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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural regeneration research 2025年第1期20卷 205-206页

作者： Sarah Fullam sean O’Dowd Antoinette O’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Direct Air Carbon Capture Takes Baby Steps-Giant Strides Are Needed sean O’Neill

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Engineering 2022年第1期8卷 3-5页

作者： sean O’Neill Senior Technology Writer

In September 2021,the world’s largest industrial plant to pull carbon dioxide(CO_(2))directly out of the atmosphere officially became operational in *** and built by the Zurich,Switzerland-based company Climeworks,it... 详细信息

关键词： remove store permanent

VOC removal from contaminated groundwater through membrane pervaporation. (Ⅱ): 1,1,1-trichloroethane-SDS surfactant solution system

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Journal of Environmental Sciences 2003年第6期15卷 821-826页

作者： sean LIU Department of Food Science Rutgers University

The conventional “pump-and-treat' technology for subsurface remediation of groundwater contaminated with volatile organic compounds(VOCs) such as 1,1,1-trichloroethane(TCA), a common chlorinated organic solvent, has limitation of prohibitively long treatment time due to extremely low water solubility of the VOCs. Surfactant-based soil remediation has emerged as the effective technology that substantially reduces the treatment time. In order to make the whole process economical, the surfactant used in soil washing has to be recovered and reused. This study examined the recovery of anionic surfactant, sodium dodecyl sulfate(SDS), from soil remediation fluids containing TCA, using a bench-scale membrane pervaporation unit. The effects of high TCA concentration, surfactant dosage, and flow rate on permeation flux and selectivity(α value) of the process were evaluated. In general, higher surfactant concentration yielded lower TCA flux and constant water flux, resulting in declining α values; higher flow rate of TCA feed stream results in higher VOC flux and selectivity, an indication of the effect of concentration polarization; higher TCA feed concentration produces higher TCA permeation across the membrane, however, the selectivity was virtually unchanged unless the total TCA concentration exceeded 2000 ppm.

关键词： pervaporation VOCs SDS surfactant groundwater remediation 1,1,1-trichloroethane

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Overcoming maladaptive plasticity through plastic compensation

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Current Zoology 2013年第4期59卷 526-536页

作者： Matthew r.J. MOrrIS sean M. rOGErS Department of Biological Sciences University of Calgary Calgary AB Canada T2N 1N4

Most species evolve within fluctuating environments, and have developed adaptations to meet the challenges posed by environmental heterogeneity. One such adaptation is phenotypic plasticity, or the ability of a single genotype to produce multiple environmentally-induced phenotypes. Yet, not all plasticity is adaptive. Despite the renewed interest in adaptive phenotypic plas- ticity and its consequences for evolution, much less is known about maladaptive plasticity. However, maladaptive plasticity is likely an important driver of phenotypic similarity among populations living in different environments. This paper traces four strategies for overcoming maladaptive plasticity that result in phenotypic similarity, two of which involve genetic changes （standing genetic variation, genetic compensation） and two of which do not （standing epigenetic variation, plastic compensation）. Plastic compensation is defined as adaptive plasticity overcoming maladaptive plasticity. In particular, plastic compensation may increase the likelihood of genetic compensation by facilitating population persistence. We provide key terms to disentangle these aspects of phenotypic plasticity and introduce examples to reinforce the potential importance of plastic compensation for under- standing evolutionary change

关键词： Homeostasis Canalization Ecological speciation Standing genetic variation Genetic compensation Countergradi-ent variation

Compressibility of a natural kyanite to 17.5 GPa

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Progress in Natural Science:Materials International 2009年第10期19卷 1281-1286页

作者： sean r. Shieh Michael E. Fleet Department of Earth Sciences University of Western Ontario

The compressional behaviour of a natural kyanite,(Al1.99Fe0.01)SiO5,has been investigated to about 17.5 GPa at 300 K using a diamond-anvil cell and synchrotron X-ray *** pressure-volume data fitted to the third-order Birch-Murnaghan equation of state(EoS) yield an isothermal bulk modulus(K0T) of 192 ± 6 GPa and pressure derivative(K00T) of 6 ± *** K00T is fixed as 4,the derived K0T is 201 ± 2 *** values are in excellent agreement with most experimental determinations in the ***,it can be concluded that the compressibility of kyanite under high pressures has been accurately constrained.

