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Targeting cell death signaling in colorectal cancer:Current strategies and future perspectives

World Journal of Gastroenterology 2014年第8期20卷 1923-1934页

作者： Bruno Christian Koehler Dirk Jger henning schulze-Bergkamen National Center for Tumor Diseases University Hospitals Heidelberg69120 HeidelbergGermany

The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. however, apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology. Various compounds have been developed and evaluated with the aim to meet with this obstacle by triggering cell death in cancer cells. The aim of this review is to illustrate current approaches and future directions in targeting cell death signaling in colorectal cancer. The complex signaling network of apoptosis will be demonstrated and the “druggability” of targets will be identified. In detail, proteins regulating mitochondrial cell death in colorectal cancer, such as Bcl-2 and survivin, will be discussed with respect to potential therapeutic exploitation. Death receptor signaling and targeting in colorectal cancer will be outlined. Encouraging clinical trials including cell death based targeted therapies for colorectal cancer are under way and will be demonstrated. Our conceptual understanding of cell death in cancer is rapidly emerging and new types of controlled cellular death have been identified. To meet this progress in cell death research, the implication of autophagy and necroptosis for colorectal carcinogenesis and therapeutic approaches will also be depicted. The main focus of this topic highlight will be on the revelation of the complex cell death concepts in colorectal cancer and the bridging from basic research to clinical use.

关键词： Colorectal cancer Apoptosis Necroptosis Autophagy Clinical trial Bcl-2 proteins Bh-3 mimetics Inflammatory bowel disease

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Birth,Survival and Death of Languages by Monte Carlo Simulation

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Communications in Computational Physics 2008年第2期3卷 271-294页

作者： C.schulze D.Stauffer S.Wichmann Institute for Theoretical Physics Cologne UniversityD-50923 KolnEuroland Department of Linguistics Max Planck Institute for Evolutionary AnthropologyDeutscher Platz 6D-04103 LeipzigGermany.

Simulations mostly by physicists of the competition between adult languagessince 2003 are reviewed. The Viviane and schulze models give good and reasonableagreement, respectively, with the empirical histogram of language sizes. Alsothe numbers of different languages within one language family is modeled reasonablyin an intermediate range. Bilingualism is now incorporated into the schulze *** the rate at which the majority shifts from one language to another is found tobe nearly independent of the population size, or to depend strongly on it, accordingto details of the schulze model. Other simulations, like Nettle-Culicover-Nowak, arereviewed more briefly.

关键词： Language competition schulze model Viviane model agent-based modeling.

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Inverted List Kinetic Monte Carlo with Rejection Applied to Directed Self-Assembly of Epitaxial Growth

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Communications in Computational Physics 2009年第8期6卷 553-564页

作者： Michael A.Saum Tim P.schulze Christian Ratsch Department of Mathematics University of TennesseeKnoxvilleTennessee 37996USA Department of Mathematics and Institute for Pure and Applied Mathematics University of California in Los AngelesLos AngelesCalifornia 90095USA

We study the growth of epitaxial thin films on pre-patterned substrates that influence the surface diffusion of subsequently deposited material using a kinetic Monte Carlo algorithm that combines the use of inverted lists with *** resulting algorithm is well adapted to systems with spatially heterogeneous hopping *** evaluate the algorithm’s performance we compare it with an efficient,binary-tree based algorithm.A key finding is that the relative performance of the inverted list algorithm improves with increasing system size.

关键词： Epitaxial growth kinetic Monte Carlo binary-tree search

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陶瓷部件的浆料打印快速成型(英文)

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硅酸盐学报 2001年第4期29卷 344-349页

作者：王树海 Jang J h schulze W A Pilgrim S M 山东工业陶瓷研究设计院山东淄博255031 NYS College of Ceramics

采用Sanders公司的四打印头快速成型机进行了陶瓷部件的浆料打印成型实验 ,实际测试了所用四打印头快速成型机的打印工作条件 ,考察了石蜡和挥发性介质两种浆料技术路线 ,并采用石蜡为介质制备了钛酸钡陶瓷浆料 ,研究了其流变性能 .实... 详细信息

采用Sanders公司的四打印头快速成型机进行了陶瓷部件的浆料打印成型实验 ,实际测试了所用四打印头快速成型机的打印工作条件 ,考察了石蜡和挥发性介质两种浆料技术路线 ,并采用石蜡为介质制备了钛酸钡陶瓷浆料 ,研究了其流变性能 .实验表明 ,虽然偶联剂的加入可以降低石蜡介质浆料的粘度 ,但是粘度足够低的可打印浆料的固相含量太低 [约 3 % (involume)以下 ] ,打印成型后不能完全烧结 ,因此 ,要通过打印成型出可完全烧结的陶瓷部件便只能采用挥发性液体作为浆料介质。

