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Management of prostatosymphyseal fistula following photoselective vaporization of the prostate:Case series and systematic review of the literature

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Current Urology 2022年第2期16卷 88-93页

作者： scott d.Lundy Nicholas Hauser Hadley Wood Amr Fergany Kenneth Angermeier Glickman Urological and Kidney Institute Cleveland ClinicClevelandOHUSA department of Urology University of MiamiMiamiFLUSA Sebastian River Medical Center SebastianFLUSA

Background:This study is aimed to describe our institutional experience and review the literature to date on prostatosymphyseal fistula(PSF),or puboprostatic fistula,following bladder outlet procedures such as transurethral resection of the prostate(TURP)or laser photoselective vaporization of the prostate(PVP).Materials and methods:We retrospectively queried our institutional experience for management of PSF following PVP performed for symptomatic benign prostatic *** also performed a systematic literature review for PSF following PVP or ***,we describe our surgical approach to the management of this challenging ***:We identified 7 cases of PSF following PVP from our institution,as well as an additional 7 cases following PVP and 9 cases following TURP from literature *** diagnosis of PSF was made between 0.5 and 24 months following PVP,and the most specific symptoms were pubic pain and difficulty *** patients requiring several evaluations before the diagnosis was made using appropriate imaging *** percent of patients required surgical intervention including fistula repair or *** surgical approach has evolved,and we now routinely perform robotic fistula repair with Y-V plasty and interposition flap with excellent ***:Puboprostatic fistula is a rare and poorly described complication of PVP or *** the best of our knowledge,this case series of PSF following PVP represents the largest series to date and doubles the number of reported cases in the *** fistula repair with interposition of either peritoneal or perivesical fat flaps appears to be a viable management strategy.

关键词： Fistula Laser Prostatosymphyseal fistula Puboprostatic fistula Reconstructive surgery

Glutamine-released ammonia acts as an unprecedented signaling molecule activating lipid production

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Genes & diseases 2023年第2期10卷 307-309页

作者： Chunming Cheng scott Kelsey deliang Guo department of Radiation Oncology Ohio State Comprehensive Cancer CenterArthur G. James Cancer Hospital and Richard J. Solove Research Instituteand College of Medicine at The Ohio State UniversityColumbusOH 43210USA Center for Cancer Metabolism James Comprehensive Cancer Center at The Ohio State UniversityColumbusOH 43210USA

In healthy humans, ammonia circulates in the bloodstream at a concentration around 11–32 μmol/L. Whether ammonia plays any physiological role has been unknown until a recent report published in Nature Metabolism.1 Ammonia, long thought to be a toxic waste product of amino acid metabolism, needs to be excreted from the human body as urea. Intriguingly, in this paper, Cheng et al1 for the first time reported that ammonia is not a waste product;rather, it is an unprecedented signaling molecule tying glucose and glutamine to lipid production in human cells. This study revealed that ammonia released from glutamine triggers a cascade of cellular processes leading to the activation of lipogenesis machinery for lipid production (Fig. 1). This discovery has major implications for developing treatments for human diseases such as cancers and metabolic syndromes, as dysregulated metabolism is a hallmark of these diseases.

关键词： ammonia metabolism Ammonia

development of starch-based films reinforced with cellulosic nanocrystals and essential oil to extend the shelf life of red grapes

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Food Bioscience 2022年第3期47卷 403-412页

作者： Sneh Punia Bangar William scott Whiteside Fatih Ozogul Kyle d.dunno George Armstrong Cavender Paul dawson department of Food Nutrition and Packaging SciencesClemson UniversitySC 29634USA department of Seafood Processing Technology Faculty of FisheriesCukurova UniversityBalcaliAdana01330Turkey department of Packaging Science Rochester Institute of TechnologyRochesterNYUSA

Packaging material has an important role in extending the shelf-life of *** study investigated the effectiveness of cellulose nanocrystals(CNCs)derived from Kudzu(Pueraria montana)vine to reinforce to starch-based *** addition,the essential oil was incorporated into these nanocomposite films to evaluate further improvement in film properties and *** packaging materials,including the pearl millet starch(PMS),PMS reinforced with Kudzu CNCs,and PMS reinforced with Kudzu CNCs stabilized pickering emulsion containing clove bud oil(CBO),was used to develop biodegradable nanocomposite *** films were investigated for their thermal,morphological,mechanical,and barrier *** addition,the films were used as packaging material to improve the shelf life of the grapes for 15 days at 5℃.PMS films reinforced with Kudzu CNCs stabilized pickering emulsion of CBO were most effective in extending the shelf life of red grapes up to 15 days at 5℃ by maintaining the weight,firmness,and soluble solids in grapes for a longer duration during *** study suggests that PMS+Kudzu CNCs+EO films have the potential for commercial packaging of fruits during short storage periods without adversely affecting their quality and sensory attributes.

