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The role of Islet-1 in cell specification,differentiation,and maintenance of phenotypes in the vertebrate neural retina

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neural Regeneration Research 2015年第12期10卷 1951-1952页

作者： Gervasio Martín-Partido Javier Francisco-Morcillo Departamento de Biología Celular Facultad de CienciasUniversidad de Extremadura

Many blinding diseases,such as retinitis pigmentosa,age-related macular degeneration,and glaucoma involve the permanent loss of retinal neurons,especially photoreceptors or the centrally projecting retinal ganglion **... 详细信息

关键词： cell RGCs The role of Islet-1 in cell specification,differentiation,and maintenance of phenotypes in the vertebrate neural retina

Investigating the effects of Pentoxifylline on human breast cancer cells using Raman spectroscopy

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Journal of Innovative Optical Health Sciences 2015年第2期8卷 26-36页

作者： Peeyush n.Goel S.P.Singh C.Murali Krishna R.P.Gude Gude Lab ACTRECTata Memorial Center KhargharNavi Mumbai 410210 India Chilakapati Lab ACTRECTata Memorial Center KhargharNavi Mumbai 410210 India

Breast cancer is one of the leading causes of cancer-related deaths in a global *** the present study,biochemical changes exerted upon Pentoxifylline(PTX)treatment had been ap-praised in human breast cancer cells using Raman *** are no clinically approved methods to monitor such therapeutic responses *** spectral profiling is suggestive of changes in DnA,protein and lipid contents showing a linear relationship with drug ***,multivariate analysis using principal component based linear-discriminant-analysis(PC-LDA)was employed for dlassifying the control and the PTX treated *** findings support the feasibility of Raman spectroscopy as an alternate/adjunct label-free,objective method for monitoring drug-induced modifications against breast cancer cells.

关键词： Pentoifylline MDA-MB-231 breast cancer cells Raman spectroscopy spectra multivariate analysis

Complex causes and consequences of rangeland greening in South America -multiple interacting natural and anthropogenic drivers and simultaneous ecosystem degradation and recovery trends

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Geography and Sustainability 2020年第4期1卷 304-316页

作者： Wang Li Robert Buitenwerf Renata nicora Chequín Javier Elias Florentín Roberto Manuel Salas Julia Carolina Mata Li Wang Zheng niu Jens-Christian Svenning Center for Biodiversity Dynamics in a Changing World(BIOCHAnGE) Aarhus UniversityNy Munkegade 114Aarhus C 8000Denmark Section for Ecoinformatics and Biodiversity Department of BiologyAarhus UniversityNy Munkegade 114Aarhus C 8000Denmark State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China Instituto de Botánica del nordeste(COnICET-UnnE) Sargento Cabral 2131c.c.209C.P.3400Argentina University of Chinese Academy of Sciences Beijing 100049China

Land-surface greening has been reported globally over the past *** often seen to represent ecosystem recovery,the impacts on biodiversity and society can also be *** has been widely reported from rangelands,where drivers and processes are complex due to its high environmental heterogeneity and societal ***,we assess the complexity behind greening and assess its links to various drivers in an iconic,heterogeneous rangeland area,the IberáWetlands and surroundings,in ***-series satellite imagery over the past 19 years showed overall net greening,but also substantial local browning both in protected and unprotected areas,linking to land use,temporal changes in surface water,fire,and *** found substantial woody expansion mainly in the unprotected land,with 37%contributed by tree plantations and the remaining 63%by spontaneous woody expansion,along with widespread transitions from terrestrial land to seasonal surface *** occurrences tended to reduce greening with unprotected areas experiencing widespread and frequent ***,protected areas had more browning in unburnt areas than burned *** variation in annual precipitation and temperature tended to nonlinearly influence fire occurrences with an interplay of human fire management,further shaping the vegetation greening,pointing to high complexity behind the observed rangeland greening involving interactions among local *** findings highlight that the observed overall greening is an outcome of multiple trends with clear negative impacts on biodiversity and the local livestock-oriented culture(notably expanding tree plantations)and spontaneous vegetation dynamics,partly involving spontaneous woody *** latter has positive potential for biodiversity and ecosystem services in terms of woodland recovery,but can become negative in such a natural savanna region if expansions develop on a too broad scale,highlighting the importance of ensu

