yet the pandemic caused by SARS-CoV-2 has strongly emphasized the importance of the olfactory mucosa as an immune *** in the nasal passages,the olfactory mucosa is directly exposed to the environment to sense airborne odorants;however,this also means it can serve as a direct route of entry from the outside world into the *** a result,olfactotropic infections can have serious consequences,including dysfunction of the olfactory system,CNS invasion,dissemination to the lower respiratory tract,and transmission between *** research has shown that a distinctive immune response is needed to protect this neuronal and mucosal tissue.A better understanding of innate,adaptive,and structural immune barriers in the olfactory mucosa is needed to develop effective therapeutics and vaccines against olfactotropic microbes such as ***,we summarize the ramifications of SARS-CoV-2 infection of the olfactory mucosa,review the subsequent immune response,and discuss important areas of future research for olfactory immunity to infectious disease.

关键词： Mucosal immunology Neuroimmunology Infectious Disease Sars-CoV-2

Revealing and exploiting hierarchical material structure through complex atomic networks

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npj Computational Materials 2017年第1期3卷 163-170页

作者： sebastian e.Ahnert William P.Grant Chris J.Pickard Theory of Condensed Matter Group Cavendish LaboratoryUniversity of CambridgeJJ Thomson AvenueCambridge CB30HEUK Sainsbury Laboratory University of CambridgeBateman StreetCambridge CB21LRUK Department of Materials Science&Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB30FSUK Advanced Institute for Materials Research Tohoku University 2-1-1 KatahiraAobaSendai 980-8577Japan

One of the great challenges of modern science is to faithfully model,and understand,matter at a wide range of *** with atoms,the vastness of the space of possible configurations poses a formidable challenge to any simulation of complex atomic and molecular *** introduce a computational method to reduce the complexity of atomic configuration space by systematically recognising hierarchical levels of atomic structure,and identifying the individual *** a list of atomic coordinates,a network is generated based on the distances between the *** the technique of modularity optimisation,the network is decomposed into *** procedure can be performed at different resolution levels,leading to a decomposition of the system at different scales,from which hierarchical structure can be *** considering the amount of information required to represent a given modular decomposition we can furthermore find the most succinct descriptions of a given atomic *** straightforward,automatic and general approach is applied to complex crystal *** show that modular decomposition of these structures considerably simplifies configuration space,which in turn can be used in discovery of novel crystal structures,and opens up a pathway towards accelerated molecular dynamics of complex atomic *** power of this approach is demonstrated by the identification of a possible allotrope of boron containing 56 atoms in the primitive unit cell,which we uncover using an accelerated structure search,based on a modular decomposition of a known dense phase of boron,γ-B_(28).

关键词： structure atomic complex

The German energiewende and its roll-out of renewableenergies： An economic perspective

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Frontiers in energy 2017年第2期11卷 126-134页

作者： sebastian KReUZ Felix MUSGeNS Faculty of Mechanical engineering Electrical and Energy SystemsBrandenburg University of Technology 03046 Cottbus Germany

This paper gives a short overview of the German energiewende, i.e. the transition of a large and mostly thermal electricity system towards electricity generation from renewable energy source. It discusses both, the motivation of the transitions as future goals and current status. Furthermore, it gives an in-depth view into the changes in economic costs for society as well as electricity price effects, especially for average private households and industrial consumers. It also discusses the benefits of the promotion of renewable energies in Germany.

关键词： electricity system renewable energy cost-benefit analysis

Micro-Task Processing in Heterogeneous Reconfigurable Systems

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Journal of Computer Science & Technology 2005年第5期20卷 624-634页

作者： sebastian Wallner Department of Distributed Systems Technical University of Hamburg-Harburg Schwarzenbergstrasse 95 D-21073 Hambur9 Germany

New reconfigurable computing architectures are introduced to overcome some of the limitations of conventional microprocessors and fine-grained reconfigurable devices （e.g., FPGAs）. One of the new promising architectures axe Configurable System-on-Chip （CSoC） solutions. They were designed to offer high computational performance for real-time signal processing and for a wide range of applications exhibiting high degrees of parallelism. The programming of such systems is an inherently challenging problem due to the lack of an programming model. This paper describes a novel heterogeneous system architecture for signal processing and data streaming applications. It offers high computational performance and a high degree of flexibility and adaptability by employing a micro Task Controller （mTC） unit in conjunction with programmable and configurable hardware. The hierarchically organized architecture provides a programming model, allows an efficient mapping of applications and is shown to be easy scalable to future VLSI technologies. Several mappings of commonly used digital signal processing algorithms for future telecommunication and multimedia systems and implementation results axe given for a standard-cell ASIC design realization in 0.18 micron 6-layer UMC CMOS technology.

关键词： system-on-chip reconfigurable heterogeneous architectures configuration instructions descriptors parallel processing system signal processing

Occult hepatitis B—the result of the host immune response interaction with different genomic expressions of the virus

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World Journal of Clinical Cases 2022年第17期10卷 5518-5530页

作者： George sebastian Gherlan Department of Infectious Diseases “Carol Davila”University of Medicine and PharmacyBucharest 030303Romania Department of Infectious Diseases “Dr.Victor Babes”Hospital of Infectious and Tropical DiseasesBucharest 030303Romania

With over 40 years of history,occult hepatitis B infection(OBI)continues to remain an important and challenging public health *** as the presence of replication-competent hepatitis B virus(HBV)DNA(i.e.,episomal HBV covalently closed circular DNA)in the liver and/or HBV DNA in the blood of people who test negative for hepatitis B surface antigen(HBsAg)in currently available assays,OBI is currently diagnosed using polymerase chain reaction(PCR)and real-time PCR ***,all efforts should be made to exclude a false negative HBsAg in order to completely follow the definition of *** recent years,significant advances have been made in understanding the HBV lifecycle and the molecular mechanisms that lead to the persistence of the virus in the occult *** factors are mainly related to the host immune system and,to a smaller proportion,to the *** innate and adaptive immune responses are important in HBV infection management,and epigenetic changes driven by host mechanisms(acetylation,methylation,and microRNA implication)are added to such *** greater genetic variability in the S gene of HBV isolated from OBIs was found compared with overt infection,the mechanisms of OBI are not mainly viral mutations.

