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Neural Regeneration Research 2024年第4期19卷 788-799页

作者： R.scott duncan Sean m.Riordan m.tthew C.Gernon Peter Koulen Departm.nt of.Ophthalm.logy School of MedicineUniversity of Missouri Departm.nt of.Biom.dical Sciences School of MedicineUniversity of Missouri

Cannabinoids are lipophilic substances derived f.om.Cannabis sativa that can exert a variety of.ef.ects in the hum.n *** have been studied in cellular and anim.l m.dels as well as in hum.n clinical trials f.r their therapeutic benef.ts in several hum.n *** of.these include central nervous system.CNS)diseases and dysf.nctions such as f.rm. of.epilepsy,m.ltiple sclerosis,Parkinson’s disease,pain and neuropsychiatric *** addition,the endogenously produced cannabinoid lipids,endocannabinoids,are critical f.r norm.l CNS f.nction,and if.controlled or m.dif.ed,m.y represent an additional therapeutic avenue f.r CNS *** review discusses in vitro cellular,ex vivo tissue and in vivo anim.l m.del studies on cannabinoids and their utility as therapeutics in m.ltiple CNS *** addition,the review provides an overview on the use of.cannabinoids in hum.n clinical trials f.r a variety of.CNS *** and endocannabinoids hold prom.se f.r use as disease m.dif.ers and therapeutic agents f.r the prevention or treatm.nt of.neurodegenerative diseases and neurological disorders.

关键词： anandam.de cannabidiol cannabinoid endocannabinoid epilepsy m.ltiple sclerosis neurodegeneration neuroprotection tetrahydrocannabinol

Control and vibration analyses of.a sandwich doubly curved m.cro-com.osite shell with honeycom.,truss,and corrugated cores based on the f.urth-order shear def.rm.tion theory

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Applied m.them.tics and m.chanics(English Edition) 2024年第10期45卷 1773-1790页

作者： f.SHIRDELAN m.m.HAm.ADIm.HR f.BARGOZINI Departm.nt of.Solid m.chanics Faculty of Mechanical EngineeringUniversity of KashanKashan 87317-53153Iran

Curved shells are increasingly utilized in applied engineering due to their shared characteristics with other sandwich structures,f.exibility,and attractive ***,the inability of.controlling and regulating vibrations and destroying them.af.erward is a challenge to *** this paper,the curve shell equations and a linear quadratic regulator are adopted f.r the state f.edback design to m.nage the structure vibrations in state space f.rm..A f.ve-layer sandwich doubly curved m.cro-com.osite shell,com.rising two piezoelectric layers f.r the sensor and actuator,is m.deled by the f.urth-order shear def.rm.tion *** core(honeycom.,truss,and corrugated)is analyzed f.r the bearing of.transverse shear *** results show that the honeycom. core has a greater ef.ect on the *** the param.ters related to the core and the weight percentage of.graphene increase,the f.equency *** unif.rm.distribution of.graphene platelets results in the lowest natural f.equency while the natural f.equency ***,without taking into account the piezoelectric layers,the third-order shear def.rm.tion theory(TSDT)and f.urth-order shear def.rm.tion theory(f.SDT)align ***,when the piezoelectric layers are incorporated,these two theories diverge signif.cantly,with the f.equencies in the f.SDT being lower than those in the TSDT.

关键词： vibration and control doubly curved shell m.cro-com.osite honeycom. truss corrugate core

Stom.tal dynam.cs are regulated by leaf.hydraulic traits and guard cell anatom. in nine true m.ngrove species

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Plant Diversity 2024年第3期46卷 395-405页

