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Journal of Environmental Sciences 2011年第3期23卷 372-380页

作者： Xiaohong Guan Haoran Dong Jun Ma Irene M. C. lo State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology Harbin 150090 China Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology Hong Kong 999077 China

Chromium and/or arsenate removal by Fe（Ⅱ） as a function of pH, Fe（Ⅱ） dosage and initial Cr（Ⅵ）/As（Ⅴ） ratio were examined in batch tests. The presence of arsenate reduced the removal efficiency of chromium by Fe（Ⅱ）, while the presence of chromate significantly increased the removal efficiency of arsenate by Fe（Ⅱ） at pH 6-8, In the absence of arsenate, chromium removal by Fe（Ⅱ） increased to a maximum with increasing pH from 4 to 7 and then decreased with a further increase in pH. The increment in Fe（Ⅱ） dosage resulted in an improvement in chromium removal and the improvement was more remarkable under alkaline conditions than that under acidic conditions. Chromium removal by Fe（Ⅱ） was reduced to a larger extent under neutral and alkaline conditions than that under acidic conditions due to the presence of 10 μtmol/L arsenate. The presence of 20 μmol/L arsenate slightly improved chromium removal by Fe（Ⅱ） at pH 3.9-5,8, but had detrimental effects at pH 6.7-9.8. Arsenate removal was improved significantly at pH 4-9 due to the presence of 10μmol/L chromate at Fe（Ⅱ） dosages of 20-60 μmol/L. Elevating the chromate concentration from 10 to 20μmol/L resulted in a further improvement in arsenate removal at pH 4.0-4.6 when Fe（Ⅱ） was dosed at 30-60 μmol/L.

关键词： chromium removal arsenate removal ferrous iron groundwater treatment

An Improved Time Feedforward Connections Recurrent Neural Networks

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Intelligent Automation & Soft Computing 2023年第6期36卷 2743-2755页

作者： Jin Wang Yongsong Zou se-Jung Lim School of Hydraulic&Environmental Engineering Changsha University of Science&TechnologyChangsha410014China School of Computer&Communication Engineering Changsha University of Science&TechnologyChangsha410014China AI Liberal Arts Studies Division of ConvergenceHonam UniversityGwangju-si62399Korea

Recurrent Neural Networks(RNNs)have been widely applied to deal with temporal problems,such as flood forecasting and financial data *** the one hand,traditional RNNs models amplify the gradient issue due to the strict time serial dependency,making it difficult to realize a long-term memory *** the other hand,RNNs cells are highly complex,which will signifi-cantly increase computational complexity and cause waste of computational resources during model *** this paper,an improved Time Feedforward Connections Recurrent Neural Networks(TFC-RNNs)model was first proposed to address the gradient issue.A parallel branch was introduced for the hidden state at time t−2 to be directly transferred to time t without the nonlinear transforma-tion at time t−*** is effective in improving the long-term dependence of ***,a novel cell structure named Single Gate Recurrent Unit(SGRU)was *** cell structure can reduce the number of parameters for RNNs cell,consequently reducing the computational ***,applying SGRU to TFC-RNNs as a new TFC-SGRU model solves the above two ***,the performance of our proposed TFC-SGRU was verified through sev-eral experiments in terms of long-term memory and anti-interference *** results demonstrated that our proposed TFC-SGRU model can cap-ture helpful information with time step 1500 and effectively filter out the *** TFC-SGRU model accuracy is better than the LSTM and GRU models regarding language processing ability.