关键词：陶瓷部件浆料打印成型烧结四打印头快速成型机

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Seroconversion of hBsAG coincides with hepatitis A superinfection: A case report

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World Journal of Clinical Cases 2020年第9期8卷 1651-1655页

作者： Claudia Beisel Marylyn M Addo Julian schulze zur Wiesch Department of Internal Medicine Division of Infectious DiseaseUniversity Medical Center Hamburg-EppendorfHamburg 20251Germany German Center for Infection Research Hamburg 20251Germany

BACKGROUND hepatitis B virus(hBV)is a hepatotropic virus that can cause acute and chronic liver *** to the world health organization 257 million people are infected with chronic hBV infection ***-infection with other hepadnaviruses,including hepatitis A virus(hAV),hepatitis C virus,hepatitis D virus,and hepatitis E virus is associated with increased risk of acute liver failure in patients with chronic *** SUMMARY here,we report a case of a 47-year old male patient with hBV-related compensated Child A cirrhosis,who presented with general fatigue,malaise and laboratory signs of acute *** the patient was regularly seen at a specialized university liver unit,the hAV vaccination status was *** hAV super-infection was diagnosed by positive serological and polymerase chain reaction *** acute hAV super-infection,spontaneous hBsAg elimination and development of an anti-hBs titer were *** This case illustrates the importance of carefully checking the vaccination *** our patient,unspecific immunological responses to hAV led to functional cure of hBV.

关键词： Chronic hepatitis B infection Liver cirrhosis Acute hepatitis A infection hBsAg clearance Functional cure Case report

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Lipid droplet dynamics in alcoholic fatty liver disease

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Liver Research 2019年第3期3卷 185-190页

作者： Ryan J.schulze Wen-Xing Ding Department of Biochemistry and Molecular Biology and the Division of Gastroenterology and hepatology Mayo ClinicRochesterMNUSA Department of Pharmacology Toxicologyand TherapeuticsThe University of Kansas Medical CenterKansas CityKSUSA

The rising incidence of alcohol-related liver disease(ALD)demands making urgent progress in understanding the fundamental molecular basis of alcohol-related hepatocellular *** of the key early events accompanying chronic alcohol usage is the accumulation of lipid droplets(LDs)in the hepatocellular *** are far from inert sites of neutral lipid storage;rather,they represent key organelles that play vital roles in the metabolic state of the *** this review,we will examine the biology of these structures and outline recent efforts being made to understand the effects of alcohol exposure on the biogenesis,catabolism,and motility of LDs and how their dynamic nature is perturbed in the context of ALD.

关键词： Lipid droplet(LD) Alcohol Autophagy Lipolysis hepatocyte Steatosis

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Drug-and herb-Induced Liver Injury in Clinical and Translational hepatology:Causality Assessment Methods, Quo Vadis?

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Journal of Clinical and Translational hepatology 2013年第1期1卷 59-74页

作者： Rolf Teschke Axel Eickhoff Johannes schulze Department of Internal Medicine Ⅱ Division of Gastroenterology and Hepatology Klinikum Hanau Academic Teaching Hospital of the Medical Faculty Goethe University Frankfurt/Main Germany Institute of Industrial Environmental and Social Medicine Medical Faculty Goethe University Frankfurt/Main Germany

Drug-induced liver injury (DILI) and herb-induced liver injury (hILI) are typical diseases of clinical and translational hepatology. Their diagnosis is complex and requires an experienced clinician to translate basic science into clinical judgment and identify a valid causality algorithm. To pro-spectively assess causality starting on the day DILI or hILI is suspected, the best approach for physicians is to use the Council for International Organizations of Medical Sciences (CIOMS) scale in its original or preferably its updated version. The CIOMS scale is validated, liver-specific, structured, and quantitative, providing final causality grades based on scores of specific items for individual patients. These items include latency period, decline in liver values after treatment cessa-tion, risk factors, co-medication, alternative diagnoses, hepatotoxicity track record of the suspected product, and unintentional re-exposure. Provided causality is established as probable or highly probable, data of the CIOMS scale with all individual items, a short clinical report, and complete raw data should be transmitted to the regulatory agencies, manufacturers, expert panels, and possibly to the scientific community for further refinement of the causality evaluation in a setting of retrospective expert opinion. Good-quality case data combined with thorough CIOMS-based assessment as a standardized approach should avert subsequent necessity for other complex causality assessment methods that may have inter-rater problems because of poor-quality data. In the future, the CIOMS scale will continue to be the preferred tool to assess causality of DILI and hILI cases and should be used consistently, both prospectively by physicians, and retrospectively for subsequent expert opinion if needed. For comparability and international harmonization, all parties assessing causality in DILI and hILI cases should attempt this standardized approach using the updated CIOMS scale.