作者： Ya-Dong Qie Qi-Wei Zhang scott A.m.m.Adam.Kun-f.ng Cao State Key Laboratory f.r Conservation and Utilization of.Subtropical Agro-Bioresources College of ForestryGuangxi UniversityNanning 530004China Guangxi Key Laboratory of.f.rest Ecology and Conservation College of ForestryGuangxi UniversityNanning 530004China Key Laboratory of.Ecology of.Rare and Endangered Species and Environm.ntal Protection Ministry of EducationGuangxi Normal UniversityGuilin 541001China Guangxi Key Laboratory of.Landscape Resources Conservation and Sustainable Utilization in Lijiang River Basin Guangxi Normal UniversityGuilin 541001China Purdue Center f.r Plant Biology Department of Botany and Plant PathologyPurdue UniversityWest LafayetteIN 47907USA

Stom.tal regulation is critical f.r m.ngroves to survive in the hyper-saline intertidal zone where water stress is severe and water availability is highly ***,very little is known about the stom.tal sensitivity to vapour pressure def.cit(VPD)in m.ngroves,and its co-ordination with stom.tal m.rphology and leaf.hydraulic *** m.asured the stom.tal response to a step increase in VPD in situ,stom.tal anatom.,leaf.hydraulic vulnerability and pressure-volum. traits in nine true m.ngrove species of.f.ve f.m.lies and collected the data of.genom. *** aim.d to answer two questions:(1)Does stom.tal m.rphology inf.uence stom.tal dynam.cs in response to a high VPD in m.ngroves?with a consideration of.possible inf.uence of.genom. size on stom.tal m.rphology;and(2)do leaf.hydraulic traits inf.uence stom.tal sensitivity to VPD in m.ngroves?We f.und that the stom.ta of.m.ngrove plants were highly sensitive to a step rise in VPD and the stom.tal responses were directly af.ected by stom.tal anatom. and hydraulic ***,denser stom.ta was correlated with f.ster stom.tal closure at high VPD across the species of.Rhizophoraceae,and stom.ta size negatively and vein density positively correlated with genom. *** negative leaf.osm.tic pressure at the f.ll turgor(πo)was related to higher operating steady-state stom.tal conductance(gs);and a higher leaf.capacitance(Cleaf.and m.re em.olism.resistant leaf.xylem.were associated with slower stom.tal responses to an increase in *** addition,stom.tal responsiveness to VPD was indirectly af.ected by leaf.m.rphological traits,which were af.ected by site salinity and consequently leaf.water *** results dem.nstrate that m.ngroves display a unique relationship between genom. size,stom.tal size and vein packing,and that stom.tal responsiveness to VPD is regulated by leaf.hydraulic traits and stom.tal *** work provides a quantitative f.am.work to better understand of.stom.tal regulation in m.ngroves

关键词： Stom.tal tem.oral kinetics Vapour-pressure def.cit(VPD) Leaf.water relations Leaf.hydraulic vulnerability Leaf.osm.tic potential Genom. size

ATP-binding cassette transporters as possible targets f.r the intervention of.neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 721-722页

作者： Hiu Chuen Lok Glenda m.Halliday Woojin scott Kim Brain and m.nd Centre&School of.m.dical Sciences The University of SydneySydneyNSWAustralia

ATP-binding cassette(ABC)transporters are ubiquitous m.m.rane-bound proteins that are responsible f.r the translocation of.a broad spectrum.of.substrates across cellular m.m.ranes,including lipids,am.no acids,nucleosides,sugars,and ***,ABC transporters are highly expressed in the *** their f.nctions in the brain still need to be elucidated,several m.m.ers are im.licated in the pathogenesis of.neurodegenerative diseases,including Alzheim.r’s disease(AD),Parkinson’s disease(PD),and f.ontotem.oral *** this perspective,we will review current knowledge of.ABC transporters in the central nervous system.in term. of.physiological f.nctions and pathology in ***,we will explore the possibilities of.ABC transporters as potential targets in the developm.nt of.therapeutics f.r neurodegenerative diseases.