关键词： Packaging material Nanocomposites Cellulose nanocrystals Red grapes Shelf life

Gas flow in rotary kilns

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Particuology 2010年第6期8卷 613-616页

作者： Patrick R.davies Michael J.S.Norton d.Ian Wilson John F.davidson david M.scott department of Chemical Engineering and Biotechnology University of CambridgePembroke StreetCambridgeCB2 3RAUK

This paper describes an experimental investigation on the flow characteristics within a rotating cylinder containing a rolling bed of sand. The axis of the cylinder was horizontal and there was no axial bulk flow of particles. The velocity field of the gas flowing through the cylinder was measured by hot-wire anemometry. The measurements indicate that the velocity field is asymmetric with respect to a diameter perpendicular to the granular bed. CFd calculations confirm this finding. The gas velocity profiles are crucial in determining heat transfer from gas to solid.

关键词： Rotating cylinderVelocity profile

Exploring the effects of coronary artery disease as a preexisting comorbidity on mortality in hospitalized septic patients:a retrospective observation study

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Emergency and Critical Care Medicine 2024年第2期4卷 47-51页

作者： Anmol Multani Greg Stahl Kerry Johnson scott Goade Robert d.Arnce College of Osteopathic Medicine Kansas City UniversityJoplinMOUSA department of data Improvement Freeman Health SystemJoplinMOUSA department of Mathematics Missouri Southern State UniversityJoplinMOUSA department of Pharmacy Freeman Health SystemJoplinMOUSA

Background:Sepsis has high prevalence and mortality rate,and it is imperative to identify populations at risk of poor sepsis *** patients with preexisting chronic comorbidities are shown to have worse sepsis *** identifying comorbidities with greater influence on sepsis progression,we can direct limited resources to septic patients with comorbidities and reduce health care *** comorbidities can impact the risk of developing sepsis and having worse *** artery disease(CAd)is a common comorbidity,especially in the elderly,and a leading cause of death *** wished to investigate the influence of CAd as a comorbidity on sepsis and hypothesized that preexisting CAd would increase mortality in hospitalized septic ***:We conducted retrospective observational study using patient data from Freeman Health System in Joplin,*** analyzed patient records from Freeman Health System database from January 1,2019,to June 30,*** patients were identified using the International Classification of diseases,Tenth Revision sepsis *** identify septic patients with preexisting CAd,we used International Classification of diseases,Tenth Revision codes for *** compared mortality rates for septic patients with and without ***:Two-sample proportion test was conducted to test the difference in mortality between septic patients with and without preexisting *** difference in mortality for the total population was−0.016(P=0.553).In the male and female subgroups,the differences in mortality were 0.0122(P=0.739)and−0.0511(P=0.208),*** differences in mortality in patients aged 40 to 64 years and 65 years and older were−0.0077(P=0.870)and 0.0007(P=0.983),*** statistical tests failed to find significant differences when comparing septic patients with and without preexisting *** was no significant difference in the age and sex ***:Our study showed that CAd alone was n

关键词： Comorbidity Coronary artery disease Inflammation Mortality rate in sepsis prognosis Sepsis

Open and Closed： The Roles of Linker Histones in Plants and Animals

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Molecular Plant 2014年第3期7卷 481-491页

作者： Ryan S. Over scott d. Michaels departments of Biology/Molecular and Cellular Biochemistry Indiana University 915 E. Third Street Bloomington IN 47405 USA

Histones package dNA in all eukaryotes and play key roles in regulating gene expression. Approximately 150 base pairs of dNA wraps around an octamer of core histones to form the nucleosome, the basic unit of chromatin. Linker histones compact chromatin further by binding to and neutralizing the charge of the dNA between nucleosomes. It is well established that chromatin packing is regulated by a complex pattern of posttranslational modifications （PTMs） to core histones, but linker histone function is less well understood. In this review, we describe the current understand- ing of the many roles that linker histones play in cellular processes, including gene regulation, cell division, and devel- opment, while putting the linker histone in the context of other nuclear proteins. Although intriguing roles for plant linker histones are beginning to emerge, much of our current understanding comes from work in animal systems. Many unanswered questions remain and additional work is required to fully elucidate the complex processes mediated by linker histones in plants.

关键词： linker histone histone H1 chromatin gene regulation development differentiation imprinting posttrans-lational modifications dNA methylation high mobility group proteins.

Self-Supervised Plant Phenotyping by Combining domain Adaptation with 3d Plant Model Simulations: Application to Wheat Leaf Counting at Seedling Stage

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Plant Phenomics 2023年第2期5卷 226-238页

作者： Yinglun Li Xiaohai Zhan Shouyang Liu Hao Lu Ruibo Jiang Wei Guo scott Chapman Yufeng Ge Benoit de Solan Yanfeng ding Frédéric Baret Plant Phenomics Research Centre Academy for Advanced Interdisciplinary StudiesJiangsu Collaborative Innovation Center for Modern Crop ProductionNanjing Agricultural UniversityNanjingChina Key Laboratory of Image Processing and Intelligent Control School of Artificial Intelligence and AutomationHuazhong University of Science and TechnologyWuhanChina Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan School of Agriculture and Food Sciences The University of QueenslandSt.LuciaQueensland 4072Australia department of Biological Systems Engineering University of Nebraska-LincolnLincolnNebraska 68583United States INRAE Avignon UniversitéUMR EMMAHUMT CAPTE228route de l’aérodrome-CS 4050984914 Avignon Cedex 9France ARVALIS Institut du Végétal 3 Rue Joseph et Marie Hackin75116 ParisFrance