关键词： South America Rangeland Vegetation greening Climate change Sustainability Remote sensing

γ"variant-sensitive deformation behaviour of Inconel 718 superalloy

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Journal of Materials Science & Technology 2022年第31期126卷 169-181页

作者： R.Y.Zhang H.L.Qin Z.n.Bi Y.T.Tang J.Araújo de Oliveira T.L.Lee C.Panwisawas S.Y.Zhang J.Zhang J.Li H.B.Dong Centre of Excellence for Advanced Materials Dongguan 523808China School of Engineering University of LeicesterUniversity RoadLeicester LE17RHUnited Kingdom Beijing Key Laboratory of Advanced High Temperature Materials Central Iron and Steel Research InstituteBeijing 100081China Department of Materials University of OxfordParks RoadOxford OX13PHUnited Kingdom StressMap Engineering and Innovation DepartmentThe Open UniversityWalton HallMilton Keynes MK76AAUnited Kingdom ISIS neutron Source Rutherford Appleton LaboratoryHarwell Science and Innovation CampusChiltonOxfordshire OX110QXUnited Kingdom School of Material Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Strengthening in Inconel 718 superalloy is derived from dislocation interaction withγ"precipitates,which exist in disk-shaped three possible orientation variants with their{100}habit plane normal to each *** interactions between dislocations andγ"precipitates vary according to theγ"orienta-tion variants,which makes the deformation behaviour complicated and difficult to reveal *** this work,γ"variant distributions of Inconel 718 samples were tailored by ageing heat treatment under either tensile or compressive ***γ"variant-sensitive deformation behaviours were then studied by in situ tensile tests via neutron diffraction at room *** is demonstrated that yield-ing first takes place in grains oriented withparallel to the loading *** identical lattice strain response to applied stress of both theγmatrix and theγ"precipitates was observed during yield-ing,suggesting that dislocations shearing through theγ"precipitates is predominant at this ***-ations in yield strength for samples with differentγ"variant distributions were observed,which can be attributed to different strengthening that arises from interactions between dislocation and differentγ"variants.

关键词： ni-base superalloys Precipitation strengthening neutron diffraction Lattice strains Plastic deformation

Enhancement of Sister Chromatid Exchanges (SCEs) in Peripheral Blood Lymphocytes of Women with Polycystic Ovary Syndrome (PCOS) <i>in Vitro</i>

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Open Journal of Obstetrics and Gynecology 2015年第7期5卷 378-384页

作者： Evagelia Dafa Maria Kontou Tzegiaver B. Mantratzi Emmanouel n. Kontomanolis nikoletta G. Koutlaki Vasilios A. Liberis Theodore S. Lialiaris Laboratory of Genetics Medical School Democritus University of Thrace Alexandroupolis Greece Department of Obstetrics and Gynaecology Medical School Democritus University of Thrace Alexandroupolis Greece

The aim of the present study was to determine the level of underlying DnA damage in females with PCOS. Twenty-two women with PCOS and twenty-two healthy controls were included in this study. Patients were further categorized into three phenotypic subgroups: Subgroup A, oligo/anovulation (AnOV) and polycystic ovaries (PCO);Subgroup B, hyperandrogenism (HA) as a main characteristic (HA + AnOV or HA + PCO);Subgroup C, all three conditions present (HA + AnOV + PCO). The frequency of sister chromatid exchanges (SCEs) was used as an index of cytogenetic damage. Proliferation rate index (pri), mitotic index (MI), average generation time (AGT) and population doubling time (PDT) were also evaluated. A significant (p ncrease in SCE levels along with a significant (p n in pris and MIs were observed in women with PCOS compared with healthy subjects. Additionally, subgroup C demonstrated statistically significant differences compared with others, while subgroup A had similar results with healthy females. Our results suggest that females with PCOS show increased chromosomal instability in peripheral lymphocytes and a consequent inability of the cells to promote their own mitotic cycle. A positive correlation between DnA damage and PCOS phenotypes is also reported.