关键词： sugar degenerative diseases

The viscous strip approach to sim.lif. the calculation of.the surf.ce acoustic wave generated stream.ng

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Applied m.them.tics and m.chanics(English Edition) 2024年第4期45卷 711-724页

作者： f.JAZINI DORCHEH m.GHASSEm. f.el Cells and Nano System.(f.NS)Laboratory Department of Mechanical EngineeringK.N.Toosi University of TechnologyTehran 19697Iran

In recent decades,the im.ortance of.surf.ce acoustic waves,as a biocom.atible tool to integrate with m.crof.uidics,has been proven in various m.dical and biological *** num.rical m.deling of.acoustic stream.ng caused by surf.ce acoustic waves in m.crochannels requires the ef.ect of.viscosity to be considered in the equations which com.licates the *** this paper,it is shown that the m.jor contribution of.viscosity and the horizontal com.onent of.actuation is concentrated in a narrow region alongside the actuation *** the inviscid equations are considerably easier to solve,a division into the viscous and inviscid dom.ins would alleviate the com.utational load *** particles'traces calculated by this approxim.tion are excellently alongside their counterparts f.om.the com.letely viscous *** is also shown that the optim.m.thickness f.r the viscous strip is about 9-f.ld the acoustic boundary layer thickness f.r various f.ow patterns and am.litudes of.actuation.

关键词： surf.ce acoustic wave m.crof.uidics num.rical sim.lation particle tracing acoustic stream.ng

Ef.ects of.Supplem.ntal Glutam.ne and Lysine on Growth Perf.rm.nce of.Broiler Chickens

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Open Journal of.Anim.l Sciences 2024年第2期14卷 101-122页

作者： Ali f. Alsogair Naif.m. Alhawiti Sam.el N. Nahashon National Center f.r Wildlif. Riyadh KSA Calif.rnia Anim.l Health and f.od Saf.ty Laboratory University of California Davis Davis USA Departm.nt of.Agricultural and Environm.ntal Sciences College of Agriculture Tennessee State University Nashville Tennessee USA

The optim.m.levels of.Lysine and Glutam.ne needed f.r growth perf.rm.nce and m.intenance of.the chicken broilers were evaluated in a random.zed 3 × 4 f.ctorial arrangem.nt of.dietary treatm.nts. The battery cages m.asured 99 × 66 × 25 cm.that can be suf.icient f.r 5 birds. Day old Chicken broilers totaling 180 were assigned to dietary treatm.nts com.rising of.3 concentrations of.Lysine (0.85, 1.14, and 1.42) each in com.ination with 4 concentrations of.Glutam.ne (0, 1, 2, and 3). Each dietary treatm.nt was replicated 3 tim.s and each replication had 5 birds. The birds were given f.ed and water ad libitum.with a 23-hour light regim.n f.r a period of.4 weeks. Then, the experim.ntal birds were evaluated f.r body weight gain, f.ed consum.tion, and f.ed conversion in order to determ.ne their optim.m.requirem.nt f.r dietary Lysine and Glutam.ne. Based on the f.ndings of.this study, the highest perf.rm.nce was observed in birds f.d the diet supplem.nted with 1.42 lysine and 1% glutam.ne, but the highest im.rovem.nt in f.ed conversion was observed in diet contain 1.14 and 1.42 with 1% and 3% glutam.ne, respectively. Birds f.d 1.42 lysine and 1% glutam.ne had the highest total body weight gain and f.ed consum.tion. The lysine requirem.nts in the diet f.r Chicken are between 1.14 and 1.42 with glutam.ne level of.1%.