The number of leaves at a given time is important to characterize plant growth and *** this work,we developed a high-throughput method to count the number of leaves by detecting leaf tips in RGB *** digital plant phenotyping platform was used to simulate a large and diverse dataset of RGB images and corresponding leaf tip labels of wheat plants at seedling stages(150,000 images with over 2 million labels).The realism of the images was then improved using domain adaptation methods before training deep learning *** results demonstrate the efficiency of the proposed method evaluated on a diverse test dataset,collecting measurements from 5 countries obtained under different environments,growth stages,and lighting conditions with different cameras(450 images with over 2,162 labels).Among the 6 combinations of deep learning models and domain adaptation techniques,the Faster-RCNN model with cycle-consistent generative adversarial network adaptation technique provided the best performance(R^(2)=0.94,root mean square error=8.7).Complementary studies show that it is essential to simulate images with sufficient realism(background,leaf texture,and lighting conditions)before applying domain adaptation ***,the spatial resolution should be better than 0.6 mm per pixel to identify leaf *** method is claimed to be self-supervised since no manual labeling is required for model *** self-supervised phenotyping approach developed here offers great potential for addressing a wide range of plant phenotyping *** trained networks are available at https://***/YinglunLi/Wheat-leaf-tip-detection.

关键词： Wheat seedling Plant

Polymer-mediated immunocamouflage of red blood cells: Effects of polymer size on antigenic and immunogenic recognition of allogeneic donor blood cells

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Science China(Life Sciences) 2011年第7期54卷 589-598页

作者： WANG dunCheng dana L. KYLUIK Kari L. MURAd Wendy M. TOYOFUKU Mark d. scott Canadian Blood Services Vancouver V6T 1Z3 British Columbia Canada Centre for Blood Research and the department of Pathology and Laboratory Medicine University of British Columbia Vancouver V6T 1Z3 British Columbia Canada department of Biology College of St. Rose Albany 12208 New York USA

developing a practical means of reducing alloimmunization in chronically transfused patients would be of significant clinical benefit. Immunocamouflaging red blood ceils （RBCs） by membrane grafting of methoxypoly（ethylene glycol）（mPEG） may reduce the risk of allo-immunization. The results of this study showed that antibody recognition of non-ABO antigens was sig- nificantly reduced in an mPEG-dose- and polymer size-dependent manner, with higher molecular weight mPEGs providing better immunoprotection. Furthermore, in vivo immunogenicity was significantly reduced in mice serially transfused with mPEG-modified xenogeneic （sheep; sRBCs）, allogeneic （C57B1/6）, or syngeneic （Balb/c） RBCs. Following a primary transfu- sion of sRBCs, mice receiving mPEG-sRBCs showed a 〉90% reduction in anti-sRBC IgG antibody levels. After two transfusions, mice receiving mPEG-sRBCs showed reductions of 〉80% in anti-sRBC IgG levels. Importantly, mPEG-modified autologous cells did not induce neoantigens or an immune （IgG or IgM） response. These data suggest that the global immuno- camouflage of RBCs by polymer grafting may provide a safe and cost-effective means of reducing therisk of alloimmunization.

关键词： methoxypoly(ethylene glycol) erythrocyte blood group antigens mice alloimmunization

2024 Wheelchair Compendium of Physical Activities:An update of activity codes and energy expenditure values

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Journal of Sport and Health Science 2024年第1期13卷 18-23页

作者： scott A.Conger Stephen d.Herrmann Erik A.Willis Tom E.Nightingale Joseph R.Sherman Barbara E.Ainsworth department of Kinesiology Boise State UniversityBoiseID 83725USA Kansas Center for Metabolism and Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and disease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirmingham AL B152TTUK College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and Health Shanghai University of SportShanghai 200438China

Purpose:This paper presents an update of the 2011 Wheelchair Compendium of Physical Activities designed for wheelchair users and is referred to as the 2024 Wheelchair *** Wheelchair Compendium aims to curate existing knowledge of the energy expenditure for wheelchair physical activities(PAs).Methods:A systematic review of the published energy expenditure of PA for wheelchair users was completed between 2011 and May *** added these data to the 2011 Wheelchair Compendium data that was compiled previously in a systematic review through ***:A total of 47 studies were included,and 124 different wheelchair PA reported energy expenditure values ranging from 0.8 metabolic equivalents for wheelchair users(filing papers,light effort)to 11.8 metabolic equivalents for wheelchair users(Nordic sit skiing).Conclusion:In introducing the updated 2024 Wheelchair Compendium,we hope to bridge the resource gap and challenge the prevailing narratives that inadvertently exclude wheelchair users from physical fitness and health PAs.

关键词： disability Exercise MET Mobility