关键词： Drug-induced liver injury Drug hepatotoxicity herb-induced liver injury herbal hepatotoxicity Causality assessment

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high Quality Doloma Refractories-Essential for Stainless Steel Production

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China's Refractories 2021年第2期30卷 22-29页

作者： hilmar schulze-BERGKAMEN Eric LIU Clemens EBNER RhI Magnesita Dalian 116600China RhI Magnesita Chizhou 247000China RhI Magnesita Leoben 8700Austria

Since early 2020 RhI Magnesita has been running a fully integrated dolomite plant in Chizhou,Anhui Province,*** current operation consists of a world-class dolomite mine including a state-of-the art sinter plant equipped with rotary kiln plus a plant where shaped and unshaped doloma products are being *** raw dolomite has been a technically usable carbonate rock for decades the article describes the way from raw dolomite stone to doloma production.

关键词： dolomite doloma refractories stainless steel

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Novel Flexibilizer for Cement Rotary Kiln Bricks

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China's Refractories 2021年第2期30卷 7-11页

作者： Qiang DING Martin GEITh hilmar schulze-BERGKAMEN RhI Magnesita Dalian 116600China RhI Magnesita Leoben 8700Austria

A new type of magnesia spinel brick containing a novel flexibilizer was *** publication presents an investigation on its chemical composition,physical properties and cement clinker *** to conventional magnesia spinel bricks,the new brick type shows reduced amounts of alumina,significantly improved hot properties and resistance against cement clinker attack whilst keeping its textural flexibility on the same *** trials revealed satisfactory results and confirmed the novel flexibilizer concept.

关键词： magnesia spinel brick flexibilizer cement clinker resistance

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Glycolytic Shunts Replenish the Calvin-Benson-Bassham Cycle as Anaplerotic Reactions in Cyanobacteria

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Molecular Plant 2020年第3期13卷 471-482页

作者： Alexander Makowka Lars Nichelmann Dennis schulze Katharina Spengler Christoph Wittmann Karl Forchhammer Kirstin Gutekunst Department of Biology Botanical InstituteUniversity Kiel24118 KielGermany Institute for Systems Biotechnology Saarland University66123 SaarbruckenGermany Organismic Interactions Department Interfaculty Institute for Microbiology and Infection MedicineUniversity

The recent discovery of the Entner-Doudoroff(ED)pathway as a third glycolytic route beside Embden-Meyerhof-Parnas(EMP)and oxidative pentose phosphate(OPP)pathway in oxygenic photoautotrophs requires a revision of their central carbohydrate *** this study,unexpectedly,we observed that deletion of the ED pathway alone,and even more pronounced in combination with other glycolytic routes,diminished photoautotrophic growth in continuous light in the cyanobacterium Synechocystis *** ***,we found that the ED pathway is required for optimal glycogen catabolism in parallel to an operating Calvin-Benson-Bassham(CBB)*** is counter-intuitive that glycolytic routes,which are a reverse to the CBB cycle and do not provide any additional biosynthetic intermediates,are important under photoautotrophic ***,observations on the ability to reactivate an arrested CBB cycle revealed that they form glycolytic shunts that tap the cellular carbohydrate reservoir to replenish the *** together,our results suggest that the classical view of the CBB cycle as an autocatalytic,completely autonomous cycle that exclusively relies on its own enzymes and C02 fixation to regenerate ribulose-1,5-bisphosphate for Rubisco is an *** propose that in common with other known autocatalytic cycles,the CBB cycle likewise relies on anaplerotic reactions to compensate for the depletion of intermediates,particularly in transition states and under fluctuating light conditions that are common in nature.

关键词： central carbohydrate metabolism Calvin-Benson-Bassham cycle Entner-Doudoroff pathway oxidative pentose phosphate pathway Embden-Meyerhof-Parnas pathway cyanobacteria

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