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Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKα1 pathways in linear cell differentiation and asymmetric cell division models

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Cellular & Molecular Immunology 2022年第10期19卷 1073-1076页

作者： Junqiong Huang scot.Leary Jim Xiang Cancer Research Cluster Saskatchewan Cancer AgencySaskatoonSKCanada Department of Oncology College of MedicineUniversity of SaskatchewanSaskatoonSKCanada Department of Blood Transfusion Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhouChina Department of Biochemistry Microbiology and ImmunologyCollege of MedicineUniversity of SaskatchewanSaskatoonSKCanada

CD8^(+)effector T(T_(E))cells play a critical role in immunity against *** response to a pathogenic stimulus,antigenpresenting cells(APCs)deliver three signals[via T-cell receptor(TCR),costimulation,and cytokines]to naive CD8^(+)T cells,stimulating their entry into a developmental program characterized by T-cell expansion followed by a contraction *** the contraction phase,90-95%of IL-7R^(-)CD62L^(-)KLRG1^(+)T_(E)cells undergo cell apoptosis.

关键词： FOXO1 immunity stimulation

Author Correction:Distinct strengths of mTORC1 control T-cell memory via transcriptional FOXO1 and metabolic AMPKa1 pathways in linear cell differentiation and asymmetric cell division models

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Cellular & Molecular Immunology 2023年第3期20卷 311-312页

作者： Junqiong Huang scot.Leary Jim Xiang Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon SK Canada Department of Oncology College of Medicine University of Saskatchewan Saskatoon SK Canada Department of Blood Transfusion Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China Department of Biochemistry Microbiology and Immunology College of Medicine University of Saskatchewan Saskatoon SK Canada

In the version of this article initially published,unintended typographical errors in the original version of Fig.1B were made during manuscript *** revised Fig.1,including the correct Fig.1B,isshown below.

关键词： FOXO1 mTORC1 initially

Sparfloxacin在小鼠体内比氟嗪酸杀麻风菌的活性更强

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地方病译丛 1994年第3期15卷 60-61页

作者： scot.,GF 韩法举

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操作人员高度评价太空气象预报

863航天技术通讯 1998年第1期 50-53页

作者： scot.,WB

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多探测器脉冲中子孔隙度测井仪器的响应

测井科技 1995年第4期 21-28页

作者： scot.,HD 张磊

Optimal design of velocity sensor for open channel flow using CFD

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International Journal of Agricultural and Biological Engineering 2017年第3期10卷 130-142页

作者： Joseph scot.Dvorak Naiqian Zhang Department of Biosystems and Agricultural Engineering University of KentuckyLexingtonKentucky 40546-0276USA Department of Biological and Agricultural Engineering Kansas State UniversityManhattanKansas 66506USA

In this study,computational fluid dynamics(CFD)was used to design the geometry of a new velocity sensor for measuring open channel *** sensor determined velocity by observing the travel of dye carried in the *** of this design required the development of fluid dynamics models to determine potential errors in fluid velocity measurement due to velocity changes caused by intrusion of the sensor in the *** also required an analysis technique to determine the expected sensor response to the flow fields that resulted from the CFD *** models were then used to improve the geometry of the sensor to minimize the measurement *** with a simple design for the sensor geometry,the CFD analysis modeled the open channel flow around the sensor as turbulent using both the k-ωand k-εReynolds Averaged Navier-Stokes(RANS)turbulence *** model predicted that the original sensor design would underestimate the free-stream velocities of open channels by 7.9%to 2.0%across a range from 0.1 m/s to 5.0 m/*** using CFD to improve the sensor design,the velocity measurement error was limited to less than 4%across the same velocity range.

关键词： computational fluid dynamics flow measurement sensors flow velocity open channel