关键词： Broiler Chickens Lysine Glutam.ne Am.no Acid Dietary Protein Essentials AAs Non-Essential Am.no Acids

Bio-f.rtilizer Im.roved Oil Palm.Seedling Growth

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Am.rican Journal of.Plant Sciences 2024年第7期15卷 455-466页

作者： Gabriel Ddam.lira f. m.sika A. Asiim.e L. Zubairi m. Otuba Horticulture & Oil Palm.Program National Crops Resources Research Institute Kampala Uganda

In m.st f.rm.ng system. newly introduced com.ercial f.rtilizers to be accepted, adopted and used by f.rm.rs, their ef.ectiveness and appropriate application rates m.st be exhibited. This study was conducted to validate the ef.ect and rates of.a bio-f.rtilizer (super agric) on oil palm.seedling growth. The trial was laid out in a random.zed com.lete block design (RCBD) with three application rates of.0, 4 and 8 m./L of.water (treatm.nts) replicated thrice. f.llowing the application of.super agric to oil palm.seedlings f.r a period of.six m.nths, observations drawn f.om.the analysis of.growth data were as f.llows: Three m.nths af.er treatm.nt, super agric signif.cantly (P f.oil palm.seedling com.ared to those which were not applied with super agric. The results also showed that when super agric was applied at a rate of.4 m./L, the leaf.length and breadth were higher com.ared to the control were super agric was not used. f.rtherm.re, applications of.super agric im.roved oil palm.seedling nitrogen uptake by 31% in treatm.nt groups as com.ared to the control which explained the height and breadth increase in the oil palm.seedlings that were applied with super agric. On the other hand, the ef.ect of.super agric application on phosphorus uptake by seedlings was not signif.cant. Although the height, breadth, leaf.width and length were all signif.cantly af.ected by super agric application, the num.er of.oil palm.leaves and spears were not af.ected f.r the period the experim.nt was conducted. Six m.nths af.er application of.super agric the growth of.oil palm.seedlings was f.vorably im.acted, hence we recom.end super agric to be prom.ted am.ng oil palm.seedling growers.

关键词： Bio-f.rtilizer Seedling Growth Application Rates Super Agric

A Rare Case of.Aortic Valve Endocarditis and Acute m.ningitis Due to Haem.philus inf.uenzae

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Case Reports in Clinical m.dicine 2024年第6期13卷 207-211页

作者： Zachary m. Visinoni Justin D. Tse Christopher f. Pease Departm.nt of.Graduate m.dical Education Internal m.dicine Residency Sutter Roseville Medical Center Roseville USA Sutter m.dical Group Roseville USA

HACEK organism. represent a rare but im.ortant group of.causative pathogens in endocarditis. These bacteria have historically been associated with culture-negative endocarditis;however, m.dern laboratory techniques have m.de this less com.on. In this case, we present a 74-year-old m.n who presented with acute onset altered m.ntation, f.ver, and sepsis. He was ultim.tely f.und to have Haem.philus inf.uenzae m.ningitis, cerebral em.yem., aortic valve endocarditis, psoas m.ositis, and L2 - L3 diskitis with osteom.elitis. Although HACEK organism. are com.only f.und in the oropharynx and upper respiratory tract in hum.ns, our patient did not report recent preceding dental or ENT procedures. H. inf.uenzae is responsible f.r approxim.tely 0.16% of.all cases of.bacterial endocarditis, representing a very lim.ted subset. Although generally considered low virulent pathogens, this case dem.nstrates the unusual extent of.inf.ction f.om.a HACEK organism. H. inf.uenzae, causing aortic valve endocarditis as well as atypical non-cardiac sequelae, including acute m.ningitis.

关键词： HACEK Haem.philus inf.uenzae Aortic Valve Endocarditis Bacterial m.ningitis Cerebral Em.yem.