关键词： Polycystic Ovary Syndrome Proliferative Rate Index Mitotic Index Genotoxicity Cytostaticity

视神经病变患者的明适应ERGs:与灵长类动物视网膜内层药物阻塞后ERGs的比较

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 37-38页

作者： Rangaswamy n.V. Frishman L.J. Dorotheo E.U. 齐翔云 College of Optometry University of Houston 505 J. Davis Armistead Houston TX 77204-202 0 United States

PURPOSE. To determine whether anterior ischemic optic neuropathy and compressi ve optic neuropathy in humans alter the photopic flash ERG and to investigate th e cellular origins of the waves that are affected by pharmacologic agents in pri mates. METHODS. Photopic flash ERGs were recorded differentially, with DTL elect rodes, between the two eyes of 22 patients with diagnosed optic neuropathy (n=17 , anterior ischemic optic neuropathy AIOn; n=5, compressive optic neuropathy) and 25 age-matched control subjects and in 17 eyes of 13 monkeys (Macaca mulatt a). The stimulus consisted of brief (nm) Ganzfeld flashes (energy range, 0.5-2.0 log td-s) delivered on a rod-saturating blue backgrou nd of 3.7 log sc td (λmax=460 nm). An eye of the patient with ischemic changes at the disc was classified as symptomatic if it showed visual field defects with a mean deviation (MD) of Pngs in macaque monkeys were made before and after inner retinal blockade with tetrodotoxin (TTX) (1.2-2.1 μM; n=7), TTX+n-methyl-D-aspart ate (nMDA; 1.4-6.4 mM; n=7), and cis-2, 3 piperidine dicarboxylic acid (PDA; 3 .3-3.8 mM; n=3). RESULTS. The PhnR amplitude was significantly reduced in both symptomatic (P=3.4×10 -8) and asymptomatic (P=0.036) eyes of patients with AIO n or compressive optic neuropathy (P=0.0054) compared with control subjects. The PhnR amplitude in the symptomatic eye showed a moderate correlation with field defects (P ndings in open-angle glaucoma. The a- wave also was reduced significantly in the symptomatic eye (P=0.0002) of patient s with AIOn. The i-wave, a positive wave on the trailing edge of the b-wave pe aking around 50 ms, became more prominent in eyes in which the PhnR was signific antly reduced. In monkeys, the PhnR was eliminated by TTX. The a-wave at the pe ak and later times was reduced by TTX, further reduced by nMDA, and eliminated a fter PDA in response to the red stimuli. PDA also eliminated the i-

关键词：视神经病变 ERGs 灵长类动物明适应内层神经节细胞开角型青光眼视野缺损压迫性能量范围

临床实践调查:英国坏死性小肠结肠炎的外科治疗方案

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 17-18页

作者： Rees C.M. Hall n.J. Eaton S. Pierro A. 朱新菊 Department of Surgery Institute of Child Health 30 Guilford Street LondonWC1NIEHUnitedKingdom Prof.

Background: Strategies for the surgical management of necrotising enterocolit is are various and controversial. Objective: To characterise variation in surgic al management of this disease across the United Kingdom. Methods: Postal survey of 104 consultant paediatric surgeons with a 77% response rate. Results: Durat ion of antibiotic treatment (median 10 days, range 6- 14), time until the start of enteral feeding (median 10 days, range 4- 21), and absolute indications for surgery all vary between surgeons. Peritoneal drainage is used by 95% of surg eons. Forty two percent use it in neonates of all weights, whereas 36% restric t its use to those neal drainage is used for stabilisation by 9 5% and as definitive treatment by 58% . At laparotomy, operative procedures i nclude diverting jejunostomy, resection and stoma, resection with primary anasto mosis, and “ clip and drop” . All procedures are used in infants of all weight s except resection and pri mary anastomosis, which is used predominantly in larger infants (55% in n > 1000 g; p=0.005). Infants may be considered too unwell for peritoneal drainage by 11% of surgeons compared with 90% for laparotomy (p nclusions: There is considerable variation in surgical strategies f or necrotising enterocolitis. Peritoneal drainage is used by most surgeons, with controversial indications and expectations. The use of resection and primary an astomosis is influenced by the weight of the neonate.