关键词： Time feedforward connections long-short term memory gated recurrent unit SGRU RNNs

loss-of-function of zebrafish cdt1 causes retarded body growth and underdeveloped gonads resembling human Meier-Gorlin syndrome

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第11期24卷 1037-1046页

作者： Yinan HE Yong WANG Yanqing ZHU Li Jan lo MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou310058China Pathology Department of Taizhou Hospital Zhejiang UniversityTaizhou317000China

The cell cycle consists of four distinct phases:GO/Gl,S(DNA synthesis),G2,and M(mitosis).The Gl to S transition is typified by an accumulation of 4',6-diamidino-2-phenylindole(DAPI)signal that indicates the rapid DNA ... 详细信息

关键词： synthesis initiated function

Evaluating Fecal Sieving Tool as an Indicator of Feed Valorization and the Impact of Feeding Strategy on Dairy Cow Performance under Farm Conditions

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Agricultural Sciences 2023年第10期14卷 1420-1435页

作者： Nizar Salah Héloïse Legendre Laurine Faivre Maxime Briche Raphael Gourdon Valentin Nenov Phileo by Lesaffre Marcq-en-Baroeul France Huvepharma Flemish Region Antwerp Belgium

The objective of this study was to evaluate the use of a faeces sieving tool “Digescan” as an indicator of feed valorization, and to test the influence of feeding strategy on fecal particle size (PS) distribution and weight, milk performance and the possible association between them. Data from 95 trials were used. During each trial, two periods were identified: before and during live yeast probiotic (LYP) supplementation. The LYP used at 5 g/d/cow was Saccharomyces cerevisiae (CNCM I-4407, 1010 CFU/g, Actisaf® Sc47;Phileo by Lesaffre, France). Milk yield and composition were recorded. Fecal samples were taken at the end of each period and sieved with a set of two wire-mesh screens with pore sizes of 5 mm and 2 mm under running tap water. Yeast probiotic supplementation significantly reduced (P 5 mm was accompanied by 1.2 and 0.65 kg/d decrease in MY, 2.5 and 2 kg/d decrease in ECM and 3.2 and 2.6 kg/d in FCM before and during LYP supplementation, respectively. Fecal particle distribution appears to be a practicable tool to predict influences of feeding systems on feed valorization and performance in dairy cows. Live yeast increases dairy performance and decreases the quantity of fecal particles remaining in the two sieves after rinsing.

关键词： Feces Sieving Yeast Probiotic Dairy Cow Milk Particle Size

Sonographic fatty liver, overweight and ischemic heart disease

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World Journal of Gastroenterology 2005年第31期11卷 4838-4842页

作者： Yu-Cheng Lin Huey-Ming lo Jong-Dar Chen Department of Family Medicine and Center for Environmental and Occupational Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan China Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital School of Medicine Fu Jen Catholic University Taioei 111 Taiwan China

AIM: To demonstrate the prevalence of sonographic fatty liver, overweight and ischemic heart disease (IHD) among the male workers in Taiwan, and to investigate the possible association of these three ***: From July to september 2003, a total of 2 088 male aircraft-maintenance workers aged from 22to 65 years (mean 40.5) underwent an annual health examination, including anthropometrical evaluation, blood pressure measurement, personal medical history assessment,biochemical blood analysis, abdominal ultrasonographic examination and digital electrocardiography (ECG). The Student's t-test, x2 test and multivariate logistic regression analysis were utilized to evaluate the relationship between IHD and salient risk ***: The all-over prevalence of overweight was 41.4%, and that of fatty liver was 29.5% (mild, moderate and severe fatty liver being 14.5%, 11.3%, and 3.7%,respectively); while the prevalence of ischemic changes on ECG was 17.1% in this study. The abnormal rates for conventional IHD risk factors including hypertension,dyslipidemia, hyperglycemia and overweight increased in accordance with the severity of fatty liver. Overweight and severity of fatty liver were independently associated with increased risks for developing IHD. Overweight subjects had a 1.32-fold (95%CI: 1.01-1.73) increased IHD risk. Participants with mild, moderate, and severe fatty liver had a 1.88-fold (95%CI: 1.37-2.6), 2.37-fold (95%CI: 1.66-3.37) and 2.76-fold (95%CI: 1.62-4.72)increased risk for developing IHD. The prevalence of ischemic ECG for the fatty liver-affected subjects with or without overweight was 30.1% and 19.1%, while that of overweight subjects free from fatty liver was 14.4%.Compared to the subjects without fatty liver nor overweight,IHD risk for the three subgroups above was as follows:OR: 2.95 (95%CI:2.31-4.09), OR: 1.60 (95%CI: 1.07-2.39)and OR: 1.11 (95%CI: 0.78-1.56), ***: The presence of fatty liver and its severity should be