Adaptation in brain structure and respiratory and olf.ctory structures across environm.ntal gradients in Af.ican and North Am.rican m.roid rodents

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Integrative Zoology 2024年第1期19卷 165-181页

作者： Peter J.TAYLOR Aluwani NENGOVHELA Christiane DENYS Graham.R.scott Catherine m.IVY Departm.nt of.Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Af.om.ntane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa Departm.nt of.m.m.alogy National MuseumBloemfonteinSouth Africa Institut de Systém.tique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance Departm.nt of.Biology McMaster UniversityHamiltonOntarioCanada Guglielm. and Shoem.ker Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

m.rphom.tric studies of.3D m.cro CT-scanned im.ges can provide insights into the evolution of.the brain and sensory structures but such data are still scarce f.r the m.st diverse m.m.alian order of.*** reviewed and new data,we tested f.r convergence to extrem. aridity and high elevation in the sensory and brain m.rphology of.rodents,f.om.m.rphom.tric data f.om.m.cro-CT X-ray scans of.174 crania of.16 species of.three distantly re-lated Af.ican m.rid(sof.-f.rred m.ce,Praom.ini,lam.nate-toothed rats,Otom.ini,and gerbils,Gerbillinae)clades and one North Am.rican cricetid(deer m.ce and white-f.oted m.ce,Perom.scus)*** studies dem.n-strated convergent evolution acting on the oval window area of.the cochlea(enlarged in extrem.ly arid-adapted species of.Otom.ini and Gerbillinae)and on endocranial volum.(reduced in high elevation taxa of.Otom.ini and Perom.scus).However,contrary to our predictions,we did notf.nd evidence of.convergence in brain struc-ture to aridity,or in the olf.ctory/respiratory system.turbinate bones)to high *** structure dif.ered,particularly in the petrosal lobules of.the cerebellum.and the olf.ctory bulbs,between Otom.ini and Gerbillinae,with extrem. arid-adapted species in each clade being highly divergent(not convergent)f.om.other species in the sam. *** observed greater“packing”of.the m.xillary turbinate bones,which have im.ortant respiratory f.nctions,in Perom.scus m.ce f.om.high and low elevations com.ared to the high-elevation Af.ican Praom.ini,but m.re com.lex patterns within Perom.scus,probably related to trade-of.s in respiratory physiology and heat exchange in the nasal epithelium.associated with high-elevation adaptation.

关键词： 3D m.rphom.trics Af.ica brain size North Am.rica Rodentia sensory evolution

Langm.ir-Schaef.r f.lm.Investigation and Density f.nctional Theory Band Gap Calculations of.Calix[n]arene-Para-Am.nobenzoic Acid f.r Drug Nanosensor Application

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Journal of.Wuhan University of.Technology(m.terials Science) 2024年第5期39卷 1311-1318页

作者： WONG Yeong Yi f.L Supian A Radzwan m.m.sa N f.N Abd Karim Departm.nt of.Physics Sultan Idris Education UniversityTanjong Malim 35900Malaysia Departm.nt of.Chem.stry Sultan Idris Education UniversityTanjong Malim 35900Malaysia

Calix[n]arenes was utilized to detect PABA,the prim.ry sunscreen *** study investigates the interaction of.calix[4]arene(C4),calix[6]arene(C6),and PABA using the Langm.ir m.thod and f.rst-principle density f.nctional theory(Df.).Using the Langm.ir-Schaef.r(LS)technique,an ultrathin f.lm.com.osed of.calix[n]arenes and their com.lexes with PABA was deposited on various *** on the Langm.ir study,the PABA m.lecule was bonded to the lower rim. of.both C4 and C6 with the host-guest ratio of.1:*** of.the LS f.lm. f.rm.d were then characterized by ultravioletvisible spectroscopy(UV-Vis),f.urier-transf.rm.inf.ared spectroscopy(f.IR)and carbon,hydrogen,nitrogen,sulf.r elem.ntal analyzer(CHNS).The band gap reduction obtained in the Df. study denotes the charge transf.r interaction with prom.sing reactivity between the calix[n]arenes and *** sensing of.PABA by C4 and C6 is successf.l based on the f.rm.tion of.bonding between them.due to the hosts’ef.ective trapping *** outcom.s of.this study could be applied to drug delivery system. f.r f.ture pharm.ceutical and m.dical applications.

关键词： calix[n]arenes band gap density f.nctional theory Langm.ir-Schaef.r PABA sensor