关键词：临床实践胃肠道喂养绝对指征反馈率空肠造口术

TOPOGRAPHIC MEASUREMEnTS OF RETInAL VASCULATURE WITH A SCAn-nInG LASER OPHTHALMOSCOPE In pri-MARY OPEn AnGLE GLAUCOMA

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国际眼科杂志 2003年第1期3卷 118-118页

作者： P.H.Galloway F.S.Mikelberg n.V.Swindale Bristol Eye Hospital UKUniversity of British Columbia CanadaUniversity of British Columbia Canada

Purpose: This study evaluates peripapillary retinal vasculature in primary open angle glaucoma (POAG) using automated analysis of Heidelberg Retina Tomograph (HRT) images. Methods: The width and contour of retinal vessels surrounding the optic disc, and vessel parameters relating to optic disc morphology were analyzed using automated software for each HRT

关键词：原发性开角型青光眼视网膜血管形态测量诊断扫描激光局部记载检眼镜检查法

Light Triggers the miRnA-Biogenetic Inconsistency for De-etiolated Seedling Survivability in Arabidopsis thaliana

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Molecular Plant 2020年第3期13卷 431-445页

作者： Suk Won Choi Moon Young Ryu Andras Viczian Hyun Ju Jung Gu Min Kim Agustin LArce natalia PAchkar Pablo Manavella Ulla Dolde Stephan Wenke Attila Molnar Ferenc nagy Seok Keun Cho Seong Wook Yang Department of Systems Biology Institute of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Korea Institute of Plant Biology Biological Research Centre(BRC)Hungarian Academy of SciencesTemesvari krt.62Szeged 6726Hungary Instituto de Agrobiotecnologia del Litoral(IAL)Centro Cientifico Tecnologico Santa Fe(CCT) Santa FeArgentina Laboratoire de Recherche en Sciences Vegetates 24chemin de Borde-RougeBP 42617 AuzevilleCastanet-Tolosan 31326France Department of Plant and Environmental Sciences Faculty of ScienceUniversity of CopenhagenThorvaldsensvej 40FrederiksbergCopenhagen 1871Denmark Institute of Molecular Plant Sciences School of Biological SciencesThe King’s BuildingsUniversity of EdinburghEdinburgh EH93BFUK These authors contributed equally to this article

The shift of dark-grown seedlings into light causes enormous transcriptome changes followed by a dramatic developmental ***,we show that microRnA(miRnA)biogenesis also undergoes regulatory changes during *** seedlings maintain low levels of primary miRnAs(pri-miRnAs)and miRnA processing core proteins,such as Dicer-like 1,SERRATE,and HYPOnASTIC LEAVES 1,whereas during de-etiolation both pri-miRnAs and the processing components accumulate to high ***,the levels of most miRnAs do not notably increase in response to *** reconcile this inconsistency,we demonstrated that an unknown suppressor decreases miRnA-processing activity and light-induced SMALL RnA DEGRADInG nUCLEASE 1 shortens the half-life of several miRnAs in de-etiolated *** together,these data suggest a novel mechanism,miRnA-biogenetic inconsistency,which accounts for the intricacy of miRnA biogenesis during *** mechanism is essential for the survival of de-etiolated seedlings after long-term skotomorphogenesis and their optimal adaptation to ever-changing light conditions.

关键词： Light signaling miRnA biogenesis