关键词： Fatty liver Ischemic heart disease Overweight Male Middle-aged

Neurovascular unit in diabetic retinopathy:pathophysiological roles and potential therapeutical targets

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Eye and Vision 2021年第3期8卷 135-153页

作者： Shen Nian Amy C.Y.lo Yajing Mi Kai Ren Di Yang Department of Pathology Xi’an Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology LKS Faculty of MedicineThe University of Hong KongHong KongHong Kong Institute of Basic Medicine Science Xi’an Medical UniversityXi’anShaanxi ProvinceChina Department of Biochemistry and Molecular Biology Xi’an Medical UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology First Affiliated Hospital of Kunming Medical UniversityKunming Medical UniversityKunmingYunnan ProvinceChina

Diabetic retinopathy(DR),one of the common complications of diabetes,is the leading cause of visual loss in working-age individuals in many industrialized *** has been traditionally regarded as a purely microvascular disease in the ***,an increasing number of studies have shown that DR is a complex neurovascular disorder that affects not only vascular structure but also neural tissue of the *** of neural retina could precede microvascular abnormalities in the DR,leading to microvascular ***,disruption of interactions among neurons,vascular cells,glia and local immune cells,which collectively form the neurovascular unit,is considered to be associated with the progression of DR early on in the ***,it makes sense to develop new therapeutic strategies to prevent or reverse retinal neurodegeneration,neuroinflammation and impaired cell-cell interactions of the neurovascular unit in early stage ***,we present current perspectives on the pathophysiology of DR as a neurovascular disease,especially at the early *** novel treatments for preventing or reversing neurovascular injuries in DR are discussed as well.

关键词： Diabetic retinopathy Neurovascular unit Neurodegeneration Gliosis Inflammation treatment

Physical exercise in locally advanced pancreatic adenocarcinoma: "If I walk, I live. Although one can die of cancer, now I am living"

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Journal of Cancer Metastasis and Treatment 2019年第12期4卷 41-48页

作者： Giovanni lo Re Silvia Magnaldi Paolo Doretto Roberto Innocente Francesco lo Re Medical Oncology and Immune-related tumors CRO IRCCSAviano 33081Italy Radiology AAS5 PordenonesePordenone 33170Italy Clinical pathology AAS5 PordenonesePordenone 33170Italy Radiotherapy Centro di Riferimento Oncologico(CRO)Aviano 33081Italy Chemotherapy and Medical Toxicology Study UniversityMilan 20129Italy

The most widely used chemotherapeutic combinations in locally advanced (LA) or metastatic pancreatic ductal adenocarcinoma(PDAC)areNab-Paclitaxel-Gemcitabine(Nab-PCT-GEM)andFluorouracil,Folinicacid,Oxaliplatin, and irinotecan (FOLFIRINOX). Chemo-resistance, typical of PDAC, appears to be due to the negative influence of stroma population cells, namely regulatory T cells (Treg) and myeloid-derived suppressor cells, macrophages with inhibitory effects on the antitumor activity of the innate and adaptive immune systems, and resistance to cancer treatment. Among other factors that may influence immune surveillance, constant physical activity appears to reduce the risk of cancer-related mortality and cardiovascular risk. However, this does not seem to increase the survival of patients with PDAC. The exception is our young inoperable patient. For LA head PDAC, he was treated with seven cycles of Nab-PCT-GEM and RT 50 Gy/15 fractions combined to biweekly GEM and salvage FOLFIRINOX. The five-year surviving patient travelled 15,000 km on foot and continues inexorably his "walking therapy".