关键词： Compressibility High-pressure Isothermal bulk modulus Kyanite Synchrotron X-ray diffraction

A comparative analysis of alternative approaches to fitting species-abundance models

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Journal of Plant Ecology 2012年第1期5卷 32-45页

作者： sean r.Connolly Loïc M.Thibaut School of Marine and Tropical Biology and ArC Centre of Excellence for Coral reef Studies James Cook UniversityTownsvilleQueensland 4811Australia

Aims Fits of species-abundance distributions to empirical data are increasingly used to evaluate models of diversity maintenance and community structure and to infer properties of communities,such as species *** distributions predicted by several models are the Poisson lognormal(PLN)and the negative binomial(NB)distribution;however,at least three different ways to parameterize the PLN have been proposed,which differ in whether unobserved species contribute to the likelihood and in whether the likelihood is conditional upon the total number of individuals in the *** of these has an analogue for the ***,we propose a new formulation of the PLN and NB that includes the number of unobserved species as one of the estimated *** investigate the performance of parameter estimates obtained from this reformulation,as well as the existing alternatives,for drawing inferences about the shape of species abundance distributions and estimation of species *** We simulate the random sampling of a fixed number of individuals from lognormal and gamma community relative abundance distributions,using a previously developed‘individual-based’bootstrap *** use a range of sample sizes,community species richness levels and shape parameters for the species abundance distributions that span much of the realistic range for empirical data,generating 1000 simulated data sets for each parameter *** then fit each of the alternative likelihoods to each of the simulated data sets,and we assess the bias,sampling variance and estimation error for each *** Findings Parameter estimates behave reasonably well for most parameter values,exhibiting modest levels of median ***,for the NB,median error becomes extremely large as the NB approaches either of two limiting *** both the NB and PLN,>90%of the variation in the error in model parameters across parameter sets is explained by three quantities that corresponded to t

关键词： Poisson lognormal negative binomial Poisson gamma species-abundance distributions species richness

XML by example building E-Commerce applications sean McGrath.

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Assessment of muscle strength in para-athletes:A systematic review of observational studies

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作者： sean McGrath.

来源：畅想之星图书光盘版（南... 评论

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Sports Medicine and Health Science 2022年第4期4卷 225-238页

作者： sean r.O'Connor Kristina Fagher Samuel williamson Babette M.Pluim Clare L.Ardern Dina C.Janse van rensburg Neil Heron Centre for Public Health Queen's University BelfastBelfastUK School of Psychology Queen's University BelfastBelfastUK rehabilitation Medicine research Group Department of Health SciencesLund UniversityLundSweden English Institute of Sport ManchesterUK royal Netherlands Lawn Tennis Association AmstelveenNetherlands Section Sports Medicine Faculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa Amsterdam Collaboration on Health&Safety in Sports(ACHSS) IOC Research Center of ExcellenceAmsterdam UMCAmsterdamNetherlands Department of Family Practice University of British ColumbiaVancouverCanada Medical Board Member World NetballManchesterUK School of Medicine Keele UniversityStaffordshireUK

Accurate and reliable evaluation of muscle strength in para-athletes is essential for monitoring the effectiveness of strength training and/or rehabilitation programmes,and sport *** aim is to synthesise evidence related to assessing muscle strength in *** databases were searched from January 1990 to July 2021 for observational studies focusing on strength *** screening,data extraction,and quality assessment were performed in duplicate.A total of 1764 potential studies were *** met the inclusion criteria and were included in the *** mean age of participants was 30.7 years(standard deviation[SD]:2.4).The majority were men(88%)participating in wheelchair sports,including basketball,rugby,and tennis(23/30:76%).Overall quality varied,with more than half of the studies failing to identify strategies for dealing with confounding *** manual muscle testing being a standard component of para-sport classification systems,evidence examining strength characteristics in para-athletes is derived primarily from isometric and isokinetic *** studies that included comparative strength data,findings were *** studies found strength values were similar to or lower than able-bodied athletic ***,an important observation was that others reported higher shoulder strength in para-athletes taking part in wheelchair sports than both able-bodied and disabled *** need to develop accessible,standardised strength testing methods that account for training influence and establish normative strength values in *** is also a need for additional studies that include female para-athletes and para-athletes with greater functional impairments.

关键词： Systematic review Para-athletes Disabled sport Muscle strength Assessment

Comment on “Using a modern analogue to interpret depositional position in ancient fluvial-tidal channels:Example from the McMurray Formation,Canada” by Andrew *** Croix,Shahin ***,James ***,Geoscience Frontiers,Volume 10,Issue 6,Pages 2

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Geoscience Frontiers 2020年第3期11卷 1081-1086页

作者： Paul r.Durkin sean C.Horner Cynthia A.Hagstrom Department of Geological Sciences University of ManitobaWinnipegMBCanada Department of Geoscience University of CalgaryCalgaryABCanada CNOOC International CalgaryABCanada

*** La Croix et al.(2019)attempt to interpret the depositional position of the Lower Cretaceous McMurray Formation"A Valley"deposits using the tidally-influenced Fraser river in British Columbia as a modern *** of a portion of seven cores from three study areas(South,Central,and North)positioned along a 145-km basinward transect suggests that observed sedimentological and ichnological trends are indicative of a time-equivalent fluvial-tidal transition(FTT)zone within the"A Valley".

关键词： tidal fluvial depositional