关键词： Hepatitis B virus Occult hepatitis B Covalently closed circular DNA epigenetic factors Immune factors MicroRNA

Deep Drawing with Local Hardening on Digital Multi-axis Servo Press

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Acta Metallurgica Sinica(english Letters) 2015年第12期28卷 1490-1495页

作者： sebastian Kriechenbauer Reinhard Mauermann Dirk Landgrebe Fraunhofer IWU

The paper discusses a new drawing technology, based on a synchronized movement of ram and cushion with multiple bending operations in alternating directions called ＂bi-directional deep drawing（BDD）.＂ The goal is to avoid local thinning by strengthening the weak point using local hardening. BDD operations are realized before the conventional deep drawing process. This results in a local strain hardening at the weak point of the workpiece, which is usually located at the bottom punch radius. Two major aspects have to be given attention due to the high number of process parameters. On the one hand, for process design, it is helpful to have a tool by means of which it is possible to simultaneously create both the machine program for the servo press and the initial configuration for the process simulation. From the authors＇ point of view, this complexity can only be represented by a numerical analysis method, on the other hand. Consequently, both aspects are given attention in this paper.

关键词： Bi-directional deep drawing(BDD) Local hardening Servo press Pulsation

Robustness analysis metrics for worldwide airport network：A comprehensive study

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Chinese Journal of Aeronautics 2017年第2期30卷 500-512页

作者： Sun Xiaoqian Volker Gollnick sebastian Wandelt School of electronic and Information engineering Beihang University 100083 Beijing China Beijing Key Laboratory for Network-based Cooperative A TM Beijing 100083 China Beijing Laboratory for General Aviation Technology Beijing 100083 China Institute of Air Transportation Systems German Aerospace Center Blohmstrasse 18 21079 Hamburg Germany

Robustness of transportation networks is one of the major challenges of the 21 st *** paper investigates the resilience of global air transportation from a complex network point of view,with focus on attacking strategies in the airport network,i.e.,to remove airports from the system and see what could affect the air traffic system from a passenger＇s ***,we identify commonalities and differences between several robustness measures and attacking strategies,proposing a novel notion of functional robustness：unaffected passengers with *** apply twelve attacking strategies to the worldwide airport network with three weights,and evaluate three robustness *** find that degree and Bonacich based attacks harm passenger weighted network *** evaluation is geared toward a unified view on air transportation network attack and serves as a foundation on how to develop effective mitigation strategies.

关键词： Air transportation systems resilience Airport network Attacking strategy Robustness measure

Charge carrier mobilities of organic semiconductors:ab initio simulations with mode-specific treatment of molecular vibrations

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npj Computational Materials 2022年第1期8卷 2199-2209页

作者： sebastian Hutsch Michel Panhans Frank Ortmann School of Natural Sciences Department of ChemistryTechnische Universität MünchenGarching b.MünchenGermany

The modeling of charge transport in organic semiconductors usually relies on the treatment of molecular vibrations by assuming a certain limiting case for all vibration modes,such as the dynamic limit in polaron theory or the quasi-static limit in transient localization *** opposite limits are each suitable for only a subset of ***,we present a model that combines these different *** is based on a separation of the vibrational spectrum and a quantum-mechanical treatment in which the slow modes generate a disorder landscape,while the fast modes generate polaron band *** apply the combined method to 20 organic crystals,including prototypical acenes,thiophenes,benzothiophenes,and their *** mobilities span several orders of magnitude and we find a close agreement to the experimental *** analysis reveals clear correlations to simple mobility predictors and a combination of them can be used to identify high-mobility materials.

关键词： theory semiconductors limit

An Optimised Surface Structure for Passive, Unidirectional Fluid Transport Bioinspired by True Bugs

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Journal of Bionic engineering 2021年第2期18卷 375-386页

作者： sebastian Lifka Florian Hischen Johannes Heitz Werner Baumgartner Institute of Biomedical Mechatronics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria Institute of Applied Physics Johannes Kepler University LinzAltenberger Straße 694040 LinzAustria

Some true bug species use droplet-shaped,open-capillary structures for passive,unidirectional fluid transport on their body surface in order to spread a defensive fluid to protect themselves against *** this paper we investigated if the shape of the structures found on bugs(bug-structure)could be optimised with regard to better performance in unidirectional fluid ***,to use this kind of surface structure in technical applications where fluid surface interaction occurs,it is necessary to adapt the structure geometry to the contact angle between fluid and *** on the principal of operation of the droplet-shaped structures,we optimised the structure shape for better performance in targeted fluid flow and increase in flexibility in design of the structure *** adapt the structure geometry and the structure spacing to the contact angle,we implemented an equilibrium simulation of the,the structure surrounding,*** order to verify the functionality of the optimised structure,we designed and manufactured a *** testing this prototype with pure water used as fluid,the functionality of the optimised structure and the simulation could be *** kind of structure may be used on technical surfaces where targeted fluid transport is needed,*** of condensate in order to prevent the surface from mold growth,microfluidics,lab-on-a-chip applications and on microneedles for efficient drug/vaccine coating.

关键词： biomimetics true bugs liquid-surface interaction passive unidirectional fluid transport microfluidics lab-on-a-chip