关键词： Pancreatic adenocarcinoma depression physical activity Nab-paclitaxel fluorouracil regulatory T cells myeloid-derived suppressor cells

p27、细胞周期素E、p21在角化棘皮瘤皮损中的表达

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中华皮肤科杂志 2002年第1期35卷 51-52页

作者：沈宏许爱娥杭州市第三人民医院 310009

p27是一种细胞周期蛋白依赖性激酶抑制物(cyclin-dependent-kinasein-hibitor,cki),对结肠癌、乳腺癌、肺癌、子宫内膜癌和HPV感染性皮肤病及恶性角质形成细胞肿瘤的研究发现,p27蛋白表达与肿瘤的发生、分化、转移及预后等有密切关系 ... 详细信息

p27是一种细胞周期蛋白依赖性激酶抑制物(cyclin-dependent-kinasein-hibitor,cki),对结肠癌、乳腺癌、肺癌、子宫内膜癌和HPV感染性皮肤病及恶性角质形成细胞肿瘤的研究发现,p27蛋白表达与肿瘤的发生、分化、转移及预后等有密切关系 [1～5]。为探讨p27在角化棘皮瘤的发生、发展、消退中的作用,我们采用免疫组化方法检测p27在进展期和消退期角化棘皮瘤皮损中的表达,及与细胞周期素E、同种抑癌基因p21间存在何种关系。

关键词：角化棘皮瘤皮损 p27 细胞周期素E p21

Early bile duct cancer

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World Journal of Gastroenterology 2007年第25期13卷 3409-3416页

作者： Jae Myung Cha Myung-Hwan Kim se Jin Jang Department of Internal Medicine University of Kyunghee College of Medicine East-West Neo Medical Center Seoul Korea Department of Internal Medicine University of Ulsan College of Medicine Asan Medical Center Seoul Korea Department of Pathology University of Ulsan College of Medicine Asan Medical Center Seoul Korea

Bile duct cancers are frequently diagnosed as advanced diseases. Over half of patients with advanced bile duct cancer present with unresectable malignancies and their prognosis has been very poor even after curative resections. Although there has been a need to diagnose bile duct cancer at its eady stage, it has been a difficult goal to achieve due to our lack of knowledge regarding this disease entity. Early bile duct cancer may be defined as a carcinoma whose invasion is confined within the fibromuscular layer of the extrahepatic bile duct or intrahepatic large bile duct without distant metastasis irrespective of lymph node involvement. Approximately 3%-10% of resected bile duct cancers have been reported to be early cancers in the literature. The clinicopathological features of patients with early bile duct cancer differ from those of patients with advanced bile duct cancer, with more frequent asymptomatic presentation, characteristic histopathological findings, and excellent prognosis. This manuscript is organized to emphasize the need for convening an international consensus to develop the concept of early bile duct cancer.

关键词： Early bile duct cancer Prognosis Histopathology

An ethnobotanical study of medicinal plants in Güce district,north-eastern Turkey

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Plant Diversity 2022年第6期44卷 577-597页

作者： Mustafa Karakose Giresun University Espiye Vocational SchoolProgramme of Medicinal and Aromatic PlantsEspiyeGiresun28600Turkey

This study aims to identify medicinal plants traditionally used to treat diseases by local people living in Güce district,north-eastern *** study was carried out between 2018 and 2021 using a two-part semi-structured,open-ended questionnaire with 165 local *** were analysed using use-report,frequency of citation,and informant consensus *** identified 128 vascular medicinal plant taxa belonging to 54 families and 106 *** most common plant taxa belong to Rosaceae(16 taxa/12.5%),Asteraceae(12 taxa/9.4%),and Lamiaceae(9 taxa/7%)*** most frequently used preparation method reported was decoction(39.8%);the most commonly utilized plant parts were leaves(40.3%).Statistical analysis reveals that women in Güce district(df?163,p?0.043sess the most traditional *** highest frequency of citation(61)and use report(92)were recorded for Tilia rubra ***,and the highest informant consensus factors were cited for respiratory system disorders(0.86),digestive system disorders(0.73),and skin disorders(0.71).This study reported nine plant taxa as medicinal plants for the first time,and documented a total of 293 new therapeutic ***,the study indicates that the transfer of traditional knowledge to future generations is limited(F?3.355,p?0.020).Action should be taken as soon as possible to preserve existing traditional knowledge and to ensure its transfer to future generations.

关键词： Colchic Ethnobotany Informant consensus factor Frequency of citation Traditional medicine Use-record